Article
Cell & Tissue Engineering
Desheng Kong, Baofeng Feng, Asiamah Ernest Amponsah, Jingjing He, Ruiyun Guo, Boxin Liu, Xiaofeng Du, Xin Liu, Shuhan Zhang, Fei Lv, Jun Ma, Huixian Cui
Summary: The study shows that using human iPSC-derived neural stem cells can promote neural functional recovery in mice with acute SCI, while also reducing fibrosis, glial scar formation, and inflammation.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Clinical Neurology
Max I. Myers, Kevin J. Hines, Andrew Gray, Gabrielle Spagnuolo, Robert Rosenwasser, Lorraine Iacovitti
Summary: This study found that intracerebral transplantation of autologous MSCs may be a promising treatment for chronic stroke, while allogenic MSCs showed less effectiveness.
TRANSLATIONAL STROKE RESEARCH
(2023)
Article
Multidisciplinary Sciences
Byeongtaek Oh, Sruthi Santhanam, Matine Azadian, Vishal Swaminathan, Alex G. Lee, Kelly W. McConnell, Alexa Levinson, Shang Song, Jainith J. Patel, Emily E. Gardner, Paul M. George
Summary: Stroke is a major cause of long-term disability worldwide, and effective recovery therapies are highly needed. A study found that electrical modulation of stem cells using a conductive polymer system can improve functional stroke recovery, and identified important therapeutic targets.
NATURE COMMUNICATIONS
(2022)
Article
Clinical Neurology
Amara Larpthaveesarp, Praneeti Pathipati, Samuel Ostrin, Anthony Rajah, Donna Ferriero, Fernando F. Gonzalez
Summary: The study found that both single-dose MSC/EPO and multidose systemic EPO can improve long-term neurobehavioral outcomes even when administered after a delay, with EPO showing the most overall effectiveness.
Article
Clinical Neurology
Mitsuhiro Takemura, Masanori Sasaki, Yuko Kataoka-Sasaki, Ryo Kiyose, Hiroshi Nagahama, Shinichi Oka, Ryo Ukai, Takahiro Yokoyama, Jeffery D. Kocsis, Tetsuya Ueba, Osamu Honmou
Summary: Repeated systemic administration of MSCs over 3 weeks resulted in greater functional improvement compared to single administration and/or vehicle infusion. Administration of MSCs is associated with promotion of interhemispheric connectivity through the corpus callosum in the chronic phase of cerebral infarction.
JOURNAL OF NEUROSURGERY
(2022)
Article
Environmental Sciences
Bowen Hu, Zhanwen Cheng, Shengxian Liang
Summary: This article reviews the effects of nanomaterials on the proliferation and differentiation of various types of stem cells and discusses the advantages of using stem cells in nanotoxicology research.
Article
Veterinary Sciences
Eva Punzon, Maria Garcia-Castillo, Miguel A. Rico, Laura Padilla, Almudena Pradera
Summary: This study aimed to evaluate the safety of intra-articular administration of equine umbilical cord mesenchymal stem cells (EUC-MSC) in young healthy dogs under field conditions. The safety profile of allogenic canine adipose derived mesenchymal stem cells (CAD-MSC) and placebo was also compared. The results show that the intra-articular administration of equine umbilical cord mesenchymal stem cells in dogs is safe.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Retraction
Biochemistry & Molecular Biology
Sabine Wislet-Gendebien, Emerence Laudet, Virginie Neirinckx, Philippe Alix, Pierre Leprince, Aneta Glejzer, Christophe Poulet, Benoit Hennuy, Lukas Sommer, Olga Shakhova, Bernard Rogister
Summary: A correction to this paper has been published.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Neurosciences
Kaichuang Yang, Ruijie Lu, Jianan Lu, Shucai Fan, Qiang Zhang, Zijian Lou, Yuyuan Ma, Gang Lu, Ruolang Pan, Jianmin Zhang
Summary: This study isolated and purified MSCs from human cranial bone marrow (CB-MSCs) and characterized their differentiation capacity and immunomodulatory functions. The results showed that CB-MSCs exhibited neural-like cell differentiation potential and had regulatory effects on the immune system. These findings suggest that CB-MSCs may be promising candidates for the treatment of neurodegenerative diseases.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Chemistry, Multidisciplinary
Jessica Aijia Liu, Kin Wai Tam, Yong Long Chen, Xianglan Feng, Christy Wing Lam Chan, Amos Lok Hang Lo, Kenneth Lap-Kei Wu, Man-Ning Hui, Ming-Hoi Wu, Ken Kwok-Keung Chan, May Pui Lai Cheung, Chi Wai Cheung, Daisy Kwok-Yan Shum, Ying-Shing Chan, Martin Cheung
Summary: The study found that neural stem cells derived from human pluripotent stem cells have therapeutic potential for spinal cord injury. By reducing the expression of the SOX9 gene, the neurogenic capacity of the transplanted cells is enhanced, leading to improved integration and functional recovery.
Article
Biochemistry & Molecular Biology
Yu-Show Fu, Chang-Ching Yeh, Pei-Ming Chu, Wen-Hsing Chang, Maan-Yuh Anya Lin, Yung-Yang Lin
Summary: Transplantation of human umbilical mesenchymal stem cells (HUMSCs) in rats with chronic stroke showed therapeutic benefits, improving motor function and reducing cerebral atrophy. HUMSCs did not differentiate into neurons or astrocytes but may release cytokines to improve neuroprotection and increase angiogenesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Engineering, Biomedical
Tiange Chen, Yuguo Xia, Liyang Zhang, Tao Xu, Yan Yi, Jianwei Chen, Ziyuan Liu, Liting Yang, Siming Chen, Xiaoxi Zhou, Xin Chen, Haiyu Wu, Jinfang Liu
Summary: Neural stem cells (NSCs) have potential therapeutic effects in treating traumatic brain injury (TBI) due to their ability to replenish dysfunctional neurons and stimulate neurorestorative processes. However, their efficacy is hindered by low cell retention rates after transplantation into the brain. This study found that cerebrospinal fluid (CSF) flow after TBI is a crucial factor in NSC loss post-transplantation. Hydrogel scaffolds, particularly the GelMA/Alg scaffold, can promote NSC adherence, growth, and differentiation while preventing CSF flow-induced cell loss.
MATERIALS TODAY BIO
(2023)
Review
Cell Biology
Mehrdad Hajinejad, Sajad Sahab-Negah
Summary: Neuroinflammation plays a crucial role in neurological disorders, and mesenchymal stem cells can modulate inflammation and microglia/macrophage polarization through exosome secretion. Studies have shown that miRNAs contained in exosomes have the potential to impact recipient cell behavior, providing a novel therapeutic approach for addressing inflammatory pathways in neurological diseases.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Multidisciplinary Sciences
Nidaa A. Ababneh, Ban Al-Kurdi, Fatima Jamali, Abdalla Awidi
Summary: This study compared the differentiation abilities of MSCs isolated from different human tissue sources, and found that WJ-MSCs had a higher potential to differentiate into NSC and dopaminergic-like cells. This could provide an additional or alternative source of cells for neurological cell-based therapies.
Article
Cell Biology
Qiuli Liu, Xiaoyong Chen, Chang Liu, Lijie Pan, Xinmei Kang, Yanli Li, Cong Du, Shuai Dong, Andy Peng Xiang, Yan Xu, Qi Zhang
Summary: CHI3L1 is a novel immunosuppressive factor secreted by MSCs, which plays a crucial role in inhibiting T cell activation and inflammatory responses in immune-mediated liver injury. Downregulating CHI3L1 in hUC-MSCs mitigates their therapeutic effects on liver injury by affecting T cell function. Additionally, CHI3L1 exerts its immunosuppressive effects by upregulating PPAR δ to inhibit the JAK/STAT signaling pathway in T cells.
CELL DEATH & DISEASE
(2021)