Article
Cardiac & Cardiovascular Systems
Xinying Yang, Xiaoyu Du, Ke Ma, Guoqi Li, Zhuohui Liu, Wei Rong, Huangtai Miao, Fuli Zhu, Qinghua Cui, Shaowei Wu, Yulin Li, Jie Du
Summary: This study found that circulating miR-26a-5p, miR-21-5p, and miR-191-5p levels were lower in patients who experienced major adverse cardiovascular events after acute myocardial infarction compared to those who did not. Multivariate conditional logistic regression analysis showed that these miRNAs were significantly inversely associated with incident primary composite outcomes. Combining these miRNAs with B-type natriuretic peptide improved risk scores recommended in the current guidelines.
CANADIAN JOURNAL OF CARDIOLOGY
(2021)
Review
Medicine, General & Internal
Jia Wang, Liwenjing Xu, Lu Tian, Qiyu Sun
Summary: The study demonstrates the effectiveness of miR-208 as a biomarker for early diagnosis of acute myocardial infarction, with high sensitivity and specificity, being able to differentiate between AMI patients and healthy controls.
Article
Medicine, General & Internal
Omid Shirvani Samani, Johannes Scherr, Elham Kayvanpour, Jan Haas, David H. Lehmann, Weng-Tein Gi, Karen S. Frese, Rouven Nietsch, Tobias Fehlmann, Steffi Sandke, Tanja Weis, Andreas Keller, Hugo A. Katus, Martin Halle, Norbert Frey, Benjamin Meder, Farbod Sedaghat-Hamedani
Summary: This study investigates the specificity of serum microRNAs as biomarkers for myocardial infarction by examining their behavior during strenuous exercise. The results show that some microRNAs associated with myocardial infarction have similar kinetics during exercise, suggesting limited diagnostic specificity. However, combining certain microRNAs with cardiac troponin within a multi-marker strategy may enhance diagnostic accuracy.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Kai M. Eggers, Lars Lindhagen, Tomasz Lars Lindhagen Baron, David Erlinge, Marcus Hjort, Tomas Jernberg, Gyorgy Marko-Varga, Melinda Rezeli, Jonas Spaak, Bertil Lindahl
Summary: This study analyzed the prognostic value of 175 biomarkers in acute myocardial infarction patients, and found that TRAIL-R2, CA-125, FGF-23 emerged as risk predictors for all-cause mortality and heart failure hospitalizations. However, the prognostic value of biomarkers was abrogated following additional adjustment for clinical variables.
EUROPEAN HEART JOURNAL-ACUTE CARDIOVASCULAR CARE
(2021)
Review
Endocrinology & Metabolism
Lingli Ma, Yan Wen, Zimeng Li, Nan Wu, Qing Wang
Summary: This study found that miRNAs can be used as potential diagnostic markers for DR, with high accuracy of diagnoses observed with the detection of miRNAs in plasma and serum.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Clinical Neurology
Jimin He, Yao Jiang, Liang Liu, Zhihua Zuo, Chun Zeng
Summary: A meta-analysis was conducted on 24 studies involving a total of 2,170 glioma patients and 1,456 healthy participants, which revealed the potential of circulating miRNAs as diagnostic biomarkers for gliomas, pending validation through large prospective studies.
FRONTIERS IN NEUROLOGY
(2021)
Review
Medicine, General & Internal
Gien-Kuo Lee, Yen-Ping Hsieh, Shang-Wei Hsu, Shou-Jen Lan
Summary: A systematic review revealed that circulating miRNAs (miR-1, miR-133, miR-208, and miR-499) showed diagnostic values in acute myocardial infarction (AMI) with good sensitivity and specificity.
Review
Cardiac & Cardiovascular Systems
Soudeh Ghafouri-Fard, Mahdi Gholipour, Mohammad Taheri
Summary: miRNAs play a crucial role in the pathophysiological process of CAD, with up-regulated and down-regulated miRNAs associated with the development of CAD, which can be utilized for diagnostic and prognostic evaluation of CAD.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Multidisciplinary Sciences
Yasmina Chouik, Fanny Lebosse, Marie-Laure Plissonnier, Jean-Christophe Lega, Pierre Pradat, Teresa Antonini, Miroslava Subic, Kerstin Hartig-Lavie, Domitille Erard, Francois Villeret, Celine Guichon, Audrey Payance, Sylvie Radenne, Pierre-Emmanuel Rautou, Fabien Zoulim, Massimo Levrero
Summary: Bacterial infections are a common and dangerous complication in patients with acute decompensation of cirrhosis. This study investigated the potential of circulating microRNAs to diagnose bacterial infections and predict survival in these patients. The analysis found that certain miRNAs can be used as biomarkers to accurately diagnose bacterial infections, and a combination of other miRNAs can help predict survival. Circulating miRNAs show dysregulation in patients with acute decompensation of cirrhosis, suggesting their potential as diagnostic and prognostic tools.
Review
Medical Laboratory Technology
Yudong Wu, Qian Li, Renshuai Zhang, Xiaoli Dai, Wujun Chen, Dongming Xing
Summary: MicroRNAs, approximately 20-24 nucleotides in length, are considered reliable diagnostic and prognostic biomarkers for various diseases due to their reflection of disease progression and drug resistance. They play a crucial role in the diagnosis, prognosis, and treatment response prediction of diseases, potentially improving cure rates.
CLINICA CHIMICA ACTA
(2021)
Review
Biochemistry & Molecular Biology
Cristian Statescu, Larisa Anghel, Bogdan-Sorin Tudurachi, Andreea Leonte, Laura-Catalina Benchea, Radu-Andy Sascau
Summary: Despite lacking an ideal biomarker for risk assessment in patients with AMI, recent studies have shown promising results. Several novel biomarkers related to the pathophysiological processes in AMI patients have been identified, and their inclusion in multi-biomarker strategies may provide additional prognostic value. Additionally, the use of artificial intelligence algorithms for risk stratification and prognostic assessment has the potential to significantly improve outcomes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Cardiac & Cardiovascular Systems
Yuling Wu, Nana Pan, Yi An, Mengyuan Xu, Lijuan Tan, Lijuan Zhang
Summary: The incidence of myocardial infarction is increasing globally, driving the need for better diagnostic and prognostic biomarkers. Circulating biomarkers play a crucial role in the diagnosis, prognosis, and treatment monitoring of MI patients. Emphasizing on preexisting biomarkers in blood circulation before MI incidents could be key for future MI prevention efforts.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Genetics & Heredity
Yunjin Yao, Yongfeng Ding, Yuntong Bai, Quan Zhou, Hyun Lee, Xiawei Li, Lisong Teng
Summary: This study identified three miRNAs with high sensitivity and specificity in distinguishing gastric cancer cases from non-cancer controls, suggesting their potential as biomarkers for gastric cancer screening.
FRONTIERS IN GENETICS
(2021)
Article
Medicine, General & Internal
Marta Lozano-Prieto, David Adlam, Marcos Garcia-Guimaraes, Ancor Sanz-Garcia, Paula Vera-Tome, Fernando Rivero, Javier Cuesta, Teresa Bastante, Anna A. Baranowska-Clarke, Alicia Vara, Enrique Martin-Gayo, Miguel Vicente-Manzanares, Pilar Martin, Nilesh J. Samani, Francisco Sanchez-Madrid, Fernando Alfonso, Hortensia de la Fuente
Summary: The study found that specific miRNAs have significantly different expression in the plasma of SCAD and AT-AMI patients, and the combined expression of these four miRNAs can better distinguish between the two diseases. Functional analysis revealed an association of these miRNAs with blood vessel biology, TGF-beta pathway, and cytoskeletal traction force.
Review
Biochemistry & Molecular Biology
Tamilla Muzafarova, Zuzana Motovska
Summary: Cardiogenic shock is a life-threatening cardiovascular disease with high morbidity and mortality. This review summarizes the current evidence on predictors of prognosis and discusses the practical implementation of management strategies for cardiogenic shock initially complicating acute myocardial infarction. Developing new scoring systems based on established and new biomarkers would be of interest for predicting clinical outcomes in this group of patients.