Article
Critical Care Medicine
Ryuichi Nakayama, Naofumi Bunya, Shinshu Katayama, Yuya Goto, Yusuke Iwamoto, Kenshiro Wada, Keishi Ogura, Naoya Yama, Shintaro Takatsuka, Masumi Kishimoto, Kanako Takahashi, Ryuichiro Kakizaki, Keigo Sawamoto, Shuji Uemura, Keisuke Harada, Eichi Narimatsu
Summary: The study found that the normalized maximal distance (NMD) of the quasi-static pressure-volume curve (PV curve) and the recruitment-to-inflation ratio (R/I ratio) are highly correlated with lung recruitability assessment. Additionally, NMD and R/I ratio are moderately correlated with the ratio of respiratory system compliance (C-rs) at higher positive end-expiratory pressure (PEEP) to C-rs at lower PEEP.
ANNALS OF INTENSIVE CARE
(2022)
Review
Pediatrics
Jennifer A. Blumenthal, Melody G. Duvall
Summary: There is a lack of research on the best practices in managing pediatric severe COVID-19 with respiratory failure, highlighting the urgent need for more studies as the pandemic continues to impact children and as vaccination efforts progress. Management of acute respiratory failure in children with COVID-19 requires individualized approach based on lung conditions.
CURRENT OPINION IN PEDIATRICS
(2021)
Article
Medicine, General & Internal
Chun Pan, Cong Lu, Xiaobin She, Haibo Ren, Huazhang Wei, Liang Xu, Yingzi Huang, Jia'an Xia, Yuetian Yu, Lu Chen, Bin Du, Haibo Qiu
Summary: Different PEEP strategies for COVID-19-induced ARDS patients were compared, with the ARDSnet low PEEP/FIO2 table and the best-oxygenation strategy leading to higher PEEP levels and potentially higher risk of ventilator-induced lung injury compared to the best-compliance strategy.
FRONTIERS IN MEDICINE
(2021)
Article
Critical Care Medicine
Ivor S. Douglas, Chester A. Rosenthal, Diandra D. Swanson, Terra Hiller, Judy Oakes, Jamie Bach, Christopher Whelchel, Jennifer Pickering, Tobias George, Mark Kearns, Michael Hanley, Kara Mould, Sarah Roark, Jason Mansoori, Anuj Mehta, Eric P. Schmidt, Anna Neumeier
Summary: This study demonstrates that prolonged prone position ventilation for patients with coronavirus disease 2019 acute respiratory distress syndrome is feasible and relatively safe, with implications for wider adoption in treating critically ill coronavirus disease 2019 patients and acute respiratory distress syndrome of other etiologies.
CRITICAL CARE MEDICINE
(2021)
Article
Critical Care Medicine
Luis F. Angel, Nancy E. Amoroso, Samaan Rafeq, Brian Mitzman, Ronald Goldenberg, Saketh Palasamudram Shekar, Andrea B. Troxel, Yan Zhang, Stephanie H. Chang, Paul Kwak, Milan R. Amin, Kimberly Sureau, Heidi B. Nafday, Sarun Thomas, Zachary Kon, Philip M. Sommer, Leopoldo N. Segal, William H. Moore, Robert Cerfolio
Summary: This study found that early modified percutaneous dilational tracheostomy was safe for both patients with coronavirus disease 2019 on mechanical ventilation and healthcare providers, and it was associated with improved clinical outcomes. Specifically, patients who underwent early procedures had a higher probability of successful weaning off mechanical ventilation and lower mortality rates.
CRITICAL CARE MEDICINE
(2021)
Article
Medicine, General & Internal
Yolanda M. Lopez-Fernandez, Amelia Martinez-de-Azagra, Jose M. Gonzalez-Gomez, Cesar Perez-Caballero Macarron, Maria Garcia-Gonzalez, Julio Parrilla-Parrilla, Maria Minambres-Rodriguez, Paula Madurga-Revilla, Ana Gomez-Zamora, Patricia Rodriguez-Campoy, Juan Mayordomo-Colunga, Laura Butragueno-Laiseca, Rocio Nunez-Borrero, Jesus M. Gonzalez-Martin, Arthur S. Slutsky, Jesus Villar
Summary: This study found that children with AHRF due to SARS-CoV2 infection had fewer comorbidities and better oxygenation than patients with non-COVID-19 AHRF. Progression to severe PARDS was rarely observed in children with COVID-19 in this study.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Critical Care Medicine
Giacomo Grasselli, Emanuele Cattaneo, Vittorio Scaravilli
Summary: COVID-19 ARDS is not a unique type of ARDS, and evidence-based lung-protective ventilation strategies should be used to avoid the use of rescue therapies that lack evidence support.
CURRENT OPINION IN CRITICAL CARE
(2021)
Article
Critical Care Medicine
Michael H. Lazar, Raef Fadel, Jayna Gardner-Gray, Geneva Tatem, Martina T. Caldwell, Jennifer Swiderek, Jeffrey H. Jennings
Summary: In critically ill patients infected with coronavirus disease 2019, people of color had a lower 28-day mortality than Whites with no difference in hospital mortality, ICU length of stay, or rates of intubation.
CRITICAL CARE MEDICINE
(2021)
Article
Critical Care Medicine
Roberta De Santis Santiago, Maddalena Teggia Droghi, Jacopo Fumagalli, Francesco Marrazzo, Gaetano Florio, Luigi G. Grassi, Susimeire Gomes, Caio C. A. Morais, Ozires P. S. Ramos, Maurizio Bottiroli, Riccardo Pinciroli, David A. Imber, Aranya Bagchi, Kenneth Shelton, Abraham Sonny, Edward A. Bittner, Marcelo B. P. Amato, Robert M. Kacmarek, Lorenzo Berra
Summary: The study found that obese patients with ARDS require higher airway pressure to improve lung function during mechanical ventilation, but it does not lead to lung overdistension, and they can tolerate lung recruitment maneuvers with high airway pressure. In addition, LRM and PEEP can reduce pulmonary vascular resistance and normalize ventilation-perfusion ratio.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2021)
Article
Critical Care Medicine
Saeed Mirsadraee, Diana A. Gorog, Ciara F. Mahon, Bhavin Rawal, Thomas R. Semple, Edward D. Nicol, Deepa R. J. Arachchillage, Anand Devaraj, Susanna Price, Sujal R. Desai, Carole A. Ridge, Suveer Singh, Simon P. G. Padley
Summary: This study analyzed 72 critically ill patients with severe coronavirus disease 2019 and found a high prevalence of thrombotic complications, especially pulmonary thromboses, in 58% of the patients. The detection of thrombus was usually incidental, not predicted by coagulation or inflammatory biomarkers, and associated with increased risk of death.
CRITICAL CARE MEDICINE
(2021)
Article
Critical Care Medicine
Steven L. Shein, Aline B. Maddux, Margaret J. Klein, Anoopindar Bhalla, George Briassoulis, Mary K. Dahmer, Guillaume Emeriaud, Heidi R. Flori, Rainer Gedeit, Stavroula Ilia, Martin C. J. Kneyber, Natalie Napolitano, Shinichiro Ohshimo, Marti Pons-Odena, Sarah Rubin, Benjamin R. White, Nadir Yehya, Robinder Khemani, Lincoln Smith
Summary: This study aimed to characterize the frequency and outcomes of children meeting at risk for pediatric acute respiratory distress syndrome criteria. The results showed that the criteria identified high-risk critically ill children and were associated with increased mortality and longer treatment durations.
CRITICAL CARE MEDICINE
(2022)
Review
Critical Care Medicine
Giacomo Grasselli, Emanuele Cattaneo, Gaetano Florio, Mariachiara Ippolito, Alberto Zanella, Andrea Cortegiani, Jianbo Huang, Antonio Pesenti, Sharon Einav
Summary: Available data on respiratory mechanics and MV settings in mechanically ventilated patients with COVID-19 are heterogeneous but similar to classical ARDS. However, complete data regarding mechanical properties of the respiratory system, optimal MV settings, and rescue treatments for refractory hypoxemia are still lacking in the medical literature.
Article
Critical Care Medicine
Karuna Wongtangman, Peter Santer, Luca J. Wachtendorf, Omid Azimaraghi, Elias Baedorf Kassis, Bijan Teja, Kadhiresan R. Murugappan, Shahla Siddiqui, Matthias Eikermann
Summary: Compared to patients with acute respiratory distress syndrome of other causes, patients with COVID-19 received higher doses of hypnotics, leading to prolonged coma and higher mortality.
CRITICAL CARE MEDICINE
(2021)
Review
Critical Care Medicine
Chiara Mega, Irene Cavalli, Vito Marco Ranieri, Tommaso Tonetti
Summary: Though there are some studies suggesting distinct pathophysiological behavior in COVID-19-ARDS compared to classical ARDS, most research indicates similar characteristics between the two. Lung protective ventilation is beneficial for COVID-19-ARDS patients, potentially leading to improved survival, but careful evaluation and consideration of individualized treatment are still necessary.
CURRENT OPINION IN CRITICAL CARE
(2022)
Article
Critical Care Medicine
Alessandro Protti, Alessandro Santini, Francesca Pennati, Chiara Chiurazzi, Michele Ferrari, Giacomo E. Iapichino, Luca Carenzo, Francesca Dalla Corte, Ezio Lanza, Nicolo Martinetti, Andrea Aliverti, Maurizio Cecconi
Summary: Prone positioning in COVID-19 patients decreases alveolar collapse, hyperinflation, and improves lung aeration. This supports the use of prone positioning in COVID-19, similar to its benefits in other cases of ARDS.
Letter
Critical Care Medicine
Malcolm Lemyze, Matthieu Komorowski
CRITICAL CARE MEDICINE
(2020)
Review
Public, Environmental & Occupational Health
Michel Bielecki, Dipti Patel, Jochen Hinkelbein, Matthieu Komorowski, John Kester, Shahul Ebrahim, Alfonso J. Rodriguez-Morales, Ziad A. Memish, Patricia Schlagenhauf
Summary: Air travel during the COVID-19 pandemic faces challenges for travellers, airlines, and authorities, with reduced flights, effective preventive measures like hygiene, mask use, and social distancing, but unreliable temperature screening. The risk of in-flight transmission is low but caution is necessary, with ongoing research needed for evidence-based preventive measures and safety assessments.
TRAVEL MEDICINE AND INFECTIOUS DISEASE
(2021)
Review
Anesthesiology
Matthieu Komorowski, Seamus Thierry, Clement Stark, Mark Sykes, Jochen Hinkelbein
Summary: The focused review in this article summarizes the medical, logistical, and environmental challenges that would be associated with dealing with a traumatic surgical case during an interplanetary space mission in the near future.
Article
Critical Care Medicine
Brijesh Patel, Shlomi Haar, Rhodri Handslip, Chaiyawan Auepanwiriyakul, Teresa Mei-Ling Lee, Sunil Patel, J. Alex Harston, Feargus Hosking-Jervis, Donna Kelly, Barnaby Sanderson, Barbara Borgatta, Kate Tatham, Ingeborg Welters, Luigi Camporota, Anthony C. Gordon, Matthieu Komorowski, David Antcliffe, John R. Prowle, Zudin Puthucheary, Aldo A. Faisal
Summary: The study included mechanically ventilated COVID-19 patients and found that refractory hypoxemia was associated with high mortality, yet evidence-based ARDS interventions, especially prone positioning, were not implemented, were applied with delay, and had reduced responsiveness.
INTENSIVE CARE MEDICINE
(2021)
Letter
Anesthesiology
Matthieu Komorowski
Editorial Material
Anesthesiology
Dominic C. Marshall, Matthieu Komorowski
Summary: Artificial intelligence has the potential to improve clinical decision-making for ventilated patients, but the majority of current studies suffer from methodological bias and are not ready for deployment.
BRITISH JOURNAL OF ANAESTHESIA
(2022)
Article
Medicine, General & Internal
Jan Schmitz, Anton Ahlback, James DuCanto, Steffen Kerkhoff, Matthieu Komorowski, Vanessa Loew, Thais Russomano, Clement Starck, Seamus Thierry, Tobias Warnecke, Jochen Hinkelbein
Summary: This study describes two new methods for CPR in microgravity and compares their effectiveness. The results show that the Schmitz-Hinkelbein method is superior in compression rates, correct compression depth, and rates of correct thoracic release after compression.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Medicine, General & Internal
Matthieu Komorowski, Ashleigh Green, Kate C. Tatham, Christopher Seymour, David Antcliffe
Summary: In recent years, data-driven techniques have made advances in the diagnosis, treatment, and individualization of sepsis, particularly through the discovery and evaluation of biomarkers and digital signatures. These advancements have improved diagnostic accuracy, treatment outcomes, and provided important guidance for clinical trials and management.
Editorial Material
Critical Care Medicine
Matthieu Komorowski, Maria del Pilar Arias Lopez, Anthony C. Chang
INTENSIVE CARE MEDICINE
(2023)
Article
Multidisciplinary Sciences
Seamus Thierry, Francois Jaulin, Clement Starck, Philippe Aries, Jan Schmitz, Steffen Kerkhoff, Cecile Isabelle Bernard, Matthieu Komorowski, Tobias Warnecke, Jochen Hinkelbein
Summary: Long duration spaceflights to the Moon or Mars may face emergency medical events, making emergency medical procedures more challenging under weightlessness. Free-floating intubation is not recommended due to high failure rates, but using a video-laryngoscope may improve the success rate compared to a conventional direct laryngoscope.
Proceedings Paper
Computer Science, Information Systems
Paul Festor, Ibrahim Habli, Yan Jia, Anthony Gordon, A. Aldo Faisal, Matthieu Komorowski
Summary: Levels of autonomy are crucial in guiding our understanding of capability, expectation, and safety in autonomous systems, particularly in the context of digital healthcare. The focus is on mapping autonomy levels to clinical decision support systems and discussing the differences in safety evidence generation between supervised and reinforcement learning approaches in medical applications. The latter, being capable of intervening on patients, should be considered autonomous systems.
COMPUTER SAFETY, RELIABILITY, AND SECURITY (SAFECOMP 2021)
(2021)
Letter
Health Care Sciences & Services
Ahmed Ezzat, Harpreet Sood, Josephine Holt, Hashim Ahmed, Matthieu Komorowski
BMJ HEALTH & CARE INFORMATICS
(2021)
Review
Public, Environmental & Occupational Health
Michel Bielecki, Dipti Patel, Jochen Hinkelbein, Matthieu Komorowski, John Kester, Shahul Ebrahim, Alfonso J. Rodriguez-Morales, Ziad A. Memish, Patricia Schlagenhauf
TRAVEL MEDICINE AND INFECTIOUS DISEASE
(2020)
Article
Computer Science, Information Systems
Remy Kusters, Dusan Misevic, Hugues Berry, Antoine Cully, Yann Le Cunff, Loic Dandoy, Natalia Diaz-Rodriguez, Marion Ficher, Jonathan Grizou, Alice Othmani, Themis Palpanas, Matthieu Komorowski, Patrick Loiseau, Clement Moulin Frier, Santino Nanini, Daniele Quercia, Michele Sebag, Francoise Soulie Fogelman, Sofiane Taleb, Liubov Tupikina, Vaibhav Sahu, Jill-Jenn Vie, Fatima Wehbi
FRONTIERS IN BIG DATA
(2020)
Article
Emergency Medicine
Jochen Hinkelbein, Steffen Kerkhoff, Christoph Adler, Anton Ahlbaeck, Stefan Braunecker, Daniel Burgard, Fabrizio Cirillo, Edoardo De Robertis, Eckard Glaser, Theresa K. Haidl, Pete Hodkinson, Ivan Zefiro Iovino, Stefanie Jansen, Kolaparambil Varghese Lydia Johnson, Saskia Juenger, Matthieu Komorowski, Marion Leary, Christina Mackaill, Alexander Nagrebetsky, Christopher Neuhaus, Lucas Rehnberg, Giovanni Marco Romano, Thais Russomano, Jan Schmitz, Oliver Spelten, Clement Starck, Seamus Thierry, Rochelle Velho, Tobias Warnecke
SCANDINAVIAN JOURNAL OF TRAUMA RESUSCITATION & EMERGENCY MEDICINE
(2020)