Article
Medicine, Research & Experimental
Poliana C. Marinello, Paola S. Cella, Mayra T. J. Testa, Phillipe B. Guirro, Walison Augusto da Silva Brito, Camila S. Padilha, Alessandra L. Cecchini, Robin P. da Silva, Jose Alberto R. Duarte, Rafael Deminice
Summary: This study investigated the effects of creatine supplementation on the pathogenesis of non-alcoholic fatty liver disease and alcoholic liver disease. The results showed that creatine supplementation prevented high-fat diet-induced non-alcoholic fatty liver disease but exacerbated ethanol-induced alcoholic liver disease. The exacerbating effects may be related to oxidative stress and inflammation-mediated upregulation of ethanol metabolism.
Article
Biochemistry & Molecular Biology
Yunjia Li, Mengchen Qin, Weichao Zhong, Chang Liu, Guanghui Deng, Menghan Yang, Junjie Li, Haixin Ye, Hao Shi, Chaofeng Wu, Haiyan Lin, Yuyao Chen, Shaohui Huang, Chuying Zhou, Zhiping Lv, Lei Gao
Summary: The study indicates the important role of RAGE in alcoholic liver disease (ALD). Deficiency or inhibition of RAGE can alleviate hepatic inflammation and oxidative stress, as well as affect iron metabolism pathways, thereby improving liver injury.
Article
Biochemistry & Molecular Biology
Xiyue Shen, Saddam Muhammad Ishaq, Qiao'e Wang, Juntao Yuan, Junling Gao, Zhongbing Lu
Summary: DDAH1 plays a protective role in APAP-induced liver injury by attenuating oxidative stress, inflammation, and damage to the liver through influencing xenobiotic metabolism and glutathione metabolism pathways. Increasing hepatic DDAH1 expression and activity may be a novel approach for treating drug-induced acute liver injury.
Review
Pharmacology & Pharmacy
Maneesh Mohan, Ashi Mannan, Thakur Gurjeet Singh
Summary: "The Role of Sonic Hedgehog (SHh) Signaling Pathway in Ischemia" provides insights into the protective and harmful roles of SHh in ischemia, as well as how pharmacological modifications to this pathway alter ischemic conditions. This review article offers comprehensive knowledge on how SHh impacts the progression and outcomes of ischemic injuries.
PHARMACOLOGICAL REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Qian Li, Jia-Xin Tan, Yong He, Fang Bai, Shi-Wei Li, Yi-Wen Hou, Long-Shan Ji, Ya-Ting Gao, Xin Zhang, Zhen-Hua Zhou, Zhuo Yu, Miao Fang, Yue-Qiu Gao, Man Li
Summary: This study suggests that Atractylenolide III (ATL III) is a potential therapeutic drug for the treatment of NAFLD. ATL III can inhibit liver injury and lipid accumulation, and reduce oxidative stress, inflammation, and fibrosis. Its mechanism may be achieved by activating the hepatic AdipoR1-mediated AMPK/SIRT1 signaling pathway.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Xin Zhang, Stephane Melik-Parsadaniantz, Christophe Baudouin, Annabelle Reaux-Le Goazigo, Nathan Moreau
Summary: The cornea, a crucial part of the eye, requires constant renewal and efficient healing to maintain ocular homeostasis. The Hedgehog signaling pathway plays a vital role in corneal wound healing, promoting cell proliferation, migration, and maintenance of the corneal epithelial barrier.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Yu-Chen Jiang, Xin Han, Jia-Yi Dou, Ming-Hui Yuan, Mei-Jie Zhou, Zhen-Yu Cui, Li-Hua Lian, Ji-Xing Nan, Xian Zhang, Yan-Ling Wu
Summary: Siberian onions (SOs) are delicious wild vegetables with unique taste and medicinal properties. This study reveals that SOs can alleviate hepatic fibrogenesis, apoptosis, and inflammation in liver dysfunction by inhibiting the STAT3 signaling pathway.
Article
Food Science & Technology
Yuchen Fu, Ziyuan Zeng, Siwen Feng, Yeyang Chen, Qi Ding, Yuanyuan Shi
Summary: Jiubanban (JBB), a 10-edible-herb formula, has shown protective effects against chronic alcoholic liver injury by accelerating ethanol metabolism and modulating multiple pathways related to inflammation, oxidative stress, and apoptosis. It may be a risk-free therapeutic strategy for treating ALD.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Review
Biochemistry & Molecular Biology
Yoon Mee Yang, Ye Eun Cho, Seonghwan Hwang
Summary: Alcoholic liver disease (ALD), caused by excessive alcohol consumption, results in liver damage. Studies have shown that there is a relationship between hepatic oxidative stress and inflammatory responses, which may be useful for developing therapeutic approaches for ALD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Plant Sciences
Jozaa Z. ALTamimi, Ghedeir M. Alshammari, Nora A. AlFaris, Reham Alagal, Dalal H. Aljabryn, Norah A. Albekairi, Mahmoud Ahmad Alkhateeb, Mohammed Abdo Yahya
Summary: Ellagic acid (EA) has anti-steatotic effects in streptozotocin-induced type 1 diabetes mellitus in rats, potentially mediated through the AMPK signaling pathway. It reduces blood glucose levels, increases insulin levels, prevents hepatic lipid accumulation, and decreases levels of triglycerides, cholesterol, and free fatty acids. It also reduces oxidative stress and inflammation in the liver.
PHARMACEUTICAL BIOLOGY
(2022)
Article
Plant Sciences
Ji-Ye Lim, Ji-Hyun Lee, Dae-Ho Yun, Young-Mi Lee, Dae-Ki Kim
Summary: Nodakenin exhibits anti-inflammatory, antioxidant, and anti-apoptotic activities by regulating oxidative stress, inflammatory response, and apoptosis-related proteins, suggesting it may be an adjunctive preventive agent for liver injury.
Article
Pharmacology & Pharmacy
Jiaji Hu, Zhoujie Zhu, Hanglu Ying, Jie Yao, Huabin Ma, Long Li, Yufen Zhao
Summary: The study showed that OEA can protect mice from LPS/D-Gal-induced acute liver injury by inhibiting apoptosis, oxidative stress, and inflammation, with mechanisms possibly involving the Nrf-2/HO-1 and NLRP3 inflammasome signaling pathways.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Food Science & Technology
Bangyan Li, Qianqian Mao, Dandan Zhou, Min Luo, Renyou Gan, Hangyu Li, Siyu Huang, Adila Saimaiti, Ao Shang, Huabin Li
Summary: Oolong tea and dark tea can prevent AFLD induced by chronic alcohol exposure by modulating gut microbiota.
Article
Food Science & Technology
Yuan Yuan, Fuquan Wu, Fengpei Zhang, Xiaomin Li, Xiaoping Wu, Junsheng Fu
Summary: Melanin from Inonotus hispidus fruiting bodies (IHFM) has a protective effect on acute alcoholic liver injury in mice. It acts through the gut-microbiota-liver axis and improves liver injury by enhancing alcohol metabolism, reducing inflammation, and strengthening antioxidant activities. IHFM also activates the Nrf2 signaling pathway and inhibits the TLR4/NF-kappa beta signaling pathway. Additionally, IHFM increases the relative abundance of Lactobacillus reuteri and Lactobacillus johnsonii, which are associated with antioxidant effects and reduced inflammation.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Yunjia Li, Menghan Yang, Haiyan Lin, Weixin Yan, Guanghui Deng, Haixin Ye, Hao Shi, Chaofeng Wu, Guoliang Ma, Shu Xu, Qinxiang Tan, Zhuowei Gao, Lei Gao
Summary: Limonin has a protective effect on NAFLD by reducing lipid droplet accumulation, regulating lipogenic transcription factors, suppressing inflammation and oxidative stress, and reversing unfavorable changes through activating the NRF2/HO-1 signaling pathway.
FRONTIERS IN PHARMACOLOGY
(2022)