Article
Food Science & Technology
Hye-Young Youn, Kun-Ho Seo, Hyeon-Jin Kim, Young-Seon Kim, Hyunsook Kim
Summary: Bioconversion of whey and polyphenol-rich citrus pomace extract using kefir lactic acid bacteria may be effective in combating obesity and obesity-related diseases.
FOOD RESEARCH INTERNATIONAL
(2022)
Article
Medicine, General & Internal
Jun Seok Son, Song Ah Chae, Liang Zhao, Hongyang Wang, Jeanene M. de Avila, Mei-Jun Zhu, Zhihua Jiang, Min Du
Summary: Maternal obesity negatively affects non-shivering thermogenesis gene expression in offspring muscle, while maternal exercise can enhance it by activating the Apelin signaling-AMPK axis to protect offspring from metabolic disorders.
Article
Endocrinology & Metabolism
Jia Liang, Ying Jia, Haijing Yan, Qingyu Shen, Weihua Bian, Dongmei Zhao, Yong Xu, Yongjun Jin, Meizi Yang
Summary: Comparative study on diet and MSG-induced obese mice showed that obesity-resistant mice had lower body weight and length, indicating resistance to obesity, with upregulation of Prdm16 and Ucp-1 levels in white adipose tissue, suggesting highest white fat browning in obesity-resistant mice.
DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
(2021)
Article
Agriculture, Multidisciplinary
Xiaoyun He, Shujuan Zheng, Yao Sheng, Tong Miao, Jia Xu, Wentao Xu, Kunlun Huang, Changhui Zhao
Summary: Supplementation with chlorogenic acid can improve high-fat diet-induced obesity and associated glucose intolerance mainly through regulating food intake and energy expenditure.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2021)
Article
Multidisciplinary Sciences
Jihyun Kim, Jiyoung Moon, Chul-Hong Park, Jisu Lee, Helia Cheng, Z. Elizabeth Floyd, Ji Suk Chang
Summary: Selective ablation of NT-PGC-1α in mice led to a lean phenotype under high-fat diet conditions, with more pronounced effects in females. This was primarily due to reduced dietary fat intake. Additionally, female NT-PGC-1α (-/-) mice showed decreased feed efficiency, increased fecal fat excretion, and decreased uptake of fatty acids by enterocytes and adipocytes under high-fat diet conditions.
SCIENTIFIC REPORTS
(2021)
Article
Endocrinology & Metabolism
Boju Sun, Misa Hayashi, Maya Kudo, Lili Wu, Lingling Qin, Ming Gao, Tonghua Liu
Summary: The pre-clinical study investigated the effects of Madecassoside (MA) on obesity in diabetic mice. The results showed that MA significantly reduced body weight, BMI, and promoted fatty acid oxidation in epididymal fat. It also promoted the browning of mesenteric fat and activated mitochondrial function in brown fat.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Food Science & Technology
Ziyuan Wang, Qing Li, Yiming Hao, Zongwei Wang, Haihong Yang, Jie Liu, Jing Wang
Summary: AR-C17 significantly improved high-fat diet-induced skeletal muscle dysfunction in mice by enhancing mitochondrial biogenesis, without affecting myofiber type conversion or myogenesis.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Chemistry, Medicinal
Xiaotong Su, Linglin Lai, Xu Li, Wenna Li, Zhentao Mo, Yiqi Li, Lu Xiao, Wenjun Wang, Feng Wang
Summary: This study investigated the effects and mechanisms of 2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone (DMC) on exercise tolerance in mice fed a high-fat diet (HFD). The results showed that DMC combined with regular exercise improved endurance performance, body composition, glucose and insulin tolerance, lipid profile, and inflammation in a dose-dependent manner. Furthermore, DMC restored normal tissue morphology, reduced fatigue-associated markers, and enhanced whole-body metabolism and protein expression in the muscle and adipose tissues of HFD-fed mice. These findings suggest that DMC has antifatigue effects by regulating glucolipid catabolism, inflammation, and energy homeostasis, and exerts a synergistic exercise-related metabolic effect via the AMPK-SIRT1-PGC-1a signaling pathway, making it a potential natural sports supplement for obesity prevention.
PHYTOTHERAPY RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Mai Abd El Hady Mousa, Hemmat Mansour, Fatma Eid, Alya Mashaal
Summary: Monosodium glutamate (MSG) has been traditionally used as a flavor enhancer, but chronic consumption may lead to toxicity and inflammation. Ginger has been found to have protective effects and potent anti-inflammatory activity. Ginger could be used for food enhancement and as a therapeutic agent for inflammatory diseases.
JOURNAL OF FOOD BIOCHEMISTRY
(2021)
Article
Agriculture, Dairy & Animal Science
Hikaru Muroi, Kouhei Hori, Yukako Tokutake, Yuki Hakamata, Fuminori Kawabata, Masaaki Toyomizu, Motoi Kikusato
Summary: This study investigated the intracellular mechanisms by which oleuropein affects mRNA expression and reactive oxygen species generation in chicken muscle cells. The results suggest that oleuropein regulates intracellular calcium levels through TRPV1 and SIRT1 pathways, leading to changes in AMPK and PGC-1 alpha protein expression.
ANIMAL SCIENCE JOURNAL
(2022)
Article
Nutrition & Dietetics
Do-Sung Kim, Hwa-Young Lee, Hwa-Jin Kim, Geum-Hwa Lee, Young Jae Lim, Bo Mi Ko, Ji-Hyun Kim, Tae Won Kim, Hye Kyung Kim, Tae Young Kim, Dae Il Hwang, Ha Kyoung Choi, Seon Min Ju, Myung Ja Chung, Han-Jung Chae
Summary: This study aims to investigate the synergistic effects and mechanisms of Mori Folium (Morus alba leaf) and Mori Cortex Radicis (Morus alba root cortex) in the treatment of obesity. The results showed that a combination of MF and MR enhanced the expression of brown adipocyte-specific genes and regulated adipocytic dysmetabolism. In vivo experiments confirmed that MF/MR supplementation significantly inhibited weight gain, reduced plasma cholesterol, and improved adipocyte morphology.
Article
Materials Science, Biomaterials
Ming Wang, Zhicheng Sun, Yanggang Ou, Wei Ge, Mengqian Yuan, Bin Xu
Summary: This study explores the potential therapeutic effects of electroacupuncture (EA) on obesity by investigating its influence on autophagy and energy metabolism. The results show that EA significantly reduces body weight, fat deposition, and lipid accumulation in mice with high-fat diet (HFD). Furthermore, EA improves metabolic imbalances and decreases blood glucose levels. The study also highlights the important role of Sirtuin 3 (Sirt3) in mediating EA's anti-obesity effects.
Article
Chemistry, Physical
Dora Domnica Baciu, Ruxandra Birjega, Valentina Marascu, Rodica Zavoianu, Andreea Matei, Angela Vlad, Anca Cojocaru, Teodor Visan
Summary: The preliminary studies show that modified electrodes exhibit higher sensitivity in detecting MSG concentrations, with the graphene composite film showing the best results. However, cyclic voltammetry tests of modified electrodes prepared by laser technique with addition of radiofrequency plasma indicated a negative effect on surface electroactivity, reducing the quality of MSG cathodic voltammetric signal.
SURFACES AND INTERFACES
(2021)
Article
Biochemistry & Molecular Biology
Indrani Mukherjee, Subhrajit Biswas, Sunil Singh, Joyeeta Talukdar, Mohammed S. S. Alqahtani, Mohamed Abbas, Tapas Chandra Nag, Asit Ranjan Mridha, Surabhi Gupta, Jai Bhagwan Sharma, Supriya Kumari, Ruby Dhar, Subhradip Karmakar
Summary: The overproduction of ROS has been linked to various human diseases. Monosodium glutamate (MSG), a food additive commonly used in Asian cuisine, has been associated with ROS generation. This study found that MSG exposure influenced trophoblast invasion and differentiation, two critical functions during placenta formation, through increased ROS production. The findings suggest that long-term exposure to MSG may have adverse health effects, compromising important trophoblast functions.
Review
Multidisciplinary Sciences
Shusong Wu, Jijun Tan, Hongfu Zhang, De-Xing Hou, Jianhua He
Summary: The accumulation of ectopic fats in certain tissues is related to metabolic syndromes and insulin resistance. However, the understanding of this process is limited. This review aims to summarize the mechanisms of fat deposition in different tissues and establish a reference for understanding the involvement of insulin actions.
JOURNAL OF ADVANCED RESEARCH
(2023)
Article
Rheumatology
Wei Jiang, Jingli Shi, Hongxia Yang, Xiaolan Tian, Hanbo Yang, Qingning Chen, Lining Zhang, Qinglin Peng, Guochun Wang, Xin Lu
Summary: This study investigated the long-term survival rates and prognostic factors in patients with idiopathic inflammatory myopathies (IIMs) based on myositis-specific antibody (MSA) stratification. The study found significant differences in survival rates among different MSA subgroups. Rapidly progressive interstitial lung disease (RP-ILD) and malignancy were found to be the most common causes of death in IIM patients.
ARTHRITIS CARE & RESEARCH
(2023)
Article
Medicine, General & Internal
Qiwen Jin, Lijun Fu, Hongxia Yang, Xixia Chen, Sang Lin, Zhenguo Huang, Baoxiang Gao, Xiaolan Tian, Wei Jiang, Xiaoming Shu, Xin Lu, Guochun Wang, Qinglin Peng
Summary: This study investigates the role of peripheral lymphocyte count in phenotyping and prognosis prediction in dermatomyositis (DM) patients with anti-MDA5 antibodies. Results show that DM patients with anti-MDA5+ have significantly lower lymphocyte count compared to other types of idiopathic inflammatory myopathy (IIM). Patients with severe lymphopenia have skin ulcers and rapidly progressive interstitial lung disease (RP-ILD), while those with a normal count have a younger age of onset and more frequent arthritis. Survival analysis reveals higher mortality rates in the severe lymphopenia group. Unsupervised machine learning identifies three clusters with different lymphocyte counts and prognoses.
JOURNAL OF INTERNAL MEDICINE
(2023)
Article
Urology & Nephrology
Zhaowei Chen, Zijing Zhu, Wei Liang, Zilv Luo, Jijia Hu, Jun Feng, Zongwei Zhang, Qiang Luo, Hongxia Yang, Guohua Ding
Summary: Activation of the renin-angiotensin system is associated with podocyte injury and progression of chronic kidney disease. The impact of angiotensin II on podocyte metabolism and its role in disease progression remains unclear. This study demonstrates that angiotensin II impairs glycolysis in podocytes, leading to energy deficiency, cytoskeletal remodeling, and apoptosis.
KIDNEY INTERNATIONAL
(2023)
Article
Medicine, General & Internal
Xuan Xiao, Jingmin Yang, Ying Li, Hongxia Yang, Yijian Zhu, Lianbing Li, Qinlinglan Zhou, Daru Lu, Ting Chen, Yafei Tian
Summary: This study investigated the genetic underpinning of a Chinese family with early-onset high myopia and identified a novel frameshift mutation in the ARR3 gene. X-chromosome inactivation experiments provided explanations for the different phenotypes of the patients. This study enriches the knowledge of ARR3 variant spectrum and provides critical information for genetic testing and counseling.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Mathematics, Applied
Yi-Zheng Fan, Ya Yang, Chuan-Ming She, Jian Zheng, Yi-Min Song, Hong-Xia Yang
Summary: In this paper, we study a uniform hypergraph 7-t with cut vertices, which is formed by merging two nontrivial connected sub-hypergraphs (branches) at a certain vertex. The traces of 7-t, also known as the traces of the adjacency tensor A(7-t), play an important role in expressing the determinant and characteristic polynomial of A(H), and are closely related to the Estrada index of 7-t. We provide a formula for the traces of 7-t in terms of the traces of its branches, and obtain some perturbation results on the traces of 7-t when a branch is relocated from one vertex to another. Additionally, we prove that the hyperpath is the unique hypertree with the minimum Estrada index among all hypertrees with a fixed number of edges, while the hyperstar is the unique hypertree with the maximum Estrada index.
LINEAR ALGEBRA AND ITS APPLICATIONS
(2023)
Article
Engineering, Chemical
Mingming Ta, Tuo Wang, Juan Guo, Yong Wang, Jian Zhang, Chuanliang Zhao, Shuaishuai Liu, Gaihui Liu, Hongxia Yang
Summary: In this study, Mn/Cu co-doped activated carbon (MCAC) particle electrodes were used in the three-dimensional electrical activation of peroxymonosulfate process (E-PMS-MCAC) for the degradation of norfloxacin (NOF). The experiments showed a significant synergy between catalytic and electric activation of PMS, achieving a 90.81% removal of NOF within 60 minutes. Reactive species including SO4•-, •OH, O1(2-), and reactive Mn(III) were involved in the E-PMS-MCAC process, with •OH being the dominant species for NOF degradation. The cathodic reduction reaction facilitated electron transfer and triggered a sustainable redox cycle. Cl- enhanced the NOF removal, while HCO3-, NO3-, and H2PO4- inhibited it. The E-PMS-MCAC process also proved effective in removing other contaminants.
SEPARATION AND PURIFICATION TECHNOLOGY
(2023)
Article
Clinical Neurology
Hongxia Yang, Guoyan Qi, Huimin Dong, Ze Liu, Mei Ma, Peng Liu
Summary: This study investigated the protein expression profiles in patients with thymoma-associated myasthenia gravis (TMG) before and after docetaxel treatment. The results showed that KRAS and SELP proteins were significantly associated with the efficacy of docetaxel treatment, suggesting their potential use as biomarkers.
NEUROLOGY AND THERAPY
(2023)
Article
Computer Science, Artificial Intelligence
Zhengxiao Du, Chang Zhou, Jiangchao Yao, Teng Tu, Letian Cheng, Hongxia Yang, Jingren Zhou, Jie Tang
Summary: CogKR is a framework that conducts multi-hop reasoning by traversing the knowledge graph, and it can handle complex reasoning scenarios. Experimental results show that CogKR outperforms existing methods in terms of accuracy and scalability.
IEEE TRANSACTIONS ON KNOWLEDGE AND DATA ENGINEERING
(2023)
Article
Computer Science, Artificial Intelligence
Jiangchao Yao, Shengyu Zhang, Yang Yao, Feng Wang, Jianxin Ma, Jianwei Zhang, Yunfei Chu, Luo Ji, Kunyang Jia, Tao Shen, Anpeng Wu, Fengda Zhang, Ziqi Tan, Kun Kuang, Chao Wu, Fei Wu, Jingren Zhou, Hongxia Yang
Summary: Influenced by the success of deep learning through cloud computing and the development of edge chips, AI research has shifted towards both cloud computing and edge computing. Significant progress has been made in developing advanced AI models on cloud servers, surpassing traditional deep learning models due to innovations in models, increase in training data, and improved computing capabilities. However, edge computing, particularly edge and cloud collaborative computing, is still in its early stages due to resource limitations and a limited number of deployed algorithms. This survey provides a systematic review of both cloud and edge AI, including the establishment of collaborative learning mechanisms and a thorough evaluation of the enabling architectures. Additionally, it discusses ongoing advanced edge AI topics and potential directions and challenges in the field.
IEEE TRANSACTIONS ON KNOWLEDGE AND DATA ENGINEERING
(2023)
Article
Computer Science, Artificial Intelligence
Zhen Yang, Ming Ding, Xu Zou, Jie Tang, Bin Xu, Chang Zhou, Hongxia Yang
Summary: Graph-based recommendation systems have been gaining popularity recently, using graph neural networks (GNNs) to model user-item interactions and learn user and item embeddings. One challenge is the lack of negative user-item pairs in the user-item graph. To address this, negative sampling is crucial and commonly used, but previous works mainly focus on designing the sampling distribution, neglecting the sampled region. In this work, we propose the Three-Region Principle for guiding negative sampling, suggesting that more items should be negatively sampled from an intermediate region and fewer from adjacent and distant regions. We present the RecNS method based on this principle, which combines positive-assisted sampling and exposure-augmented sampling to generate negative item embeddings in the embedding space. Experimental results show that RecNS outperforms other negative sampling baselines significantly, improving Recall@20 by 10.47% for PinSage, 6.02% for NGCF, and 8.20% for LightGCN on the Alibaba dataset.
IEEE TRANSACTIONS ON KNOWLEDGE AND DATA ENGINEERING
(2023)
Meeting Abstract
Rheumatology
Chao Sun, Xiaolan Tian, Hongxia Yang, Hanbo Yang, Shanshan Li, Wei Jiang, Qinglin Peng, Guochun Wang, Xin Lu
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
(2023)
Meeting Abstract
Rheumatology
Yue-Tong Xu, Ya-Mei Zhang, Hong-Xia Yang, Li-Fang Ye, Fang Chen, Xin Lu, Guo-Chun Wang, Qing-Lin Peng
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
(2023)
Meeting Abstract
Rheumatology
Hongxia Yang, Xiaolan Tian, Lining Zhang, Wei Jiang, Wenli Li, Qingyan Liu, Qinglin Peng, Xiaoming Shu, Guochun Wang, Lu Xin
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
(2023)
Meeting Abstract
Rheumatology
Puli Zhang, Chao Sun, Lining Zhang, Hongxia Yang, Xiaolan Tian, Qinglin Peng, Guochun Wang, Xin Lu
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
(2023)
Meeting Abstract
Rheumatology
Qing-Lin Peng, Ya-Mei Zhang, Yan-Chun Liu, Lin Liang, Wen-Li Li, Xiao-Lan Tian, Lu Zhang, Hong-Xia Yang, Xin Lu, Guo-Chun Wang
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
(2023)
