Neural tube development depends on notochord-derived sonic hedgehog released into the sclerotome

From top to bottom: Cell polarity in Hedgehog and Wnt trafficking

(2018) Ana-Citlali Gradilla et al.   BMC BIOLOGY

A Balance between Secreted Inhibitors and Edge Sensing Controls Gastruloid Self-Organization

(2016) Fred Etoc et al.   DEVELOPMENTAL CELL

Retinoic acid signaling regulates development of the dorsal forebrain midline and the choroid plexus in the chick

(2015) S. Gupta et al.   DEVELOPMENT

Morphogen rules: design principles of gradient-mediated embryo patterning

(2015) J. Briscoe et al.   DEVELOPMENT

Secreted HHIP1 interacts with heparan sulfate and regulates Hedgehog ligand localization and function

(2015) Alexander M. Holtz et al.   JOURNAL OF CELL BIOLOGY

Cdon acts as a Hedgehog decoy receptor during proximal-distal patterning of the optic vesicle

(2014) Marcos Julián Cardozo et al.   Nature Communications

Shh-mediated degradation of Hhip allows cell autonomous and non-cell autonomous Shh signalling

(2014) Lina Kwong et al.   Nature Communications

Vertebrate Hedgehog is secreted on two types of extracellular vesicles with different signaling properties

(2014) Neha Vyas et al.   Scientific Reports

Floor plate-derived sonic hedgehog regulates glial and ependymal cell fates in the developing spinal cord

(2013) K. Yu et al.   DEVELOPMENT

The transition from differentiation to growth during dermomyotome-derived myogenesis depends on temporally restricted hedgehog signaling

(2013) N. Kahane et al.   DEVELOPMENT

The mechanisms of Hedgehog signalling and its roles in development and disease

(2013) James Briscoe et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

LGN-dependent orientation of cell divisions in the dermomyotome controls lineage segregation into muscle and dermis

(2011) R. Ben-Yair et al.   DEVELOPMENT

Sclerotome-derived Slit1 drives directional migration and differentiation of Robo2-expressing pioneer myoblasts

(2011) O. Halperin-Barlev et al.   DEVELOPMENT

Boc and Gas1 Each Form Distinct Shh Receptor Complexes with Ptch1 and Are Required for Shh-Mediated Cell Proliferation

(2011) Luisa Izzi et al.   DEVELOPMENTAL CELL

Overlapping Roles and Collective Requirement for the Coreceptors GAS1, CDO, and BOC in SHH Pathway Function

(2011) Benjamin L. Allen et al.   DEVELOPMENTAL CELL

Regulation of Trunk Myogenesis by the Neural Crest: A New Facet of Neural Crest-Somite Interactions

(2011) Chaya Kalcheim   DEVELOPMENTAL CELL

Evidence for a dynamic spatiotemporal fate map and early fate restrictions of premigratory avian neural crest

(2010) S. Krispin et al.   DEVELOPMENT

Foxj1 regulates floor plate cilia architecture and modifies the response of cells to sonic hedgehog signalling

(2010) C. Cruz et al.   DEVELOPMENT

Distinct Sonic Hedgehog signaling dynamics specify floor plate and ventral neuronal progenitors in the vertebrate neural tube

(2010) V. Ribes et al.   GENES & DEVELOPMENT

Hedgehog Pathway Antagonist 5E1 Binds Hedgehog at the Pseudo-active Site

(2010) Henry R. Maun et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Processing-dependent trafficking of Sonic hedgehog to the regulated secretory pathway in neurons

(2010) Shawn T. Beug et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Dynamic Assignment and Maintenance of Positional Identity in the Ventral Neural Tube by the Morphogen Sonic Hedgehog

(2010) Eric Dessaud et al.   PLOS BIOLOGY

Sonic hedgehog-dependent synthesis of laminin  1 controls basement membrane assembly in the myotome

(2009) C. Anderson et al.   DEVELOPMENT

Wnt/Lef1 signaling acts via Pitx2 to regulate somite myogenesis

(2009) Muhammad Abu-Elmagd et al.   DEVELOPMENTAL BIOLOGY

Making a grade: Sonic Hedgehog signalling and the control of neural cell fate

(2009) James Briscoe   EMBO JOURNAL

Heparan Sulfate-modulated, Metalloprotease-mediated Sonic Hedgehog Release from Producing Cells

(2009) Tabea Dierker et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lateral transport of Smoothened from the plasma membrane to the membrane of the cilium

(2009) Ljiljana Milenkovic et al.   JOURNAL OF CELL BIOLOGY

Structural insights into hedgehog ligand sequestration by the human hedgehog-interacting protein HHIP

(2009) Benjamin Bishop et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Hedgehog signal transduction by Smoothened: Pharmacologic evidence for a 2-step activation process

(2009) R. Rohatgi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Establishing and Interpreting Graded Sonic Hedgehog Signaling during Vertebrate Neural Tube Patterning: The Role of Negative Feedback

(2009) V. Ribes et al.   Cold Spring Harbor Perspectives in Biology

Notochord-derived Shh concentrates in close association with the apically positioned basal body in neural target cells and forms a dynamic gradient during neural patterning

(2008) C. E. Chamberlain et al.   DEVELOPMENT

A gradient of Shh establishes mutually repressing somitic cell fates induced by Nkx3.2 and Pax3

(2008) Dana M. Cairns et al.   DEVELOPMENTAL BIOLOGY