Article
Otorhinolaryngology
Jose L. Mattos, Shahzeb Hasan, Rodney J. Schlosser, Spencer C. Payne, Zachary M. Soler
Summary: This study found a high prevalence of gustatory dysfunction (GD) in older adults, which is associated with quality of life and cognitive function. GD is also correlated with dry mouth and difficulty chewing, and may be indicative of neurocognitive decline. Taste testing may play a role in screening for cognitive decline and multisensory dysfunction may indicate worsened cognitive states.
INTERNATIONAL FORUM OF ALLERGY & RHINOLOGY
(2023)
Article
Multidisciplinary Sciences
Lala Chaimae Naciri, Mariano Mastinu, Melania Melis, Tomer Green, Anne Wolf, Thomas Hummel, Iole Tomassini Barbarossa
Summary: The gustatory, olfactory, and trigeminal systems, although anatomically separated, interact cognitively to form oral perception. A regression model was used to analyze self-ratings of oral sensitivity and found that the trigeminal component was the most significant, with astringency and spiciness providing similar contributions in controls, and astringency being most important in patients. Identifying the significance of oral perception components and differences between groups provides important information for targeted examinations.
SCIENTIFIC REPORTS
(2023)
Article
Dentistry, Oral Surgery & Medicine
Luisa Schertel Cassiano, Ana Paula Ribeiro, Marco Anselmo Peres, Rodrigo Lopez, Alexander Fjaeldstad, Leonardo Marchini, Gustavo G. Nascimento
Summary: This study investigated the association between self-reported periodontitis and the senses of taste and smell among employees of one Danish and two American universities. Data were collected through a digital survey, including 1239 individuals from Aarhus University - Denmark, the University of Iowa, and the University of Florida - USA. Self-reported periodontitis was the exposure, and the perceived senses of taste and smell were measured using a visual analog scale (VAS). Self-perceived halitosis was the mediator. Confounders were adjusted. The total effect was decomposed into direct and indirect effects using a counterfactual approach.
Article
Immunology
Noam Karni, Hadar Klein, Kim Asseo, Yuval Benjamini, Sarah Israel, Musa Nammary, Keren Olshtain-Pops, Ran Nir-Paz, Alon Hershko, Mordechai Muszkat, Masha Y. Niv
Summary: The study found that a significant number of COVID-19 patients experience changes in smell and taste, making it a specific tool for diagnosing COVID-19. Classifiers based on symptoms and degree of olfactory changes can assist in clinical diagnosis of COVID-19, with high accuracy and predictive value.
OPEN FORUM INFECTIOUS DISEASES
(2021)
Article
Otorhinolaryngology
Mihnea Cristian Trache, Josef Maria Heinrich Schipp, Mareike Haack, Christine Adderson-Kisser, Catalina Hoegerle, Sven Becker, Christian Stephan Betz
Summary: This study investigates the impact of etiology on the epidemiologic profile, disease severity, type of treatment and therapy outcome in smell and taste disorders. The results show that post-traumatic etiology is associated with young age and male sex, and has the most severe degrees of smell loss. Postinfectious causes are more frequent in females and correlate with a history of pharyngeal surgery. Sinunasal etiology with nasal polyps worsens the overall olfactory test score, but shows significant improvement after therapy. Good correlations between subjective impairment and objective dysfunction were established for each sensory modality.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2023)
Article
Medicine, General & Internal
Jeong Whun Kim, Seung Cheol Han, Hyung Dong Jo, Sung Woo Cho, Jin Youp Kim
Summary: In this meta-analysis of 55 eligible studies involving 13,527 patients with COVID-19, it was found that the prevalence rates of olfactory and gustatory dysfunction varied significantly among different geographical regions and time frames. These regional and chronological differences partly explain the wide variability in prevalence rates observed in studies.
JOURNAL OF KOREAN MEDICAL SCIENCE
(2021)
Review
Medicine, General & Internal
Mike Trott, Robin Driscoll, Shahina Pardhan
Summary: Post-COVID syndrome refers to the persistence of COVID-19 symptoms for longer than 12 weeks, with studies showing symptoms related to sensory organs continue to be present. This systematic review aimed to examine the prevalence of persistent symptoms such as anosmia, ageusia, and sensory symptoms in the eyes and ears. The analysis found a significant prevalence of these symptoms, highlighting the need for further research into the causes behind these persistent issues.
FRONTIERS IN MEDICINE
(2022)
Article
Oncology
Mirjam van den Brink, Irene IJpma, Britt van Belkom, Marta Fiocco, Remco C. Havermans, Wim J. E. Tissing
Summary: Chemotherapy can impact smell and taste function in childhood cancer patients, but psychophysical smell and taste tests have shown to be feasible in this population. Results suggest that smell and taste sensitivity may increase in children with cancer after chemotherapy, potentially leading to better management of issues such as nausea and vomiting.
SUPPORTIVE CARE IN CANCER
(2021)
Article
Otorhinolaryngology
Luigi Angelo Vaira, Paolo Boscolo-Rizzo, Jerome R. Lechien, Miguel Mayo-Yanez, Marzia Petrocelli, Laura Pistidda, Giovanni Salzano, Fabio Maglitto, Claire Hopkins, Giacomo De Riu
Summary: The study aimed to evaluate the recovery of olfactory function in individuals infected with the omicron variant of the coronavirus disease 2019. The results showed that while some patients experienced smell loss at the early stage of infection, there was no significant difference in recovery compared to the control group at six months.
JOURNAL OF LARYNGOLOGY AND OTOLOGY
(2023)
Article
Virology
Michal Chudzik, Mateusz Babicki, Agnieszka Mastalerz-Migas, Joanna Kapusta
Summary: In this study, it was found that a subset of COVID-19 patients continue to experience persistent smell and taste disorders after recovery, with a higher risk in younger individuals and those with more symptoms during the acute phase of the disease. Patients receiving outpatient treatment are more likely to develop these persistent symptoms.
Article
Otorhinolaryngology
Luigi Angelo Vaira, Jerome R. Lechien, Giovanna Deiana, Giovanni Salzano, Fabio Maglitto, Pasquale Piombino, Andrea Mazzatenta, Paolo Boscolo-Rizzo, Claire Hopkins, Giacomo De Riu
Summary: This study aimed to compare the prevalence of olfactory dysfunction (OD) at different stages of the COVID-19 pandemic. The results showed that OD was less prevalent during the Omicron wave compared to the D614G, Alpha, and Delta waves, but still significantly higher than the control group.
Article
Oncology
Glenn J. Lesser, Megan B. Irby, Richard C. Taylor, Anna Snavely, Douglas Case, Aili Wang, Andrea Dietrich, Susan Duncan
Summary: The study investigated the use of lactoferrin for taste and smell abnormalities in chemotherapy patients and found improvements in perception after 30 and 60 days of supplementation. Further evaluation of lactoferrin is needed to assess its potential for improving taste and smell abnormalities in this population.
SUPPORTIVE CARE IN CANCER
(2022)
Article
Otorhinolaryngology
Sharon H. L. Soh, Anna See, Neville W. Y. Teo, Hiang Khoon Tan, Gautham Palaniappan, Melvin L. A. Lim, Hanis B. Abdul Kadir, Song Tar Toh
Summary: This study aimed to investigate the prevalence of olfactory and taste dysfunction in COVID-19-positive subjects residing in a specialized Community Care Facility in Singapore. The overall prevalence of anosmia and ageusia was found to be 3.0% and 2.6% respectively. Olfactory and taste dysfunction were less likely to occur in subjects who were asymptomatic for acute respiratory infection.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2021)
Article
Otorhinolaryngology
Paolo Boscolo-Rizzo, Francesco Guida, Jerry Polesel, Alberto Vito Marcuzzo, Paolo Antonucci, Vincenzo Capriotti, Erica Sacchet, Fiordaliso Cragnolini, Andrea D'Alessandro, Enrico Zanelli, Riccardo Marzolino, Chiara Lazzarin, Margherita Tofanelli, Nicoletta Gardenal, Daniele Borsetto, Claire Hopkins, Luigi Angelo Vaira, Giancarlo Tirelli
Summary: The study aimed to estimate the 1-year prevalence and recovery rate of self-reported chemosensory dysfunction in patients with previous mild-to-moderate symptomatic COVID-19. The findings showed that 21.3% of patients still reported chemosensory dysfunction 1 year after onset, with 69.5% experiencing complete resolution, 21.9% reporting decreased severity, and 8.6% reporting unchanged or worse symptoms. Patients with higher baseline SNOT-22 scores and longer duration for a negative swab had a higher risk of persistence of symptoms.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2022)
Article
Medicine, General & Internal
Sophia E. Schambeck, Claudia S. Crowell, Karolin I. Wagner, Elvira D'Ippolito, Teresa Burrell, Hrvoje Mijocevic, Ulrike Protzer, Dirk H. Busch, Markus Gerhard, Holger Poppert, Henriette Beyer
Summary: Qualitative changes in taste and smell can persist for several months after COVID-19 infection and may occur as late-onset symptoms months after full recovery, with no correlation found with serological and T-cell analysis.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Clinical Neurology
S. Santos-Lasaosa, R. Belvis, M. L. Cuadradodo, S. Diaz-Insa, A. Gago-Veiga, A. L. Guerrero-Peral, M. Huerta, P. Irimia, J. M. Lainez, G. Latorre, R. Leira, J. Pascual, J. Porta-Etessam, M. Sanchez del Rio, J. Viguera, y P. Pozo-Rosich
Summary: Recent studies have shown that levels of molecules such as CGRP are elevated during migraine attacks and in chronic migraine. Pharmacological reduction of these proteins has shown clinical significance in improving patient's migraines. Therefore, studying the role of CGRP in migraine pathology is crucial.
Article
Clinical Neurology
D. Garcia-Azorina, J. Abelaira-Freirec, E. Rodriguez-Adradad, N. Gonzalez-Garcia, A. L. Guerreroa, J. Porta-Etessame, F. J. Martin-Sanchezc
Summary: A study found that more than 85% of patients were under-triaged in the emergency department due to headache, resulting in a failure to detect potential emergencies in a timely manner. Negligence in rapid assessment led to serious misdiagnosis and treatment. Therefore, there is a need to improve the diagnostic and treatment capabilities of physicians for patients with headaches.
Article
Ophthalmology
Julio Gonzalez-Martin-Moro, Jesus Porta Etessam, Belen Pilo de la Fuente, Irene Fuentes Vega, Ines Contreras
Summary: Optical coherence tomography angiography (OCTA) can be used to observe retinal vascular changes during migraine attacks. This case report demonstrates an extensive area of hypoperfusion in the macular region of the right eye using OCTA in a migraine patient. The involvement of only one eye supports the theory of selective retinal ganglion cell layer spreading depression.
EUROPEAN JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Clinical Neurology
E. Natera-Villalba, A. Cruz-Culebras, S. Garcia-Madrona, R. Vera-Lechuga, A. de Felipe-Mimbrera, C. Matute-Lozano, A. Gomez-Lopez, V. Ros-Castello, A. Sanchez-Sanchez, J. Martinez-Poles, V. Nedkova-Hristova, J. B. Escribano-Paredes, I. Garcia-Bermudez, J. Mendez, E. Fandino, J. Masjuan
Summary: This study retrospectively evaluated the safety and effectiveness of mechanical thrombectomy performed beyond 6 hours after symptom onset in patients with acute ischemic stroke and large vessel occlusion in the carotid artery territory. The results showed that mechanical thrombectomy beyond 6 hours achieved good 90-day functional outcomes. Age, NIHSS score, puncture-to-recanalization time, and the presence of atrial fibrillation affected functional prognosis.
Article
Clinical Neurology
F. Ly-Yang, V. Gomez-Calleja, P. Perez-Garcia, N. Gonzalez-Gomez, J. Porta-Etessam, E. Santos-Bueso
Summary: This article presents 30 clinical cases of photophobia and reviews the literature in order to establish diagnostic criteria for this condition. The results suggest that the underlying causes of photophobia may involve the intrinsically photosensitive retinal ganglion cells as well as neurochemical factors like calcitonin-related peptide and the pituitary activating peptide cyclase. The treatment for photophobia could potentially involve the use of monoclonal antibodies targeting calcitonin-related peptide and/or pituitary activating peptide cyclase.
Article
Clinical Neurology
Elena Natera-Villalba, Juan Carlos Martinez-Castrillo, Jose Luis Lopez-Sendon Moreno, Ana Gomez-Lopez, Arantxa Sanchez-Sanchez, Maria Jose Lopez-Martinez, Alberto Rabano, Araceli Alonso-Canovas
Summary: This study presents a case of neuropathologically confirmed multiple system atrophy with the eye-of-the-tiger sign on brain MRI, emphasizing the role of pathology in establishing a definitive diagnosis in atypical parkinsonisms. It highlights how clinical syndromes and neuroimaging can sometimes lead to misunderstandings, as well as the complexities involved in making a correct clinical diagnosis.
MOVEMENT DISORDERS CLINICAL PRACTICE
(2022)
Letter
Anesthesiology
Maria-Luz Cuadrado, Nuria Gonzalez-Garcia, Jesus Porta-Etessam
Article
Clinical Neurology
David Garcia-Azorin, Jaime Abelaira-Freire, Nuria Gonzalez-Garcia, Esther Rodriguez-Adrada, Henrik Winther Schytz, Mads Barloese, Angel Luis Guerrero, Jesus Porta-Etessam, Francisco Javier Martin-Sanchez
Summary: This study evaluated the diagnostic accuracy of the SNNOOP10 list in detecting high-risk headaches. The results showed that the red flags from the SNNOOP10 list had a high sensitivity in the detection of high-risk headache disorders.
Article
Medicine, General & Internal
Angel Luis Guerrero-Peral, Jesus Porta-Etessam, Jaime Rodriguez-Vico, Mercedes Nunez, Antonio Ciudad, Silvia Diaz-Cerezo, Carla Gari-Peris, Francisco Javier Perez-Sadaba, Luis Lizan, Sonia Santos-Lasaosa
Summary: The Spanish version of the Decisional Conflict Scale (DCS) has been validated and found to have acceptable psychometric properties in people with migraine. It demonstrates high internal consistency and construct validity, making it a useful tool for assessing decisional conflicts in this population.
PATIENT PREFERENCE AND ADHERENCE
(2022)
Article
Health Care Sciences & Services
Francisco Marin, Marcelo Sanmartin Fernandez, Gonzalo Baron-Esquivias, Vivencio Barrios, Inaki Lekuona, Alejandro Perez-Cabeza, Jaime Masjuan, Esther Recalde del Vigo, Jose Manuel Vazquez Rodriguez, Roman Freixa-Pamias, Vanessa Roldan Schilling, Fernando Arribas, Carles Rafols Priu, Manuel Anguita Sanchez
Summary: This study analyzed the impact of cardiovascular disease on the prognosis of atrial fibrillation (AF) patients and found that patients with cardiovascular disease have a higher risk of adverse cardiovascular events and cardiovascular death.
JOURNAL OF COMPARATIVE EFFECTIVENESS RESEARCH
(2023)
Article
Immunology
Susana Sainz de la Maza, Paulette Esperanza Walo-Delgado, Mario Rodriguez-Dominguez, Enric Monreal, Alexander Rodero-Romero, Juan Luis Chico-Garcia, Roberto Pariente, Fernando Rodriguez-Jorge, Ruben Ballester-Gonzalez, Noelia Villarrubia, Beatriz Romero-Hernandez, Jaime Masjuan, Lucienne Costa-Frossard, Luisa Maria Villar
Summary: This study evaluated the immune responses to SARS-CoV-2 vaccines in multiple sclerosis (MS) patients treated with different disease-modifying therapies (DMTs). The results showed that patients undergoing fingolimod and anti-CD20 therapies had a lower humoral response compared to those treated with other DMTs. Robust antigen-specific T-cell responses were detected in all patients except those treated with fingolimod.
Article
Clinical Neurology
J. Porta-Etessam, S. Santos-Lasaosa, J. Rodriguez-Vico, M. Nunez, A. Ciudad, S. Diaz-Cerezo, M. Comellas, F. J. Perez-Sadaba, L. Lizan, A. L. Guerrero-Peral
Summary: Shared decision-making (SDM) training for neurologists in migraine care does not significantly impact patients’ decisional conflict and patient-physician relationship. However, physicians reported greater satisfaction and confidence in communicating with patients after the training.
NEUROLOGY AND THERAPY
(2023)
Article
Clinical Neurology
Julian Benito-Leon, Ana Belen del Pino, Yolanda Aladro, Constanza Cuevas, Angela Domingo-Santos, Victoria Galan Sanchez-Seco, Andres Labiano-Fontcuberta, Ana Gomez-Lopez, Paula Salgado-Camara, Lucienne Costa-Frossard, Enrique Monreal, Susana Sainz de la Maza, Jordi A. Matias-Guiu, Jorge Matias-Guiu, Alfonso Delgado-Alvarez, Paloma Montero-Escribano, Maria Luisa Martinez-Gines, Yolanda Higueras, Lucia Ayuso-Peralta, Norberto Malpica, Helena Melero
Summary: This study found abnormal brain connectivity and worse cognitive performance in patients with Radiologically Isolated Syndrome (RIS). These findings provide important insights into considering RIS as an exclusively non-motor (neurocognitive) variant of multiple sclerosis.
MULTIPLE SCLEROSIS JOURNAL
(2023)
Article
Clinical Neurology
Alvaro Beltran-Corbellini, Maria Romeral-Jimenez, Pablo Mayo, Irene Sanchez-Miranda Roman, Pablo Iruzubieta, Juan Luis Chico-Garcia, Paloma Parra-Diaz, Irene Garcia-Morales, Rafael Toledano, Angel Aledo-Serrano, Antonio Gil-Nagel
Summary: The purpose of this study was to determine the effectiveness and safety of cenobamate in patients with highly refractory focal epilepsy. The results showed that cenobamate significantly reduced seizure frequency and intensity, with a manageable safety profile.
SEIZURE-EUROPEAN JOURNAL OF EPILEPSY
(2023)
Correction
Ophthalmology
J. Gonzalez-Martin-Moro, J. P. Etessam, B. Pilo-de-la-Fuente
EUROPEAN JOURNAL OF OPHTHALMOLOGY
(2023)