Sterile signals generate weaker and delayed macrophage NLRP3 inflammasome responses relative to microbial signals

Innate immune perturbations, accumulating DAMPs and inflammasome dysregulation: A ticking time bomb in ageing

(2015) Ronan Kapetanovic et al.   AGEING RESEARCH REVIEWS

The Inflammasomes and Autoinflammatory Syndromes

(2015) Lori Broderick et al.   Annual Review of Pathology-Mechanisms of Disease

Gasdermin D is an executor of pyroptosis and required for interleukin-1β secretion

(2015) Wan-ting He et al.   CELL RESEARCH

A20 Restricts Ubiquitination of Pro-Interleukin-1β Protein Complexes and Suppresses NLRP3 Inflammasome Activity

(2015) Bao H. Duong et al.   IMMUNITY

IL-18 Triggered by the Nlrp3 Inflammasome Induces Host Innate Resistance in a Pulmonary Model of Fungal Infection

(2015) Natália Ketelut-Carneiro et al.   JOURNAL OF IMMUNOLOGY

Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling

(2015) Nobuhiko Kayagaki et al.   NATURE

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

(2015) Jianjin Shi et al.   NATURE

Mechanism of NLRP3 inflammasome activation

(2014) Fayyaz S. Sutterwala et al.   Annals of the New York Academy of Sciences

Mechanisms and Functions of Inflammasomes

(2014) Mohamed Lamkanfi et al.   CELL

Type I NKT-cell-mediated TNF-α is a positive regulator of NLRP3 inflammasome priming

(2014) Melvyn T. Chow et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Antimicrobial functions of inflammasomes

(2013) Kaiwen W Chen et al.   CURRENT OPINION IN MICROBIOLOGY

K+ Efflux Is the Common Trigger of NLRP3 Inflammasome Activation by Bacterial Toxins and Particulate Matter

(2013) Raúl Muñoz-Planillo et al.   IMMUNITY

Cutting Edge: TLR Signaling Licenses IRAK1 for Rapid Activation of the NLRP3 Inflammasome

(2013) T. Fernandes-Alnemri et al.   JOURNAL OF IMMUNOLOGY

IRAK-1 bypasses priming and directly links TLRs to rapid NLRP3 inflammasome activation

(2013) K.-M. Lin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Acute lipopolysaccharide priming boosts inflammasome activation independently of inflammasome sensor induction

(2012) Kate Schroder et al.   IMMUNOBIOLOGY

The mycobacterial cord factor adjuvant analogue trehalose-6,6′-dibehenate (TDB) activates the Nlrp3 inflammasome

(2012) Katrin Schweneker et al.   IMMUNOBIOLOGY

NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice

(2012) Michael T. Heneka et al.   NATURE

Conservation and divergence in Toll-like receptor 4-regulated gene expression in primary human versus mouse macrophages

(2012) K. Schroder et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Type I Interferon Inhibits Interleukin-1 Production and Inflammasome Activation

(2011) Greta Guarda et al.   IMMUNITY

Inflammasome-dependent Pyroptosis and IL-18 Protect against Burkholderia pseudomallei Lung Infection while IL-1β Is Deleterious

(2011) Ivonne Ceballos-Olvera et al.   PLoS Pathogens

The Inflammasomes

(2010) Kate Schroder et al.   CELL

Redundant roles for inflammasome receptors NLRP3 and NLRC4 in host defense againstSalmonella

(2010) Petr Broz et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes

(2010) Seth L Masters et al.   NATURE IMMUNOLOGY

An Essential Role for the NLRP3 Inflammasome in Host Defense against the Human Fungal Pathogen Candida albicans

(2009) Amy G. Hise et al.   Cell Host & Microbe

Cutting Edge: TNF-  Mediates Sensitization to ATP and Silica via the NLRP3 Inflammasome in the Absence of Microbial Stimulation

(2009) L. Franchi et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: NF- B Activating Pattern Recognition and Cytokine Receptors License NLRP3 Inflammasome Activation by Regulating NLRP3 Expression

(2009) F. G. Bauernfeind et al.   JOURNAL OF IMMUNOLOGY

Syk kinase signalling couples to the Nlrp3 inflammasome for anti-fungal host defence

(2009) Olaf Gross et al.   NATURE

Origin and physiological roles of inflammation

(2008) Ruslan Medzhitov   NATURE

The NALP3 inflammasome is involved in the innate immune response to amyloid-β

(2008) Annett Halle et al.   NATURE IMMUNOLOGY