期刊
DEVELOPMENT
卷 147, 期 6, 页码 -出版社
COMPANY BIOLOGISTS LTD
DOI: 10.1242/dev.175703
关键词
SUMO; Signal transduction; Epigenetics; Neurodegenerative disorder; Ubiquitin-like protein; Post-translational protein modification
资金
- National Institute of General Medical Sciences MARC fellowship [T34GM008563]
- National Institutes of Health [GM63596]
In essentially all eukaryotes, proteins can bemodified by the attachment of small ubiquitin-relatedmodifier (SUMO) proteins to lysine side chains to produce branched proteins. This process of `SUMOylation' plays essential roles in plant and animal development by altering protein function in spatially and temporally controlled ways. In this Primer, we explain the process of SUMOylation and summarize how SUMOylation regulates a number of signal transduction pathways. Next, we discuss multiple roles of SUMOylation in the epigenetic control of transcription. In addition, we evaluate the role of SUMOylation in the etiology of neurodegenerative disorders, focusing on Parkinson's disease and cerebral ischemia. Finally, we discuss the possibility that SUMOylation may stimulate survival and neurogenesis of neuronal stem cells.
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