Review
Immunology
Joshua M. Moreau, Maria Velegraki, Chelsea Bolyard, Michael D. Rosenblum, Zihai Li
Summary: TGF-beta 1 plays a crucial role in the development and function of T-reg, although its pleiotropic and context-dependent activity makes it complicated.
SCIENCE IMMUNOLOGY
(2022)
Review
Gastroenterology & Hepatology
Aswathy R. Devan, Keechilat Pavithran, Bhagyalakshmi Nair, Maneesha Murali, Lekshmi R. Nath
Summary: Transforming growth factor-beta 1 (TGF-β1) plays a dual role as a tumor suppressor and promoter in cancer, particularly in hepatocellular carcinoma (HCC). Elevated levels of TGF-β1 in HCC contribute to poor prognosis and immunosuppression in the tumor microenvironment. TGF-β1 is an important diagnostic, prognostic, and therapeutic target for HCC.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Oncology
Juanni Li, Kuan Hu, Dongren He, Lei Zhou, Zhiming Wang, Yiming Tao
Summary: The study found that PLXND1 expression is significantly higher in HCC tissues compared to normal liver tissue, and it is correlated with tumor grade and other clinical characteristics. The research used various databases and experiments to validate these findings, while also exploring the role of PLXND1 in the immune system, providing new insights for the clinical prognosis and treatment of HCC.
FRONTIERS IN ONCOLOGY
(2021)
Article
Immunology
Joris van der Veeken, Clarissa Campbell, Yuri Pritykin, Michail Schizas, Jacob Verter, Wei Hu, Zhong-Min Wang, Fanny Matheis, Daniel Mucida, Louis-Marie Charbonnier, Talal A. Chatila, Alexander Y. Rudensky
Summary: The role of Foxp3 in peripheral pTreg cells and the mechanisms supporting their differentiation remain poorly understood. This study used genetic tracing to identify microbiota-induced pTreg cells and found that many of their distinguishing features were Foxp3 independent. While Foxp3 was critical for the suppression of certain diseases, pTreg cells could suppress colonic effector T cell expansion in a Foxp3-independent manner. Thus, Foxp3 and the tolerogenic signals preceding and promoting its expression confer distinct facets of pTreg functionality.
Review
Medicine, General & Internal
Xinhui Shi, Qisong Li, Yungang Wang
Summary: This meta-analysis systematically reviewed the impact of regulatory T cells (Tregs) on the prognosis of hepatocellular carcinoma (HCC) based on available literature. The findings will provide useful guidance for the treatment of HCC.
Article
Oncology
Deniz Arik, Tutku Benli, Elcin Telli
Summary: This study evaluated the infiltration of FoxP3+ lymphocytes in early-stage vulvar squamous cell carcinoma (SCC) and determined its relationship with prognosis and clinicopathological parameters. The results showed a positive correlation between high FoxP3+ lymphocyte count and good prognostic parameters. Higher FoxP3+ lymphocyte count was associated with lower recurrence rate in tumoral cell islands.
JOURNAL OF GYNECOLOGIC ONCOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Yong-Fa Zhang, Yi-Xiu Wang, Ning- Zhang, Zhen-Hai Lin, Long-Rong Wang, Yun Feng, Qi Pan, Lu Wang
Summary: RBM25 is overexpressed in HCC patients and associated with poor prognosis, especially in male patients and those in the N0 stage. RBM25 may interact with CDCA5 and INCENP to regulate HCC.
Article
Oncology
Dieuwke L. Marvin, Vivian M. Spaans, Cor D. De Kroon, Roderick C. Slieker, Maryam Khelil, Peter Ten Dijke, Laila Ritsma, Ekaterina S. Jordanova
Summary: Cervical cancer is the fourth most common cancer in women worldwide, with adenocarcinoma patients having a worse prognosis. The tumor suppressor function of TGF-beta is lost in tumor cells. Analysis of RNA-seq data showed that TGF-beta plays different roles in squamous cell carcinoma and adenocarcinoma. In adenocarcinoma patients, low expression of T beta R2 and SMAD4 was associated with worse survival, while high expression of PAI-1 and alpha v beta 6 was also correlated with worse survival.
FRONTIERS IN ONCOLOGY
(2022)
Article
Pathology
Shuohui Liu, Honglong Zhang, Jun Yan, Jun Zhu, Zhongtian Bai, Xun Li
Summary: This study found that abnormal expression of FOXP3 and P62 is associated with prognosis and immune cell infiltration in hepatocellular carcinoma (HCC) patients. Downregulation of FOXP3 and upregulation of P62 are closely related to decreased overall survival (OS) in HCC patients. Additionally, abnormal expression of FOXP3 and P62 is correlated with infiltration levels of various immune cells. These findings suggest that FOXP3 and P62 may serve as important prognostic factors and potential therapeutic targets for HCC treatment.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Article
Oncology
Changwei Ke, Shejiao Dai, Fangshi Xu, Jia Yuan, Shuting Fan, Yang Chen, Longbao Yang, Yong Li
Summary: A novel cuproptosis-related risk signature was established, and DLAT gene was found to have cancer-promoting capacities in HCC, suggesting it as a potential therapeutic target.
Article
Immunology
Takashi MaruYama, Shuhei Kobayashi, Hiroko Nakatsukasa, Yuki Moritoki, Daiki Taguchi, Yoichi Sunagawa, Tatsuya Morimoto, Atsuko Asao, Wenwen Jin, Yuji Owada, Naoto Ishii, Yoshiharu Iwabuchi, Akihiko Yoshimura, WanJun Chen, Hiroyuki Shibata
Summary: Regulatory T cells (Tregs) orchestrate antitumor immune responses, with TGF-beta promoting Treg generation through NF-kappa B/p300 and SMAD signaling pathways. GO-Y030 inhibits Treg generation and stability by blocking these pathways, resulting in potent anticancer effects in vivo tumor models.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Genetics & Heredity
Xiawei Yang, Feng Yang, Liugen Lan, Ning Wen, Haibin Li, Xuyong Sun
Summary: This study reveals the genetic and prognostic significance of m5C-related regulators in hepatocellular carcinoma (HCC) using data from TCGA and GEO, and constructs a prognostic model with high predictive ability.
FRONTIERS IN GENETICS
(2022)
Article
Immunology
Suniti Bhaumik, Michel Edwar Mickael, Monica Moran, Marion Spell, Rajatava Basu
Summary: ROR gamma t plays crucial roles in Th17 cells and colonic Tregs, with its mechanism in regulating pTreg function remaining unclear. Research found that ROR gamma t is essential in maintaining Foxp3 expression, as ROR gamma t-deficient Tregs transition to Th1-like effector cells, losing their suppressor function and leading to severe colitis.
JOURNAL OF IMMUNOLOGY
(2021)
Article
Oncology
Kim A. Reiss, Max M. Wattenberg, Nevena Damjanov, Elizabeth Prechtel Dunphy, Mona Jacobs-Small, M. Judy Lubas, James Robinson, Lisa Dicicco, Luis Garcia-Marcano, Michael A. Giannone, Thomas B. Karasic, Emma E. Furth, Erica L. Carpenter, Andrzej P. Wojcieszynski, Robert H. Vonderheide, Gregory L. Beatty, Edgar Ben-Josef
Summary: The combination therapy of oral TGF beta inhibitor galunisertib with SBRT showed tolerability and antitumor activity in patients with advanced HCC. Changes in immune cell activity associated with the treatment could help distinguish between progressors and nonprogressors.
MOLECULAR CANCER THERAPEUTICS
(2021)
Review
Biochemistry & Molecular Biology
Zhuo Chen, Hanjie Yu, Xiangqin Chen, Wentian Chen, Wanghua Song, Zheng Li
Summary: TGF-beta superfamily members play important roles in various diseases, and glycosylation modification is involved in the regulation of TGF-beta signaling pathway. There is a complex mutual regulation between glycosylation and TGF-beta signaling, which affects biological processes.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Rheumatology
Yuanyuan Wang, Tao Meng, Guangfeng Ruan, Shuang Zheng, Jimin Zhu, Han Cen, Benny Antony, Anita E. Wluka, Flavia Cicuttini, Tania Winzenberg, Jean-Pierre Pelletier, Johanne Martel-Pelletier, Changhai Ding
Summary: The study found that blood pressure and arterial stiffness are associated with knee cartilage volume in patients with knee OA, supporting the involvement of blood pressure and arterial stiffness in the progression of knee OA.
Article
Nutrition & Dietetics
Guangfeng Ruan, Chengliang Yang, Tao Meng, Shuang Zheng, Yan Zhang, Jimin Zhu, Han Cen, Yuanyuan Wang, Zhaohua Zhu, Weiyu Han, Yujin Tang, Jia Liu, Benny Antony, Tania Winzenberg, Anita E. Wluka, Flavia Cicuttini, Changhai Ding
Summary: The study found that higher diet quality, particularly a vegetable-based diet quality, was associated with greater lower limb muscle strength, fewer depressive symptoms, and higher quality of life in knee osteoarthritis patients, rather than being related to knee joint structures and OA symptoms.
CLINICAL NUTRITION
(2021)
Article
Nanoscience & Nanotechnology
Haisi Dong, Guangqi Song, Danhui Ma, Tiedong Wang, Shisong Jing, Haimiao Yang, Ye Tao, Yong Tang, Yan Shi, Zhen Dai, Ji-min Zhu, Taotao Liu, Bingmei Wang, Xiangyang Leng, Xizhong Shen, Changfeng Zhu, Yicheng Zhao
Summary: The use of DNA self-assembled nanostructures as vehicles for delivering small interfering RNA has shown to be an effective antiviral strategy. The modified tetrahedral framework nucleic acids (tFNAs) were able to inhibit the viral proliferation of classical swine fever virus in porcine cells more effectively than free siRNAs. Additionally, a dual-targeting DNA nanostructure was constructed to further enhance the antiviral capabilities of tFNAs, showing great potential for virus therapy.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Nanoscience & Nanotechnology
Guangqi Song, Haisi Dong, Danhui Ma, Heming Wang, Xinran Ren, Yishen Qu, Hao Wu, Jimin Zhu, Wu Song, Ying Meng, Li Wang, Taotao Liu, Xizhong Shen, Yicheng Zhao, Changfeng Zhu
Summary: Copper is essential for various life processes but can be highly toxic at excessive levels. In multiple malignancies, including pancreatic cancer, copper overload is common, and targeting metal ion transporters for treatment may offer an effective strategy. Therapeutic tFNAs may serve as vehicles for delivering small molecular RNAs to regulate copper intake in cancer cells, potentially attenuating cancer progression.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Medicine, Research & Experimental
Jia-Lei Sun, Ning-Ping Zhang, Ru-Chen Xu, Guang-Cong Zhang, Zhi-Yong Liu, Weinire Abuduwaili, Fu Wang, Xiang-Nan Yu, Xuan Shi, Guang-Qi Song, Hao Wu, Tao-Tao Liu, Xi-Zhong Shen, Bin Deng, Shu-Qiang Weng, Ling Dong, Ji-Min Zhu
Summary: In this study, we found that ferrous iron levels were lower in M2-like TAM compared to M1-like TAM. Loss of iron induced immunosuppressive M2 polarization of mouse macrophages. TFRC, the primary receptor for transferrin-mediated iron uptake, was overexpressed on HCC cells but not TAM. Mechanistically, HCC cells competed with macrophages for iron to upregulate the expression of M2-related genes via induction of HIF-1 alpha, thus contributing to M2-like TAM polarization. Additionally, TFRC is significantly increased in various malignancies, including HCC, and HCC patients with high TFRC levels have considerably shortened overall survival. Furthermore, TFRC is shown to be positively related to tumor-infiltrating M2 macrophages.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Oncology
Baikun Li, Xingyu Dong, Jimin Zhu, Ting Zhu, Xiaoxiao Tao, Daiyin Peng, Qinglin Li
Summary: This study revealed that the crosstalk between lung cancer cells and platelets can influence the proliferation, migration, and tube formation of HUVECs, potentially playing a crucial role in tumor angiogenesis by affecting or mediating changes in the properties of vascular endothelial cells (VECs).
Article
Chemistry, Physical
Jimin Zhu, Xiaoti Cui, Samuel Simon Araya
Summary: This study conducts a numerical simulation of methanol steam reforming reactions in a commercial packed-bed reactor with CuO/ZnO/Al2O3 catalyst. The results show that the inlet temperature of burner gas and tube diameter have significant effects on the temperature distribution and the formation of hot spots in the reformer tubes.
INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
(2022)
Article
Medicine, Research & Experimental
Xiang-Nan Yu, Guang-Cong Zhang, Hai-Ning Liu, Jin-Min Zhu, Tao-Tao Liu, Guang-Qi Song, Ling Dong, Jie Yin, Xi-Zhong Shen
Summary: This study reveals the correlation between elevated expression of PRP19 and DNA damage repair in hepatocellular carcinoma (HCC). PRP19 affects the DNA damage repair ability in HCC by modulating cyclin D1 expression and function. The combination of PRP19 and cyclin D1 is valuable for predicting patient prognosis in HCC.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2022)
Article
Oncology
Bilegsaikhan Enkhnaran, Guang-Cong Zhang, Ning-Ping Zhang, Hai-Ning Liu, Hao Wu, Shi Xuan, Xiang-Nan Yu, Guang-Qi Song, Xi-Zhong Shen, Ji-Min Zhu, Xiu-Ping Liu, Tao-Tao Liu
Summary: miR-106b-5p promotes cell proliferation, cell cycle progression, and resistance to sorafenib in HCC cells through the BTG3/Bcl-xL/p27 signaling pathway.
JOURNAL OF ONCOLOGY
(2022)
Article
Nanoscience & Nanotechnology
Weinire Abuduwaili, Xiang Wang, An-Tian Huang, Jia-Lei Sun, Ru-Chen Xu, Guang-Cong Zhang, Zhi-Yong Liu, Fu Wang, Chang-Feng Zhu, Tao-Tao Liu, Ling Dong, Ji-Min Zhu, Shu-Qiang Weng, Yuhao Li, Xi-Zhong Shen
Summary: The study fabricated a nano-chemo-phototherapy drug by combining an iridium-based photosensitizer with sorafenib (IPS) via a self-assembly process. The IPS exhibited significantly improved therapeutic efficacy against tumor cells by inducing apoptosis and necrosis, inhibiting HCC cell proliferation, and promoting cell apoptosis.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Medicine, Research & Experimental
Zong-Rui Li, Gang Xu, Liu-Yan Zhu, Hui Chen, Ji-Min Zhu, Jian Wu
Summary: GPM6A expression is suppressed in hepatocellular carcinoma and inhibits proliferation and migration of hepatoma cells. miR-96-5p directly targets GPM6A gene and decreases its expression. GPM6A may function as a valuable biomarker for HCC progression and prognosis.
LABORATORY INVESTIGATION
(2022)
Article
Pharmacology & Pharmacy
Zhi-Yong Liu, Dan-Ying Zhang, Xia-Hui Lin, Jia-Lei Sun, Weinire Abuduwaili, Guang-Cong Zhang, Ru-Chen Xu, Fu Wang, Xiang-Nan Yu, Xuan Shi, Bin Deng, Ling Dong, Shu-Qiang Weng, Ji-Min Zhu, Xi-Zhong Shen, Tao-Tao Liu
Summary: This study analyzed the immune cell infiltration levels and differentially expressed immune-related genes in sorafenib-resistant HCC. The results showed that macrophages and neutrophils were highly infiltrated, while CD8(+) T cells were downregulated in sorafenib-resistant HCC. Additionally, nalidixic acid was identified as a promising adjuvant drug for sorafenib-resistant HCC treatment.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Chemistry, Multidisciplinary
An-Tian Huang, Jun Du, Zhi-Yong Liu, Guang-Cong Zhang, Weinire Abuduwaili, Jia-Yan Yan, Jia-Lei Sun, Ru-Chen Xu, Tao-Tao Liu, Xi-Zhong Shen, Ling Dong, Ji-Min Zhu, Yuhao Li
Summary: This study developed a novel nanoparticle based on photothermal therapy, which can enhance the therapeutic effect and reduce the adverse effects of hepatocellular carcinoma.
Article
Oncology
Guang-Cong Zhang, Xiang-Nan Yu, Hong-Ying Guo, Jia-Lei Sun, Zhi-Yong Liu, Ji-Min Zhu, Ling Dong, Tao-Tao Liu, Xi-Zhong Shen, Jie Yin
Summary: This study identified PRP19 as a mediator of lipid metabolism reprogramming in esophageal squamous cell carcinoma (ESCC), with its upregulation correlating with poor clinical prognosis. PRP19 promotes ESCC proliferation by enhancing fatty acid synthesis through SREBF1 and stabilizing SREBF1 mRNA. Targeting PRP19 could potentially reverse metabolic reprogramming in ESCC patients.
Article
Medicine, Research & Experimental
Ru-Chen Xu, Fu Wang, Jia-Lei Sun, Weinire Abuduwaili, Guang-Cong Zhang, Zhi-Yong Liu, Tao-Tao Liu, Ling Dong, Xi-Zhong Shen, Ji-Min Zhu
Summary: In this study, a novel genetic cHCC-ICC mouse model was generated, providing insights into the molecular features and related signaling pathways of cHCC-ICC and identifying LAMB1 as a potential therapeutic target.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
