Review
Endocrinology & Metabolism
Pingnan Jiang, Qianhang Li, Yanhong Luo, Feng Luo, Qingya Che, Zhaoyu Lu, Shuxiang Yang, Yan Yang, Xia Chen, Yulan Cai
Summary: Diabetic foot ulcer (DFU) is a serious complication of diabetes that can lead to amputation and death. Proper management includes surgical treatment, topical dressings, vascular assessment, and glycemic control. Among these, dressings play a crucial role in protecting the wound and promoting healing.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Dermatology
Mohamed S. Imam, Ahmed Khalid Almutairi, Abdullah Mutrik Alhajri, Mishary Mosleh Alharby, Mohammed H. Alanazi, Ahmad G. Alotaibi, Mohamed E. A. Abdelrahim
Summary: This meta-analysis aimed to assess the effect of hyperbaric oxygen treatment on diabetic foot ulcers. The results showed that hyperbaric oxygen treatment had significantly higher rates of healed ulcers, adverse events, and ulcer area reduction, as well as lower mortality, compared to standard treatment. However, there was no significant difference in amputation and healing time between the two treatments. It is important to note that the selected studies had small sample sizes and limited comparisons.
INTERNATIONAL WOUND JOURNAL
(2023)
Article
Endocrinology & Metabolism
Shumin He, Caiyi Liang, Cailan Yi, Miaoli Wu
Summary: The combination of moist wound dressing (MWD) and continuous diffusion of oxygen (CDO) was found to be effective in promoting wound healing, reducing infection risk, and decreasing the amputation rate in diabetic foot ulcers (DFUs) patients.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2021)
Article
Dermatology
Omar Al-Jalodi, Megan Kupcella, Kristy Breisinger, Thomas E. Serena
Summary: Multiple studies have shown that advanced modalities, such as topical oxygen therapy, can accelerate the healing of diabetic foot ulcers. The durability of wound closure is important, and there is a strong trend suggesting that ulcers treated with topical oxygen therapy have more long-lasting closure.
INTERNATIONAL WOUND JOURNAL
(2022)
Article
Dermatology
Shaoting Li, Ting Xiao, Ning Ye, Guosheng Yang, Haiting Chen, Xia Liang, Tuodi Li, Jinying Wang, Yaozhong Peng, Yuan Li, Yanping Liu
Summary: A meta-analysis study found that honey dressing (HD) has a significant effect in the management of diabetic foot ulcers, showing higher wound healing rate and shorter healing time compared to the control group. However, caution should be taken when interpreting the results due to the small sample sizes of most included studies.
INTERNATIONAL WOUND JOURNAL
(2023)
Article
Dermatology
Xin-Juan Sun, Jin-An Chen, Gai Li, Lei Wang, Tian-Yuan Wang, Ai-Ping Wang
Summary: The impact of maggot debridement therapy (MDT) on macrophages during the healing process of diabetic foot ulcers (DFU) was determined in this study. The activation phenotype and markers associated with macrophage activation were evaluated. M2 macrophages were over-expressed while M1 macrophages were under-expressed in the healing process following MDT. The activation markers of macrophages exhibited a correlation with Th1/Th2 cytokines.
INTERNATIONAL WOUND JOURNAL
(2023)
Article
Pharmacology & Pharmacy
Afnan Harb, Mahmoud H. Elbatreek, Ahmed Elshahat, Nadia El-Akabawy, Waleed Barakat, Nesreen MIM. Elkomy
Summary: This study reveals the potential of alagebrium in the treatment of diabetic foot ulcer (DFU), as it promotes wound healing, improves sensory function and gait, reduces inflammation, and enhances angiogenesis.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Nanoscience & Nanotechnology
Wen Ren, Victoria Messerschmidt, Michael Tsipursky, Joseph Irudayaraj
Summary: In this study, an oxygen nanobubbles-embedded hydrogel (ONB-G) with carbopol was proposed for oxygenation of wounds to accelerate wound healing. ONB-G, prepared by integrating carbopol, hydrogel, and dextran-based oxygen nanobubbles (ONBs), can hold and release oxygen to promote wound healing. Experimental results showed that ONB-G could encapsulate oxygen for up to 34 days and maintain high oxygen levels for up to 4 weeks. HDFa cell-based studies demonstrated the potential of ONB-G in enhancing cell viability, proliferation, and wound closure. Histological evaluation using a pig model also indicated improved healing with ONB-G treatment compared to control groups. Overall, dextran-shell ONBs embedded in a gel exhibit promising potential in accelerating wound healing.
ACS APPLIED NANO MATERIALS
(2023)
Article
Medicine, General & Internal
Awni Alshurafa, Mohammed Alkhatib, Mohammad Abu-Tineh, Mohamed A. Yassin
Summary: Sickle cell leg ulcers (SCLUs) are chronic and painful complications of sickle cell disease, caused by skin vaso-occlusion, chronic inflammation, and endothelial dysfunction. Managing SCLUs is challenging and various treatments have been attempted, but there are no official recommendations for the best effective treatment. We report a successful case of a 34-year-old male patient with non-transfusion-dependent sickle cell disease, whose chronic left ankle ulcer was completely resolved with hyperbaric oxygen therapy.
FRONTIERS IN MEDICINE
(2023)
Review
Chemistry, Multidisciplinary
Yongping Liang, Jiahui He, Baolin Guo
Summary: Hydrogels have shown promising advantages as wound dressings due to their excellent biochemical and mechanical properties. This review summarizes the advanced functions of hydrogel dressings, such as antimicrobial, adhesion, hemostasis, anti-inflammatory, substance delivery, self-healing, stimulus response, and conductivity, as well as the emerging wound monitoring feature. The potential applications for different types of wounds, including chronic wounds and focus on infected, burn, and diabetic wounds, are discussed, along with proposed future directions for hydrogel wound dressings in wound healing.
Article
Dermatology
Haiting Chen, Ting Xiao, Ling Zhang, Ning Liu, Xia Liang, Tuodi Li, Jinying Wang, Yaozhong Peng, Yanping Liu, Jiali Xu
Summary: This meta-analysis study examined the effect of ultrasound-supported wound debridement (USSD) in diabetic foot ulcer (DFU) patients. The findings showed that USSD had a greater impact on wound healing compared to standard care and placebo.
INTERNATIONAL WOUND JOURNAL
(2023)
Review
Dermatology
Kevin Syam, Shaheer A. Joiya, Sumayyah Khan, P. Nithin Unnikrishnan
Summary: The analysis of existing randomized controlled trials on maggot debridement therapy (MDT) indicates its effectiveness in diabetic foot ulcers, but its efficacy in chronic peripheral vascular disease ulcers remains inconclusive. Further studies are recommended to evaluate the cost-effectiveness and patient experience.
ADVANCES IN SKIN & WOUND CARE
(2021)
Article
Chemistry, Multidisciplinary
Huanhuan Chen, Yunfei Guo, Zhewei Zhang, Wenxuan Mao, Chenying Shen, Wei Xiong, Yingfang Yao, Xiaozhi Zhao, Yiqiao Hu, Zhigang Zou, Jinhui Wu
Summary: The hydrogen-producing hydrogel made of living Chlorella and bacteria within a cell-impermeable casing can continuously produce hydrogen for 60 hours, selectively reduce highly toxic ·OH and ONOO- species, and reduce inflammation. Studies have shown that the microbe-hydrogel dressing can promote cell proliferation and diabetic wound healing by almost 50% at day 3. This symbiotic algae-bacteria hydrogel demonstrates excellent biocompatibility and reactive oxygen species scavenging capabilities, suggesting great promise for clinical use.
Review
Polymer Science
Pavel Yudaev, Yaroslav Mezhuev, Evgeniy Chistyakov
Summary: This review examines the use of dressings containing nanoparticles for wound repair and evaluates their antimicrobial effects and healing actions. The analysis of 31 sources published between 2021 and 2022 demonstrates a trend towards the development of modern antibacterial wound-healing nanomaterials.
Review
Multidisciplinary Sciences
Suriadi Jais, Kharisma Pratama
Summary: Indonesia is facing challenges in controlling the burden of diabetic foot ulcers, and a nursing care management approach is needed to accurately monitor wound healing progress. This literature review identified five assessment tools for chronic wounds, with the DMIST tool receiving sufficient rating for its predictive validity and responsiveness.
Article
Endocrinology & Metabolism
Shobitha Puvaneswaralingam, Albin Kjellbom, Ola Lindgren, Magnus Londahl, Henrik Olsen
Summary: In the investigation of adrenal incidentalomas, ACTH(ONDST) and ACTH ratio were found to be markers of HPA axis suppression. For patients with cortisol(ONDST) >= 50 nmol/L, ACTH(ONDST) >= 0.6 pmol/L and ACTH ratio >= 18% were effective in detecting inadequate suppression of the HPA axis.
CLINICAL ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Erika Vainieri, Raju Ahluwalia, Hani Slim, Daina Walton, Chris Manu, Surabhi Taori, Jason Wilkins, Dean Y. Huang, Mike Edmonds, Hisham Rashid, Venu Kavarthapu, Prashanth R. J. Vas
Summary: This study analyzed the clinical outcomes of hospitalized patients with diabetic foot attack (DFA) and found excellent healing and limb salvage rates, but also a high 18-month mortality rate.
EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES
(2022)
Article
Dermatology
Prashanth R. J. Vas, George S. Georgiadis, Nikolaos Papanas
Summary: There is increasing evidence of an association between COVID-19 and cutaneous eruptions, particularly chilblains-like perniosis, but a definitive causal relationship with SARS-CoV-2 has not been proven yet. It is important to investigate potential long-term sequelae.
INTERNATIONAL JOURNAL OF LOWER EXTREMITY WOUNDS
(2022)
Article
Dermatology
Daina Walton, Michael E. Edmonds, Maureen Bates, Prashanth R. J. Vas, Nina L. Petrova, Chris A. Manu
Summary: The study found that people with diabetes and foot disease are often unaware of their foot risk status or the reasons for being referred to a multidisciplinary team. They have varying levels of interest in further understanding foot complications. This indicates possible communication barriers between patients and health professionals.
JOURNAL OF WOUND CARE
(2021)
Article
Endocrinology & Metabolism
Catherine Gooday, Wendy Hardeman, Frances Game, Jim Woodburn, Fiona Poland
Summary: This qualitative study aimed to understand the experiences of individuals with Charcot neuroarthropathy (CN). The study found that CN has substantial physical, social, and emotional impacts on patients and their families, including confinement at home, disruption of roles and responsibilities, pain, and self-blame. The results of this study highlight the importance of raising clinical awareness of CN.
Review
Endocrinology & Metabolism
William Jeffcoate, Fran Game
Summary: This article emphasizes the importance of the inflammation process in the development and resolution of neuropathic osteoarthropathy, pointing out that the interaction between neuropathy and inflammation is essential for the occurrence of Charcot foot.
Article
Endocrinology & Metabolism
Sicco Bus, Matilde Monteiro-Soares, Fran J. Game, Jaap van Netten, Jan Apelqvist, Robert Fitridge, Eric C. Senneville, Nicolaas Schaper
Summary: The International Working Group on the Diabetic Foot (IWGDF) has published updated guidelines in 2023 on the prevention and management of diabetes-related foot disease. These guidelines cover various aspects such as prevention, classification, offloading, peripheral artery disease, infection, wound healing interventions, and Charcot neuro-osteoarthropathy. Implementing these guidelines by healthcare providers, public health agencies, and policymakers is expected to improve the management of diabetes-related foot disease and reduce the burden caused by this condition worldwide.
DIABETES-METABOLISM RESEARCH AND REVIEWS
(2023)
Article
Endocrinology & Metabolism
Jaap J. A. van Netten, Sicco A. Bus, Jan Apelqvist, Pam Chen, Vivienne Chuter, Robert Fitridge, Frances J. Game, Robert J. A. Hinchliffe, Peter A. Lazzarini, Joseph Mills, Matilde Monteiro-Soares, Edgar J. G. M. Peters, Katherine M. Raspovic, Eric K. Senneville, Dane K. C. Wukich, Nicolaas C. Schaper
Summary: In order to facilitate clear communication between individuals with diabetes-related foot disease and professionals worldwide, the International Working Group on the Diabetic Foot (IWGDF) has developed a set of definitions and criteria for diabetes-related foot disease based on systematic reviews of the literature. This document describes the 2023 update of these definitions and criteria.
DIABETES-METABOLISM RESEARCH AND REVIEWS
(2023)
Article
Endocrinology & Metabolism
Matilde Monteiro-Soares, Emma J. J. Hamilton, David A. A. Russell, Gulapar Srisawasdi, Edward J. J. Boyko, Joseph L. L. Mills, William Jeffcoate, Fran Game
Summary: This study aimed to assess published systems used to characterise ulcers in people with diabetes in order to determine recommended systems for aiding communication between health professionals, predicting clinical outcomes, characterising patients with infection or peripheral arterial disease, and comparing outcomes in different populations. The systematic review found 28 systems, with low certainty of evidence for each classification, but provided enough evidence to support recommendations on the use of six systems in specific clinical scenarios.
DIABETES-METABOLISM RESEARCH AND REVIEWS
(2023)
Article
Endocrinology & Metabolism
Matilde Monteiro-Soares, Emma J. Hamilton, David A. Russell, Gulapar Srisawasdi, Edward J. Boyko, Joseph L. Mills, William Jeffcoate, Frances Game
Summary: This publication updates the 2019 guidelines of the International Working Group of the Diabetic Foot (IWGDF) on the use of classification systems for foot ulcers in people with diabetes in routine clinical practice. Based on a systematic review and expert consensus, specific classification systems are recommended for communicating, predicting outcomes, characterizing infected ulcers and peripheral artery disease, as well as auditing outcomes of populations.
DIABETES-METABOLISM RESEARCH AND REVIEWS
(2023)
Article
Endocrinology & Metabolism
Nicolaas J. Schaper, Jaap van Netten, Jan A. Apelqvist, Sicco Bus, Robert Fitridge, Fran Game, Matilde Monteiro-Soares, Eric Senneville, IWGDF Editorial Board
Summary: The International Working Group on the Diabetic Foot (IWGDF) has updated their practical guidelines on the prevention and management of diabetes-related foot disease. These guidelines aim to reduce the frequency of lower-extremity amputations caused by diabetes-related foot disease and provide better care for patients worldwide.
DIABETES-METABOLISM RESEARCH AND REVIEWS
(2023)
Article
Dermatology
Jennie E. Hancox, Charlotte Hilton, Katie Gray, Fran Game, Kavita Vedhara
Summary: Patients with diabetic foot ulcers often do not adhere to the advice of limiting weight-bearing activity, which is necessary for ulcers to heal. Communication of the advice, including rapport, empathy, and rationale, as well as individual factors such as daily demands, exercise enjoyment, and health benefits, influence patients' adherence. Healthcare professionals should employ a more person-centred approach tailored to patients' specific needs and consider patient priorities and constraints.
INTERNATIONAL WOUND JOURNAL
(2023)
Article
Medicine, General & Internal
Venu Kavarthapu, Jasdeep Giddie, Varun Kommalapati, Joanne Casey, Maureen Bates, Prashanth Vas
Summary: The management of diabetic foot osteomyelitis is challenging with high amputation rates and mortality risks. This study describes the use of adjuvant antibiotic-loaded bio-composite material in the surgical management of infected Charcot foot reconstruction. The results show a high proportion of patients achieving infection clearance, limb salvage, and decreased postoperative antibiotic therapy duration.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Endocrinology & Metabolism
Marcus Lind, Sergiu-Bogdan Catrina, Neda R. Ekberg, Sofia Gerward, Tariq Halasa, Jarl Hellman, Detlef Hess, Magnus Londahl, Veronica Qvist, Jan Bolinder
Summary: This study analyzed the effects of switching to faster aspart treatment in adults with T1D using continuous glucose monitoring data. The results showed that switching to faster aspart led to improvements in glycemic control without increasing the risk of hypoglycemia.
Article
Endocrinology & Metabolism
Sanjeev Sharma, Prashanth Vas, Gerry Rayman
Summary: Diabetes polyneuropathy is a significant complication of diabetes, but is often undiagnosed until late in its progression and lacks interventions to reverse its clinical progress. Assessing small fiber neuropathy in diabetes can help detect abnormalities early and prevent the development of severe complications.
JOURNAL OF DIABETES SCIENCE AND TECHNOLOGY
(2022)
