Article
Geriatrics & Gerontology
Jose Luis Perez-Lasierra, Jose A. Casajus, Alejandro Gonzalez-Aguero, Belen Moreno-Franco
Summary: The study aimed to analyze the association of physical activity with the prevalence of sarcopenia, osteoporosis, and osteoarthritis in non-institutionalized American population aged over 50. Results showed that performing a certain amount of physical activity per week was associated with reduced odds for each of the three diseases, indicating the benefits of physical activity in preventing sarcopenia, osteoporosis, and osteoarthritis among Americans over 50 years old.
EXPERIMENTAL GERONTOLOGY
(2022)
Review
Medicine, General & Internal
Elena Tsourdi, Athanasios D. Anastasilakis, Lorenz C. Hofbauer, Martina Rauner, Franziska Lademann
Summary: Irisin is a hormone-like myokine produced by skeletal muscle during exercise. It plays a role in the browning process, thermogenesis, and regulates the functions of osteoblasts, osteoclasts, and osteocytes. Recent studies have shown that serum irisin levels decrease with age and in conditions involving bone diseases. However, the validity and reproducibility of current methods of irisin measurement are under question.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Nutrition & Dietetics
Maryam Pourhassan, Bjoern Buehring, Ulrik Stervbo, Sven Rahmann, Felix Moelder, Sebastian Ruetten, Ulrike Trampisch, Nina Babel, Timm Henning Westhoff, Rainer Wirth
Summary: The study found that osteoporosis and sarcopenia are common in older hospitalized patients, with some overlap between the two conditions known as osteosarcopenia. Nearly all sarcopenic patients also had osteoporosis, while only a small percentage of patients with low BMD also had sarcopenia.
Review
Biochemistry & Molecular Biology
Peter Pietschmann, Maria Butylina, Katharina Kerschan-Schindl, Wolfgang Sipos
Summary: Patients with RA are at increased risk of developing osteoporosis, potentially due to autoimmune inflammatory processes leading to systemic inflammation and osteoporosis. Specific treatment for osteoporosis should be considered in RA patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Endocrinology & Metabolism
Ruth Durdin, Camille Parsons, Elaine M. Dennison, Suzanne Williams, Therese Tillin, Nishi Chaturvedi, Cyrus Cooper, Nicholas C. Harvey, Kate A. Ward
Summary: The study aimed to investigate whether central adiposity or inflammatory status contribute to ethnic differences in bone mineral density (BMD). The study found that despite adjustment for body composition, central adiposity, and inflammation, ethnic differences in BMD still existed. Additionally, ethnic differences were observed in the relationship between BMI, LMI or VAT mass and lumbar spine BMD in women.
Article
Endocrinology & Metabolism
Leo D. Westbury, Holly E. Syddall, Nicholas R. Fuggle, Elaine M. Dennison, Nicholas C. Harvey, Jane A. Cauley, Eric J. Shiroma, Roger A. Fielding, Anne B. Newman, Cyrus Cooper
Summary: The study found that components of sarcopenia and other body composition parameters were related to adverse clinical outcomes such as mortality, hospital admission, low trauma fracture, and recurrent falls. Lower baseline levels and greater declines in these parameters were associated with increased rates of adverse outcomes, suggesting interventions to reduce age-related decline may be beneficial.
CALCIFIED TISSUE INTERNATIONAL
(2021)
Article
Food Science & Technology
Mijin Kim, Hiroko Isoda, Tomohiro Okura
Summary: The study suggests that the combined intake of citrulline and leucine, along with exercise, can improve body weight, BMI, body mass, and physical activity in older women with low BMI, which may help prevent sarcopenia and frailty.
Article
Multidisciplinary Sciences
Franziska Alexandra Meister, Suekran Verhoeven, Anna Mantas, Wen-Jia Liu, Decan Jiang, Lara Heij, Daniel Heise, Philipp Bruners, Sven Arke Lang, Tom Florian Ulmer, Ulf Peter Neumann, Jan Bednarsch, Zoltan Czigany
Summary: Osteopenia is significantly associated with worse overall survival and disease-free survival in patients undergoing curative intent-surgery for hepatocellular carcinoma. It is also confirmed as an independent risk-factor for inferior overall survival in this patient population.
SCIENTIFIC REPORTS
(2022)
Article
Immunology
Anjali Sharma, Donald R. Hoover, Qiuhu Shi, Phyllis C. Tien, Kathleen M. Weber, Jayesh G. Shah, Michael T. Yin
Summary: Among pre-, peri-, and postmenopausal women, low bone mineral density (BMD) was more common in women with HIV compared to those without HIV. HIV infection and menopausal stage were independent predictors of lower BMD and had additive effects on lumbar spine and total hip BMD.
CLINICAL INFECTIOUS DISEASES
(2022)
Article
Nutrition & Dietetics
Marie Mathieu, Pascale Guillot, Typhaine Riaudel, Anne-Sophie Boureau, Guillaume Chapelet, Celine Brouessard, Laure de Decker, Gilles Berrut
Summary: This study aimed to explore the relationship between osteoporosis and sarcopenia in women aged 75 or older, revealing a significant association between fat mass and bone density, with osteosarcopenic patients having lower fat mass and body mass index.
Article
Orthopedics
Lulu Cheng, Siyu Wang
Summary: This study investigated the relationship between lumbar bone mineral density (BMD) and low muscle mass, as well as the muscle-bone-lipid link. The results showed a negative association between lumbar BMD and sarcopenia in US adults. This association may be related to the pathogenesis of bone loss.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Dong-Cheol Baek, Seung-Ju Hwang, Jin-Seok Lee, Jing-Hua Wang, Chang-Gue Son, Eun-Jung Lee
Summary: This study aimed to evaluate the therapeutic effects and underlying mechanisms of a mixture (BPX) of Cervus elaphus sibiricus and Glycine max on osteoporosis using an ovariectomized mouse model. The results showed that BPX significantly improved bone mineral density and volume by regulating bone formation-related molecules and signaling pathways. These findings provide experimental evidence for the pharmaceutical potential of BPX as a candidate for anti-osteoporosis treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Endocrinology & Metabolism
Philippe Paul Wagner, Danielle E. Whittier, Dominique Foesser, Steven K. Boyd, Roland Chapurlat, Pawel Szulc
Summary: In men, those with low lower-limb relative appendicular lean mass (RALM-LL) and poor physical performance showed faster decline in bone microarchitecture and estimated bone strength, leading to higher risk of falls and fractures.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Endocrinology & Metabolism
Giulia Gregori, Arjun Paudyal, Yoann Barnouin, Alessandra Celli, Martha Belen Segoviano-Escobar, Reina Armamento-Villareal, Nicola Napoli, Clifford Qualls, Dennis T. Villareal
Summary: This study aimed to determine the relationship between indices of sarcopenic obesity (SO) and bone strength in older adults with obesity. The findings suggest that lower muscle mass and strength and higher fat mass may impair bone quality.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Kristina Norman, Catrin Herpich, Ursula Mueller-Werdan
Summary: Age-related changes in body composition are linked to increased risk for disease and disability. The phase angle, derived from bioimpedance analysis, decreases with age and disease and can predict various clinical outcomes and mortality. This review summarizes the association between the phase angle and geriatric syndromes, as well as its reaction to interventions.
REVIEWS IN ENDOCRINE & METABOLIC DISORDERS
(2023)
Review
Multidisciplinary Sciences
Anahita Rashid, Sabina Chaudhary Hauge, Charlotte Suetta, Ditte Hansen
Summary: This systematic review explored the occurrence of osteoporosis, falls, and fractures in patients with sarcopenia and CKD, and found a significant association between sarcopenia and decreased bone mineral density/osteoporosis in patients with CKD. However, due to the heterogeneity of the included studies, a meta-analysis could not be conducted.
Article
Geriatrics & Gerontology
Rikke S. Kamper, Julian Alcazar, Lars L. Andersen, Bryan Haddock, Niklas Rye Jorgensen, Peter Hovind, Charlotte Suetta
Summary: The study investigated the relationship between chronic low-grade inflammation and age-related muscle decline and physical performance. Results showed that with age, levels of certain inflammatory biomarkers in the blood increased significantly, correlating with decreased muscle strength and physical function.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2021)
Article
Medicine, Research & Experimental
Jonas Ammundsen Ipsen, Lars T. Pedersen, Bjarke Viberg, Birgitte Norgaard, Charlotte Suetta, Inge H. Bruun
Summary: Hip fracture is a serious event for older adults, and the gap in healthcare delivery might contribute to inferior rehabilitation and care. This study aims to assess the effect of continuous and progressive rehabilitation and care across sectors for older adults after hip fracture.
Article
Physiology
Christoph Centner, Simon Jerger, Alistair Mallard, Anna Herrmann, Eugenia Varfolomeeva, Sandra Gollhofer, Steffen Oesser, Carsten Sticht, Norbert Gretz, Per Aagaard, Jakob L. Nielsen, Ulrik Frandsen, Charlotte Suetta, Albert Gollhofer, Daniel Koenig
Summary: This study investigated the effects of specific collagen peptides (CP) intake on gene expression pathways related to skeletal muscle signal transduction during acute high-load resistance exercise. The results showed that intake of CP led to a more pronounced upregulation of key anabolic pathways in human skeletal muscle, compared to placebo. Further studies should explore the potential relationships between upregulated gene expression and changes in myofibrillar protein synthesis as well as the long-term effects on anabolic pathways on the protein level.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Endocrinology & Metabolism
S. E. Bonlokke, M. S. Rand, B. Haddock, S. Arup, C. D. Smith, J. E. B. Jensen, P. Schwarz, P. Hovind, P. S. Oturai, L. T. Jensen, S. Moller, P. Eiken, K. H. Rubin, M. F. Hitz, B. Abrahamsen, N. R. Jorgensen
Summary: Anti-resorptive osteoporosis treatment may be more effective in patients with high bone turnover, as indicated by biochemical markers. Pre-treatment levels of bone turnover markers can predict patients' response to antiresorptive treatment. Patients with high pre-treatment levels of CTX and/or PINP may benefit more from antiresorptive treatment with larger increases in BMD.
OSTEOPOROSIS INTERNATIONAL
(2022)
Article
Oncology
Lise H. Omland, Ulla N. Joensen, Birgitte G. Toft, Cecilia M. Lund, Henriette Lindberg, Mark B. Knudsen, Anders Tolver, Charlotte Suetta, Helle Pappot
Summary: This study investigated the proportion of patients with locally advanced, unresectable or metastatic urothelial carcinoma who did not receive systemic anticancer treatment, as well as the reasons for lack of treatment and overall survival. The results showed that one in three patients in the pre-immunotherapy era did not receive treatment, primarily due to poor physical condition, decreased renal function, or patient preferences. The findings emphasize the urgent need for novel and better tolerated treatment regimens for this frail patient group.
Review
Psychology, Biological
Samuel Amorim, Andre Carvalho Felicio, Per Aagaard, Charlotte Suetta, Rolf Ankerlund Blauenfeldt, Grethe Andersen
Summary: The aging process can lead to a decline in cognitive function, but Remote Ischemic Conditioning (RIC) may help improve these changes. This study compared the effects of single, repeated short-term, and long-term RIC treatments on cognitive performance. It found that single RIC treatment did not have a lasting effect on cognition, but repeated short-term RIC showed some improvement and long-term RIC may improve cognitive performance after stroke or in patients with vascular dementia.
PHYSIOLOGY & BEHAVIOR
(2022)
Article
Chemistry, Multidisciplinary
Youssif Merhi, Pablo F. Betancur, Teresa S. Ripolles, Charlotte Suetta, Morten R. Brage-Andersen, Sofie K. Hansen, Anders Frydenlund, Jens Vinge Nygaard, Peter H. Mikkelsen, Pablo P. Boix, Shweta Agarwala
Summary: Muscle atrophy is a common problem caused by immobilization and critical illness, leading to rehabilitation difficulties and increased mortality. This study presents a solution for preserving muscle mass through the use of a customized biocompatible neuromuscular electrical stimulation (NMES) device. The integration of dry and biocompatible electrodes into a compressive stocking textile was demonstrated, resulting in extended usage without skin irritation. Electrochemical analysis showed improved performance of the printed electrodes compared to commercial ones, and promising results were obtained in a hospital setting for muscle atrophy evaluation.
Article
Oncology
Troels Gammeltoft Dolin, Marta Kramer Mikkelsen, Henrik Loft Jakobsen, Anders Vinther, Bo Zerahn, Dorte Lisbet Nielsen, Julia Sidenius Johansen, Cecilia Margareta Lund, Charlotte Suetta
Summary: This study aimed to investigate the prevalence of preoperative sarcopenia and cachexia in older vulnerable patients with localized colorectal cancer. The results showed that 28% of patients had low muscle strength, 13% met the criteria for sarcopenia, and 33% had low muscle mass. There was an association between low muscle mass and cachexia, but no association between sarcopenia and cachexia.
JOURNAL OF GERIATRIC ONCOLOGY
(2023)
Review
Oncology
Sandra Jensen, Zina Bloch, Morten Quist, Tobias Tuse Dunk Hansen, Christoffer Johansen, Helle Pappot, Charlotte Suetta, Bolette Skjodt Rafn
Summary: In patients with lung cancer, chemotherapy treatment leads to significant loss of skeletal muscle mass and a high prevalence of sarcopenia. This is associated with poor clinical outcomes and emphasizes the need for assessment and interventions targeting skeletal muscle mass during treatment.
Article
Physiology
Christopher T. A. Lewis, Lee Tabrizian, Joachim Nielsen, Jenni Laitila, Thomas N. Beck, Mathilde S. Olsen, Marija M. Ognjanovic, Per Aagaard, Rune Hokken, Simon Laugesen, Arthur Ingersen, Jesper L. Andersen, Casper Soendenbroe, Jorn W. Helge, Flemming Dela, Steen Larsen, Ronni E. Sahl, Tue Romer, Mikkel T. Hansen, Jacob Frandsen, Charlotte Suetta, Julien Ochala
Summary: Lewis et al. investigated the influence of training status on relaxed myosin conformations and found that moderate physical activity leads to a shift in relaxed myosin conformation, resulting in reduced ATP consumption. Their study revealed that physical activity level and training type can influence resting skeletal muscle myosin dynamics, suggesting that environmental stimuli such as exercise can rewire the molecular metabolism of human skeletal muscle through myosin.
JOURNAL OF GENERAL PHYSIOLOGY
(2023)
Article
Neurosciences
Javier Botella, Camilla T. Schytz, Thomas F. Pehrson, Rune Hokken, Simon Laugesen, Per Aagaard, Charlotte Suetta, Britt Christensen, Niels Ortenblad, Joachim Nielsen
Summary: This study investigated the mitochondrial structural characteristics in skeletal muscle of strength athletes compared to untrained controls. The results showed that strength athletes had increased mitochondrial cristae density, decreased mitochondrial size, and increased surface-to-volume ratio in their mitochondrial pool, despite similar mitochondrial volume density. In addition, resistance exercise led to mild mitochondrial stress but did not increase the number of damaged mitochondria. Moreover, the study found that acute resistance exercise increased the expression of markers of mitochondrial biogenesis, fission, and mitochondrial unfolded protein responses (UPRmt), and strength-trained individuals showed an enrichment of the UPRmt in their basal transcriptome. These findings suggest that strength athletes have a unique mitochondrial remodeling that minimizes the space required for mitochondria.
JOURNAL OF PHYSIOLOGY-LONDON
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Thomas E. H. Justesen, Per Borghammer, Joel Aanerud, Peter Hovind, Lisbeth Marner
Summary: The commonly used antidepressant sertraline has been found to interfere with the results of [F-18]FE-PE2I PET, leading to reduced binding in the caudate nucleus. It is recommended to take sertraline treatment into account when performing [F-18]FE-PE2I PET, especially in patients with apparent globally reduced PE2I binding. Consideration should be given to pausing sertraline treatment, particularly for doses above 50 mg/day.
Article
Geriatrics & Gerontology
Morten Bruun Korsholm, Thea Winther Podenphanth, Sofie Kirstine Stromgaard, Linda Wiuff Petersen, Christina Alexandersen, Sarah Samama Hoffmann, Hanne K. Rasmusen, Charlotte Suetta, Kirsten Damgaard, Eckart Pressel, Flemming Dela
Summary: This study examined the potential subclinical muscle discomfort and loss of muscle mass and strength in older people with long-term statin treatment. The results showed that muscle performance improved and muscle discomfort decreased after discontinuation of statins, but worsened when statins were reintroduced. These findings suggest a possible statin-related decline in muscle function in older individuals.
Article
Neurosciences
Cecilia Elam, Lars G. Hvid, Ulrik Christensen, Michael Kjaer, S. Peter Magnusson, Per Aagaard, Lina Bunketorp Kall, Charlotte Suetta
Summary: The study found that two weeks of lower limb immobilization led to decreases in maximal muscle power in both old and young men, while postural control was impaired selectively in old men. Sit-to-stand performance and step test improved in old men following retraining, and all parameters returned to baseline levels after retraining in both groups.
JOURNAL OF MUSCULOSKELETAL & NEURONAL INTERACTIONS
(2022)