Review
Microbiology
Abdulaziz H. Alanazi, Mir S. Adil, Xiaorong Lin, Daniel B. Chastain, Andres F. Henao-Martinez, Carlos Franco-Paredes, Payaningal R. Somanath
Summary: Intracranial hypertension is the main cause of increased mortality in cryptococcal meningoencephalitis. Pharmacologic therapy aimed at reducing cerebrospinal fluid production or increasing resorption may improve clinical outcomes for patients with this condition.
Article
Medicine, Research & Experimental
Paola Garcia-Huertas, Nora Cardona-Castro
Summary: Chagas disease is currently treated with only two drugs, benznidazole and nifurtimox, which have limitations including efficacy in specific infection stages, adverse effects, and parasite resistance. Some institutions and research groups are exploring new therapeutic alternatives through strategies like dosage modification, drug repurposing, combined therapy, the study of medicinal plants, and identification of essential parasite genes for targeted drug design. Collaboration and knowledge exchange among these entities could lead to the development of innovative treatments for Chagas disease.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Review
Medicine, Research & Experimental
Junyi Ren, Bo Wang, Qifeng Wu, Guiling Wang
Summary: Niclosamide, besides treating parasitic infections, can also be used to treat cancer and other diseases. Studies have shown that combining it with chemotherapeutic drugs, targeted drugs, radiotherapy, and immunotherapy can enhance its anti-tumor effect.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Review
Pharmacology & Pharmacy
Maria John Newton Amaldoss, Jia-Lin Yang, Pramod Koshy, Ashwin Unnikrishnan, Charles C. Sorrell
Summary: Inorganic nanoparticles used for drug delivery in cancer treatment offer numerous advantages, such as maximizing therapeutic effect through targeting ligands and minimizing side-effects. They have shown promising combined therapeutic capabilities, including anticancer effects and inhibition of cancer cell signaling pathways. Inorganic nanoparticles serve as synergistic platforms for RNA interference and as drug delivery agents for targeting cancer cell signaling pathways.
DRUG DISCOVERY TODAY
(2022)
Review
Microbiology
Marco da Silva, Catia Teixeira, Paula Gomes, Margarida Borges
Summary: Toxoplasmosis is a parasitic disease caused by Toxoplasma gondii that infects around one-third of the world population and can lead to serious complications. Current treatment options are limited with toxic side effects, requiring long treatment durations. Promising drug targets and compounds for anti-T. gondii drug discovery offer new perspectives for future research in this field.
Review
Chemistry, Multidisciplinary
Mei Zhang, Xianfeng Chen, Norbert Radacsi
Summary: Combination therapy has long been used to improve anti-tumor efficacy and address multidrug resistance in cancer treatment. Repurposed non-chemo drugs and dietary phytochemicals are promising alternatives that offer a safe and cost-effective strategy for conventional anti-tumor therapeutics.
JOURNAL OF CONTROLLED RELEASE
(2021)
Review
Pharmacology & Pharmacy
Fujing Ge, Yuekang Li, Tao Yuan, Yulian Wu, Qiaojun He, Bo Yang, Hong Zhu
Summary: This article focuses on the significant role of DUBs in the development of drug resistance and the potential application of DUB inhibitors in combination therapies to overcome drug resistance.
DRUG DISCOVERY TODAY
(2022)
Article
Endocrinology & Metabolism
Matthew D. Ringel
Summary: Treatment of progressive metastatic follicular cell-derived and medullary thyroid cancers is challenging, with limited complete remissions, short response durations, and common toxicities. Further research into resistance mechanisms, biomarker development, and new therapeutic strategies is needed.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Pharmacology & Pharmacy
Joseph Ho, Constance Fiocco, Kristen Spencer
Summary: Biliary tract cancers are rare and aggressive tumors that are often diagnosed at an advanced stage. Current treatment options include chemotherapy and targeted therapies, but new combination strategies and immunotherapies show promise in clinical research. Molecular profiling has enabled the development of novel targeted therapy drugs, and clinical trials have successfully targeted molecular abnormalities in genes such as FGFR, IDH, HER2, and BRAF. The management of BTCs is rapidly evolving, and this article reviews the emerging targets and therapies in this field.
Review
Biochemistry & Molecular Biology
Zdenek Fisar
Summary: Damage or loss of brain cells and impaired neurochemistry, neurogenesis, and synaptic and nonsynaptic plasticity of the brain lead to dementia in neurodegenerative diseases, such as Alzheimer's disease (AD). Injury to synapses and neurons and accumulation of extracellular amyloid plaques and intracellular neurofibrillary tangles are considered the main morphological and neuropathological features of AD. Age, genetic and epigenetic factors, environmental stressors, and lifestyle contribute to the risk of AD onset and progression. These risk factors are associated with structural and functional changes in the brain, leading to cognitive decline. Biomarkers of AD reflect or cause specific changes in brain function, especially changes in pathways associated with neurotransmission, neuroinflammation, bioenergetics, apoptosis, and oxidative and nitrosative stress. Even in the initial stages, AD is associated with A beta neurotoxicity, mitochondrial dysfunction, and tau neurotoxicity. The integrative amyloid-tau-mitochondrial hypothesis assumes that the primary cause of AD is the neurotoxicity of A beta oligomers and tau oligomers, mitochondrial dysfunction, and their mutual synergy. For the development of new efficient AD drugs, targeting the elimination of neurotoxicity, mutual potentiation of effects, and unwanted protein interactions of risk factors and biomarkers (mainly A beta oligomers, tau oligomers, and mitochondrial dysfunction) in the early stage of the disease seems promising.
Review
Biochemistry & Molecular Biology
Huiling Shu, Rongxin Zhang, Ke Xiao, Jing Yang, Xiao Sun
Summary: G-quadruplexes are non-canonical secondary nucleic acid structures that play important roles in genome regulation. Interactions between G-quadruplexes and proteins have diverse biological functions and potential therapeutic applications.
Review
Oncology
Laura Bracci, Alessia Fabbri, Manuela Del Corno, Lucia Conti
Summary: Colorectal cancer is a major global cause of death, and the current medical treatments are not sufficient to control metastatic disease. Combination therapy involving cytotoxic treatments and non-toxic natural compounds is seen as a promising more effective and safer alternative. Polyphenols found in fruit and vegetables have shown potential for enhancing colorectal cancer therapy, but further clinical studies are needed to definitively prove their value.
Review
Oncology
Masaki Kuwatani, Naoya Sakamoto
Summary: The poor prognosis of cholangiocarcinoma can be overcome with highly targeted therapies such as antibody-drug conjugates, photodynamic therapy, and experimental photoimmunotherapy. These therapies have shown promising results in preclinical trials and have the potential to be effective treatments for cholangiocarcinoma. Further research and development are needed to identify universal targets for highly targeted therapies and advance their use in human cases.
Review
Immunology
Yong Chiang Tan, Chandrajit Lahiri
Summary: In parallel with the uncontrolled use of antibiotics, the emergence of multidrug-resistant bacteria has posed a severe threat to human health. Recent research has shown that designing vaccines is a realistic alternative strategy to combat this threat. By utilizing methods such as pan-genomics and network analysis, potential antigens for anti-A. baumannii vaccines can be discovered. As conventional approaches have limitations, in silico techniques, particularly network analysis, have shown promise in uncovering novel vaccine candidates.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Chemistry, Medicinal
Gemma S. Perry, Mohua Das, Esther C. Y. Woon
Summary: The AlkB family of nucleic acid demethylases is currently a focus of intense research due to its critical roles in key cellular processes and its potential involvement in various human diseases. Developing selective inhibitors for these enzymes is of strong interest for therapeutic purposes. Researchers have made significant progress in understanding and targeting these enzymes, paving the way for novel inhibitor design and drug discovery in this field.
JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Immunology
Carolina Coelho, Ana Camila Oliveira Souza, Lorena da Silveira Derengowski, Carlos de Leon-Rodriguez, Bo Wang, Rosiris Leon-Rivera, Anamelia Lorenzetti Bocca, Teresa Goncalves, Arturo Casadevall
JOURNAL OF IMMUNOLOGY
(2015)
Article
Biochemistry & Molecular Biology
Efstathios G. Stamatiades, Marie-Eve Tremblay, Mathieu Bohm, Lucile Crozet, Kanchan Bisht, Daniela Kao, Carolina Coelho, Xiying Fan, William T. Yewdell, Anne Davidson, Peter S. Heeger, Sandra Diebold, Falk Nimmerjahn, Frederic Geissmann
Article
Immunology
Sabriya Stukes, Carolina Coelho, Johanna Rivera, Anne E. Jedlicka, Katherine A. Hajjar, Arturo Casadevall
JOURNAL OF IMMUNOLOGY
(2016)
Article
Microbiology
Diego C. P. Rossi, Julie E. Gleason, Hiram Sanchez, Sabrina S. Schatzman, Edward M. Culbertson, Chad J. Johnson, Christopher A. McNees, Carolina Coelho, Jeniel E. Nett, David R. Andes, Brendan P. Cormack, Valeria C. Culotta
Article
Immunology
Joudeh B. Freij, Man Shun Fu, Carlos M. De Leon Rodriguez, Amanda Dziedzic, Anne E. Jedlicka, Quigly Dragotakes, Diego C. P. Rossi, Eric H. Jung, Carolina Coelho, Arturo Casadevall
INFECTION AND IMMUNITY
(2018)
Article
Immunology
Carlos M. De Leon-Rodriguez, Diego C. P. Rossi, Man Shun Fu, Quigly Dragotakes, Carolina Coelho, Ignacio Guerrero Ros, Benjamin Caballero, Sabrina J. Nolan, Arturo Casadevall
JOURNAL OF IMMUNOLOGY
(2018)
Review
Immunology
Arturo Casadevall, Carolina Coelho, Radames J. B. Cordero, Quigly Dragotakes, Eric Jung, Raghav Vij, Maggie P. Wear
Article
Biochemistry & Molecular Biology
Carolina Coelho, Lisa Brown, Maria Maryam, Raghav Vij, Daniel F. Q. Smith, Meagan C. Burnet, Jennifer E. Kyle, Heino M. Heyman, Jasmine Ramirez, Rafael Prados-Rosales, Gregoire Lauvau, Ernesto S. Nakayasu, Nathan R. Brady, Anne Hamacher-Brady, Isabelle Coppens, Arturo Casadevall
JOURNAL OF BIOLOGICAL CHEMISTRY
(2019)
Article
Microbiology
Maria Maryam, Man Shun Fu, Alexandre Alanio, Emma Camacho, Diego S. Goncalves, Eden E. Faneuff, Nina T. Grossman, Arturo Casadevall, Carolina Coelho
Article
Microbiology
Otavio Hatanaka, Caroline Patini Rezende, Pedro Moreno, Fabricio Freitas Fernandes, Patricia Kellen Martins Oliveira Brito, Roberto Martinez, Carolina Coelho, Maria Cristina Roque-Barreira, Arturo Casadevall, Fausto Almeida
Review
Biochemistry & Molecular Biology
Carolina Coelho, Arturo Casadevall
BIOCHEMICAL SOCIETY TRANSACTIONS
(2019)
Article
Microbiology
Carolina Coelho, Emma Camacho, Antonio Salas, Alexandre Alanio, Arturo Casadevall
Editorial Material
Immunology
Carolina Coelho, Rebecca A. Drummond
TRENDS IN IMMUNOLOGY
(2019)
Article
Microbiology
Carolina Coelho