Article
Chemistry, Applied
Silvia Leccese, Thomas Onfroy, Adjele Wilson, Diana Kirilovsky, Sandra Casale, Saremble Guira, Mohamed Selmane, Claude Jolivalt, Alberto Mezzetti
Summary: This study focuses on the immobilization of the photoactive Orange Carotenoid Protein (OCP) on mesoporous silica nanoparticles and investigates its structural characterization. The results highlight the enhanced immobilization of OCP by pre-photoactivation, leading to photochromic nanoparticles. The study also explores the possibility of releasing OCP from the nanoparticles and suggests potential applications in nanoscale optical devices and antioxidant drug delivery.
MICROPOROUS AND MESOPOROUS MATERIALS
(2022)
Review
Biotechnology & Applied Microbiology
Ranjith Kumar Kankala, Ya-Hui Han, Hong-Ying Xia, Shi-Bin Wang, Ai-Zheng Chen
Summary: Mesoporous silica nanoparticles (MSNs) have great potential in biomedical applications, but traditional MSNs have limitations such as reduced drug encapsulation efficacy and poor degradability. Hierarchically-engineered MSNs have been developed by tuning the pore sizes, modifying the surfaces, and engineering the siliceous networks. These engineered MSNs have complex structures and can be applied in drug delivery, bioimaging, tissue engineering, and other fields.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Chemistry, Physical
Gyeongseok Yang, Sangpil Kim, Jun Yong Oh, Dohyun Kim, Seongeon Jin, Eunshil Choi, Ja-Hyoung Ryu
Summary: In this paper, a strategy for targeted delivery and controlled drug release using disulfide-incorporated mesoporous organosilica nanoparticles (MONs) was presented. The MONs were loaded with the chemodrug doxorubicin (DOX) and conjugated with a cell-specific affibody (Afb) fused with glutathione-S-transferase (GST). The particles exhibited prompt responsivity to the SS bond-dissociating glutathione (GSH), resulting in significant degradation of the particles and release of DOX, thereby enhancing cancer-therapeutic outcomes.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2023)
Article
Engineering, Biomedical
Wei Pei, Ling Cai, Xing Gong, Li Zhang, Jiarong Zhang, Ping Zhu, Huijun Jiang, Chao Wang, Shoulin Wang, Jin Chen
Summary: This study developed oleic acid-modified mesoporous silica nanoparticles (OA-MSNs) conjugated with bovine alpha-lactalbumin as a potential drug delivery system for the anticancer drug docetaxel (DTX). The resulting MSN-BAMLET/DTX exhibited sustained and pH-responsive drug release behavior, enhanced cytotoxic effect against cancer cells, improved dispersion in solution, and inhibitory effect on cancer cell migration. The protein corona analysis showed low adsorption of plasma proteins on the alpha-lactalbumin coated siliceous composite, indicating its potential for long circulation. In vivo study demonstrated the effective cancer ablation and prolonged survival with MSN-BAMLET/DTX, suggesting its potential as a manipulable nanoplatform for therapeutic applications.
MATERIALS TODAY BIO
(2022)
Review
Pharmacology & Pharmacy
Eleen Dayana Mohamed Isa, Haslina Ahmad, Mohd Basyaruddin Abdul Rahman, Martin R. Gill
Summary: Mesoporous silica nanoparticles (MSNs) as drug delivery agents show great potential in cancer treatment by enhancing efficacy and reducing side effects. Through the development of smart DDAs and the capability to efficiently trap cargo molecules, MSNs have a bright future in both the diagnosis and treatment of cancer.
Review
Biochemistry & Molecular Biology
Ying Kuang, Junjun Zhai, Qinjian Xiao, Si Zhao, Cao Li
Summary: Mesoporous silica nanoparticles (MSNs) play a significant role in drug delivery systems, and natural polysaccharides are widely used as gate materials, providing good biocompatibility and important biological functions.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Materials Science, Ceramics
Langston Tillman, Albert Voskanyan, Alexandra Navrotsky
Summary: This study successfully synthesized mesoporous silica with an average pore size of 10 nm using forsterite as a silica source, providing a potentially cheaper and more environmentally friendly route to making technologically important porous silica materials.
JOURNAL OF THE AMERICAN CERAMIC SOCIETY
(2023)
Article
Pharmacology & Pharmacy
Jie Zhuang, Yiming Yu, Rui Lu
Summary: Due to abuse of antibiotics, antibiotic resistance has become a global health threat. Many existing antibiotics have lost their effectiveness against drug-resistant bacteria, and the discovery of new antibiotics is becoming increasingly difficult. It is necessary to develop new strategies to combat antibiotic resistance. Nano-drug delivery systems, particularly mesoporous silica nano-particles (MSNs), have been extensively investigated as carriers of antibiotics. MSNs improve the delivery of antibiotics by reducing size, modifying surface, and regulating shapes. Furthermore, MSNs hybridized with metal ions or nanoparticles enhance the antibacterial effect by controlling the release of metal ions or increasing active oxygen species. Metal-capped MSNs can also load antibiotics to exert a synergistic antibacterial effect. This paper reviews the current application of various nanomaterials as antibacterial agents, with a focus on MSNs and approaches for improving their antibacterial effect.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Biochemistry & Molecular Biology
Min-Hsuan Tsou, Cheng-Chang Lee, Zhi-Yuan Wu, Zui-Harng Lee, Hsiu-Mei Lin
Summary: In this study, fucoidan was extracted from brown algae using a hot water extraction method, and synthesized into drug carrier-nanoparticles for drug delivery. Experimental results showed that rMSN-EuGd@Fucoidan exhibited higher cytotoxicity against A549 cancer cells compared to fucoidan itself.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Review
Pharmacology & Pharmacy
Chengcheng Zhang, Hongyi Xie, Zhengyan Zhang, Bingjian Wen, Hua Cao, Yan Bai, Qishi Che, Jiao Guo, Zhengquan Su
Summary: The preparation of mesoporous silica nanocarriers (MSN) has a wide range of medical applications. Different types of MSNs have been developed for various applications, especially in tumor treatment and biomedical imaging. MSNs have shown promise in improving drug therapeutics, introducing new drug delivery strategies, and addressing the limitations of traditional drugs. It is important to both innovate MSNs and understand their biological distribution in order to further develop their potential clinical applications.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Engineering, Environmental
Kaijun Gou, Yumei Wang, Linlin Xie, Xianmou Guo, Yingyu Guo, Jia Ke, Lulu Wu, Sanming Li, Heran Li
Summary: Chiral mesoporous silica nanoparticles (CMSNs) have unique physicochemical properties and advantages in biological behavior, making them valuable in various applications such as chiral catalysis, chiral selectivity, chiral recognition, separation, drug delivery, and medical research. Studies on CMSNs have made significant progress in synthesis, chirality origination mechanisms, structural properties, and practical applications, indicating great potential in the field of pharmaceutical science and beyond.
CHEMICAL ENGINEERING JOURNAL
(2021)
Article
Biophysics
Ling Cai, Ping Zhu, Fei Huan, Jun Wang, Liuzhu Zhou, Huijun Jiang, Minghui Ji, Jin Chen
Summary: The study synthesized CHO-SBA-15/DOX nanocomposite, utilizing acid-sensitive imine bonds for pH-responsive drug release, resulting in enhanced cytotoxic effect on DOX-resistant tumor cells and significantly reduced systemic toxicity in mice.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Nanoscience & Nanotechnology
Hua Yan, Jiangtao Dong, Xuan Huang, Xuezhong Du
Summary: Two novel stimuli-responsive drug delivery systems were successfully created using upconversion nanoparticle-embedded mesoporous silica nanovehicles controlled by bovine serum albumin or myoglobin via Se-Se linkages. These systems showed controlled release of drugs in tumor microenvironments and promising prospects in targeted drug delivery for cancer chemotherapy.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Engineering, Mechanical
Li Wan, Yi Wang, Xiaolong Tan, Yulong Sun, Jing Luo, Hongyu Zhang
Summary: This study developed biodegradable lubricating drug-loaded nanoparticles for the treatment of osteoarthritis. The nanoparticles showed enhanced lubrication and sustained drug release behavior. The results suggest that these nanoparticles may be a promising approach for osteoarthritis therapy.
Article
Chemistry, Physical
Md Aquib, Hang Zhang, Faisal Raza, Parikshit Banerjee, Rohit Bavi, Samuel Kesse, Kofi Oti Boakye-Yiadom, Mensura Sied Filli, Muhammad Asim Farooq, Bo Wang
Summary: Aminated mesoporous silica nanoparticles (AMPSNPs) were developed as a nanocarrier for disulfiram (DSF) delivery in cancer therapies. The optimized AMPSNPs showed excellent properties and compatibility, providing potential for effective drug delivery.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Article
Pharmacology & Pharmacy
Sajjad Khan, Vivek Trivedi, John Mitchell, Joshua S. Boateng
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2016)
Article
Pharmacology & Pharmacy
Shashi Ravi Suman Rudrangi, Waseem Kaialy, Muhammad U. Ghori, Vivek Trivedi, Martin J. Snowden, Bruce David Alexander
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2016)
Article
Instruments & Instrumentation
Adejumoke Lara Ajiboye, Vivek Trivedi, John C. Mitchell
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2018)
Article
Instruments & Instrumentation
Vivek Trivedi, Uttom Nandi, Mohammed Maniruzzaman, Nichola J. Coleman
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2018)
Article
Chemistry, Medicinal
Uttom Nandi, Vivek Trivedi, Dennis Douroumis, Andrew P. Mendham, Nichola J. Coleman
Article
Pharmacology & Pharmacy
Uttom Nandi, Md. S. H. Mithu, Andrew P. Hurt, Vivek Trivedi, Dennis Douroumis
Review
Chemistry, Multidisciplinary
Md Sadeque Hossain Mithu, Sophia Economidou, Vivek Trivedi, Saumil Bhatt, Dennis Douroumis
Summary: Pharmaceutical salt formation is a preferred method to enhance the properties of an active pharmaceutical ingredient; however, the traditional solvent-mediated process has environmental concerns. Recent advancements have led to a few reported solvent-free methods for salt manufacturing. This article reviews the trends in salt synthesis and manufacturing, as well as regulatory issues related to patent applications for salt forms of APIs compared to other multicomponent forms.
CRYSTAL GROWTH & DESIGN
(2021)
Review
Pharmacology & Pharmacy
Uttom Nandi, Vivek Trivedi, Steven A. Ross, Dennis Douroumis
Summary: Twin-screw granulation (TSG) is a pharmaceutical process that has gained increased interest from the pharmaceutical industry for its potential for the development of oral dosage forms. The technology offers benefits of both batch and continuous manufacturing for pharmaceutical products, accompanied by excellent process control and high product quality which can be achieved through the implementation of Quality by Design (QbD) approaches and the integration of Process Analytical Tools (PAT).
Article
Pharmacology & Pharmacy
D. Nadarassan, A. Loni, L. T. Canham, N. Scoutaris, V. Trivedi, D. Douroumis
Summary: Supercritical fluid (SCF) assisted drying of porous silicon results in higher mesopore volumes and surface areas, achieving higher drug payloads and improved in-vitro drug release performance.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Chemistry, Medicinal
Uttom Nandi, Adejumoke Lara Ajiboye, Preksha Patel, Dennis Douroumis, Vivek Trivedi
Summary: The study demonstrates that SIM-SOL dispersions can be successfully prepared using a solvent-free supercritical fluid process to enhance the dissolution rate of the drug.
Article
Polymer Science
Vivek Trivedi, Adejumoke Lara Ajiboye, Nichola J. Coleman, Ruchir Bhomia, Marion Bascougnano
Summary: The melting behavior of triblock polymers Pluronic F38, F68, F77, F108, and F127 was studied in pressurized CO2 and in the presence of menthol. The results showed that the melting point of these polymers was dependent on molecular weight, poly(propylene oxide) (PPO) content, and menthol percentage. Most of the polymers could be melted to room temperature, which is crucial for the formulation development of thermolabile substances using these polymers.
Article
Pharmacology & Pharmacy
Adejumoke Lara Ajiboye, Amelie Jacopin, Claudia Mattern, Uttom Nandi, Andrew Hurt, Vivek Trivedi
Summary: In this study, progesterone and testosterone were impregnated onto mesoporous silica particles using supercritical carbon dioxide processing. The effects of pressure, temperature, time, and co-solvent on impregnation efficiency were investigated. The impregnation of both drugs was found to be influenced by pressure, time, and co-solvent, while temperature had a minor effect. The drug release rate was significantly increased after impregnation, which can be attributed to the amorphization of the drugs on mesoporous silica.
Article
Pharmacology & Pharmacy
Adejumoke Lara Ajiboye, Uttom Nandi, Martin Galli, Vivek Trivedi
Summary: This study aimed to investigate the impact of high shear homogenization (HSH) and ultrasonication (US) on the physicochemical properties of blank and olanzapine loaded nanostructured lipid carriers (NLCs). The results showed that US significantly reduced the particle size of NLCs, while an increase in Miglyol content led to an increase in particle size. Olanzapine was successfully encapsulated in the NLCs, with a total release of 89% achieved in 24 hours.
SCIENTIA PHARMACEUTICA
(2021)
Article
Chemistry, Medicinal
Vivek Trivedi, Ruchir Bhomia, John C. Mitchell