Review
Clinical Neurology
Zili Wang, Xudong Wang, Yidong Liao, Guangtang Chen, Kaya Xu
Summary: Stroke is a major cause of death and disability worldwide, and current treatment options are limited. Bone marrow mesenchymal stromal cells (BMSCs) offer a new approach for stroke treatment, but research on the precise inflammatory mechanism is lacking. In this review, we summarize the immune response of BMSCs in stroke treatment and provide a new perspective for stem cell therapy.
FRONTIERS IN NEUROLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Kaibin Shi, Ming Zou, Dong-Mei Jia, Samuel Shi, Xiaoxia Yang, Qiang Liu, Jing-Fei Dong, Kevin N. Sheth, Xiaoying Wang, Fu-Dong Shi
Summary: The study reveals that tPA has significant effects on immune cells in stroke patients and a rat model, leading to brain hemorrhage. Precision immune modulation can mitigate hemorrhagic transformation and improve neurological function post thrombolysis.
CIRCULATION RESEARCH
(2021)
Review
Immunology
Mattia Gallizioli, Maria Arbaizar-Rovirosa, David Brea, Anna M. Planas
Summary: Aging is associated with progressive changes in cellular and tissue functions, particularly through the vascular and immune systems. These changes increase the risk and worsen the outcome of stroke. The hallmarks of aging, such as chronic inflammation and immunometabolic disturbances, are also involved in the cerebral response to stroke. Aging reduces the ability to control these responses, leading to increased inflammation, metabolic dysregulation, and impaired waste disposal. Additionally, aging-related diseases and alterations in gut microbiota composition further exacerbate these effects and increase the risk of post-stroke infection. Advances in aging research may offer potential strategies to improve stroke outcomes in the elderly.
SEMINARS IN IMMUNOPATHOLOGY
(2023)
Review
Immunology
Tian-Yu Lei, Ying-Ze Ye, Xi-Qun Zhu, Daniel Smerin, Li-Juan Gu, Xiao-Xing Xiong, Hong-Fei Zhang, Zhi-Hong Jian
Summary: Recent research has highlighted the significant role of T cells in both the acute and chronic phases of ischaemic stroke, with potential therapeutic approaches focusing on modulating the balance between proinflammatory and anti-inflammatory functions of T cells. Understanding the immune responses, especially T cell responses, in the post-stroke recovery period may provide new directions for treatments beyond tissue plasminogen activator therapy.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Biochemistry & Molecular Biology
Marc Strinitz, Mirko Pham, Alexander G. Maerz, Jorn Feick, Franziska Weidner, Marius L. Vogt, Fabian Essig, Hermann Neugebauer, Guido Stoll, Michael K. Schuhmann, Alexander M. Kollikowski
Summary: It is still uncertain whether principal components of the local cerebral stroke immune response can be reliably observed in acute large-vessel-occlusion (LVO) stroke patients. A study found that total leukocyte counts were significantly higher within the occluded ischemic cerebral vasculature compared to systemic controls, driven by an increase in neutrophils. This inflammatory response may compromise cerebral hemodynamics and tissue integrity in human stroke.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Xin Yin, Laura Riva, Yuan Pu, Laura Martin-Sancho, Jun Kanamune, Yuki Yamamoto, Kouji Sakai, Shimpei Gotoh, Lisa Miorin, Paul D. De Jesus, Chih-Cheng Yang, Kristina M. Herbert, Sunnie Yoh, Judd F. Hultquist, Adolfo Garcia-Sastre, Sumit K. Chanda
Summary: Recent studies show that cellular responses to SARS-CoV-2 infection may influence disease severity, with MDA5 and LGP2 primarily regulating IFN induction in lung epithelial cells. Further analysis revealed that viral intermediates specifically activate the IFN response through MDA5-mediated sensing, and transcription factors IRF3, IRF5, and NF-kappa B/p65 play key roles in regulating the IFN response during SARS-CoV-2 infection. These findings provide valuable insights into the molecular mechanisms of innate immune recognition and signaling response to SARS-CoV-2.
Review
Clinical Neurology
Wanqing Xie, Alba Simats, Yunlu Guo, Tingting Huang, Xiaoyu Sun, Weijie Chen, Yuxuan Lin, Xin Wang, Zhongmeng Lai, Weifeng Yu, Arthur Liesz, Peiying Li
Summary: Ischemic stroke has a profound impact on the peripheral immune system, leading to rapid brain ischemia response and the development of poststroke neuroinflammation, accompanied by a period of systemic immunosuppression. Myeloid cells, including neutrophils and monocytes, play a crucial role in poststroke immunosuppression as the most abundant cell population in the fast-responding innate immune system. The change in myeloid response after stroke can be regulated by circulating DAMPs and neuromodulatory mechanisms involving the sympathetic nervous system, hypothalamic-pituitary-adrenal axis, and parasympathetic nervous system. This review summarizes the emerging roles and newly identified mechanisms underlying myeloid cell response in poststroke immunosuppression. A deeper understanding of these points may facilitate the development of novel therapeutic strategies for poststroke immunosuppression.
Review
Pediatrics
Josephine Herz, Ivo Bendix, Ursula Felderhoff-Mueser
Summary: Perinatal brain injury is the leading cause of neurological mortality and morbidity in childhood, with various noxious stimuli contributing to the pathogenesis; Neuroinflammation plays an important role in perinatal brain injury, affecting the evolution of cell damage and repair activities; Different immune cell subsets, as well as sex differences and maturational stage, are critical factors in understanding perinatal brain injury.
PEDIATRIC RESEARCH
(2022)
Article
Cell & Tissue Engineering
Yusuke Minato, Akiko Nakano-Doi, Seishi Maeda, Takayuki Nakagomi, Hideshi Yagi
Summary: This study found that LDN193189 can induce NSPC-like cells from iSCs, suggesting that bioactive molecules regulating BMP signaling are potential targets for promoting neurogenesis from iSCs. These findings contribute to the clinical application of iSCs.
STEM CELLS AND DEVELOPMENT
(2022)
Article
Oncology
Bin Liu, Yufei Cao, Yanyan Li, Haifeng Ma, Mingfei Yang, Qiang Zhang, Guofeng Li, Kai Zhang, Yue Wu, Youxin Zhou, Wei Yang, Ting Sun
Summary: CD39 plays a crucial role in maintaining an immunosuppressive microenvironment by decreasing extracellular ATP concentration around glioma stem cells. The combination of ADM and CD39 blockade increases immune cell infiltration and reduces tumor size.
Review
Pharmacology & Pharmacy
V Duran-Laforet, C. Pena-Martinez, A. Garcia-Culebras, L. Alzamora, M. A. Moro, I Lizasoain
Summary: The immune response plays a crucial role in ischemic stroke, mainly by activating circulating immune cells to induce an inflammatory response. Antagonists targeting TLR4 have the potential to serve as pharmacological tools for stroke treatment.
PHARMACOLOGY & THERAPEUTICS
(2021)
Article
Neurosciences
Yunwei Shi, Xinyi Chen, Jiaxing Liu, Xingjuan Fan, Ying Jin, Jingxiao Gu, Jiale Liang, Xinmiao Liang, Caiping Wang
Summary: Isoquercetin has been identified as a neuroprotective agent against ischemic stroke, showing the potential to suppress inflammatory response and improve cell recovery in rats with cerebral ischemia/reperfusion injury. The study suggests that targeting the TLR4 and C5aR1-mediated cAMP/PKA/I-kappa B/NF-kappa B signaling pathway may provide a promising therapeutic strategy for ischemic stroke.
FRONTIERS IN NEUROSCIENCE
(2021)
Review
Cell Biology
Maryam Adenike Salaudeen, Stuart Allan, Emmanuel Pinteaux
Summary: Promising preclinical stroke research has not been successful in clinical trials, leading to the need for refining preclinical studies to optimize clinical success. Mesenchymal stem/stromal cells (MSCs) have gained popularity as a potential treatment for stroke due to their ability to differentiate into neurons and other brain cells. However, these cells also have drawbacks that need to be addressed to make them suitable for treating ischemic stroke.
Article
Neurosciences
Hao-Lun Chen, Li Yang, Xiao-Li-Na Zhang, Qiu-Ye Jia, Zhao-Da Duan, Juan-juan Li, Li-yang Zheng, Teng-teng Liu, Zhi Qi, Yun Yuan, Chun-Yun Wu
Summary: Scutellarin can alleviate local inflammatory response by activating the expression of M2 microglia, and promote M2 polarization through inhibiting JNK and p38 signaling pathways while enhancing ERK1/2 signaling pathway. Therefore, scutellarin has the potential to be a therapeutic target for mitigating microglia-mediated neuroinflammation.
MOLECULAR NEUROBIOLOGY
(2023)
Review
Health Care Sciences & Services
Jau-Ling Huang, Si-Yun Chen, Chang-Shen Lin
Summary: Cancer stem cells (CSCs) play a critical role in tumor initiation and maintenance, and possess features that allow them to evade immune surveillance. This review explores the roles of epigenetic modifiers in CSC characteristics and discusses the interplay between CSCs and interferon response. The emerging strategy of targeting these modifiers to eliminate CSCs is also discussed.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Nanoscience & Nanotechnology
Kai Wu, Vinit Kumar Chugh, Venkatramana D. Krishna, Arturo di Girolamo, Yongqiang Andrew Wang, Renata Saha, Shuang Liang, Maxim C-J Cheeran, Jian-Ping Wang
Summary: Amid the ongoing global COVID-19 pandemic, there is a growing demand for accessible, easy-to-use, rapid, inexpensive, and highly accurate diagnostic tools. Traditional diagnostic methods may be too slow and cumbersome for effective disease surveillance and control. Therefore, developing a rapid, one-step, user-friendly, and high-accuracy diagnostic platform is crucial for future epidemic control.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Chemistry, Physical
Vinit Kumar Chugh, Kai Wu, Venkatramana D. Krishna, Arturo di Girolamo, Robert P. Bloom, Yongqiang Andrew Wang, Renata Saha, Shuang Liang, Maxim C-J Cheeran, Jian-Ping Wang
Summary: Magnetic particle spectroscopy (MPS) is a highly sensitive and versatile sensing technique for quantitative bioassays, utilizing the dynamic magnetic responses of magnetic nanoparticles (MNPs) to detect target analytes. An MPS system with a one-stage lock-in design enhances sensitivity and can be applied for detecting various analytes such as viruses and toxins.
JOURNAL OF PHYSICAL CHEMISTRY C
(2021)
Article
Immunology
Igor A. D. Paploski, Nakarin Pamornchainavakul, Dennis N. Makau, Albert Rovira, Cesar A. Corzo, Declan C. Schroeder, Maxim C-J. Cheeran, Andrea Doeschl-Wilson, Rowland R. Kao, Samantha Lycett, Kimberly VanderWaal
Summary: The study reveals the evolutionary dynamics of PRRSV sub-lineages in the U.S., showing that a new sub-lineage emerges every 1-4 years and replaces the dominant sub-lineage every 3 years on average. The turnover of sub-lineages may be linked to immune-mediated competition, suggesting important implications for the understanding of genetic diversity and emergence of new PRRSV variants in the U.S.
Article
Neurosciences
Svitlana Garbuzova-Davis, Kayla J. Boccio, Alexander Llauget, Robert Shell, Surafuale Hailu, Hilmi Mustafa, Jared Ehrhart, Paul R. Sanberg, Stanley H. Appel, Cesario V. Borlongan
Summary: In ALS research, treatment with human bone marrow-derived stem cells in mutant mice significantly increased levels of tight junction proteins, capillary pericyte coverage, and endothelial cytoskeletal F-actin expressions, helping to repair the barrier and prolong motor neuron survival.
Article
Neurosciences
Evan M. Dastin-van Rijn, Seth D. Konig, Danielle Carlson, Vasudha Goel, Andrew Grande, Donald R. Nixdorf, Sarah Benish, Alik S. Widge, Ziad Nahas, Michael C. Park, Tay I. Netoff, Alexander B. Herman, David P. Darrow
Summary: Central pain disorders are clinically challenging to treat, but a personalized approach using Bayesian optimization has shown promise. In this case report, simultaneous stimulation of the motor cortex and dorsolateral prefrontal cortex successfully reduced the patient's pain without side effects.
Review
Nanoscience & Nanotechnology
Kai Wu, Jinming Liu, Vinit Kumar Chugh, Shuang Liang, Renata Saha, Venkatramana D. Krishna, Maxim C-J Cheeran, Jian-Ping Wang
Summary: This article firstly summarizes the design and application of nanoparticles in the field of medicine, with a focus on the development of magnetic particle spectroscopy (MPS) as an independent platform in biomedical applications. The mechanisms and applications of different MPS platforms are discussed, and the applications of MPS in disease diagnosis, food safety, drug screening, etc. are introduced. Finally, the rapid development of MPS in the first 15 years is commented on, and the prospects and challenges faced by portable MPS devices in the growing demand for fast, inexpensive, and easy-to-use biometric techniques are discussed.
Article
Biology
Chong Li, Marie R. Culhane, Declan C. Schroeder, Maxim C-J Cheeran, Lucina Galina Pantoja, Micah L. Jansen, Montserrat Torremorell
Summary: Vaccination against swine influenza reduces reassortment viruses but has limited impact on viral variation.
Review
Ecology
Dennis N. Makau, Samantha Lycett, Matthew Michalska-Smith, Igor A. D. Paploski, Maxim C-J Cheeran, Meggan E. Craft, Rowland R. Kao, Declan C. Schroeder, Andrea Doeschl-Wilson, Kimberly VanderWaal
Summary: Interactions among co-circulating viral strains in host populations have significant implications for virus transmission dynamics and can be influenced by host immune responses and strain fitness. This review highlights the importance of studying multi-strain dynamics from ecological and evolutionary perspectives and provides an overview of the scales at which these dynamics occur. The review also summarizes various approaches, including immunological, phylogenetic, and mathematical modeling, used to quantify interactions among strains and explores the influence of host-pathogen interactions on pathogen coexistence. Outstanding questions and knowledge gaps in the field of multi-strain virus dynamics are discussed, with a focus on opportunities for future work.
NATURE ECOLOGY & EVOLUTION
(2022)
Article
Chemistry, Physical
Vinit Kumar Chugh, Arturo di Girolamo, Venkatramana D. Krishna, Kai Wu, Maxim C-J Cheeran, Jian-Ping Wang
Summary: Magnetic particle spectroscopy (MPS) is a bioassay technique based on magnetic nanoparticles that has various applications in disease diagnosis, foodborne pathogen detection, and virus detection. This study systematically investigates the effect of alternating magnetic field frequencies and amplitudes on the response of single- and multicore magnetic nanoparticles. The results suggest that different MPS modalities are suitable for different types of bioassays, and sensitivity can be improved by selecting appropriate frequencies and amplitudes.
JOURNAL OF PHYSICAL CHEMISTRY C
(2022)
Article
Ophthalmology
Venkatramana D. D. Krishna, Heidi Roehrich, Declan C. C. Schroeder, Maxim C. -J. Cheeran, Ching Yuan, Joshua H. H. Hou
Summary: This study evaluated the infectivity of two lineage A variants of SARS-CoV-2 on human ocular tissues in vitro and the stability of these variants in corneal preservation medium. The results showed that both variants can infect various ocular tissues and remain infectious in the preservation medium for up to 14 days.
Article
Nanoscience & Nanotechnology
Kai Wu, Vinit Kumar Chugh, Venkatramana D. Krishna, Yongqiang Andrew Wang, Timothy D. Gordon, Maxim C. -J. Cheeran, Jian-Ping Wang
Summary: In this work, a 5-minute bioassay strategy based on magnetic particle spectroscopy (MPS) is reported. By incubating surface-functionalized magnetic nanoparticles with target analytes at 37 degrees C for 3 minutes and taking the MPS reading at the fifth minute, the feasibility of ultrafast detection of SARS-CoV-2 spike protein with a detection limit below 5 nM (0.2 pmol) is demonstrated. The proposed 5-minute bioassay strategy can be applied to reduce the assay time for other liquid-phase, volumetric biosensors such as NMR, quantum dots, and fluorescent biosensors.
ACS APPLIED NANO MATERIALS
(2022)
Review
Chemistry, Analytical
Parsa Yari, Shuang Liang, Vinit Kumar Chugh, Bahareh Rezaei, Shahriar Mostufa, Venkatramana Divana Krishna, Renata Saha, Maxim C. -J. Cheeran, Jian-Ping Wang, Jenifer Gomez-Pastora, Kai Wu
ANALYTICAL CHEMISTRY
(2023)
Meeting Abstract
Critical Care Medicine
Nicole Emmitt, Venkatramana Krishna, Susanne Var, Erin Lind, Andrew Grande, Walter Low, Maxim Cheeran
JOURNAL OF NEUROTRAUMA
(2022)
Meeting Abstract
Critical Care Medicine
Venkatramana Krishna, Andrew Crane, Nicole Emmitt, Michael Patterson, Walter Low, Andrew Grande, Jesse Williams, Maxim Cheeran
JOURNAL OF NEUROTRAUMA
(2022)
Article
Cell & Tissue Engineering
Paul Sanberg, Donna C. Morrison, Kimberly Bjugstad
Summary: The 28th American Society for Neural Therapy and Repair (ASNTR) conference returned to Sheraton Sand Key in Clearwater Beach, Florida after an 18 month hiatus. The conference was held in person with a virtual option, allowing for both in-person connections and remote participation. Highlights included the return of awards and lectures, along with discussions on the long-term effects of SARS-CoV2 infection on the central nervous system.
CELL TRANSPLANTATION
(2021)
