Article
Developmental Biology
Najat Dzaki, Shufeng Bu, Samuel Song Yuan Lau, Wei Lin Yong, Fengwei Yu
Summary: A study found that the Drosophila GSK3β homologue, Sgg, is cell-autonomously required for dendrite pruning of sensory neurons. Sgg promotes microtubule depolymerization and reorganization to facilitate dendrite pruning.
Article
Biochemistry & Molecular Biology
Shufeng Bu, Wei Lin Yong, Bryan Jian Wei Lim, Shu Kondo, Fengwei Yu
Summary: This research systematically investigated microtubule-destabilizing factors and identified Efa6 and Stai as new regulators of dendrite pruning in ddaC sensory neurons during Drosophila metamorphosis. They facilitate microtubule turnover and disassembly prior to dendrite pruning without affecting microtubule orientation, highlighting the importance of microtubule disassembly in promoting dendrite pruning and establishing a causal link between the two processes.
Article
Computer Science, Information Systems
Shuangbao Song, Qiang Xu, Jia Qu, Zhenyu Song, Xingqian Chen
Summary: This study focuses on training the logic dendritic neuron model (LDNM) using a heuristic algorithm called the gradient-based optimizer (GBO). The research describes the architecture of LDNM, proposes neuronal structure pruning mechanisms, applies GBO training, and evaluates the performance through experiments. The results indicate that training LDNM with GBO enhances its classification performance.
Article
Cell Biology
Gabriel M. Gihana, Arthur A. Cross-Najafi, Soni Lacefield
Summary: In budding yeast, the Cdc42 GTPase establishes a polar front during G1, with the activity of the Cdc14 phosphatase released through the mitotic exit network playing a crucial role in redistributing Cdc42 between mother and daughter cells. The interaction between Bem3, a Cdc42 GAP, and Cdc14 is important for the dephosphorylation and activation of Bem3, allowing for the inactivation and redistribution of Cdc42. These findings reveal a mechanism by which Cdc14 regulates the spatial and temporal activity of Cdc42 to maintain normal cell size at cytokinesis.
JOURNAL OF CELL BIOLOGY
(2021)
Article
Neurosciences
Stephanie A. Getz, Kamran Tariq, Dylan H. Marchand, Conor R. Dickson, James R. Howe, Patrick D. Skelton, Wei Wang, Meijie Li, Jeremy M. Barry, Jennifer Hong, Bryan W. Luikart
Summary: PTEN loss leads to dendritic overgrowth in neurons, possibly due to increased microtubule polymerization rate. Inhibiting microtubule polymerization can reduce dendritic overgrowth in Pten KO neurons and improve performance in spatial memory tasks.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Daiki Jingu, Mika Iino, Joji Kawasaki, Eriko Urano, Shinya Kusakari, Yuriko Hayashi, Takashi Matozaki, Hiroshi Ohnishi
Summary: SIRPα is a cold stress-responsive signaling molecule in neurons, and its phosphorylation is involved in regulating behavioral changes in mice. The phosphorylation of SIRPα induced by cold stress is related to the activity of protein tyrosine phosphatases (PTPases).
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Biology
Shufeng Bu, Samuel Song Yuan Lau, Wei Lin Yong, Heng Zhang, Sasinthiran Thiagarajan, Arash Bashirullah, Fengwei Yu
Summary: The study reveals the important roles of PcG and Hox genes in regulating ecdysone signalling and neuronal pruning in Drosophila. The findings suggest a non-canonical and PRC2-independent role of PRC1 in Hox gene silencing during neuronal pruning.
Article
Biology
Maximilian A. H. Jakobs, Assaf Zemel, Kristian Franze, Kang Shen
Summary: Enhanced growth of plus-end-out microtubules is critical for achieving uniform microtubule orientation in axons, according to a study using live imaging of primary Drosophila melanogaster neurons. The study also revealed the effects of physical modeling and computer simulations on axonal microtubule development.
Article
Neurosciences
Tamas Papp, Zsuzsanna Ferenczi, Bernadette Szilagyi, Matyas Petro, Angelika Varga, Eva Kokai, Ervin Berenyi, Gabor Olah, Gabor Halmos, Peter Szucs, Zoltan Meszar
Summary: The regulation of neuronal differentiation and synaptogenesis requires precise coordination of intrinsic and extrinsic factors. While ultrasound is known to acutely alter neuronal migration and activity, its chronic effect on neuronal behavior or morphology is not well understood. This study investigated the neurobiological effects of high-frequency ultrasound on cortical pyramidal cell morphology in a transgenic mouse model, finding that low-intensity ultrasound stimulation led to increased dendritic branching and activation of certain signaling pathways.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Neurosciences
Maxsam S. Donta, Yogesh Srivastava, Christina M. Di Mauro, Adriana Paulucci-Holthauzen, M. Neal Waxham, Pierre D. McCrea
Summary: Dendritic arborization is crucial for neuronal connectivity and function, and abnormal morphology is linked to neurological disorders. This study investigates the impact of four proteins involved in cytoskeletal remodeling on dendrite morphology, revealing their distinct roles. The expression of p120-catenin and delta-catenin correlates with increased dendritic length and branching, ARVCF-catenin has no observable effect, and p0071-catenin is associated with increased dendritic branching. These findings highlight the shared and unique roles of these proteins in dendrite morphogenesis.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2023)
Article
Materials Science, Multidisciplinary
L. Abou-Khalil, Z. Thompson, G. Reinhart, T. Stan, L. Sturz, G. Zimmermann, P. W. Voorhees, N. Mangelinck-Noel, H. Nguyen-Thi
Summary: Three-dimensional reconstruction of the microstructure of Al - 7 wt.% Si samples solidified in microgravity conditions on the International Space Station revealed that the number of dendrite fragments depends on the dendrite network configuration. Samples with multiple dendrites with different orientations had more fragments compared to samples with well-aligned dendrites. The highest number of fragments was found in the region corresponding to an incipient grain boundary where dendrites with different orientations compete, indicating that dendrite misorientation during solidification leads to the formation of dendrite fragmentation.
Article
Developmental Biology
Ravi Das, Shatabdi Bhattacharjee, Jamin M. Letcher, Jenna M. Harris, Sumit Nanda, Istvan Foldi, Erin N. Lottes, Hansley M. Bobo, Benjamin D. Grantier, Jozsef Mihaly, Giorgio A. Ascoli, Daniel N. Cox
Summary: Dendrite shape is influenced by cytoskeletal fiber organization and dynamics, impacting functional connectivity. Formin 3 is identified as a key regulator of cytoskeletal architecture in nociceptive sensory neurons, playing a crucial role in dendritic arbor complexity. Mutations in the human ortholog of Formin 3 have been linked to Charcot-Marie-Tooth disease, highlighting the importance of understanding cytoskeletal regulation in neuronal function and related neuropathies.
Article
Multidisciplinary Sciences
Han-Hsuan Liu, Chien-Hsiang Hsu, Lily Y. Jan, Yuh-Nung Jan
Summary: The study established a photo-switchable assay system for detecting dendrite degeneration and repair, and used the WldS protein as a test case to investigate the mechanisms underlying dendrite regeneration and repair.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Biology
Lisa A. E. Catsburg, Manon Westra, Annemarie M. L. van Schaik, Harold D. MacGillavry
Summary: This study reveals the dynamic organization of the clathrin-coated structure at postsynaptic sites and its role in synaptic plasticity. The endocytic zone (EZ) acts as a stable and highly organized molecular platform, where different components are recruited and positioned to regulate the endocytosis of synaptic receptors.
Article
Cell Biology
Heather Tsong, Erika L. F. Holzbaur, Andrea K. H. Stavoe
Summary: Misregulation of neuronal autophagy is involved in age-related neurodegenerative diseases. Aging leads to a decrease in autophagosome formation rate and density along the axon, but an increase in autophagic vesicle maturation. Late aging results in a significant loss of acidified vesicles in the distal axon, while the efficient transport of autophagic vesicles in both proximal and distal axons is maintained during early aging. These findings suggest that aging differentially impacts distinct aspects of neuronal autophagy.
Article
Biology
Guanglin Xing, Moyi Li, Yichen Sun, Menglong Rui, Yan Zhuang, Huihui Lv, Junhai Han, Zhengping Jia, Wei Xie
Article
Biology
Yan Wang, Menglong Rui, Quan Tang, Shufeng Bu, Fengwei Yu
Article
Biochemistry & Molecular Biology
Quan Tang, Menglong Rui, Shufeng Bu, Yan Wang, Liang Yuh Chew, Fengwei Yu
Article
Developmental Biology
Menglong Rui, Shufeng Bu, Liang Yuh Chew, Qiwei Wang, Fengwei Yu
Article
Multidisciplinary Sciences
Jianzheng He, Alice Mei Xien Tan, Si Yun Ng, Menglong Rui, Fengwei Yu
Summary: The study found that fruit flies prefer to consume cannabinoids independent of two important sensory regulators. Cannabinoids inhibit food intake in fruit flies, and endocannabinoids and their metabolites can reduce lipid metabolism and promote resistance to starvation.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Shufeng Bu, Wei Lin Yong, Bryan Jian Wei Lim, Shu Kondo, Fengwei Yu
Summary: This research systematically investigated microtubule-destabilizing factors and identified Efa6 and Stai as new regulators of dendrite pruning in ddaC sensory neurons during Drosophila metamorphosis. They facilitate microtubule turnover and disassembly prior to dendrite pruning without affecting microtubule orientation, highlighting the importance of microtubule disassembly in promoting dendrite pruning and establishing a causal link between the two processes.
Article
Cell Biology
Shufeng Bu, Quan Tang, Yan Wang, Samuel Song Yuan Lau, Wei Lin Yong, Fengwei Wu
Summary: In this study, the researchers identified the role of CLASP protein in dendrite pruning in fruit flies. They found that CLASP regulates microtubule orientation in dendrites and that the TOG2 domain is crucial for this function. The study also revealed that the Par-1 kinase acts as a suppressor of CLASP in dendritic microtubule orientation.
Article
Developmental Biology
Najat Dzaki, Shufeng Bu, Samuel Song Yuan Lau, Wei Lin Yong, Fengwei Yu
Summary: A study found that the Drosophila GSK3β homologue, Sgg, is cell-autonomously required for dendrite pruning of sensory neurons. Sgg promotes microtubule depolymerization and reorganization to facilitate dendrite pruning.
Article
Biology
Wanyue Xu, Weiyu Kong, Ziyang Gao, Erqian Huang, Wei Xie, Su Wang, Menglong Rui
Summary: Developmental neuronal pruning is a process in which neurons selectively remove excessive or unnecessary neurites without causing neuronal death. This process is important for the refinement of neural circuits and may contribute to the pathogenesis of neuropsychiatric disorders. In Drosophila, different types of neurons undergo specific pruning mechanisms during development. The motor neurons offer a unique advantage for studying axon pruning, as their long-range projecting axon bundle undergoes degeneration instead of retraction during metamorphosis. This pruning process can be easily investigated via live imaging and involves several known axon pruning regulators.
Article
Biochemistry & Molecular Biology
Menglong Rui, Weiyu Kong, Wanting Wang, Ting Zheng, Su Wang, Wei Xie
Summary: Developmental remodeling of neurite is crucial for neural circuit wiring and related neuropsychiatric disorders, and the molecular mechanisms behind this process are not fully understood. In this study, Droj2 and Arf102F are identified to play important roles in dendrite sculpting and neurite pruning of sensory neurons in Drosophila. Both genes promote the downregulation of Neuroglian, a cell-adhesion molecule, to initiate dendrite severing. This study provides new insights into the functions of Droj2 and Arf102F in neuronal development.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)