Article
Biochemistry & Molecular Biology
Mikhail Melnikov, Mikhail Pashenkov, Alexey Boyko
Summary: Dopamine functions as a neurotransmitter in the central nervous system and has modulatory effects on both innate and adaptive immune system cells. It plays a critical role in regulating neuroinflammation in multiple sclerosis, and holds therapeutic potential for MS treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Immunology
Marlies Burgelman, Pieter Dujardin, Charysse Vandendriessche, Roosmarijn E. E. Vandenbroucke
Summary: The complement system is involved in neuroinflammatory disorders like Alzheimer's disease and multiple sclerosis. Measuring complement levels in biofluids could potentially serve as a biomarker for these diseases. Extracellular vesicles (EVs) that contain complement proteins may provide a platform to improve the diagnostic power of these proteins.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Soe Maung Maung Phone Myint, Liou Y. Sun
Summary: L-serine is a crucial amino acid involved in protein synthesis, cell proliferation, development, and sphingolipid formation in the central nervous system. It has neuroprotective and anti-inflammatory effects by activating glycine receptors and upregulating PPAR-γ. L-serine has potential as a protective agent in various neurological diseases and neurodegenerative disorders.
Review
Biochemistry & Molecular Biology
Sylwia Pietrasik, Angela Dziedzic, Elzbieta Miller, Michal Starosta, Joanna Saluk-Bijak
Summary: Multiple sclerosis is a neurodegenerative disease with a variable course, often characterized by alternating periods of exacerbation and stabilization. Distinguishing between subtypes early can lead to faster implementation of appropriate treatment. Research suggests circulating microRNAs may be valuable for MS diagnosis and predicting disease subtype.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Medicine, Research & Experimental
Yueran Li, Huifang Xu, Huifang Wang, Kui Yang, Jiajie Luan, Sheng Wang
Summary: Alzheimer's disease is a common neurodegenerative disease that leads to cognitive decline and memory loss. Current treatments only provide symptom relief and do not reverse the disease. Studies have shown that TREM2, predominantly expressed in microglia of the central nervous system, plays a protective role by regulating microglial function and promoting the clearance of toxic substances. However, the specific mechanism of action is not fully understood.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Cell & Tissue Engineering
Molly Monsour, Jonah Gordon, Gavin Lockard, Cesar V. Borlongan
Summary: The inflammation caused by multiple sclerosis (MS) promotes the development of ischemic stroke (IS), making IS a deadly complication of MS. The inflammation in both MS and IS is a precursor to vascular pathology, and it exacerbates neurovascular unit (NVU) impairment in disease progression. Despite the current lack of therapies for reducing IS incidence in MS patients, cell-based regenerative medicine shows promise in ameliorating IS risk by targeting NVU dysfunction and inflammation.
CELL TRANSPLANTATION
(2023)
Article
Cell Biology
Raed AlRuwaili, Hayder M. M. Al-kuraishy, Mubarak Alruwaili, Amira Karam Khalifa, Athanasios Alexiou, Marios Papadakis, Hebatallah M. M. Saad, Gaber El-Saber Batiha
Summary: Acute ischemic stroke (AIS) is a focal neurological disorder caused by occlusion of cerebral arteries, and is associated with neuroinflammation which worsens the severity of AIS.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2023)
Article
Neurosciences
Wenfang He, Zhiping Hu, Yanjun Zhong, Chenfang Wu, Jinxiu Li
Summary: The NLRP3 inflammasome plays a critical role in the innate immune system and is implicated in various diseases, especially neurological disorders. However, the mechanism of NLRP3 activation remains unclear. This review discusses recent advances and gaps in understanding the regulation of NLRP3 inflammasome and presents several potential pharmacological approaches, including Chinese herbal medicine, targeting the NLRP3 inflammasome for neurological diseases. It aims to provide new perspectives for the treatment of neurological disorders.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Genetics & Heredity
Danyang Li, Lifang Li, Fei Quan, Tianfeng Wang, Si Xu, Shuang Li, Kuo Tian, Meng Feng, Ni He, Liting Tian, Biying Chen, Huixue Zhang, Lihua Wang, Jianjian Wang
Summary: This study identified CLEC4D and CD163 as immune biomarkers of IS, and a classification model was constructed and verified. The results also showed a strong correlation between CLEC4D and neutrophil proportion.
FRONTIERS IN GENETICS
(2022)
Article
Clinical Neurology
Kevin Connolly, Mikael Lehoux, Ryan O'Rourke, Benedetta Assetta, Guzide Ayse Erdemir, Jack A. Elias, Chun Geun Lee, Yu-Wen Alvin Huang
Summary: CHI3L1 is a biomarker for early detection of neuroinflammation and disease diagnosis of AD. It is primarily provided by astrocytes in the brain and may play a crucial role in neuroinflammation and neurodegenerative diseases. In peripheral tissues, it is also a master regulator for injury and repair events.
ALZHEIMERS & DEMENTIA
(2023)
Review
Pharmacology & Pharmacy
Paola Nobili, Weida Shen, Katarina Milicevic, Jelena Bogdanovic Pristov, Etienne Audinat, Ljiljana Nikolic
Summary: Epilepsy and multiple sclerosis, two common neurological diseases, have limited treatment options. This article discusses the potential of targeting astrocytes as a new therapeutic approach and explores their role in modulating neuroinflammatory responses.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Neurosciences
Richard Fairless, Hilmar Bading, Ricarda Diem
Summary: Glutamate signalling plays a crucial role in neuroinflammatory diseases, influencing neurodegeneration as well as regulating blood vessels, immune cells, and glial cells. Efforts are being made to utilize the growing understanding of these processes in the development of neuroprotective strategies.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Materials Science, Multidisciplinary
Shenzhong Jiang, Ruxu Geng, Renzhi Wang, Xiaoguang Li, Xinjie Bao
Summary: Ischemic stroke is a major cause of long-term disability and a significant social and economic burden. Current treatments are ineffective in promoting CNS regeneration, highlighting the urgent need to develop biomaterials that facilitate neurogenesis. Injectable hydrogels show great potential in tissue repair by modulating neuroinflammation to create a conducive microenvironment for regenerative processes.
MATERIALS & DESIGN
(2023)
Review
Neurosciences
Juan Gao, Jifei Liu, Yonghong Li, Junxi Liu, He Wang, Miao Chai, Ying Dong, Zhenchang Zhang, Gang Su, Manxia Wang
Summary: There is a lack of specific therapies for neuroinflammation, making p53 a potential crucial target for regulation. This article provides a comprehensive review on the potential of targeting p53 in the treatment of neuroinflammation after ischemic stroke (IS). It describes the function of p53, the major immune cells involved in neuroinflammation, and the role of p53 in inflammatory responses mediated by these cells. Finally, it summarizes the therapeutic strategies of targeting p53 in regulating the neuroinflammatory response after IS, providing new directions and ideas for the treatment of ischemic brain injury.
JOURNAL OF NEUROSCIENCE RESEARCH
(2023)
Review
Pharmacology & Pharmacy
Tao Liang, Yang Zhang, Suyuan Wu, Qingjie Chen, Lin Wang
Summary: Alzheimer's disease is a common age-related neurodegenerative disease with characteristic pathological features, and the activation of NLRP3 inflammasome plays a crucial role in its pathogenesis. Chronic neuroinflammation is an important factor in the development of AD, and targeting NLRP3 inflammasome pharmacologically can provide new therapeutic strategies.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Gloria Bonaccorsi, Alessandro Trentini, Pantaleo Greco, Veronica Tisato, Donato Gemmati, Nicoletta Bianchi, Melchiore Giganti, Maurizio Rossini, Giuseppe Guglielmi, Carlo Cervellati
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2019)
Review
Biochemistry & Molecular Biology
Mauro Vaccarezza, Veronica Papa, Daniela Milani, Arianna Gonelli, Paola Secchiero, Giorgio Zauli, Donato Gemmati, Veronica Tisato
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Biochemistry & Molecular Biology
Donato Gemmati, Barbara Bramanti, Maria Luisa Serino, Paola Secchiero, Giorgio Zauli, Veronica Tisato
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Genetics & Heredity
Donato Gemmati, Veronica Tisato
Article
Medicine, General & Internal
Fabio Manfredini, Sofia Straudi, Nicola Lamberti, Simone Patergnani, Veronica Tisato, Paola Secchiero, Francesco Bernardi, Nicole Ziliotto, Giovanna Marchetti, Nino Basaglia, Massimo Bonora, Paolo Pinton
Review
Genetics & Heredity
Veronica Tisato, Juliana A. Silva, Giovanna Longo, Ines Gallo, Ajay Singh, Daniela Milani, Donato Gemmati
Summary: Autism spectrum disorder (ASD) is a complex neurodevelopmental condition with diverse clinical phenotypes. Various candidate genes, including folate gene polymorphisms, have been implicated in ASD, with a strong sex gap in onset-risk and progression, highlighting the importance of understanding their roles in the disorder.
Review
Cell Biology
Amruta Shelar, Ajay Vikram Singh, Romi Singh Maharjan, Peter Laux, Andreas Luch, Donato Gemmati, Veronica Tisato, Shubham Pratap Singh, Maria Fernanda Santilli, Akanksha Shelar, Manohar Chaskar, Rajendra Patil
Summary: The global community set 17 goals for sustainable development in 2015, with the second goal being to end hunger. Advancements in nanotechnology have shown potential to enhance seed resistance to environmental stresses, ultimately leading to improved crop yield and ensuring the quality and safety of seeds for sustainable agriculture.
Article
Chemistry, Medicinal
Annalisa Marcuzzi, Erika Rimondi, Elisabetta Melloni, Arianna Gonelli, Antonio Giacomo Grasso, Egidio Barbi, Natalia Maximova
Summary: Janus kinases (JAKs), as a family of tyrosine kinases, play important roles in immune cell regulation by transducing cytokine-mediated signals through the JAK-STAT pathway. In recent years, JAK inhibitors have shown promise in the treatment of various inflammatory conditions, including acute steroid-refractory graft-versus-host disease (SR-aGVHD). Ruxolitinib, a JAK1/2 inhibitor, has been approved by the FDA for the treatment of SR-aGVHD and has demonstrated rapid and effective response.
Article
Cell Biology
Ajay Vikram Singh, Vaisali Chandrasekar, Peter Laux, Andreas Luch, Sarada Prasad Dakua, Paolo Zamboni, Amruta Shelar, Yin Yang, Vaibhav Pandit, Veronica Tisato, Donato Gemmati
Summary: This study proposes a hybrid blood-brain barrier (BBB)-on-chip cell culture device that integrates microcontact printing and perfusion co-culture to facilitate the study of BBB function. The research reveals the biochemical regulation of BBB function by astrocytes and the geometry-force control of astrocyte-endothelial cell interactions in the BBB model.
Review
Biochemistry & Molecular Biology
Matteo Fields, Annalisa Marcuzzi, Arianna Gonelli, Claudio Celeghini, Natalia Maximova, Erika Rimondi
Summary: Neurodegenerative diseases are characterized by progressive loss of neuronal functions and structures. Mitochondrial dysfunction and oxidative stress have been identified as common mechanisms leading to neurodegeneration. Antioxidant therapies, specifically targeting mitochondria, have become increasingly important in reverting neuronal damage. Novel mitochondria-targeted antioxidant compounds, such as MitoQ, SkQ1, MitoVitE and MitoTEMPO, have been developed and studied to address the need for effective treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Domenico Sergi, Enrico Zauli, Veronica Tisato, Paola Secchiero, Giorgio Zauli, Carlo Cervellati
Summary: Cerebrovascular diseases and brain hypoperfusion form the basis of vascular dementia. Dyslipidemia, characterized by an increase in triglycerides and LDL-cholesterol levels and a decrease in HDL-cholesterol, promotes atherosclerosis in cardiovascular and cerebrovascular diseases. The quality and functionality of HDL-cholesterol play a significant role in cardiovascular health and cognitive function, and ceramides embedded in lipoproteins are proposed as a novel risk factor for atherosclerosis. This review discusses the role of HDL lipoprotein and ceramides in cerebrovascular diseases and their impact on vascular dementia, as well as the influence of saturated and omega-3 fatty acids on HDL levels and ceramide metabolism.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Meeting Abstract
Oncology
P. Franco, A. Porreca, M. Di Nicola, G. Mantello, F. Valvo, N. Slim, S. Manfrida, M. A. Gambacorta, F. De Felice, S. Vagge, M. Krengli, E. Palazzari, M. F. Osti, A. Gonelli, G. Catalano, P. Pittoni, M. Lupattelli, M. R. Niespolo, M. E. Rosetto, G. Macchia, O. Durante, F. Munoz, R. M. D'Angelillo, D. Genovesi, L. Caravatta
RADIOTHERAPY AND ONCOLOGY
(2022)
Article
Oncology
Erika Rimondi, Elisabetta Melloni, Arianna Romani, Veronica Tisato, Fabio Casciano, Gian Matteo Rigolin, Daniela Milani, Claudio Celeghini, Giorgio Zauli, Paola Secchiero, Rebecca Voltan
Summary: The study investigates the ability of ibrutinib in combination with the MDM2-inhibitor nutlin-3 to counteract the protective effect of the tumor microenvironment in B-CLL. The combined treatment significantly increases apoptosis levels, antagonizes c-MYC up-regulation, and enhances mitochondrial apoptotic pathway components, suggesting a new therapeutic strategy to overcome drug resistance in B-CLL and potentially other cancers.
Article
Immunology
Alessandra Bortoluzzi, Cecilia Beatrice Chighizola, Micaela Fredi, Elena Raschi, Caterina Bodio, Daniela Privitera, Arianna Gonelli, Ettore Silvagni, Marcello Govoni, Ilaria Cavazzana, Paolo Airo, Pier Luigi Meroni, Angela Tincani, Franco Franceschini, Silvia Piantoni, Fabio Casciano
FRONTIERS IN IMMUNOLOGY
(2020)