Article
Biochemistry & Molecular Biology
Xiangmei Hua, Conrad Dean Blosch, Hannah Dorsey, Maria K. Ficaro, Nicole L. Wallace, Richard P. Hsung, Jun Dai
Summary: The study found that the expression of epidermal RORα is highly expressed in normal skin and positively regulates the expression of differentiation markers and skin barrier-related genes in keratinocytes. However, in inflammatory skin diseases including atopic dermatitis (AD), the expression of RORα is downregulated. By using a mouse model with epidermis-specific Rora deficiency, it was found that the deficiency intensified AD-like symptoms and impaired the skin barrier function. These results demonstrate the importance of epidermal RORα in suppressing AD development by maintaining normal keratinocyte differentiation and skin barrier function.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Chunying Xiao, Zhongbin Sun, Jixin Gao, Yaxing Bai, Chen Zhang, Bingyu Pang, Hongjiang Qiao, Meng Fu, Erle Dang, Gang Wang
Summary: This study demonstrated the critical role of skin barrier protein FLG in the pathogenesis of atopic dermatitis, with CPT-induced dermatitis being more severe in Flg(-/-) mice compared to wild-type mice. Additionally, emollients MPS and ceramide partially restored epidermal function and alleviated skin inflammation in the Flg(-/-) mouse model of AD induced by CPT.
Article
Plant Sciences
Yajing Gu, Xinxin Wang, Fang Liu, Jin Zhang, Xiufang Zhang, Jiping Liu, Sijia Li, Decheng Wang, Hongquan Guan, Diandong Hou
Summary: The present study investigated the effects of total flavonoids of Hippophae rhamnoides (TFH) on MC903-induced atopic dermatitis (AD)-like lesions in mice. TFH showed anti-inflammatory and immunomodulatory effects by regulating Th1/Th2 balance, inhibiting mast cell infiltration, and promoting the expression of filaggrin (FLG). TFH also reduced the expressions of cytokines and signaling proteins related to inflammation and repaired the skin barrier. These findings suggest that TFH may have potential as an external treatment for AD.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Allergy
Rinkesh K. Gupta, Jacqueline Miller, Michael Croft
Summary: This study found that the TNF family cytokine TWEAK plays an important role in keratinocyte dysregulation and the pathogenesis of AD. Blocking TWEAK and IL-13 had similar therapeutic effects in treating AD. Therefore, neutralizing TWEAK could be a potential therapeutic option for treating AD.
Review
Immunology
Risa Tamagawa-Mineoka
Summary: The skin acts as a physical barrier and toll-like receptors (TLRs) play a role in both infectious and non-infectious inflammatory diseases. In atopic dermatitis (AD), skin barrier dysfunction allows stimuli to penetrate the skin and activate the innate immune system, leading to inflammation.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Mengjie Li, Benjin Chen, Lingling Xu, Yu Wang, Zhu Chen, Bingyan Ma, Shichun Qin, Yechun Jiang, Cheng Gu, Haisheng Qian, Fengli Xiao
Summary: The study found that Bi2-xMnxO3 nanospheres (BM) were effective in alleviating skin inflammation in AD-like C57BL/6 mice. BM treatment reduced the level of inflammatory factors and increased the expression of barrier proteins in the skin. Furthermore, BM reduced the expression of phosphorylated STAT6, which resulted in decreased expression of GATA3 and Th2 cells, leading to a reduction in IL-4 expression.
JOURNAL OF NANOBIOTECHNOLOGY
(2023)
Article
Agriculture, Multidisciplinary
Shaoze Chen, Liu Tang, Tingting Nie, Mingyu Fang, Xiaoqin Cao
Summary: This study aimed to investigate the protective effects and underlying mechanisms of fructo-oligofructose (FOS) on AD-like skin manifestations and comorbid anxiety and depression in AD mice. The results showed that FOS could alleviate AD-like skin lesions and improve comorbid anxiety and depressive-like behaviors in AD mice.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2023)
Article
Immunology
Zhehuan Wang, Huiru Zhang, Caihong Qi, Hui Guo, Xiangyue Jiao, Jia Yan, Yifei Wang, Qiangsheng Li, Mingming Zhao, Xinhao Guo, Baoluo Wan, Xiaotian Li
Summary: The study found that ursolic acid (UA) has a therapeutic effect on atopic dermatitis (AD) mice, potentially by inhibiting the TLR4/NF-kappa B pathway and activating the Nrf2/HO-1 pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Food Science & Technology
Seon Gyeong Bak, Hyung Jin Lim, Yeong-Seon Won, Eun Jae Park, Young Hee Kim, Seung Woong Lee, Je Hun Oh, Ji Eun Kim, Min Jee Lee, Soyoung Lee, Seung Jae Lee, Mun Chual Rho
Summary: This study investigated the therapeutic effect of Ampelopsis brevipedunculata extract on atopic dermatitis. It was found that the extract inhibited the expression of cytokines and chemokines, leading to reduced inflammation. These findings suggest that Ampelopsis brevipedunculata extract could be used to enhance skin immunity and promote skin health and beauty.
FOOD SCIENCE & NUTRITION
(2023)
Article
Biochemistry & Molecular Biology
Anupriya Gupta, Keunwook Lee, Kwonik Oh
Summary: This study assessed the role of mTORC signaling in the development of atopic dermatitis (AD). The results showed that mTORC1 plays a dual role in AD, with pro-inflammatory effects in immune cells and anti-inflammatory effects in keratinocytes. Further studies on the role of HIF in AD are warranted.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Ana B. Arroyo, Martin Bernal-Carrion, Joaquin Canton-Sandoval, Isabel Cabas, Raul Corbalan-Velez, Teresa Martinez-Menchon, Belen Ferri, Maria L. Cayuela, Diana Garcia-Moreno, Victoriano Mulero
Summary: Atopic dermatitis (AD) is a highly prevalent chronic inflammatory skin disease with no specific treatment. Recent research has shown the critical role of NAD(+) and PAR metabolism in oxidative stress and skin inflammation. Alterations in NAMPT and PARP expression were observed in AD patients, indicating their potential as therapeutic targets for skin inflammatory disorders. Pharmacological inhibition of NAMPT and PARP reduced AD-associated biomarkers in a human 3D organotypic skin model, suggesting new potential treatments for AD patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Plant Sciences
Byung-Hak Kim, Sanghyun Lee
Summary: Sophoricoside can improve AD-like allergic skin diseases mainly by inhibiting pathogenic CD4(+) T cell differentiation and immune responses.
Article
Immunology
Chandra K. K. Singh, Charlotte A. A. Mintie, Mary A. A. Ndiaye, Gagan Chhabra, Sushmita Roy, Ruth Sullivan, B. Jack Longley, Stefan M. M. Schieke, Nihal Ahmad
Summary: In this study, dietary grape powder was found to alleviate AD-like symptoms in mice. It reduced skin lesions, decreased inflammation markers, and modulated various cytokines/chemokines. These findings suggest that grape powder may be a promising approach for AD management.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Dermatology
Bolor Nasanbat, Akihiko Uchiyama, Syahla Nisaa Amalia, Yuta Inoue, Yoko Yokoyama, Sachiko Ogino, Ryoko Torii, Mari Hosoi, Sei-ichiro Motegi
Summary: The study found that kaempferol has anti-inflammatory activity and may alleviate symptoms of atopic dermatitis by suppressing type 2 inflammation and improving barrier function. This research provides potential for kaempferol to be a new treatment for atopic dermatitis.
JOURNAL OF DERMATOLOGICAL SCIENCE
(2023)
Article
Dermatology
Liu Tang, Xiaoqin Cao, Xiaolei Li, Hong Ding
Summary: The study showed that topical application of conjugated linoleic acid (CLA) significantly improved skin lesions, itching, and inflammation in a murine model of AD. CLA modulated skin barrier function and inflammation response, providing protective effects against AD lesional skin.
EXPERIMENTAL DERMATOLOGY
(2021)