Review
Endocrinology & Metabolism
Virginia Bellido, Pedro Jose Pines-Corrales, Rocio Villar-Taibo, Francisco Javier Ampudia-Blasco
Summary: While HbA1c has been the gold standard for evaluating glucose control, its limitations have led to the increasing use of Time in Range (TIR) as a metric for assessing the quality of glucose control and its correlation with preventing diabetes complications.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2021)
Review
Biochemistry & Molecular Biology
Vadim V. Klimontov, Olga Saik, Anton Korbut
Summary: Glucose variability plays a crucial role in the development of diabetes complications, affecting target organs through oxidative stress, glycation, chronic inflammation, and other pathways. This creates a vicious cycle that worsens the condition and highlights the need to consider GV as a therapeutic target in diabetes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Immunology
Dan Ke, Zhen Zhang, Jieting Liu, Peijian Chen, Yucen Dai, Xinhai Sun, Yanhui Chu, Luxin Li
Summary: Diabetes is a metabolic disease that causes chronic high blood sugar, leading to harmful inflammation and complications. Anti-inflammatory drugs, specifically targeting RIPK1 and RIPK3, have shown potential in managing inflammation and treating diabetes complications. This review provides a summary of the current research on the mechanism of action and drug development of RIPK1 and RIPK3.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Endocrinology & Metabolism
Louis Monnier, Claude Colette, David Owens
Summary: Variability in glucose homeostasis plays a significant role in diabetes complications, especially in relation to hypoglycemic events. It is important to avoid excessive glucose fluctuations within a day and to understand that variability in glucose homeostasis is not only associated with cardiovascular events but also a causative factor for hypoglycemia.
DIABETES & METABOLISM
(2021)
Article
Endocrinology & Metabolism
Anass El Malahi, Michiel Van Elsen, Sara Charleer, Eveline Dirinck, Kristien Ledeganck, Bart Keymeulen, Laurent Crenier, Regis Radermecker, Youri Taes, Chris Vercammen, Frank Nobels, Chantal Mathieu, Pieter Gillard, Christophe De Block
Summary: This study investigated the association between glycemic variability and time in range with chronic and acute diabetes complications. The results showed that lower time in range was associated with the presence of microvascular complications and hospitalization for hypoglycemia or ketoacidosis. However, glycemic variability was not associated with macrovascular complications.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Editorial Material
Psychiatry
Rafael Penades, Til Wykes
Summary: Cognitive remediation is recommended for treating cognitive and functional impairments in patients with schizophrenia. Recent research suggests that it could also help reduce negative symptoms, but more studies focusing on individuals with primary negative symptoms are needed. Furthermore, the role of moderators and mediators and the use of more specific assessments should be investigated. Despite these challenges, cognitive remediation shows promise as a treatment option for primary negative symptoms.
BRITISH JOURNAL OF PSYCHIATRY
(2023)
Editorial Material
Multidisciplinary Sciences
Amber Dance
Summary: After a series of well-publicized cases of tenure denials, American academics are reconsidering how to make this embattled academic process more fair.
Review
Endocrinology & Metabolism
Bettina Schuppelius, Beeke Peters, Agnieszka Ottawa, Olga Pivovarova-Ramich
Summary: Time-restricted eating (TRE) is an attractive and easy-to-adapt dietary strategy that may be beneficial for weight loss, improving cardiometabolic health, and overall well-being. However, the effects of TRE on glucose and lipid metabolism are controversial. Current evidence shows that TRE can lower blood glucose, triglycerides, and cholesterol levels, as well as improve insulin sensitivity, but some studies suggest that TRE may not have positive effects in all individuals. Further research is needed to confirm these effects and understand the mechanisms underlying TRE's impact on metabolic health.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Jessy Chen, Thomas Fleming, Sylvia Katz, Matthias Dewenter, Kai Hofmann, Alireza Saadatmand, Mariya Kronlage, Moritz P. Werner, Bianca Pokrandt, Friederike Schreiter, Jihong Lin, Daniel Katz, Jakob Morgenstern, Ahmed Elwakiel, Peter Sinn, Hermann-Josef Groene, Hans-Peter Hammes, Peter P. Nawroth, Berend Isermann, Carsten Sticht, Britta Bruegger, Hugo A. Katus, Marco Hagenmueller, Johannes Backs
Summary: This study investigated the role of CaMKII δ in diabetes and found that diabetic mice lacking CaMKII δ did not develop hyperglycemia, but still exhibited diabetic nephropathy while diabetic retinopathy was prevented. This challenges the clinical concept of normalizing hyperglycemia in diabetes for late diabetic complications and emphasizes the need for detailed analysis of intracellular metabolic signals in different organs affected by diabetes.
Review
Endocrinology & Metabolism
Yifei Mo, Jingyi Lu, Jian Zhou
Summary: Continuous glucose monitoring devices have been advancing in accuracy and complexity, providing valuable insights into blood glucose dynamics. Glycemic variability, as a measure of glucose fluctuations, has uncertain role in the development of diabetes complications. This literature review summarizes existing evidence regarding GV measurement, target level, pathophysiological mechanisms, population-based studies, and also introduces novel methods and unresolved issues of GV.
JOURNAL OF DIABETES INVESTIGATION
(2023)
Review
Ophthalmology
S. Robert Levine, Przemyslaw Sapieha, Sanjoy Dutta, Jennifer K. Sun, Thomas W. Gardner
Summary: This article discusses the pathogenesis and treatment options for diabetic retinal disease (DRD), as well as new approaches to clinical assessment and trial design. The Restoring Vision Moonshot framework aims to address gaps in knowledge and accelerate the development of potential curative interventions for vision restoration and prevention of vision loss in individuals with diabetes.
PROGRESS IN RETINAL AND EYE RESEARCH
(2022)
Article
Endocrinology & Metabolism
M. Angelyn Bethel, Rafael Diaz, Noelia Castellana, Indranil Bhattacharya, Hertzel C. Gerstein, Mark C. Lakshmanan
Summary: The study found that HbA(1c) reduction was significantly associated with increased retinopathy risk in GLP-1RA CVOTs. However, no relationship was found for SBP or weight. The magnitude of HbA(1c) reduction was correlated with retinopathy risk in people with diabetes.
Review
Obstetrics & Gynecology
P. Petric, E. Vrtacnik-Bokal, M. Stimpfel
Summary: Stem cell therapy for infertility can be divided into direct transplantation and in vitro differentiation methods. While these approaches have shown improvements in reproductive potential in animal models, there is insufficient evidence to suggest successful applications in humans.
REPRODUCTIVE SCIENCES
(2021)
Review
Endocrinology & Metabolism
Elizabeth O. Buschur, Eileen Faulds, Kathleen Dungan
Summary: The use of continuous glucose monitoring (CGM) in the hospital setting is growing, especially during the COVID-19 pandemic. Recent studies have shown that CGM is accurate and effective in reducing hypoglycemia in hospitalized patients, and can also improve glycemic control. Additionally, CGM can reduce nursing workload, cost, and minimize face-to-face patient care during the pandemic.
CURRENT DIABETES REPORTS
(2022)
Article
Endocrinology & Metabolism
Leena Mamilly, Lucy D. Mastrandrea, Claudia Mosquera Vasquez, Brett Klamer, Mahmoud Kallash, Ahmad Aldughiem
Summary: Diabetic nephropathy is a common microvascular complication in type 1 diabetes mellitus. Urinary markers of renal damage or oxidative stress may signal early stages of DN, but their association with blood pressure patterns and glycemic variability in children is not yet well understood. This study found that while microalbuminuria was negative, urinary NGAL/Cr and pentosidine/Cr ratios were significantly elevated in diabetic patients. Additionally, poor nocturnal systolic blood pressure dipping was found in nearly half of the cases, and urinary NGAL/Cr negatively correlated with this dipping pattern. Both NGAL/Cr and pentosidine/Cr ratios were also higher in the high glycemic variability group. Overall, this pilot study highlights the potential role of ABPM and urinary markers in the early detection of diabetic nephropathy, with glycemic variability possibly playing a role in the disease process.
FRONTIERS IN ENDOCRINOLOGY
(2021)