Article
Cell Biology
Qun-Guang Jiang, Cheng-Feng Xiong, Yun-Xia Lv
Summary: Kin17 is significantly upregulated in thyroid cancer, where it functions as an oncogene by activating the p38 MAPK signaling pathway to promote cell proliferation, migration, and invasion, while also affecting the sensitivity of cancer cells to Doxorubicin.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2021)
Article
Multidisciplinary Sciences
Kui Xiao, Shenggang Liu, Yijia Xiao, Yang Wang, Zhiruo Zhu, Yaohui Wang, De Tong, Jiehan Jiang
Summary: This study identified a miRNA, hsa-mir-30a, that is differentially expressed in NSCLC and mainly affects the disease by regulating the cell cycle and drug metabolism.
Article
Cell Biology
Romain Larrue, Sandy Fellah, Nihad Boukrout, Corentin De Sousa, Julie Lemaire, Carolane Leboeuf, Marine Goujon, Michael Perrais, Bernard Mari, Christelle Cauffiez, Nicolas Pottier, Cynthia van der Hauwaert
Summary: Non-small cell lung cancer is characterized by poor prognosis due to low diagnosis efficiency and drug resistance. Targeting a specific small RNA (miR-92a-3p) may be an effective strategy to overcome chemotherapy resistance in cancer cells.
CELL DEATH & DISEASE
(2023)
Article
Oncology
Hernando Lopez-Bertoni, John Laterra
Summary: Cutting-edge developments in nanomedicine and the recent FDA approval of two siRNA-based therapeutics have reignited interest in RNA interference (RNAi) as potential novel cancer treatments. MiRNAs are emerging as the next-generation RNAi therapeutics, advancements in delivery vehicles for in vivo miRNA delivery are progressing, and the clinical translation of miRNA technology is being explored.
TRANSLATIONAL ONCOLOGY
(2021)
Review
Oncology
Faheem Hyder Pottoo, Ashif Iqubal, Mohammad Kashif Iqubal, Mohammed Salahuddin, Jawad Ur Rahman, Noora AlHajri, Mustafa Shehadeh
Summary: miRNAs can modulate multiple signaling pathways of the immune system, aiding in cancer diagnosis and treatment to reduce immune escape. Although immunotherapy holds promise for cancer treatment, it faces challenges like high treatment costs, unpredictable toxicity, and uncertain clinical outcomes.
Article
Pharmacology & Pharmacy
Babak Jahangiri, Mohammad Khalaj-Kondori, Elahe Asadollahi, Leyli Purrafee Dizaj, Majid Sadeghizadeh
Summary: This study found that exosomes derived from mesenchymal stem cells (MSC-Exos) can suppress proliferation, migration, invasion, and metastasis while inducing apoptosis of colorectal cancer (CRC) cells through the miR-100/mTOR/miR-143 axis. These findings suggest that MSC-Exo treatment and miR-100 restoration may be potential therapeutic strategies for CRC.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Cell Biology
Shuo Wang, Peng Du, Yudong Cao, Jinchao Ma, Xiao Yang, Ziyi Yu, Yong Yang
Summary: Cancer-associated fibroblasts (CAFs) play important roles in promoting tumor growth and metastasis in prostate cancer (PC) through the transfer of exosomes. This study reveals that the exosomal miR-1290 from CAFs enhances PC cell growth and metastasis by inhibiting GSK3 beta/beta-catenin signaling.
CELL DEATH DISCOVERY
(2022)
Article
Oncology
Heng-Heng Yuan, Xin-Chen Zhang, Xiao-Li Wei, Wen-Jie Zhang, Xiao-Xue Du, Peng Huang, Hao Chen, Lu Bai, Hong-Feng Zhang, Yu Han
Summary: This study elucidates the detailed role of UCA1 in cetuximab resistance in colorectal cancer (CRC) and its underlying molecular mechanism. UCA1 decreases CRC cell sensitivity to cetuximab by suppressing apoptosis and activating the HGF/c-MET pathway. This discovery provides evidence for UCA1 as a predictor and therapeutic target for cetuximab resistance.
Review
Biochemistry & Molecular Biology
Petra Korac, Mariastefania Antica, Maja Matulic
Summary: miR-7 is an ancient miRNA involved in cell signaling pathways, acting primarily as a tumor suppressor by inhibiting cell proliferation and promoting apoptosis. It also has additional roles in cell regulation and protection, with potential for use in biotherapeutics.
Review
Oncology
Amir Abbas Hamidi, Negin Taghehchian, Zahra Basirat, Amir Sadra Zangouei, Meysam Moghbeli
Summary: Thyroid cancer is a common endocrine malignancy, with a higher prevalence in females. Tumor recurrence is a significant clinical manifestation in differentiated thyroid cancer, and it is influenced by factors such as age, tumor size, and histological features. Molecular processes like genetic and epigenetic modifications, as well as non-coding RNAs, are also involved in the progression and metastasis of thyroid cancer.
BIOMARKER RESEARCH
(2022)
Article
Multidisciplinary Sciences
Sang Eun Park, Wonju Kim, Ji-Ye Hong, Dayeon Kang, Seulki Park, Jungyo Suh, Dalsan You, Yun-Yong Park, Nayoung Suh, Jung Jin Hwang, Choung-Soo Kim
Summary: This study identified miR-96-5p as a key regulator in sunitinib resistance in CCRCC by direct suppression of PTEN, leading to poor prognosis in patients with high miR-96-5p and low PTEN levels.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Huyan Ting, Lina Gao, Na Gao, Chaochao Wang, Wuli Guo, Xiaojie Zhou, Qi Li
Summary: Bladder cancer impairs NK cell function and immune surveillance through exosomes. Specific miRNAs in exosomes may interfere with gene stability in NK cells and can be potential targets for BC therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, Research & Experimental
Carlotta Boscaro, Giovanni Eugenio Ramaschi, Lucia Trevisi, Andrea Cignarella, Chiara Bolego
Summary: miR-206 can interfere with GPER-mediated signaling and cell motility, and has the potential to act as pathway-selective antagonists in estrogen-dependent EOC.
Article
Integrative & Complementary Medicine
Hui Qiao, Na Wang, Quan-Lin Guan, Peng Xie, Xiang-Kai Li
Summary: This study revealed that miR-22-3p is downregulated in gastric cancer cells. Further experiments demonstrated that miR-22-3p suppresses the proliferation and migration of gastric cancer cells and induces cell death. The study also discovered the involvement of miR-22-3p in glycolysis by regulating lactate generation and glucose consumption. ENO1 was identified as a target gene of miR-22-3p.
ALTERNATIVE THERAPIES IN HEALTH AND MEDICINE
(2023)
Review
Oncology
Ying Yang, Wen-Jian Meng, Zi-Qiang Wang
Summary: Colorectal cancer is one of the most common and lethal malignant tumors in the world. MicroRNAs have been identified as key regulators in CRC and potential targets to overcome drug resistance.
FRONTIERS IN ONCOLOGY
(2022)