Article
Immunology
Yingping Wu, Shufa Zheng, Tian Liu, Xueke Liu, Huina Tang, Yutong He, Wei Xu, Lele Li, Wenxu Yu, Ke Xing, Xiaoping Xia
Summary: Whole-genome sequencing analysis of three COVID-19-confirmed patients revealed that the haplotype diversity of SARS-CoV-2 may lead to viral adaptation for persistent shedding in multiple recurrences, impacting the clinical management of COVID-19 patients with long-term hospitalization or cases of recurrence.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Virology
Seongman Bae, Ji Yeun Kim, So Yun Lim, Heedo Park, Hye Hee Cha, Ji-Soo Kwon, Mi Hyun Suh, Hyun Jung Lee, Joon Seo Lim, Jiwon Jung, Min Jae Kim, Yong Pil Chong, Sang-Oh Lee, Sang-Ho Choi, Yang Soo Kim, Ho Young Lee, Sohyun Lee, Man-Seong Park, Sung-Han Kim
Summary: The study found that asymptomatic COVID-19 patients have a similar viral load to symptomatic patients during the early stages of the disease, but their infectivity rapidly decreases with the loss of symptoms.
Article
Virology
Tong-Zeng Li, Zhen-Huan Cao, Yu Chen, Miao-Tian Cai, Long-Yu Zhang, Hui Xu, Jia-Ying Zhang, Chun-Hua Ma, Yang Liu, Li-Juan Gao, Zhong-Hui Duan, Dan-Lei Mou, Lian-Chun Liang
Summary: This study found that corticosteroid treatment, fever (temperature>38.5 degrees C), and longer time from onset to hospitalization were associated with prolonged viral shedding duration in COVID-19 patients.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Virology
Xinchun Zheng, Jiehua Chen, Lisi Deng, Zhaoxiong Fang, Gongqi Chen, Di Ye, Jinyu Xia, Zhongsi Hong
Summary: The study identified that the severity of COVID-19 in the early stage is associated with the duration of fever, elevated CRP levels, and low PO2 levels upon admission. It was also found that viral RNA of SARS-CoV-2 could persist in respiratory and fecal samples for a prolonged period, but the duration of viral shedding does not correlate with disease severity.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Immunology
Fatemeh Fotouhi, Mostafa Salehi-Vaziri, Behrokh Farahmand, Ehsan Mostafavi, Mohammad Hassan Pouriayevali, Tahmineh Jalali, Vahideh Mazaheri, Mona Sadat Larijani, Mahsa Tavakoli, Azita Eshratkhah Mohammadnejad, Neda Afzali, Afsaneh Zokaei, SeyedeAtefe Hosseini, Mohamad Mahdi Mortazavipour, FaridehNiknam Oskouei, Amitis Ramezani
Summary: The study investigated the viral shedding duration and antibody development against SARS-CoV-2 in 255 COVID-19 suspected individuals, finding a median viral shedding duration of 34.16 days and presence of IgG in 84% of patients after 150 days. This suggests that a 14-day isolation period may not be sufficient for proper control, and the persistence of IgG in a majority of patients for nearly 6 months brings hope for vaccine effectiveness and application.
MICROBES AND INFECTION
(2021)
Article
Microbiology
Yang Wang, Yanping Chen, Lina Gu, Lixin Lou, Jian Zhang, Kaiyu Zhang
Summary: This study found an association between age, pneumonia, antibody IgG, and RNA negative conversion time in COVID-19 and TB coinfection patients, and age and increased PCT were risk factors for the severity of COVID-19.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Public, Environmental & Occupational Health
Arwa E. Alsaud, Arun Prabhakaran Nair, Ahmad S. Matarneh, Sreethish Sasi, Rania El Hassan, Fahmi Khan, Peter Coyle, Mohamed Abu Khattab, Mouhand F. H. Mohamed
Summary: COVID-19 is a multi-organ disease that primarily affects the respiratory system, and RT-PCR testing is the preferred method for diagnosis. Patients may shed SARS-CoV-2 for several weeks, and the implications of prolonged viral shedding on management and isolation decisions require further research.
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
(2021)
Article
Virology
Denise Utami Putri, Cheng-Hui Wang, Po-Chun Tseng, Wen-Sen Lee, Fu-Lun Chen, Han-Pin Kuo, Chih-Hsin Lee, Chiou-Feng Lin
Summary: The study aims to evaluate the changes in immune cell profile of COVID-19 patients and found that in patients with longer viral RNA-shedding period, certain immune cells show abnormal upregulation or downregulation. Additionally, during the disease course, the pro-inflammatory Th1 cells showed a declining trend, while immunoregulatory cells were upregulated before declining.
Letter
Oncology
Changqian Bao, Xiandong Tao, Wei Cui, Yuanyuan Hao, Shuaike Zheng, Bin Yi, Tiewen Pan, Ken H. Young, Wenbin Qian
Summary: COVID-19 patients are discharged based on two consecutive negative viral RNA tests, improved respiratory symptoms, and obvious absorption of inflammation in pulmonary imaging. Differences in various blood cell counts and infection-related parameters were found between severe and non-severe groups. Higher counts of certain immune cells were associated with faster clearance of the virus and better outcomes.
EXPERIMENTAL HEMATOLOGY & ONCOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Hui-ru Cao, Xin-yun Zhu, Lin Zhou, Hua Zhang, Bin-bin Gu, Wei Tang, Jian Ding, Jianan Huang, Xing-hua Shen, Cheng Chen
Summary: This retrospective study on 87 hospitalized patients in Suzhou identified excessive cumulative corticosteroid use, hospitalization within 5 days from illness onset, and arbidol-included therapy as independent risk factors for delayed COVID-19 RNA shedding. These findings could help clinicians tailor treatment strategies for patients with delayed viral shedding.
RESPIRATORY MEDICINE
(2021)
Article
Virology
Li Xin, Anthony Raymond Tam, Wing-Ming Chu, Wan-Mui Chan, Jonathan Daniel Ip, Allen Wing-Ho Chu, Syed Muhammad Umer Abdullah, Cyril Chik-Yan Yip, Kwok-Hung Chan, Samson Sai-Yin Wong, Vincent Chi-Chung Cheng, Kwok-Yung Yuen, Ivan Fan-Ngai Hung, Kelvin Kai-Wang To
Summary: This retrospective cohort study investigated viral shedding kinetics and risk factors associated with slow viral decline in adult patients hospitalized for COVID-19 during the Omicron wave in early 2022. The study identified older age as an independent risk factor for slow viral decline and suggested that age should be considered when determining the timing of de-isolation.
Article
Virology
Sung Woon Kang, Heedo Park, Ji Yeun Kim, Sunghee Park, So Yun Lim, Sohyun Lee, Joon-Yong Bae, Jeonghun Kim, Seongman Bae, Jiwon Jung, Min Jae Kim, Yong Pil Chong, Sang -Oh Lee, Sang -Ho Choi, Yang Soo Kim, Sung-Cheol Yun, Man-Seong Park, Sung -Han Kim
Summary: This study developed a clinical scoring system to predict viable viral shedding in patients with COVID-19. By identifying clinical predictors, the system provides objective probability of culture-negative state, which could be useful for implementing personalized de-isolation policies.
JOURNAL OF CLINICAL VIROLOGY
(2022)
Article
Peripheral Vascular Disease
Xiaoping Chen, Wenjia Hu, Miao Yang, Jiaxin Ling, Yongxi Zhang, Liping Deng, Jinlin Li, Ake Lundkvist, Johanna F. Lindahl, Yong Xiong
Summary: The study found that hypertension and intravenous immunoglobulin treatment have a negative impact on the time of viral clearance in COVID-19 patients, with hypertension being the most important risk factor for delaying SARS-CoV-2 virus clearance.
JOURNAL OF CLINICAL HYPERTENSION
(2021)
Article
Immunology
Sergey G. Shcherbak, Anna Yu Anisenkova, Sergei V. Mosenko, Oleg S. Glotov, Alexander N. Chernov, Svetlana V. Apalko, Stanislav P. Urazov, Evgeny Y. Garbuzov, Dmitry N. Khobotnikov, Olga A. Klitsenko, Evdokia M. Minina, Zakhar P. Asaulenko
Summary: This study identified prognostic biomarkers for cytokine storm development in COVID-19 patients and developed a useful prognostic scale for identifying high-risk patients requiring early anti-inflammatory therapy.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, General & Internal
Huan Yang, Xiangyu Xi, Weimin Wang, Bing Gu
Summary: The study revealed that COVID-19 patients with gastrointestinal symptoms were more likely to experience fatigue, elevated levels of creatine kinase and lactate dehydrogenase, increased neutrophil-to-lymphocyte ratio, and were at higher risk of developing into severe disease.
FRONTIERS IN MEDICINE
(2021)
