Article
Genetics & Heredity
Odelia Chorin, Yoel Hirsch, Rachel Rock, Liat Salzer Sheelo, Yael Goldberg, Hanna Mandel, Tova Hershkovitz, Nicole Fleischer, Lior Greenbaum, Uriel Katz, Ortal Barel, Nasrin Hamed, Bruria Ben-Zeev, Shoshana Greenberger, Nadra Nasser Samra, Michal Stern Zimmer, Annick Raas-Rothschild, Ben Pode-Shakked
Summary: Vici Syndrome is a rare and severe neurodevelopmental/neurodegenerative disorder that mainly affects infants. The disorder is characterized by global developmental delay, seizures, agenesis of the corpus callosum, hair and skin hypopigmentation, bilateral cataract, and immunodeficiency. This study aims to characterize the clinical and molecular findings of individuals with biallelic EPG5 variants in Israel, and to utilize machine learning-based tool to assess facial features of Vici syndrome.
FRONTIERS IN GENETICS
(2022)
Review
Cell Biology
Shan Liang, Yun-Shan Wu, Dong-Yi Li, Ji-Xin Tang, Hua-Feng Liu
Summary: Autophagy, as a crucial cellular process, plays a vital role in cellular metabolism and viral infections, but viruses can also manipulate autophagy for their own benefit. Understanding the function of host autophagy in viral infections and pathogenesis helps in developing more specific therapeutic strategies.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Immunology
Wenxin Wu, Wei Zhang, Jeremy S. S. Alexandar, J. Leland Booth, Craig A. A. Miller, Chao Xu, Jordan P. P. Metcalf
Summary: A family of short synthetic RNAs has been designed to activate the RIG-I pathway and induce a potent interferon response. In this study, SLR10 administration protected mice from influenza virus infection, both in non-smoking and cigarette smoke-exposed mice. SLR10 treatment promoted M1 macrophage polarization in the lung, suggesting its potential as a therapy for viral infections.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Virology
Huasong Chang, Hao Wu, Peili Hou, Muhammad Aizaz, Rukun Yang, Aibiao Xiang, Wenjing Qi, Hongbin He, Hongmei Wang
Summary: This study reveals the important role of DLG1 in antiviral innate immunity by promoting the IFN-I response and inhibiting viral replication. DLG1 inhibits the autophagic degradation of IKK epsilon, a crucial adaptor in the innate immune signaling pathway, leading to the attenuation of virus propagation. Mechanistically, DLG1 competitively binds to March2 to prevent the ubiquitination and subsequent degradation of IKK epsilon. Additionally, negative-stranded RNA virus infection decreases DLG1 expression.
JOURNAL OF VIROLOGY
(2023)
Article
Cell Biology
Jing Zeng, Zhenzhen Zhang, Qing Liao, Qijin Lu, Jiemei Liu, Lixia Yuan, Gang Liu
Summary: This study demonstrates that circPan3 promotes ghrelin synthesis and chondrocyte autophagy by targeting miR-667-5p, protecting against OA injury. The circPan3/miR-667-5p/ghrelin axis could be potential targets for drug development for OA treatment.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Samanthi Narayanan, Srikanth Elesela, Andrew J. Rasky, Susan H. Morris, Surinder Kumar, David Lombard, Nicholas W. Lukacs
Summary: The upregulation of ER stress in RSV-infected DC was closely associated with the PERK pathway, leading to altered innate cytokine profiles. Blocking PERK activity resulted in decreased inflammation and respiratory dysfunction in infected DC, suggesting a potential target for modifying immune responses to RSV infection.
JOURNAL OF LEUKOCYTE BIOLOGY
(2022)
Article
Cell Biology
Huijun Zhang, Xiangwei Wang, Min Qu, Zhiyong Li, Xiangping Yin, Lijie Tang, Xiangtao Liu, Yuefeng Sun
Summary: This study reveals that histone deacetylase 8 (HDAC8) inhibits the replication of foot-and-mouth disease virus (FMDV) by regulating innate immune signal transduction and antiviral response. In response, FMDV utilizes autophagy to promote the degradation of HDAC8. Further investigations demonstrate that FMDV structural protein VP3 promotes autophagy during virus infection, interacting with and degrading HDAC8 through an AKT-MTOR-ATG5-dependent autophagy pathway. These findings highlight a strategy employed by FMDV to counteract host antiviral activity through autophagic degradation of a protein involved in innate immune response.
Article
Cardiac & Cardiovascular Systems
Yue Zheng, Wenqing Gao, Qiang Zhang, Xian Cheng, Yanwu Liu, Zhenchang Qi, Tong Li
Summary: This study investigates the relationship between ferroptosis, autophagy, and myocardial infarction (MI) progression. By analyzing differentially expressed genes (DEGs) and performing pathway enrichment analysis and protein-protein interaction network analysis, 10 hub genes were identified as potential therapeutic targets for MI. Validations using qPCR analysis and single-cell sequencing were conducted. The findings suggest that targeting these hub genes may prevent adverse cardiovascular events in patients with MI.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cell Biology
Zhen-Zhen Liu, Wei Chen, Cheng-Kai Zhou, Ke Ma, Yu Gao, Yong-Jun Yang
Summary: This study revealed the importance of STING in promoting extracellular traps (ETs) formation through the ROS-ERK signaling pathway during Staphylococcus aureus infection. STING deficiency led to decreased cell-free DNA (cfDNA) level, reduced expression of citrullinated histone H3 (CitH3), and diminished DNA colocalization with CitH3 and myeloperoxidase (MPO). Additionally, STING(-/-) BMDMs exhibited increased levels of extracellular bacteria compared to WT BMDMs.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Immunology
Srabasti Sengupta, Barsa Nayak, Michael Meuli, Peter Sander, Snehasish Mishra, Avinash Sonawane
Summary: This study reveals a previously unknown mechanism in which Mycobacterium tuberculosis inhibits autophagy by inducing histone hypermethylation in autophagy-related genes, promoting intracellular bacterial survival.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Review
Neurosciences
Jiao Ding, Yijie Dai, Jiahui Zhu, Xuemei Fan, Hao Zhang, Bo Tang
Summary: The cGAS-STING pathway is a crucial immune signaling pathway involved in the regulation of various diseases, particularly playing a key role in central nervous system diseases.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2022)
Article
Immunology
Wei Sun, Xin Hua, Yanli Gu, Qiuli Xu, Suhua Zhu, Tangfeng Lv, Yong Song
Summary: This study identifies RNF6 as an interferon-inducible ubiquitin ligase that plays a positive role in interferon-dependent antiviral responses. Knockdown of RNF6 reduces the expression of immune-related genes and transcriptional activity of interferon response elements. Additionally, high expression of RNF6 in myeloid cells of SLE patients is correlated with increased expression of immune-related genes.
CLINICAL IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Baihong Zhang, Shuqin Huang, Zetian Guo, Yixuan Meng, Xue Li, Yuzhen Tian, Wenli Chen
Summary: This study reveals that salicylic acid promotes carbon starvation-induced leaf senescence by inhibiting autophagy via NPR1.
Article
Immunology
Albert Perlas, Jordi Argilaguet, Kateri Bertran, Raul Sanchez-Gonzalez, Miquel Nofrarias, Rosa Valle, Antonio Ramis, Marti Cortey, Natalia Majo
Summary: The study aimed to evaluate the mechanisms of disease resistance to HPAIV in chickens of different breeds. RNA-Seq results showed minor transcriptomic changes in resistant chickens and significant alterations in susceptible chickens, with some genes related to NF-κB and mitogen-activated protein kinase signaling pathways. The early inactivation of important host genes could prevent an exaggerated immune response and/or viral replication, conferring resistance to HPAIV in chickens.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Microbiology
Bradley E. Hiller, Yongjun Yin, Yi-Chieh Perng, Italo de Araujo Castro, Lindsey E. Fox, Marissa C. Locke, Kristen J. Monte, Carolina B. Lopez, David M. Ornitz, Deborah J. Lenschow
Summary: This study identifies a novel antiviral and inflammatory role for FGFs in the lung airway epithelium and confirms that early and robust IAV infection of alveolar cells results in more severe disease.
Article
Cardiac & Cardiovascular Systems
Asvin M. Ganapathi, Bryan A. Whitson, Victor Heh, Brian C. Keller, Sakima A. Smith, Nahush A. Mokadam, Matthew C. Henn
Summary: This study examines the incidence of rejection after heart and lung transplantation in recipients of HCV-positive donors and HCV-positive recipients. The results show that HCV-positive donors are associated with older age, blood group O, and shorter waitlist time. However, HCV status and treatment for rejection are not significantly associated, but center variability plays a role.
ANNALS OF THORACIC SURGERY
(2023)
Editorial Material
Cell Biology
Mingming Ji, Meng Li, Long Sun, Hongyu Deng, Yan G. Zhao
Summary: In this study, the roles of VMP1 and TMEM41B in the generation of double-membrane vesicles (DMVs) during beta-coronavirus infection were investigated. It was found that TMEM41B facilitates nsp3-nsp4 interaction and ER zippering, while VMP1 is required for the subsequent closing of ER into DMVs. Additionally, appropriate phosphatidylserine (PS) levels were found to contribute to DMV formation.
Article
Critical Care Medicine
Marta Celorrio, Kirill Shumilov, Rachel Rodgers, Lawrence Schriefer, Yuhao Li, Megan T. Baldridge, Stuart H. Friess
Summary: Traumatic brain injury (TBI) patients are susceptible to disruption of the gut microbiome. Antibiotics after TBI can alter the gut microbiota and affect neuroinflammation, neurogenesis, and long-term fear memory. The impact of antibiotics on the brain's response to injury was studied through fecal microbiota transplantation (FMT) and antibiotic exposure in mice. Both approaches showed alterations in gut bacteria and neuroinflammation, supporting the role of the gut microbiota in TBI-related processes.
JOURNAL OF NEUROTRAUMA
(2023)
Article
Cell Biology
Anastasiia Gainullina, Denis A. Mogilenko, Li-Hao Huang, Helena Todorov, Vipin Narang, Ki-Wook Kim, Lim Sheau Yng, Andrew Kent, Baosen Jia, Kumba Seddu, Karen Krchma, Jun Wu, Karine Crozat, Elena Tomasello, Regine Dress, Peter See, Charlotte Scott, Sophie Gibbings, Geetika Bajpai, Jigar V. Desai, Barbara Maier, Sebastien This, Peter Wang, Stephanie Vargas Aguilar, Lucie Poupel, Sebastien Dussaud, Tyng-An Zhou, Veronique Angeli, J. Magarian Blander, Kyunghee Choi, Marc Dalod, Ivan Dzhagalov, Emmanuel L. Gautier, Claudia Jakubzick, Kory Lavine, Michail S. Lionakis, Helena Paidassi, Michael H. Sieweke, Florent Ginhoux, Martin Guilliams, Christophe Benoist, Miriam Merad, Gwendalyn J. Randolph, Alexey Sergushichev, Maxim N. Artyomov
Summary: This study focuses on the diversity and metabolic variability of mononuclear phagocyte (MNP) subpopulations. Through metabolic network analysis of large-scale transcriptional datasets, it was found that cholesterol synthesis is particularly active in migratory dendritic cells, while glutathione synthesis is essential for cysteinyl leukotriene production by peritoneal and lung macrophages.
Article
Genetics & Heredity
Daria Pinakhina, Danat Yermakovich, Ekaterina Vergasova, Evgeny Kasyanov, Grigory Rukavishnikov, Valeriia Rezapova, Nikita Kolosov, Alexey Sergushichev, Iaroslav Popov, Elena Kovalenko, Anna Ilinskaya, Anna Kim, Nikolay Plotnikov, Valery Ilinsky, Nikholay Neznanov, Galina Mazo, Alexander Kibitov, Alexander Rakitko, Mykyta Artomov
Summary: We conducted a genome-wide association study on individuals of Russian descent and identified a novel association at the chromosome 7q21 locus in depression. Gene prioritization analysis suggested that MAGI2 (S-SCAM) is the most likely gene and a potential susceptibility gene for depression based on existing knowledge of depression risk genes. The expression patterns in the brain and gut highlighted the functional relationship between MAGI2 and previously known depression risk genes. Local genetic covariance analysis provided initial evidence of a different relationship between the scales of hospital anxiety and depression and the disturbance in the gut-brain axis.
FRONTIERS IN GENETICS
(2023)
Article
Microbiology
Christina M. Kackos, Sherri L. Surman, Bart G. Jones, Robert E. Sealy, Trushar Jeevan, Christopher J. H. Davitt, Sergei Pustylnikov, Tamarand L. Darling, Adrianus C. M. Boon, Julia L. Hurwitz, Marcelo M. Samsa, Richard J. Webby
Summary: SARS-CoV-2 continues to disrupt everyday life and cause excess morbidity and mortality worldwide. Vaccination has been key to quelling the impact of this respiratory pathogen, and mRNA vaccines have led the charge on this front. The emergence of SARS-CoV-2 variants has threatened vaccine efficacy, but the mRNA vaccines developed by GreenLight Biosciences have shown robust protective efficacy against the wild-type virus and its variants.
MICROBIOLOGY SPECTRUM
(2023)
Review
Immunology
Denis A. Mogilenko, Alexey Sergushichev, Maxim N. Artyomov
Summary: Immunometabolism has become a new interdisciplinary field of research in recent years, providing important insights into the regulation of immune responses. Traditional approaches and new technologies, such as spatially resolved metabolic imaging and computational algorithms, have helped us understand the complexity of immunometabolic regulation. This review discusses recent studies and technological developments that aim to capture the interplay between immune responses and metabolism.
ANNUAL REVIEW OF IMMUNOLOGY
(2023)
Article
Veterinary Sciences
Amy M. Peiper, Emily W. Helm, Quyen Nguyen, Matthew Phillips, Caroline G. Williams, Dhairya Shah, Sarah Tatum, Neha Iyer, Marco Grodzki, Laura B. Eurell, Aqsa Nasir, Megan T. Baldridge, Stephanie M. Karst
Summary: Noroviruses are the leading cause of severe childhood diarrhea and foodborne disease worldwide. The lack of tractable small animal models has hindered the understanding of norovirus diarrhea's pathogenic mechanisms. A new small animal model system using the WU23 MNV strain has been developed, which reflects the pathology observed during human norovirus infection.
Editorial Material
Cell Biology
Rajesh Gupta, Lisa A. Purcell, Davide Corti, Herbert W. Virgin
SCIENCE TRANSLATIONAL MEDICINE
(2023)
Article
Multidisciplinary Sciences
Shivali Patel, Alec N. Sexton, Madison S. Strine, Craig B. Wilen, Matthew D. Simon, Anna Marie Pyle
Summary: Compact RNA structural motifs play a crucial role in gene expression, but identifying these structures in long RNAs has been challenging. This study introduces Tb-seq, a high-throughput sequencing method that detects sharp backbone turns indicative of compact tertiary structures in large RNAs. By detecting these structures, Tb-seq enables the search for stable structural modules and potential riboregulatory motifs in transcriptomes.
NATURE COMMUNICATIONS
(2023)
Article
Microbiology
Elizabeth A. Kennedy, Somya Aggarwal, Arko Dhar, Stephanie M. Karst, Craig B. Wilen, Megan T. Baldridge
Summary: Comparing norovirus infection in neonate and adult mice suggests age-dependent differences in passive viral uptake, cellular tropism, interferon regulation, and viral dissemination. Norovirus is the leading cause of viral gastroenteritis worldwide, with young children being the most affected. However, the factors contributing to age-associated differences in disease severity and shedding are not well understood.
NATURE MICROBIOLOGY
(2023)
Editorial Material
Microbiology
Yuhao Li, Megan T. Baldridge
Summary: The range and diversity of microbial stimuli play a crucial role in regulating the host's ability to mount an immune response to challenges like vaccination. Therefore, optimizing exposure history is essential in rodent models.
NATURE MICROBIOLOGY
(2023)
Article
Immunology
Marija S. Nadjsombati, Natalie Niepoth, Lily M. Webeck, Elizabeth A. Kennedy, Danielle L. Jones, Tyler E. Billipp, Megan T. Baldridge, Andres Bendesky, Jakob von Moltke
Summary: Chemosensory epithelial tuft cells play a role in innate immunity at barrier surfaces, but the mechanism of their differentiation is unclear. Differences in mouse strains revealed that the chromosome 9 locus, including the gene Pou2af2, regulates tuft cell differentiation and innate type 2 immunity in the small intestine. Balb/cJ mice had fewer tuft cells and failed to respond to the tuft cell ligand succinate due to a preferential expression of a nonfunctional short isoform of Pou2af2. Expression of the full-length Pou2af2 rescued the tuft cell numbers and succinate response in Balb mice. This regulation of tuft cells by Pou2af2 isoform usage impacted the immune response to helminth pathogens and commensal protozoa in the small intestine.
SCIENCE IMMUNOLOGY
(2023)
Article
Transplantation
Brian C. Keller, Jianing Ma, Jing Peng, Verai Ramsammy
Summary: NPI measures can effectively reduce the transmission of respiratory viruses in lung transplant recipients, but may increase the risk of other viral infections.
TRANSPLANTATION DIRECT
(2023)