Article
Environmental Sciences
Ziwei Chen, Jing He, Wenyu Shi
Summary: This study found an association between environmental phenols and the prevalence of cardiovascular diseases, particularly a J-curve shaped relationship between bisphenol A and cardiovascular disease risk.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Francisco Manuel Peinado, Luz Maria Iribarne-Duran, Francisco Artacho-Cordon
Summary: This study aimed to summarize the current evidence on the relationship between human exposure to bisphenols, parabens, and benzophenones and levels of inflammatory biomarkers. A systematic review of 20 articles found consistent positive associations between exposure to these chemicals, particularly bisphenol A, and levels of pro-inflammatory biomarkers. However, more studies are needed to better understand the mechanisms and role of inflammation in the adverse health effects associated with these chemicals.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Environmental Sciences
Junjie Ao, Qianlong Zhang, Weifeng Tang, Tao Yuan, Jun Zhang
Summary: A method for simultaneous determination of eighteen environmental phenols in human urine was developed, utilizing urinary concentrations as valid biomarkers for human exposure assessment. The method was time-saving, required low volumes of organic solvents, and showed good linearity, satisfactory limit of detection, and good relative recoveries and precision. This method provides a large-scale biomonitoring tool for the evaluation of human exposure to environmental phenols.
Article
Environmental Sciences
Guoyu Zhou, Meng Yang, Jian Chai, Renjie Sun, Junxi Zhang, Hui Huang, Yawei Zhang, Qihong Deng, Lifang Jiang, Yue Ba
Summary: The study found that changes in preconception ambient temperature have a significant impact on the risk of preterm birth, especially when exposed to extreme high temperatures. Changes in preconception ambient temperature within 2 weeks or longer before conception were found to be sensitive to the risk of preterm birth, providing guidance for rural couples when planning for pregnancy.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Obstetrics & Gynecology
Junjie Ao, Wei Qiu, Xiaona Huo, Yuqing Wang, Wenjuan Wang, Qianlong Zhang, Zhiwei Liu, Jun Zhang, Shanghai Birth Cohort Study
Summary: This study investigated the association between pre-conception exposure to parabens and fecundity in couples of childbearing age. The findings showed that paraben exposure in female partners was associated with reduced couple fecundity, with AMH potentially mediating this relationship.
HUMAN REPRODUCTION
(2023)
Article
Biochemistry & Molecular Biology
Manuel S. Vidal, Ramkumar Menon, Gracia Fe B. Yu, Melissa D. Amosco
Summary: This article summarizes the possible mechanisms of action of bisphenols on preterm birth by conducting an integrative literature search. The results suggest that bisphenols may have adverse effects on the placenta, decidua, and fetal membranes, leading to failure of pregnancy maintenance and preterm birth.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Environmental Sciences
Wei-Jen Chen, Candace Robledo, Erin M. Davis, Jean R. Goodman, Chao Xu, Jooyeon Hwang, Amanda E. Janitz, Tabitha Garwe, Antonia M. Calafat, Jennifer D. Peck
Summary: Prior studies have identified the associations between environmental phenol and paraben exposures and increased risk of gestational diabetes mellitus (GDM), but no study addressed these exposures as mixtures. Our study used Bayesian kernel machine regression (BKMR) to evaluate the association between phenol and paraben mixtures and GDM. We found that benzophenone-3 was positively associated with GDM, while BPA was negatively associated with GDM. No other chemical biomarkers were found to be associated with GDM in the BKMR analysis.
ENVIRONMENTAL RESEARCH
(2022)
Article
Nutrition & Dietetics
Yeyi Zhu, Monique M. Hedderson, Susan D. Brown, Sylvia E. Badon, Juanran Feng, Charles P. Quesenberry, Assiamira Ferrara
Summary: A healthy prenatal lifestyle with multiple low-risk modifiable factors was associated with lower risk of preterm birth. The combination of healthy weight, high-quality diet, and low-to-moderate stress showed a significant decrease in PTB risk. Strategies focusing on these low-risk factors may help mitigate the risk of preterm birth.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2021)
Article
Environmental Sciences
Carolin Tschersich, Aline Murawski, Gerda Schwedler, Enrico Rucic, Rebecca K. Moos, Monika Kasper-Sonnenberg, Holger M. Koch, Thomas Bruening, Marike Kolossa-Gehring
Summary: Exposure to environmental phenols such as bisphenol A, benzophenones, 2-phenylphenol, triclosan, and triclocarban is a concern due to their endocrine disrupting properties and widespread use in consumer products. A study in Germany assessed the current body burden of these substances in a population aged 3-17, finding bisphenol A to be the most prominent phenol, followed by benzophenones. Further monitoring and efforts to reduce exposure are necessary to minimize environmental health risks.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Peripheral Vascular Disease
Wenxue Xiong, Lu Han, Xijia Tang, Qiong Wang, Wen Chen, Rui Li, Hui Zhang, Xiaohua Liu, Hua Nie, Weibing Qin, Yang Hu, Zhirong Zhang, Li Ling
Summary: This study investigated the association between maternal preconception blood pressure and preterm birth, finding that preconception hypertension is associated with an increased risk of preterm birth and that the risk is higher with higher blood pressure levels. The study also found a dose-response relationship between preconception systolic and diastolic blood pressure and preterm birth, with the association being influenced by maternal age and body mass index.
HYPERTENSION RESEARCH
(2023)
Article
Environmental Sciences
Ziga Tkalec, Tina Kosjek, Janja Snoj Tratnik, Anja Stajnko, Agneta Annika Runkel, Marianthi Sykiotou, Darja Mazej, Milena Horvat
Summary: The study in Slovenian children and adolescents revealed exposure to a wide range of different endocrine disrupting chemicals, with variations in levels based on age, gender, and location. Associations were found between exposure levels and factors such as dietary habits, use of food packaging, and personal care products. Additionally, a genetic polymorphism in UGT2B15 gene was linked to levels of methyl and ethyl paraben, indicating a potential biomarker for susceptibility to adverse effects caused by exposure.
ENVIRONMENT INTERNATIONAL
(2021)
Article
Public, Environmental & Occupational Health
Erin Delker, Gladys A. Ramos, Gretchen Bandoli, D. Yvette LaCoursiere, Karen Ferran, Linda C. Gallo, Eyal Oren, Sheila Gahagan, Matthew Allison
Summary: This study found that preconception diabetes and prediabetes are associated with an increased risk of preterm birth, and that hemoglobin A1c (HbA1c) has a non-linear relationship in predicting this risk. Additionally, women with unstable health care coverage and those who only use the emergency room as their usual source of care have a four to five times higher risk of preterm birth associated with elevated HbA1c.
JOURNAL OF WOMENS HEALTH
(2023)
Article
Environmental Sciences
Hua Zhang, Jingxia Li, Yulin An, Desheng Wang, Jianfu Zhao, Meixiao Zhan, Weiguo Xu, Ligong Lu, Yunfei Gao
Summary: This study analyzed the concentrations of various endocrine-disrupting chemicals in urine and blood samples of young adults in South China. It found that females generally had higher levels of most target analytes, and some compounds showed higher enrichment capacities in human blood compared to urine.
Article
Endocrinology & Metabolism
Hanze Du, Danning Wu, Xiang Zhou, Hongbo Yang, Huijuan Zhu, Shi Chen, Hui Pan
Summary: The relationship between maternal thyroid function and pregnancy outcomes is still controversial in women planning pregnancy. This study found that preconception TSH levels were associated with preterm delivery, large for gestational age (LGA), and low birth weight (LBW). The safe range of TSH for preconception women was within 0.91 to 1.82 mIU/L.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Multidisciplinary Sciences
Hakimeh Teiri, Mohammad Reza Samaei, Mansooreh Dehghani, Abooalfazl Azhdarpoor, Farzaneh Mohammadi, Roya Kelishadi, Yaghoub Hajizadeh
Summary: The widespread use of benzophenones (BPs) is suspected to have adverse effects on human health. This study investigated the association between prenatal exposure to benzophenone derivatives and birth outcomes. The results suggested that benzophenone metabolites can influence fetal growth, and more studies are needed to confirm these findings.
SCIENTIFIC REPORTS
(2023)
Article
Environmental Sciences
Ana E. Skomal, Jasen Zhang, Kun Yang, Jessica Yen, Xin Tu, Jose Suarez-Torres, Dolores Lopez-Paredes, Antonia M. Calafat, Maria Ospina, Danilo Martinez, Jose R. Suarez-Lopez
Summary: This study found that urinary organophosphate metabolites, especially at concentrations above the 80th percentile, were associated with lower AChE activity among adolescents. These findings highlight the importance of considering multiple constructs of pesticide exposure in epidemiological studies.
ENVIRONMENTAL RESEARCH
(2022)
Article
Environmental Sciences
Weili Yang, Joseph M. Braun, Ann M. Vuong, Zana Percy, Yingying Xu, Changchun Xie, Ranjan Deka, Antonia M. Calafat, Maria Ospina, Erika Werner, Kimberly Yolton, Kim M. Cecil, Bruce P. Lanphear, Aimin Chen
Summary: This study found that maternal exposure to organophosphate esters (OPEs) may be associated with increased blood pressure during pregnancy and hypertensive disorders of pregnancy (HDP), particularly with the concentrations of diphenyl phosphate (DPHP) and bis(2-chloroethyl) phosphate (BCEP) showing stronger correlations with elevated blood pressure. Di-n-butyl phosphate (DNBP) concentrations were also associated with HDP, albeit with borderline significance.
ENVIRONMENTAL RESEARCH
(2022)
Article
Public, Environmental & Occupational Health
Seth McCormick, John E. Snawder, I-Chen Chen, Jonathan Slone, Antonia M. Calafat, Yuesong Wang, Lei Meng, Marissa Alexander-Scott, Michael Breitenstein, Belinda Johnson, Juliana Meadows, Cheryl Fairfield Estill
Summary: This study investigated the occupational exposure levels of PAHs among RCTS workers, finding that their air and skin concentrations were significantly higher than previous levels for asphalt workers, further confirming the potential risks associated with PAH exposure.
INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH
(2022)
Article
Public, Environmental & Occupational Health
Jefferey L. Burgess, Julia M. Fisher, Amy Nematollahi, Alesia M. Jung, Miriam M. Calkins, Judith M. Graber, Casey C. Grant, Shawn C. Beitel, Sally R. Littau, John J. Gulotta, Darin D. Wallentine, R. Jeffrey Hughes, Charles Popp, Antonia M. Calafat, Julianne C. Botelho, Alissa D. Coleman, Natasha Schaefer-Solle, Paola Louzado-Feliciano, Simi O. Oduwole, Alberto J. Caban-Martinez
Summary: This study compared serum PFAS concentrations in firefighters from multiple fire departments with a general population sample. The results showed elevated concentrations of several PFAS in firefighters from four departments.
AMERICAN JOURNAL OF INDUSTRIAL MEDICINE
(2023)
Article
Environmental Sciences
Pilar Requena, Celia Perez-Diaz, Vicente Mustieles, Francisco M. Peinado, Josefa Leon, Francisco M. Perez-Carrascosa, Hanne Frederiksen, Inmaculada Salcedo-Bellido, Rocio Barrios-Rodriguez, Juan Pedro Arrebola
Summary: This study investigates the associations between human phthalate exposure and the onset of chronic diseases with an immunological component. The results suggest that certain phthalates are correlated with cytokines and acute phase proteins, indicating potential subclinical immuno-inflammatory actions of these pollutants.
ENVIRONMENTAL RESEARCH
(2023)
Article
Public, Environmental & Occupational Health
Sonia Hernandez-Diaz, Krista F. Huybrechts, Yu-Han Chiu, Jennifer J. Yland, Brian T. Bateman, Miguel A. Hernan
Summary: This article describes how to use healthcare databases to estimate the effects of interventions during pregnancy, using COVID-19 vaccination as an example. It proposes a framework for emulating a target trial and emphasizes the importance of conducting target trials at different gestational ages to reduce bias and improve interpretability of effect estimates.
Article
Oncology
Shereen Cynthia D'Cruz, Chunxiang Hao, Martin Labussiere, Vicente Mustieles, Carmen Freire, Louis Legoff, Laura Magnaghi-Jaulin, Alicia Olivas-Martinez, Andrea Rodriguez-Carrillo, Christian Jaulin, Arthur David, Mariana F. Fernandez, Fatima Smagulova
Summary: This study assessed the genetic and epigenetic effects of BPA exposure in adolescent males and human cells. The results showed that adolescents with high urinary BPA levels had higher copy numbers of repetitive regions and longer telomeres. DNA methylation at certain gene promoters was reduced. Similar results were observed in in vitro experiments. These findings suggest that BPA exposure may affect the expression of DNA repair factors and telomeric binding proteins.
CLINICAL EPIGENETICS
(2022)
Article
Obstetrics & Gynecology
Alexandra Hillcoat, Jaya Prakash, Leah Martin, Yu Zhang, Gabriela Rosa, Henning Tiemeier, Nicole Torres, Vicente Mustieles, Charleen D. Adams, Carmen Messerlian
Summary: The aetiology of female reproductive disorders is poorly understood despite their prevalence and burden on women's lives. Traumatic experiences may be linked to these disorders, and further research is needed to understand the relationship between trauma and reproductive outcomes. Racism may also act as a traumatic experience, and it is important to consider the interaction between mental and reproductive health. Neuroendocrinological mechanisms may contribute to the increased risk of adverse health outcomes in these domains. Future primary research is needed to investigate the proposed pathways between traumatic experiences and adverse female reproductive outcomes.
HUMAN REPRODUCTION
(2023)
Article
Immunology
Amelia K. Wesselink, Sharonda M. Lovett, Janice Weinberg, Ruth J. Geller, Tanran R. Wang, Annette K. Regan, Mary D. Willis, Rebecca B. Perkins, Jennifer J. Yland, Martha R. Koenig, Kenneth J. Rothman, Elizabeth E. Hatch, Lauren A. Wise
Summary: We conducted a prospective cohort study to examine the association between COVID-19 vaccination and menstrual cycle characteristics. Our findings suggest that COVID-19 vaccination is associated with a temporary increase in menstrual cycle length by 1 day, but not with other menstrual cycle characteristics.
Article
Medicine, General & Internal
Yu Zhang, Vicente Mustieles, Qi Sun, Brent Coull, Thomas McElrath, Sheryl L. Rifas-Shiman, Leah Martin, Yang Sun, Yi-Xin Wang, Emily Oken, Andres Cardenas, Carmen Messerlian
Summary: The study suggests that prenatal folate status may modify the negative associations between pregnancy PFAS concentrations and adverse birth outcomes.
Article
Environmental Sciences
Vicente Mustieles, Matthieu Rolland, Isabelle Pin, Cathrine Thomsen, Amrit K. Sakhi, Azemira Sabaredzovic, Gina Muckle, Karine Guichardet, Remy Slama, Claire Philippat
Summary: Further research is needed to understand the impact of harmful substances on child social behavior, especially during infancy.
ENVIRONMENTAL HEALTH PERSPECTIVES
(2023)
Article
Engineering, Environmental
Vicente Mustieles, Aurelien Lascouts, Oscar J. Pozo, Noemi Haro, Sarah Lyon-Caen, Paulina Jedynak, Sam Bayat, Cathrine Thomsen, Amrit K. Sakhi, Azemira Sabaredzovic, Remy Slama, Isabelle Ouellet-Morin, Claire Philippat
Summary: This study assessed the associations between phthalates and hormones in pregnant women, and found that exposure to certain phthalate metabolites, especially MBzP, may affect adrenal and reproductive hormone levels during pregnancy.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
Article
Obstetrics & Gynecology
Jennifer J. Yland, Amelia K. Wesselink, Annette K. Regan, Elizabeth E. Hatch, Kenneth J. Rothman, David A. Savitz, Tanran R. Wang, Krista F. Huybrechts, Sonia Hernandez-Diaz, Michael L. Eisenberg, Lauren A. Wise
Summary: COVID-19 vaccination in either partner at any time before conception is not associated with an increased rate of miscarriage.
HUMAN REPRODUCTION
(2023)
Article
Environmental Sciences
Valentina Rosolen, Elisa Giordani, Marika Mariuz, Maria Parpinel, Vicente Mustieles, Liese Gilles, Eva Govarts, Laura Rodriguez Martin, Kirsten Baken, Greet Schoeters, Ovnair Sepai, Eva Sovcikova, Lucia Fabelova, Jiri Kohoutek, Tina Kold Jensen, Adrian Covaci, Maarten Roggeman, Lisa Melymuk, Jana Klanova, Argelia Castano, Marta Esteban Lopez, Fabio Barbone
Summary: The knowledge about the effects of organophosphate flame retardants on children's neurodevelopment is limited. This research aimed to evaluate the association between exposure to these flame retardants and children's neurodevelopment. The study found a small, negative trend between neurodevelopment and exposure to BDCIPP and DPHP, but the evidence is limited. Further investigations are needed to explore the timing of exposure and the effect of other metabolites.
Article
Obstetrics & Gynecology
J. C. Bond, C. M. Coleman, J. J. Yland, A. K. Wesselink, T. Wang, M. Willis, E. E. Hatch, K. J. Rothman, D. Savitz, M. L. Eisenberg, L. A. Wise
Summary: This study found that female sleep duration had little association with spontaneous abortion (SAB), while male short sleep duration, female night work, and discrepancies in work schedules among partners had modest positive associations with SAB incidence.
HUMAN REPRODUCTION
(2023)