期刊
DIABETES OBESITY & METABOLISM
卷 22, 期 -, 页码 46-54出版社
WILEY
DOI: 10.1111/dom.13987
关键词
chronic kidney disease; clinical trials; diabetes; kidney outcomes; SGLT2 inhibitors
资金
- Medical Research Future Fund Next Generation Clinical Researchers Program Career Development Fellowship
- National Institute of Diabetes and Digestive and Kidney Diseases [K01 DK110221, K24 DK085446]
In the past decade, many cardiovascular outcome trials (CVOT) on the efficacy and safety of glucose-lowering agents have been completed. Amongst newer agents available for treatment of type 2 diabetes mellitus (T2DM), sodium-glucose cotransporter-2 (SGLT2) inhibitors have garnered much attention in contemporary clinical practice due to observed benefits on cardiovascular and kidney outcomes among patients with T2DM, as reported in large randomized controlled trials (RCT). These findings are reflected in the updated clinical guidelines of several major professional societies. Herein, we briefly review the mechanism of action of SGLT2 inhibitors and their pleiotropic effects, summarize key findings and limitations of initial CVOTs, then discuss three major kidney disease-focused outcome trials, including the Canagliflozin and Renal Events in Diabetes and Established Nephropathy Clinical Evaluation (CREDENCE) trial as well as two ongoing RCTs: Dapagliflozin and Prevention of Adverse Outcomes in Heart Failure-chronic kidney disease and EMPA-KIDNEY.
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