期刊
ENDOCRINE-RELATED CANCER
卷 27, 期 7, 页码 R255-R265出版社
BIOSCIENTIFICA LTD
DOI: 10.1530/ERC-19-0472
关键词
prostate cancer; bone metastasis; fibroblast growth factors; fibroblast growth factor receptors
资金
- Prostate Cancer Foundation
- Cancer Center Prostate Cancer SPORE [NIH/NCI P50 CA140388-08]
- DOD-PCRP [W81XWH-14-1-0554]
Many solid tumors metastasize to bone, but only prostate cancer has bone as a single, dominant metastatic site. Recently, the FGF axis has been implicated in cancer progression in some tumors and mounting evidence indicate that it mediates prostate cancer bone metastases. The FGF axis has an important role in bone biology and mediates cell-to-cell communication. Therefore, we discuss here basic concepts of bone biology, FGF signaling axis, and FGF axis function in adult bone, to integrate these concepts in our current understanding of the role of FGF axis in bone metastases.
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