Article
Ophthalmology
Marta Blanco-Vazquez, Amanda Vazquez, Itziar Fernandez, Andrea Novo-Diez, Elena Martinez-Plaza, Carmen Garcia-Vazquez, Maria J. Gonzalez-Garcia, Eva M. Sobas, Margarita Calonge, Amalia Enriquez-de-Salamanca
Summary: The purpose of this study was to analyze inflammation-and pain-related molecules in tears of patients suffering from chronic ocular pain associated with dry eye and/or a previous corneal refractive surgery. The study found that IL-10 and SP levels in tears were increased in patients with a history of corneal refractive surgery. IL-9 levels were associated with chronic ocular pain. These findings suggest that tear cytokines and neuromodulators could serve as biomarkers for chronic ocular pain, leading to improved therapeutic and disease management decisions.
EXPERIMENTAL EYE RESEARCH
(2022)
Article
Ophthalmology
Marta Blanco-Vazquez, Amanda Vazquez, Itziar Fernandez, Andrea Novo-Diez, Elena Martinez-Plaza, Carmen Garcia-Vazquez, Maria J. Gonzalez-Garcia, Eva M. Sobas, Margarita Calonge, Amalia Enriquez-de-Salamanca
Summary: The purpose of this study was to analyze inflammation- and pain-related molecules in tears of patients suffering from chronic ocular pain associated with dry eye and/or a previous corneal refractive surgery. The results showed that IL-9 tear levels were increased in patients with chronic ocular pain, IL-10, SP, MIP-1 alpha/CCL3, IL-2, and IFN-gamma were associated with previous surgery, and IL-8/CXCL8, MIP-1 alpha/CCL3, IL-2, and IFN-gamma were associated with DE-related inflammation. Higher NGF levels were related to chronic ocular pain and DE in patients with previous surgery. These findings are important for understanding biomarkers of chronic ocular pain and making better therapeutic and disease management decisions.
EXPERIMENTAL EYE RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Benjamin Paik, Louis Tong
Summary: This study suggests that topical omega-3 is a promising treatment for dry eye, with evidence from human trials showing improvements in ocular surface staining and tear break-up time. However, further research is needed to confirm the effects on other aspects of dry eye.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Medicine, General & Internal
Lina Mikalauskiene, Andrzej Grzybowski, Reda Zemaitiene
Summary: Dry eye disease can cause ocular discomfort and visual disturbances, with older adults being at higher risk when needing ophthalmic surgery. Factors such as preoperative dry eye disease, surgical procedures, and postoperative treatment can contribute to ocular surface dysfunction.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, General & Internal
Matias Soifer, Nadim S. Azar, Hazem M. Mousa, Victor L. Perez
Summary: Ocular surface inflammatory disorders (OSID) are inflammatory reactions in the ocular adnexal connective tissues caused by systemic disorders, resulting in inflammatory dry eye. The lack of available biomarkers for detecting and quantifying inflammation in the conjunctiva and lacrimal gland is a major limitation in managing these conditions. OSID and dry eye syndrome involve different immune cells and understanding the potential role of inflammation and immune phenotype in ocular tissues is crucial.
FRONTIERS IN MEDICINE
(2022)
Review
Ophthalmology
Barry Schechter, Francis Mah
Summary: Proper preoperative management of ocular surface disease is crucial in reducing inflammation, resolving infection, improving epithelial pathology, stabilizing the tear film, and promoting positive long-term outcomes after ophthalmic surgery.
OPHTHALMOLOGY AND THERAPY
(2022)
Review
Biochemistry & Molecular Biology
Alba Ramos-Llorca, Camilla Scarpellini, Koen Augustyns
Summary: This review examines the implications of proteases in the development and severity of dry eye disease and discusses the progress in utilizing protease inhibitors as potential therapeutic tools.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Ophthalmology
Zhang Zhang, Xinrong Zou, Wenwen Xue, Pei Zhang, Shanshan Wang, Haidong Zou
Summary: The study investigated the ocular surface commensal bacteria profiles of patients with diabetes mellitus and dry eye disease, revealing differences in microbial composition between the groups. Patients with diabetes mellitus and dry eye disease had a more complex microbial composition compared to other groups, with unique core genera identified in each group. The findings provide insights into the microbial profile of dry eye disease in patients with diabetes mellitus.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2021)
Article
Medicine, General & Internal
Tal Yahalomi, Asaf Achiron, Roee Arnon, Nir Stanescu, Joseph Pikkel
Summary: Dry eye disease is a common complication after refractive surgery, with LASIK surgery and female gender being associated with higher risk. This prospective study examined the development of dry eye disease after LASIK, PRK, and LASEK surgeries, and found that LASIK patients had higher severity scores. Female gender and the amount of refractive correction were correlated with severe dry eye disease after surgery. Patients, especially those with high myopia, should be informed about the risk of developing dry eye after refractive surgeries.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Noriaki Nagai, Shunsuke Sakurai, Ryotaro Seiriki, Misa Minami, Mizuki Yamaguchi, Saori Deguchi, Eiji Harata
Summary: The MPC polymer prepared in this study showed hydrating effects without causing corneal damage, promoting tear film maintenance and improvement in dry eye symptoms.
Article
Ophthalmology
Li Yang, Ling Zhang, Ren Jian Hu, Ping Ping Yu, Xiuming Jin
Summary: The study found that wearing orthokeratology lenses may increase ocular surface disease index and damage to the meibomian glands, with significant differences in noninvasive tear breakup time and corneal fluorescein staining compared to the control group.
CONTACT LENS & ANTERIOR EYE
(2021)
Article
Medicine, General & Internal
Louis Tong, Florentin Constancias, Aihua Hou, Song Lin Chua, Daniela I. Drautz-Moses, Stephan Christoph Schuster, Liang Yang, Rohan B. H. Williams, Staffan Kjelleberg
Summary: The study describes the conjunctival microbiome in people with mild dry eye in Singapore and found that the microbial composition was similar to age-matched controls. Age was identified as an important factor that affects the composition of the conjunctival microbiome, and the relative abundance of specific microorganisms may vary according to the host environment.
FRONTIERS IN MEDICINE
(2022)
Article
Medicine, Research & Experimental
Chae Eun Kim, Young Jin Kim, Moon Won Hwang, Young-Joon Park, Jaewook Yang
Summary: This study showed that CVM was as effective as commercial drugs in improving tear production, corneal condition, and epithelial cell density in a murine dry eye model, indicating its potential as a treatment option for dry eye syndrome.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Biochemistry & Molecular Biology
Chang Ho Yoon, Jin Suk Ryu, Jung Hwa Ko, Joo Youn Oh
Summary: This study revealed that aberrant fucosylation plays a crucial role in the pathogenesis of dry eye disease (DED) and may serve as a novel target for DED therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Ophthalmology
Brandon S. Baksh, Melina Morkin, Elizabeth Felix, Carol L. Karp, Anat Galor
Summary: This study characterized ocular pain symptoms in individuals with and without a history of refractive surgery (RS). The results showed that individuals with a history of RS developed ocular pain soon after surgery, which persisted for years. The symptom profiles were similar between those with and without RS, and both groups can treat pain with topical and systemic approaches.
Article
Biochemistry & Molecular Biology
Horlando Carlota da Silva, Aurelio de Oliveira Monteiro, Francisco Wagner de Queiroz Almeida-Neto, Emanuelle Machado Marinho, Maria Kueirislene Amancio Ferreira, Francisco Rogenio da Silva Mendes, Emmanuel Silva Marinho, Marcia Machado Marinho, Lucas Lima Bezerra, Matheus Nunes da Rocha, Jane Eire Silva Alencar de Menezes, Alexandre Magno Rodrigues Teixeira, Antonio Wlisses da Silva, Emanuela de Lima Reboucas, Francisco das Chagas Lima Pinto, Helcio Silva dos Santos, Gilvandete Maria Pinheiro Santiago
Summary: Diabetes mellitus is a chronic metabolic disorder that has been increasing drastically worldwide. The study found that fisetinidol, a compound obtained from plants, has potential hypoglycemic and hepatoprotective effects, and shares the same inhibitory mechanisms as existing antidiabetic drugs.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Ophthalmology
Margarita Calonge, Marwan Sahyoun, Stephanie Baillif, Philippe Gain, Ewa Paw, Ali Mearza, Beatrice Cochener
Summary: This study compared the improvement of ocular signs and symptoms in patients with moderate to severe dry eye disease using 0.30% sodium hyaluronate (0.30%HA) ocular gel and 0.18%HA eye drops. The results showed that both concentrations significantly improved corneal staining, with 0.30%HA demonstrating a faster effect on conjunctival epithelium healing. There was no difference between the two concentrations in terms of tear film break-up time or Schirmer test improvements. Both groups showed similar improvements in dry eye disease symptoms and satisfaction with treatment. The frequency of instillation was also similar for both groups.
EUROPEAN JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Obstetrics & Gynecology
Victor Blasco, Francisco M. Pinto, Ainhoa Fernandez-Atucha, Nicolas Prados Dodd, Manuel Fernandez-Sanchez, Luz Candenas
Summary: Neurokinin B and its receptors have a significant role in the regulation of female reproduction. Abnormal expression of these molecules may be associated with decreased fertility in women with infertility, providing new insights for diagnosis and treatment.
REPRODUCTIVE SCIENCES
(2023)
Review
Clinical Neurology
Susana Lopez-Ortiz, Simone Lista, Pedro L. Valenzuela, Jose Pinto-Fraga, Ricardo Carmona, Filippo Caraci, Giuseppe Caruso, Nicola Toschi, Enzo Emanuele, Audrey Gabelle, Robert Nistico, Francesco Garaci, Alejandro Lucia, Alejandro Santos-Lozano
Summary: The study summarizes the relationship between physical activity and the development of Alzheimer's disease, as well as the impact of exercise on patients with Alzheimer's disease. The findings suggest that physical activity can lower the risk of Alzheimer's disease and exercise has positive effects on cognitive function, physical performance, and functional independence.
JOURNAL OF NEUROLOGY
(2023)
Review
Oncology
Celia Garcia-Chico, Susana Lopez-Ortiz, Saul Penin-Grandes, Jose Pinto-Fraga, Pedro L. Valenzuela, Enzo Emanuele, Claudia Ceci, Grazia Graziani, Carmen Fiuza-Luces, Simone Lista, Alejandro Lucia, Alejandro Santos-Lozano
Summary: The prevalence of breast cancer is increasing and there is a need to investigate the molecular pathways that influence its progression. This review aims to describe the effects of physical exercise on breast cancer hallmarks, which are associated with the development of the disease. Regular physical exercise has positive effects on all major hallmarks of breast cancer and may help counteract its progression.
Article
Chemistry, Physical
Francisco J. Pinto, Jose Toledo, Matias Birrell, Ramiro Bazaez, Francisco Hernandez, Rodrigo Astroza
Summary: Bridges are crucial structures in a country's logistic chain and designing them to be resilient is important. Performance-based seismic design (PBSD) using nonlinear Finite Element (FE) models can predict the response and potential damage of different structural components under earthquake excitations. This study proposes a Bayesian probabilistic framework to update the parameters of seismic bars and elastomeric bearings based on actual data from comprehensive experimental campaigns.
Article
Pediatrics
Carmen Matey-Rodriguez, Susana Lopez-Ortiz, Saul Penin-Grandes, Jose Pinto-Fraga, Pedro L. Valenzuela, Monica Pico, Carmen Fiuza-Luces, Simone Lista, Alejandro Lucia, Alejandro Santos-Lozano
Summary: This study aimed to analyze the accuracy of Evenson cut-points for estimating moderate-to-vigorous intensity physical activity (MVPA) and sedentary behavior (SB) in children and adolescents with disabilities, as well as to define new equations for estimating energy expenditure (EE) in this population, particularly in those with cerebral palsy (CP). Specific GT3X+ cut-points were also defined for estimating MVPA in individuals with CP. The results indicate that using specific ActiGraph GT3X+ cut-points is accurate for estimating MVPA levels in children and adolescents with disabilities, especially those with CP, at least in laboratory conditions.
Review
Cardiac & Cardiovascular Systems
Saul Penin-Grandes, Susana Lopez-Ortiz, Sergio Maroto-Izquierdo, Hector Menendez, Jose Pinto-Fraga, Juan Martin-Hernandez, Simone Lista, Alejandro Lucia, Alejandro Santos-Lozano
Summary: This systematic review evaluates the effects of regular exercise in patients with peripheral arterial disease (PAD) by summarizing published meta-analyses. The review finds that exercise has a positive impact on functional parameters and health-related quality of life in PAD patients. Supervised aerobic exercise is particularly effective in improving walking-related outcomes and pain, while resistance exercise is more effective for improving lower limb strength.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Article
Multidisciplinary Sciences
Ivan Fernandez-Bueno, Luis Ignacio Olcina, Cristina Andres-Iglesias, Kevin Puertas-Neyra, Itziar Fernandez-Martinez, Ricardo Usategui-Martin, Miguel Jose Maldonado-Lopez
Summary: This study evaluates the safety, biocompatibility, and functionality of a new accommodative intraocular lens (IOL) in rabbit eyes. The results show that the new lens remained centered and had fewer complications compared to the control group. Functional studies revealed no significant differences between the two materials. Overall, the new IOL showed minimal local biological effects and is comparable to the control group.
Article
Ophthalmology
Laura Valencia-Nieto, Alberto Lopez-de la Rosa, Maria J. Gonzalez-Garcia, Alberto Lopez-Miguel
Summary: This study assessed the reliability and agreement of NIBUT in symptomatic and asymptomatic contact lens wearers. The objective assessment using the CA-800 device provided more reliable measurements compared to the subjective assessment using the EasyTear device. However, the objective method indicated shorter NIBUT values.
OPHTHALMIC AND PHYSIOLOGICAL OPTICS
(2023)
Meeting Abstract
Ophthalmology
Laura Valencia-Nieto, Jose Pinto-Fraga, Marta Blanco-Vazquez, Itziar Fernandez, Alberto Lopez-Miguel, Carmen Garcia-Vazquez, Maria J. Gonzalez-Garcia, Amalia Enriquez-De-Salamanca, Margarita Calonge
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2022)
Meeting Abstract
Cardiac & Cardiovascular Systems
C. Oliveira, P. Silverio Antonio, S. Couto Pereira, P. Alves Da Silva, J. Brito, B. Valente Silva, A. M. Martins, B. Garcia, J. Rigueira, R. Placido, F. J. Pinto, A. Almeida
EUROPEAN JOURNAL OF HEART FAILURE
(2022)
Article
Ophthalmology
He-Yan Li, Li Dong, Xu-Han Shi, Rui-Heng Zhang, Wen-Da Zhou, Hao-Tian Wu, Chu-Yao Yu, Yi-Tong Li, Yi-Fan Li, Jost B. Jonas, Wen-Bin Wei, Yue-Ming Liu
Summary: This study aimed to examine the intraocular tolerability of cetuximab when applied intravitreally, and its effect on axial elongation. The results showed that intravitreal injections of cetuximab could reduce axial elongation in a dose-dependent and number of treatment-dependent manner, without causing intraocular toxic effects.
EXPERIMENTAL EYE RESEARCH
(2024)
Article
Ophthalmology
James D. Cole, John A. McDaniel, Joelle Nilak, Ashley Ban, Carlos Rodriguez, Zuhaad Hameed, Marta Grannonico, Peter A. Netland, Hu Yang, Ignacio Provencio, Xiaorong Liu
Summary: Aniridia is a panocular condition characterized by the loss of iris, caused mainly by mutations in the PAX6 gene. This study assessed the effects of Pax6-haploinsufficiency on retinal morphology and vision in Pax6Sey mice. The results showed elevated intraocular pressure and declining visual acuity in Pax6Sey mice, along with local retinal damage and a possible neuroinflammatory response.
EXPERIMENTAL EYE RESEARCH
(2024)
Article
Ophthalmology
Subao Jiang, Ning Xia, Francesco Buonfiglio, Elsa W. Boehm, Qi Tang, Norbert Pfeiffer, Dominik Olinger, Huige Li, Adrian Gericke
Summary: This study found that a high-fat diet induces endothelial dysfunction in the ophthalmic artery, leading to impaired vascular function in the eye. The high-fat diet triggers oxidative stress and involves RAGE and NOX2.
EXPERIMENTAL EYE RESEARCH
(2024)
Review
Ophthalmology
Mala Upadhyay, Vera L. Bonilha
Summary: The sodium iodate (NaIO3) model is a valuable tool in studying dry AMD and evaluating the retinal structure. Through extensive research, it has been found that the death of RPE cells caused by NaIO3 injection is closely related to vision loss in patients with dry AMD. Therefore, studying NaIO3 can provide insights into the mechanisms of RPE and photoreceptor cell death and contribute to understanding RPE degeneration in AMD.
EXPERIMENTAL EYE RESEARCH
(2024)
Article
Ophthalmology
Vicki Chrysostomou, Katharina C. Bell, Sze Woei Ng, Samyuktha Suresh, Gayathri Karthik, Marion Millet, Yingying Chung, Jonathan G. Crowston
Summary: We present a new experimental model for inducing retinal ganglion cell (RGC) dysfunction and degeneration in mice. This model allows for the reliable induction of RGC dysfunction and loss, with the resilience of the optic nerve being dependent on the age of the animal. The time-defined nature of the functional and structural changes observed in this model will facilitate the study of glial responses and the evaluation of neuroprotective treatments after intraocular pressure (IOP) injury.
EXPERIMENTAL EYE RESEARCH
(2024)