Article
Physics, Multidisciplinary
Shahriar Baghdadi, Mazdak Rad Malekshahi
Summary: In this paper, the effects of changes in magnet arrays on particle tracing based on magnetophoresis are analyzed. Different styles of magnet arrays generate different magnetic fields, resulting in stronger magnetic force and shorter particle manipulation time. The importance of this problem lies in increasing the throughput of microsystems. Analytical methods (mathematical piecewise method) on a 2D platform are used to predict the paths of particles in microchannels and insert changes in magnet arrays (gap-dimension). The efficiency and throughput are maximized by using the proper gap-dimension for the magnet arrays.
Article
Mechanics
Mohammad Charjouei Moghadam, Armin Eilaghi, Pouya Rezai
Summary: This study used numerical simulation to investigate elasto-inertial focusing of microparticles in a straight microchannel, proposing a new threshold for particle dispersion prediction. An empirical non-dimensional correlation was developed to predict elasto-inertial particle dispersion in straight square cross-sectional microchannels, reducing the predicted dispersion variation from about 15% to less than about 5%.
Article
Nanoscience & Nanotechnology
Chun-Dong Xue, Jia-Ming Zhao, Zhong-Ping Sun, Jing-Tong Na, Yong-Jiang Li, Kai-Rong Qin
Summary: This study proposes a novel strategy for microfluidic focusing of microparticles based on negative magnetophoresis and oscillatory flow. A simulation model is developed to calculate particle motion and analyze the non-monotonic size dependence of particle focusing. The effects of oscillatory flow field and magnetic field on particle focusing are quantitatively investigated. The proposed strategy can guide real applications such as the enrichment and separation of sensitive biological particles.
MICROFLUIDICS AND NANOFLUIDICS
(2021)
Article
Chemistry, Analytical
Lin Zeng, Xi Chen, Rongrong Zhang, Shi Hu, Hongpeng Zhang, Yi Zhang, Hui Yang
Summary: In this study, a microfluidic system based on negative magnetophoresis is proposed for the high-resolution separation of nanoparticles. The system can purify 200 nm particles with high purity and recovery rate. Compared with existing methods, the system shows significant improvements in particle size resolution and sample processing throughput.
Article
Biochemical Research Methods
Dan Yuan, Sharda Yadav, Hang T. Ta, Hedieh Fallahi, Hongjie An, Navid Kashaninejad, Chin Hong Ooi, Nam-Trung Nguyen, Jun Zhang
Summary: This study investigated sheathless viscoelastic focusing of particles and cells in a zigzag microfluidic channel, demonstrating its application on various types of particles and cells. The zigzag structure of the channel allows for reduced device footprint and channel length without sacrificing focusing performance.
Article
Biochemical Research Methods
Arash Dalili, Mina Hoorfar
Summary: This study compares sheath-assisted and sheathless DEP separation of three sizes of microparticles using tilted electrodes. The results show that the sheath-assisted design has higher separation efficiency, while the sheathless design offers higher sample throughput.
Article
Cell Biology
Lucie Descamps, Marie-Charlotte Audry, Jordyn Howard, Samir Mekkaoui, Clement Albin, David Barthelemy, Lea Payen, Jessica Garcia, Emmanuelle Laurenceau, Damien Le Roy, Anne-Laure Deman
Summary: Magnetophoresis-based microfluidic devices allow for simple manipulation of micro-scale objects, especially with the integration of micrometer-scale permanent magnets made from NdFeB particles. These micro-magnets not only exhibit strong trapping capabilities but also enhance magnetic forces for efficient cell sorting and high-throughput sorting applications.
Review
Engineering, Electrical & Electronic
Peng Su, Chunhui Ren, Yusheng Fu, Jinhong Guo, Jiuchuan Guo, Qi Yuan
Summary: Microfluidic technology has great application potential in various fields, and magnetophoresis is an effective method to manipulate particles in liquid media using magnetic field force. Understanding the key components and parameters of magnetophoresis equipment can provide a simple, efficient, and cost-effective solution for bioparticle analysis.
SENSORS AND ACTUATORS A-PHYSICAL
(2021)
Article
Engineering, Chemical
Yan Xia, Zhaowu Lin, Yu Guo, Zhaosheng Yu
Summary: Data from IR-DNSs of upward turbulent channel flow laden with finite-size heavy particles are used to develop improved drag correlations accounting for turbulence effects. The contribution of drag nonlinearity to drag enhancement is analyzed, and several turbulence correction models are presented. Turbulent intensity, particle size, and slip velocity are found to be the most important factors in modeling the effect of turbulence on particle drag.
Article
Engineering, Chemical
Haotian Cha, Hoseyn A. Amiri, Sima Moshafi, Ali Karimi, Ali Nikkhah, Xiangxun Chen, Hang T. Ta, Nam-Trung Nguyen, Jun Zhang
Summary: Inertial microfluidics is a technique that uses the finite inertia of fluid at high flow speed to manipulate and separate microparticles. Embedding periodic micro-obstacles into curvilinear channels has been found to be an effective strategy to improve inertial focusing and separation. This study systematically investigated the influence of micro-obstacles on inertial focusing and developed a high-resolution microfluidic device for particle and cell separation. The results showed that concave obstacles were more effective in tuning particle inertial focusing and separation compared to convex obstacles, and the square concave obstacle channel offered the highest separation resolution. The developed microfluidic device showed high-efficiency separation of polystyrene beads and U87MG cancer cells from blood.
CHEMICAL ENGINEERING SCIENCE
(2023)
Article
Engineering, Chemical
Ali Karimi, Majid Mesbah, Sahand Majidi
Summary: This study introduces the use of magnetic fields to improve engine oil filter performance for the first time. Experimental analysis of particles extracted from various filters demonstrates their sensitivity to external magnetic fields, suggesting the potential for magnetophoresis in particle separation. The study investigates the impact of different factors, such as flow velocity, particle size, oil viscosity, magnetic field intensity, and dipole arrangement, on magnetic field capture efficiency through numerical analysis. The results show that increasing magnetic field intensity, particle diameter or density, and using more equidistant dipole moments significantly enhance capture efficiency. Additionally, higher oil viscosity generally decreases magnetic field capture efficiency. The study also presents the concept of utilizing a compound magnetic field generated by a magnetic belt to aid particle separation in oil filters.
SEPARATION AND PURIFICATION TECHNOLOGY
(2023)
Article
Engineering, Chemical
Mengyao Shen, Lige Tong, Hongsheng Ding, Li Wang, Yulong Ding
Summary: The study demonstrates that as the particle size ratio and the mass fraction of coarse particles increase, the separation degree of binary particles also increases. Additionally, the thickness of the coarse particle layer increases with the increase of the mass fraction of coarse particles.
Article
Biochemical Research Methods
Umer Sajjad, Finn Klingbeil, Findan Block, Rasmus B. Hollander, Shehroz Bhatti, Enno Lage, Jeffrey McCord
Summary: The research focuses on achieving high efficiency separation for biological analytes in biomedical applications by selectively and directionally controlling the movement of microbeads through adjusting magnetic fields. Despite significant size and magnetic content distributions within microbead populations, high separation efficiencies are demonstrated.
Article
Chemistry, Physical
Patrick Ilg
Summary: In this study, a new mesoscopic model for the dynamics and flow of ferrofluids is proposed. By coupling the multi-particle collision dynamics method with the stochastic magnetization dynamics of suspended magnetic nanoparticles, this hybrid model is validated and applied to various flow phenomena.
JOURNAL OF CHEMICAL PHYSICS
(2022)
Article
Engineering, Chemical
Duanxu Hou, Peikun Liu, Qiang Zhao, Lanyue Jiang, Baoyu Cui, Dezhou Wei
Summary: This study investigates the regulation of particle circulation flow in hydrocyclones by changing the diameter of the secondary-cylindrical section to optimize separation efficiency. The results show that circulation flows are induced by the axial velocity wave zone, and increasing the secondary-cylindrical section diameter intensifies coarse particle circulation and aggregation, resulting in an increase of cut size. Adjusting the secondary-cylindrical section diameter helps improve classification efficiency and enhance separation sharpness.
Article
Biophysics
Wei-Mo Yuan, Chun-Dong Xue, Kai-Rong Qin
Summary: Studying the mechanisms of intracellular calcium responses in vascular endothelial cells induced by mechanical stimuli provides insights into vascular diseases. A mechanobiological model was developed to investigate the intracellular [Ca2+] response in single VECs being squeezed through narrow microfluidic channels, with simulation results aligning closely with experimental findings. The model was used to explore the mechanism of the two-peak intracellular [Ca2+] response in single VECs and make testable predictions for future experiments.
BIOMECHANICS AND MODELING IN MECHANOBIOLOGY
(2021)
Article
Chemistry, Analytical
Yong-Jiang Li, Miao Yu, Chun-Dong Xue, Hai-Jun Zhang, Guo-Zhen Wang, Xiao-Ming Chen, Kai-Rong Qin
Summary: This study focuses on how spatially distributed ATP and shear stress signals generated by microfluidic technology affect intracellular calcium dynamics. The results demonstrate the system's capacity to produce diverse signals, leading to different modes of calcium responses within cells.
Article
Chemistry, Applied
Jianfeng Chen, Ning Wen, Chundong Xue, Zhaocen Liu, Zhuoran Liang, Bo Wang, Lisheng Zhao, Ruijie Dang, Ningfang Liao, Guanghai Dai
Summary: The study shows that the addition of metal oxides Fe2O3 and CeO2 changes the color and reduces the light transmittance of Y-TZP, while maintaining stability of the structure. These findings provide insight into the coloration of Y-TZP and support a quantitative assessment approach for aesthetic performance of dental restoration material.
COLORATION TECHNOLOGY
(2021)
Article
Nanoscience & Nanotechnology
Xiao Zeng, Chun-Dong Xue, Ke-Jie Chen, Yong-Jiang Li, Kai-Rong Qin
Summary: This article proposes a deep neural network-assisted scalar imaging velocimetry (DNN-SIV) method for quick and precise measurement of fluid velocity in microchannels. By using physics-informed neural networks and residual neural networks, this method can robustly handle noise in the measured scalar field and achieve real-time flow visualization. Furthermore, the fundamental importance of rational construction of concentration field is emphasized.
MICROFLUIDICS AND NANOFLUIDICS
(2022)
Article
Biochemical Research Methods
Yunong Yang, Yongjiang Li, Miao Yu, Chundong Xue, Bo Liu, Yanxia Wang, Kairong Qin
Summary: This study developed a passive pump-assisted microfluidic assay to quantify endothelial wound healing in response to fluid shear stress. The method was validated using numerical simulations and fluorescein experiments, and the acceleration of wound healing under shear stress was observed.
Article
Chemistry, Physical
Chundong Xue, Yirong Huang, Xu Zheng, Guoqing Hu
Summary: This study investigates the diffusion behavior of nanoparticles in porous hydrogels through experiments and simulations. The results reveal that nanoparticles can escape from pores through connective pathways and exhibit a non-Gaussian displacement probability distribution. The anomalous diffusion can be fully described by combining the hopping mechanism and the hydrodynamic effect.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2022)
Article
Mechanics
Chun-Dong Xue, Heng-Chao Qu, Guo-Shuang Zheng, Kai-Rong Qin, De-Wei Zhao
Summary: This study experimentally investigates the diffusion of nanoparticles in model porous media and reveals the heterogeneous and spatially dependent mobility, as well as the significant hydrodynamic damping effect. The concept of ergodicity breaking is used to explain the non-Gaussian displacement probability distributions. The research also finds that interstitial viscosity only temporarily affects heterogeneity and does not modify the intrinsic non-ergodicity of the porous media.
Article
Chemistry, Analytical
Jing-Tong Na, Chun-Dong Xue, Yan-Xia Wang, Yong-Jiang Li, Yu Wang, Bo Liu, Kai-Rong Qin
Summary: Generating precise in vivo arterial endothelial hemodynamic microenvironments using microfluidics is crucial for investigating endothelial mechanobiology. This study proposes a hemodynamic similarity principle to obtain the input impedance of the microfluidic system in vitro from that of the arterial system in vivo, allowing for the precise generation of desired endothelial hemodynamic microenvironments.
Article
Biology
Xiao Zeng, Chun-Dong Xue, Yong-Jiang Li, Kai-Rong Qin
Summary: Vascular endothelial cells (ECs) are influenced by dynamic wall shear stress (WSS) induced by blood flow, and the intracellular nitric oxide (NO) and reactive oxygen species (ROS) play important roles in endothelial functions under this stress. In this study, a mathematical model of intracellular NO and ROS dynamics activated by dynamic WSS based on in vitro cell experiments is developed. The mechanism is elucidated that WSS induced by moderate-intensity exercise is most favorable to NO production in ECs.
MATHEMATICAL BIOSCIENCES
(2023)
Article
Biotechnology & Applied Microbiology
Guoshuang Zheng, Chundong Xue, Fang Cao, Minghui Hu, Maoyuan Li, Hui Xie, Weiting Yu, Dewei Zhao
Summary: In this study, an alginate/collagen (ALG/COL) hybrid hydrogel with different guluronate/mannuronate acid ratios was developed. The mechanical stiffness of the hydrogel was significantly affected by the G/M ratios of alginate. Chondrocytes cultured on the Mid-G/M hydrogels exhibited better viability and phenotype preservation.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Review
Biochemical Research Methods
Shan-Shan Li, Chun-Dong Xue, Yong-Jiang Li, Xiao-Ming Chen, Yan Zhao, Kai-Rong Qin
Summary: This paper provides an overview of recent advances in microfluidic analysis and detection systems for single-cell biophysical properties and their applications in cancer research. The importance of electrical and mechanical properties is highlighted, and the development of data acquisition and processing methods is discussed. The potential for utilizing single-cell biophysical properties for tumor cell identification, classification, and drug response assessment is outlined.
Article
Biochemical Research Methods
Heng-Chao Qu, Yi Yang, Zhi-Chao Cui, Dong Wang, Chun-Dong Xue, Kai-Rong Qin
Summary: In this study, a temperature-regulated model was constructed to investigate the diffusion of nanoparticles in complex physiological media. The results showed that as the temperature increased, the diffusion speed of nanoparticles increased and the non-Gaussian characteristics were enhanced.
Article
Engineering, Electrical & Electronic
Jia-Ming Zhao, Yi-Fan Yin, Jie Liu, Yong-Jiang Li, Yu Wang, Chun-Dong Xue, Kai-Rong Qin
Summary: This paper proposes a novel on-chip flow generator with multi-pattern outputs, which has the obvious advantages of small size, simple structure, and being easy to be implemented. The fluid flow is synergistically driven by the constant pressure and the alternating pressure in a pair of conical channels. Different flow modes can be achieved by modulating the input voltage, including steady flow, oscillatory flow, pulsatile flow, and complex flow. This flow generator can be flexibly integrated with other on-chip devices for various biomedical applications.
SENSORS AND ACTUATORS A-PHYSICAL
(2023)
Article
Chemistry, Analytical
Siyu Hu, Tianmian Liu, Chundong Xue, Yongjiang Li, Yunong Yang, Xing Xu, Bo Liu, Xiaoming Chen, Yan Zhao, Kairong Qin
Summary: This study developed a high-throughput microfluidic device based on the Wheatstone bridge principle for characterizing the mechanical properties of single cells. The results showed that the input flow rate had little effect on measuring the mechanical properties of the cells, while the ratio of cell radius to effective constriction radius was different.
ANALYTICAL METHODS
(2022)
Article
Chemistry, Physical
Chun-Dong Xue, Zhou-Yi Zheng, Guo-Shuang Zheng, De-Wei Zhao, Kai-Rong Qin
Summary: Flow instability in confined cavities is important in various natural and engineering processes. This study experimentally investigates the flow of dilute polymer solutions in confined microfluidic cavities and quantitatively characterizes the evolution of the recirculating vortex. The geometry of the cavity has little effect on the vortex evolution, providing insights into the interaction and competition among inertial, elastic, and shear-thinning effects in these cavity-induced flow instabilities.
