Laminin: loss-of-function studies

Laminin regulates PDGFRβ+ cell stemness and muscle development

(2016) Yao Yao et al.   Nature Communications

A New Mouse Model of Junctional Epidermolysis Bullosa: The LAMB3 628G>A Knockin Mouse

(2015) Johanna Hammersen et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

A dystonia-like movement disorder with brain and spinal neuronal defects is caused by mutation of the mouse laminin β1 subunit, Lamb1

(2015) Yi Bessie Liu et al.   eLife

Bortezomib Partially Improves Laminin α2 Chain–Deficient Muscular Dystrophy

(2014) Zandra Körner et al.   AMERICAN JOURNAL OF PATHOLOGY

Laminin geneLAMB4is somatically mutated and expressionally altered in gastric and colorectal cancers

(2014) Mi Ryoung Choi et al.   APMIS

The cellular origin of laminin determines its role in blood pressure regulation

(2014) Yao Yao et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Biology of the Extracellular Matrix

(2014) Beatrice Yue   JOURNAL OF GLAUCOMA

The Extracellular Matrix Protein Laminin  2 Regulates the Maturation and Function of the Blood-Brain Barrier

(2014) M. J. Menezes et al.   JOURNAL OF NEUROSCIENCE

Laminin α4 Deficient Mice Exhibit Decreased Capacity for Adipose Tissue Expansion and Weight Gain

(2014) Marcella K. Vaicik et al.   PLoS One

Lens Extrusion fromLaminin Alpha 1Mutant Zebrafish

(2014) Mallika Pathania et al.   TheScientificWorldJOURNAL

Astrocytic laminin regulates pericyte differentiation and maintains blood brain barrier integrity

(2014) Yao Yao et al.   Nature Communications

Laminins containing the  2 and  3 chains regulate astrocyte migration and angiogenesis in the retina

(2013) G. Gnanaguru et al.   DEVELOPMENT

Triggering regeneration and tackling apoptosis: a combinatorial approach to treating congenital muscular dystrophy type 1 A

(2013) J. Yamauchi et al.   HUMAN MOLECULAR GENETICS

Laminin-111 improves muscle repair in a mouse model of merosin-deficient congenital muscular dystrophy

(2013) Pam M. Van Ry et al.   HUMAN MOLECULAR GENETICS

Exome Resequencing Identifies Potential Tumor-Suppressor Genes that Predispose to Colorectal Cancer

(2013) Christopher G. Smith et al.   HUMAN MUTATION

Ablation of astrocytic laminin impairs vascular smooth muscle cell function and leads to hemorrhagic stroke

(2013) Zu-Lin Chen et al.   JOURNAL OF CELL BIOLOGY

The laminin family

(2013) Monique Aumailley   Cell Adhesion & Migration

Laminin-111 Protein Therapy Reduces Muscle Pathology and Improves Viability of a Mouse Model of Merosin-Deficient Congenital Muscular Dystrophy

(2012) Jachinta E. Rooney et al.   AMERICAN JOURNAL OF PATHOLOGY

β2 and γ3 laminins are critical cortical basement membrane components: Ablation of Lamb2 and Lamc3 genes disrupts cortical lamination and produces dysplasia

(2012) Stephanie Radner et al.   Developmental Neurobiology

Abnormal Wnt and PI3Kinase Signaling in the Malformed Intestine of lama5 Deficient Mice

(2012) Léa Ritié et al.   PLoS One

Keratinocyte-Targeted Expression of Human Laminin γ2 Rescues Skin Blistering and Early Lethality of Laminin γ2 Deficient Mice

(2012) Tracy L. Adair-Kirk et al.   PLoS One

Agrin and Synaptic Laminin Are Required to Maintain Adult Neuromuscular Junctions

(2012) Melanie A. Samuel et al.   PLoS One

Angiotensin II type 1 receptor antagonists alleviate muscle pathology in the mouse model for laminin-α2-deficient congenital muscular dystrophy (MDC1A)

(2012) Sarina Meinen et al.   Skeletal Muscle

Lama1 mutations lead to vitreoretinal blood vessel formation, persistence of fetal vasculature, and epiretinal membrane formation in mice

(2011) Malia M Edwards et al.   BMC DEVELOPMENTAL BIOLOGY

Renal collecting system growth and function depend upon embryonic  1 laminin expression

(2011) D.-H. Yang et al.   DEVELOPMENT

Apoptosis inhibitors and mini-agrin have additive benefits in congenital muscular dystrophy mice

(2011) Sarina Meinen et al.   EMBO Molecular Medicine

Autophagy is increased in laminin α2 chain-deficient muscle and its inhibition improves muscle morphology in a mouse model of MDC1A

(2011) Virginie Carmignac et al.   HUMAN MOLECULAR GENETICS

Lung-specific loss of the laminin α3 subunit confers resistance to mechanical injury

(2011) Daniela Urich et al.   JOURNAL OF CELL SCIENCE

Laminin α1 is essential for mouse cerebellar development

(2011) Naoki Ichikawa-Tomikawa et al.   MATRIX BIOLOGY

The γ3 chain of laminin is widely but differentially expressed in murine basement membranes: Expression and functional studies

(2011) Yong N. Li et al.   MATRIX BIOLOGY

Genetic Deletion of Laminin Isoforms β2 and γ3 Induces a Reduction in Kir4.1 and Aquaporin-4 Expression and Function in the Retina

(2011) Petra G. Hirrlinger et al.   PLoS One

Extracellular Matrix Degradation and Remodeling in Development and Disease

(2011) P. Lu et al.   Cold Spring Harbor Perspectives in Biology

Proteasome inhibition improves the muscle of laminin α2 chain-deficient mice

(2010) Virginie Carmignac et al.   HUMAN MOLECULAR GENETICS

Basement Membrane Deposition of Nidogen 1 but Not Nidogen 2 Requires the Nidogen Binding Module of the Laminin γ1 Chain

(2010) Sharada Mokkapati et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mutations inLama1Disrupt Retinal Vascular Development and Inner Limiting Membrane Formation

(2010) Malia M. Edwards et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Maintenance of Glomerular Filtration Barrier Integrity Requires Laminin  5

(2010) S. Goldberg et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Laminin-111: A Potential Therapeutic Agent for Duchenne Muscular Dystrophy

(2010) Sébastien Goudenege et al.   MOLECULAR THERAPY

Transgenic overexpression of laminin α1 chain in laminin α2 chain-deficient mice rescues the disease throughout the lifespan

(2010) Kinga I. Gawlik et al.   MUSCLE & NERVE

Distinct Roles for Laminin Globular Domains in Laminin α1 Chain Mediated Rescue of Murine Laminin α2 Chain Deficiency

(2010) Kinga I. Gawlik et al.   PLoS One

Laminin α4-Null Mutant Mice Develop Chronic Kidney Disease with Persistent Overexpression of Platelet-Derived Growth Factor

(2009) Christine K. Abrass et al.   AMERICAN JOURNAL OF PATHOLOGY

Laminins

(2009) Madeleine Durbeej   CELL AND TISSUE RESEARCH

Developmental and Pathogenic Mechanisms of Basement Membrane Assembly

(2009) Peter Yurchenco et al.   CURRENT PHARMACEUTICAL DESIGN

Omigapil Ameliorates the Pathology of Muscle Dystrophy Caused by Laminin- 2 Deficiency

(2009) M. Erb et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Endothelial basement membrane laminin α5 selectively inhibits T lymphocyte extravasation into the brain

(2009) Chuan Wu et al.   NATURE MEDICINE

Laminin-111 protein therapy prevents muscle disease in the mdx mouse model for Duchenne muscular dystrophy

(2009) J. E. Rooney et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pathology is alleviated by doxycycline in a laminin-α2-null model of congenital muscular dystrophy

(2008) Mahasweta Girgenrath et al.   ANNALS OF NEUROLOGY

Cortical deficiency of laminin γ1 impairs the AKT/GSK-3β signaling pathway and leads to defects in neurite outgrowth and neuronal migration

(2008) Zu-Lin Chen et al.   DEVELOPMENTAL BIOLOGY

Laminin-511 is an epithelial message promoting dermal papilla development and function during early hair morphogenesis

(2008) J. Gao et al.   GENES & DEVELOPMENT

Laminins promote postsynaptic maturation by an autocrine mechanism at the neuromuscular junction

(2008) Hiroshi Nishimune et al.   JOURNAL OF CELL BIOLOGY

Laminin  5 influences the architecture of the mouse small intestine mucosa

(2008) Z. X. Mahoney et al.   JOURNAL OF CELL SCIENCE

Laminins and their roles in mammals

(2008) Jeffrey H. Miner   MICROSCOPY RESEARCH AND TECHNIQUE

Bridging structure with function: Structural, regulatory, and developmental role of laminins

(2007) Julia Tzu et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY