Article
Nutrition & Dietetics
Yimin Zhao, Huihui Xu, Zezhong Tian, Xu Wang, Lin Xu, Kongyao Li, Xiaoli Gao, Die Fan, Xilin Ma, Wenhua Ling, Yan Yang
Summary: The study aimed to evaluate the effects of dietary anthocyanins on plasma ceramides and found that anthocyanins dose-dependently reduced ceramide species in dyslipidemia subjects, which were correlated with improvements in plasma lipids and cholesterol efflux capacity.
CLINICAL NUTRITION
(2021)
Article
Nutrition & Dietetics
Jinchao Zou, Zezhong Tian, Yimin Zhao, Xiaofen Qiu, Yuheng Mao, Kongyao Li, Yilin Shi, Dan Zhao, Ying Liang, Qiuhua Ji, Wenhua Ling, Yan Yang
Summary: The supplementation of CoQ10 for 24 weeks significantly improved HDL-mediated cholesterol efflux capacity and anti-inflammatory function of HDL in patients with dyslipidemia.
Article
Food Science & Technology
Chaiyavat Chaiyasut, Bhagavathi Sundaram Sivamaruthi, Narissara Lailerd, Sasithorn Sirilun, Suchanat Khongtan, Pranom Fukngoen, Sartjin Peerajan, Manee Saelee, Khontaros Chaiyasut, Periyanaina Kesika, Phakkharawat Sittiprapaporn
Summary: This study investigated the effects of supplementing a probiotic mixture (Lactobacillus paracasei HII01, Bifidobacterium breve, and Bifidobacterium longum) on intestinal permeability, lipid profile, obesity index, and metabolic biomarkers in elderly Thai subjects. The results showed that the supplementation of probiotics improved intestinal barrier function, increased high-density lipoprotein cholesterol levels, and improved obesity-related anthropometric biomarkers and short-chain fatty acid levels in human subjects.
Article
Biochemistry & Molecular Biology
Marcella Palumbo, Antonina Giammanco, Francesco Purrello, Chiara Pavanello, Giuliana Mombelli, Antonino Di Pino, Salvatore Piro, Angelo Baldassare Cefalu, Laura Calabresi, Maurizio Averna, Franco Bernini, Francesca Zimetti, Maria Pia Adorni, Roberto Scicali
Summary: PCSK9 inhibitors can improve lipid metabolism in patients with familial hypercholesterolemia by increasing HDL cholesterol efflux and reducing serum cholesterol loading. This treatment may have positive effects on the cardiovascular health of FH patients.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Endocrinology & Metabolism
Kylie Kavanagh, Alexander C. Bashore, Matthew A. Davis, Matthew J. Jorgensen, Christopher J. McClouth, Daniel A. Beavers, John S. Parks
Summary: This study demonstrates the efficacy of early time-restricted feeding (eTRF) in increasing high-density lipoprotein (HDL) cholesterol efflux capacity (CEC) in nonhuman primates (NHPs). eTRF induces larger-sized HDL particles, increases HDL apolipoprotein A-1 content, lowers triglyceride concentrations, and increases plasma CEC primarily to HDL particles.
Review
Biochemistry & Molecular Biology
Yasuhiro Endo, Masanori Fujita, Katsunori Ikewaki
Summary: Cardiovascular disease (CVD) is the leading cause of death in Western countries. Recent epidemiology studies have shown a U-shaped relationship between high-density lipoprotein cholesterol (HDL-C) levels and CVD mortality, with increased mortality in patients with extremely high HDL-C levels. HDL-C raising therapy using nicotinic acids or CETP inhibitors has shown limited efficacy in reducing CVD events. As a result, the focus has shifted to evaluating HDL functionality as a novel biomarker for CVD risk. This review provides an overview of the current status and future perspectives on HDL functions, based on findings from basic research and clinical trials.
Article
Cardiac & Cardiovascular Systems
Kelly M. Stanton, Vivian Kienzle, Donna Lee M. Dinnes, Irina Kotchetkov, Wendy Jessup, Leonard Kritharides, David S. Celermajer, Kerry-Anne Rye
Summary: Exercise is associated with a reduced risk of cardiovascular disease, with increased HDL-C levels playing a key role. Controlled studies show that moderate intensity exercise improves HDL function, lipid/lipoprotein profile, fitness, and body composition. A sequential moderate followed by high-intensity exercise program yields sustained or incremental benefits in these parameters.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Endocrinology & Metabolism
Himani Thakkar, Vinnyfred Vincent, Sakshi Sukhla, Manraj Sra, Uma Kanga, Sandeep Aggarwal, Archna Singh
Summary: The study found that bariatric surgery led to significant improvements in BMI, insulin sensitivity, and inflammation, as well as increased cholesterol efflux capacity (CEC) of HDL in individuals with obesity. The improvement in CEC was associated with changes in apo A-I and adiponectin levels, suggesting that enhancing adipose tissue health and insulin sensitivity may be important in reducing obesity-related cardiovascular disease risk.
DIABETOLOGY & METABOLIC SYNDROME
(2021)
Article
Medicine, Research & Experimental
Vasily A. Kudinov, Tatiana I. Torkhovskaya, Tamara S. Zakharova, Galina E. Morozevich, Rafael I. Artyushev, Marina Yu. Zubareva, Sergey S. Markin
Summary: The study demonstrates that lipidating HDL with phospholipid nanoparticles can improve HDL functionality, enhance cholesterol efflux capacity, and provide protection against atherosclerosis progression.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Biochemistry & Molecular Biology
Maria Noflatscher, Monika Hunjadi, Michael Schreinlechner, Philip Sommer, Daniela Lener, Markus Theurl, Rudolf Kirchmair, Axel Bauer, Andreas Ritsch, Peter Marschang
Summary: In this study, a negative correlation was found between high peripheral plaque volume and cholesterol efflux capacity (CEC). This result supports the role of CEC in the pathophysiology of atherosclerosis.
Review
Chemistry, Medicinal
Saba Soltani, Motahareh Boozari, Arrigo F. G. Cicero, Tannaz Jamialahmadi, Amirhossein Sahebkar
Summary: HDL plays a crucial role in cardiovascular diseases, while phytochemicals have the potential to enhance cholesterol efflux. Current research mostly focuses on preclinical studies, indicating a need for more clinical research to develop novel clinical applications.
PHYTOTHERAPY RESEARCH
(2021)
Article
Nutrition & Dietetics
Rebeca Quiros-Fernandez, Bricia Lopez-Plaza, Laura M. Bermejo, Samara Palma Milla, Andrea Zangara, Carmen Gomez Candela
Summary: The supplement containing HT and PC showed significant improvement in dyslipidemia, indicating its potential for preventing atherosclerosis and protecting the heart in adults.
Article
Nutrition & Dietetics
Peiwen Zhang, Ke Chen, Taiping He, Honghui Guo, Xu Chen
Summary: This study demonstrates that CoQ10 has beneficial effects on glucolipid metabolism and adipokine dysfunction in dyslipidemic patients. The improvement of glucolipid profile by CoQ10 is mediated by adiponectin.
NUTRITION & METABOLISM
(2022)
Article
Biochemistry & Molecular Biology
Elham Sharifi-Zahabi, Nayebali Rezvani, Fatemeh Hajizadeh-Sharafabad, Fatemeh Sadat Hosseini-Baharanchi, Farzad Shidfar, Mehrali Rahimi
Summary: The study found that supplementation of pure theobromine (TB) combined with a low-calorie diet had beneficial effects on overweight and obese individuals with metabolic syndrome. It significantly reduced waist circumference and improved lipid and metabolic markers. This suggests that TB may be an effective adjunctive treatment.
Article
Nutrition & Dietetics
Alyann Otrante, Amal Trigui, Roua Walha, Hicham Berrougui, Tamas Fulop, Abdelouahed Khalil
Summary: EVOO intake improves cholesterol efflux capacity of HDL in elderly subjects by modulating the distribution of HDL subclasses, leading to enhanced anti-atherogenic activity of HDL.
Article
Agriculture, Multidisciplinary
Yao Liu, Xu Wang, Juan Pang, Hanyue Zhang, Jing Luo, Xiaoyun Qian, Qian Chen, Wenhua Ling
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2019)
Article
Endocrinology & Metabolism
X. Wang, X. Chen, H. Zhang, J. Pang, J. Lin, X. Xu, L. Yang, J. Ma, W. Ling, Y. Chen
DIABETES & METABOLISM
(2020)
Article
Endocrinology & Metabolism
Q. Li, Q. Chen, H. Zhang, Z. Xu, X. Wang, J. Pang, J. Ma, W. Ling, D. Li
DIABETES & METABOLISM
(2020)
Article
Biochemistry & Molecular Biology
Hanyue Zhang, Zhongliang Xu, Huiwen Zhao, Xu Wang, Juan Pang, Qing Li, Yan Yang, Wenhua Ling
Article
Pharmacology & Pharmacy
Juan Pang, Huihui Xu, Xu Wang, Xu Chen, Qing Li, Qiannan Liu, Yiran You, Hanyue Zhang, Zhongliang Xu, Yimin Zhao, Yinghui Zhang, Yan Yang, Wenhua Ling
Summary: This study found that RSV can dose-dependently reduce blood cholesterol levels in mice fed with HFD or HCD, by enhancing trans-intestinal cholesterol excretion (TICE) and limiting cholesterol absorption through selective activation of intestinal LXR alpha.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Clinical Neurology
Yihan Hu, Huazhen Yang, Can Hou, Wenwen Chen, Hanyue Zhang, Zhiye Ying, Yao Hu, Yajing Sun, Yuanyuan Qu, Maria Feychting, Unnur Valdimarsdottir, Huan Song, Fang Fang
Summary: In this study, individuals with neurodegenerative diseases were found to have a higher risk of COVID-19 and were particularly susceptible to COVID-19 related deaths compared to the reference group.
Article
Nutrition & Dietetics
Hanyue Zhang, Alistair M. Senior, Christoph Saner, Nanna J. Olsen, Sofus C. Larsen, Stephen J. Simpson, David Raubenheimer, Berit L. Heitmann
Summary: The protein leverage hypothesis (PLH) was confirmed in preschool children, with protein intake being the most tightly regulated macronutrient and energy intake inversely related to dietary protein concentration. High dietary protein intake was associated with decreased waist- and hip-height ratio over time, suggesting an impact on obesity risk in children.
CLINICAL NUTRITION
(2023)
Article
Nutrition & Dietetics
Hanyue Zhang, Yu Zeng, Huazhen Yang, Yihan Hu, Yao Hu, Wenwen Chen, Zhiye Ying, Yajing Sun, Yuanyuan Qu, Qian Li, Unnur A. Valdimarsdottir, Huan Song
Summary: The study found that familial factors modify the association between diet and cardiovascular disease, highlighting the need for personalized dietary guidelines for cardiovascular disease prevention.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2021)
Article
Biochemistry & Molecular Biology
Xiaoyun Qian, Xu Wang, Jing Luo, Yao Liu, Juan Pang, Hanyue Zhang, Zhongliang Xu, Jiewen Xie, Xinwei Jiang, Wenhua Ling