Review
Microbiology
Aranzazu Portillo, Ana M. Palomar, Paula Santibanez, Jose A. Oteo
Summary: Crimean-Congo hemorrhagic fever virus (CCHFV) is a potentially fatal virus transmitted by ticks, widely distributed in Africa, Asia, and Europe. Recent cases in Western Europe and Spain suggest the possibility of virus transmission through ticks and migratory birds.
Article
Virology
Na Li, Guibo Rao, Zhiqiang Li, Jiayi Yin, Tingting Chong, Kexing Tian, Yan Fu, Sheng Cao
Summary: In this study, the structure of the Crimean-Congo hemorrhagic fever virus Gc protein was solved, revealing its critical role in virus-host membrane fusion and providing valuable insights into neutralization mechanisms.
Article
Infectious Diseases
Shohra Qaderi, Masoud Mardani, Asghar Shah, Jaffer Shah, Narges Bazgir, Jalal Sayad, Ehsan Ghandchi, Majid Samsami, Javad Zebarjadi Bagherpour
Summary: The prevalence of CCHF is increasing in Afghanistan, with a majority of cases seeking medical care during the late phase of infection, which could negatively impact treatment efficacy. Impaired Alanine aminotransferase (ALT), hemorrhagic manifestations (including epistaxis), and impaired consciousness were factors associated with a higher mortality rate, potentially providing clues for early effective interventions.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Review
Veterinary Sciences
Nighat Perveen, Gulfaraz Khan
Summary: Crimean-Congo hemorrhagic fever (CCHF) is an important tick-borne viral infection with a high fatality rate. This study reviewed 57 publications from 22 Arab countries and found that CCHF is prevalent in the region. Ticks are the main vectors and butchers, slaughterhouse workers, farmworkers, and healthcare personnel are at higher risk. The study reported 321 cases of CCHF with a case fatality rate of 29% in the Arab countries. Livestock, including cattle, goats, sheep, and camels, may also contribute to the transmission of CCHF. Preventative measures are recommended to reduce the burden of CCHF in the Arab world.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Pharmacology & Pharmacy
Sergio E. Rodriguez, David W. Hawman, Teresa E. Sorvillo, T. Justin O'Neal, Brian H. Bird, Luis L. Rodriguez, Eric Bergeron, Stuart T. Nichol, Joel M. Montgomery, Christina F. Spiropoulou, Jessica R. Spengler
Summary: This article reviews the progress in immunobiology research of Crimean-Congo hemorrhagic fever virus (CCHFV), including the relationship between different outcomes and disease severity, and provides recommendations for future research.
ANTIVIRAL RESEARCH
(2022)
Article
Virology
Boniface Pongombo Lombe, Takeshi Saito, Hiroko Miyamoto, Akina Mori-Kajihara, Masahiro Kajihara, Masayuki Saijo, Justin Masumu, Takanari Hattori, Manabu Igarashi, Ayato Takada
Summary: Studying the antibody epitopes on the nucleoprotein (NP) of Crimean-Congo hemorrhagic fever virus (CCHFV) can improve the accuracy of antibody detection assays and antigen detection tests related to this virus.
Article
Infectious Diseases
Stella A. Atim, Shirin Ashraf, Sandra Belij-Rammerstorfer, Anna R. Ademun, Patrick Vudriko, Teddy Nakayiki, Marc Niebel, James Shepherd, Stephen Balinandi, Gladys Nakanjako, Andrew Abaasa, Paul C. D. Johnson, Steven Odongo, Martin Esau, Milton Bahati, Pontiano Kaleebu, Julius J. Lutwama, Charles Masembe, Teresa Lambe, Emma C. Thomson, Robert Tweyongyere
Summary: The study reveals a high prevalence of Crimean-Congo Haemorrhagic Fever (CCHF) in livestock farming communities in Uganda, with factors such as livestock farming, age, and collecting/eating engorged ticks associated with human seropositivity. This emphasizes the importance of further surveillance and control measures against the disease.
JOURNAL OF INFECTION
(2022)
Article
Medicine, General & Internal
Shanna S. Leventhal, Kimberly Meade-White, Deepashri Rao, Elaine Haddock, Jacqueline Leung, Dana Scott, Jacob Archer, Samantha Randall, Jesse H. Erasmus, Heinz Feldmann, David W. Hawman
Summary: This study evaluated an alphavirus-based replicon RNA vaccine expressing either the CCHFV nucleoprotein or glycoprotein precursor in a stringent, heterologous lethal challenge mouse model. It was found that vaccination with the RNA expressing the nucleoprotein alone provided complete protection against clinical disease, while vaccination with a combination of both the nucleoprotein and glycoprotein precursor offered robust protection against disease and viral replication. Unexpectedly, analysis of the immune responses elicited by the vaccine components showed that vaccination resulted in antibodies against the internal viral nucleoprotein and cellular immunity against the virion-exposed glycoproteins.
Article
Microbiology
Alexis C. R. Hoste, Igor Djadjovski, Miguel Angel Jimenez-Clavero, Paloma Rueda, John N. Barr, Patricia Sastre
Summary: Crimean-Congo hemorrhagic fever virus (CCHFV) is a significant tick-borne viral disease that has recently been found in previously unaffected countries like Spain. The disease is asymptomatic in infected animals but can develop into severe illness in humans. The lack of effective treatment or vaccine calls for surveillance programs to control the spread of the virus.
MICROBIOLOGY SPECTRUM
(2023)
Article
Virology
Kubra Dogan, Serkan Bolat, Caner Oksuz, Seyit Ali Buyuktuna
Summary: Crimean-Congo hemorrhagic fever (CCHF) is a viral infection disease with unknown pathophysiology. This study investigated the levels of lipid mediators and cytokines in CCHF patients. The results showed lower 5-LO levels and higher ferritin and IL-6 levels in patients compared to healthy controls. No significant differences were found in CYSLT levels between patients and controls. The study suggests that changes in 5-LO enzyme and increased inflammation play a role in CCHF.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Veterinary Sciences
Sandra Belij-Rammerstorfer, Georgina Limon, Emmanuel A. A. Maze, Kayleigh Hannant, Ellen Hughes, Simona R. R. Tchakarova, Tsviatko Alexandrov, Blandina T. T. Mmbaga, Brian Willett, George Booth, Nicholas A. A. Lyons, Natalie Baker, Kelly M. M. Thomas, Daniel Wright, Jack Saunders, Clare Browning, Ginette Wilsden, Miles Carroll, Roger Hewson, Bryan Charleston, Teresa Lambe, Anna B. B. Ludi
Summary: Crimean-Congo hemorrhagic fever (CCHF) is an emerging disease with high fatality caused by the CCHF virus (CCHFV). We developed two in-house ELISAs for specific detection of IgG antibodies against two different CCHFV antigens, providing new insights into the immune response in domestic animals.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Pharmacology & Pharmacy
Megan C. Mears, Sergio E. Rodriguez, Katharina S. Schmitz, Angel Padilla, Sudipta Biswas, Maria N. B. Cajimat, Chad E. Mire, Stephen R. Welch, Eric Bergeron, Christopher A. Alabi, Matteo Porotto, Dennis A. Bente
Summary: Crimean-Congo hemorrhagic fever is a tick-borne viral disease that currently has no approved treatments. This study designed inhibitory peptides against the virus and demonstrated their neutralizing and fusion inhibitory effects. The research provides a basis for the development of experimental countermeasures for Crimean-Congo hemorrhagic fever.
ANTIVIRAL RESEARCH
(2022)
Article
Microbiology
David W. Hawman, Kimberly Meade-White, Shanna Leventhal, Aaron Carmody, Elaine Haddock, Kim Hasenkrug, Heinz Feldmann
Summary: Crimean-Congo hemorrhagic fever (CCHF) is a severe tick-borne febrile illness caused by the CCHFV, with host immune responses playing a crucial role in controlling the infection. Using a mouse model, it was found that T cells and interferon gamma are critical for survival following CCHFV infection.
Review
Medicine, General & Internal
Aykut Ozdarendeli
Summary: Crimean-Congo hemorrhagic fever virus (CCHFV) is a highly infectious virus transmitted to humans through tick bites or contact with infected animal blood, causing severe symptoms and a high mortality rate. The lack of effective medical countermeasures and its potential for global spread have made CCHFV a high-priority pathogen. Recent advances in biotechnology and suitable animal models have accelerated the development of CCHFV vaccines.
Article
Immunology
Johan Espunyes, Oscar Cabezon, Lola Pailler-Garcia, Andrea Dias-Alves, Lourdes Lobato-Bailon, Ignasi Marco, Maria P. Ribas, Pedro E. Encinosa-Guzman, Marta Valldeperes, Sebastian Napp
Summary: A serosurvey in Catalonia, northeastern Spain, found high seroprevalence of Crimean-Congo hemorrhagic fever virus antibodies in southern Catalonia, indicating potential presence of competent virus vectors in the region.
EMERGING INFECTIOUS DISEASES
(2021)
Article
Environmental Sciences
Hassan Nasirian, K. N. Irvine
ENVIRONMENTAL MONITORING AND ASSESSMENT
(2017)
Article
Entomology
Behroz Davari, Susan Kashani, Hassan Nasirian, Mansour Nazari, Aref Salehzadeh
ENTOMOLOGICAL RESEARCH
(2018)
Review
Entomology
Hassan Nasirian
JOURNAL OF MEDICAL ENTOMOLOGY
(2019)
Review
Parasitology
Hassan Nasirian
Review
Environmental Sciences
Hamid Kassiri, Hassan Nasirian
Summary: The study conducted a comprehensive analysis of the global tick infestation rates in humans, revealing that certain tick species pose higher risks to humans. The highest monthly average tick bites in humans were observed in June. Over the past decades, there has been a decreasing trend in tick infestation rates in humans, indicating the success of preventive measures.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Review
Parasitology
Hassan Nasirian, Amirhossein Zahirnia
Summary: The study found that adult ticks, especially females, attack humans more than larvae and nymphal ones, and adult males attack the least. The global trend of human infestation by hard ticks is sharply increasing. Ticks attack humans more in rural areas than urban areas, and the trends of tick infestation in rural and urban areas show a sharp increase and decrease, respectively.
ACTA PARASITOLOGICA
(2021)
Article
Public, Environmental & Occupational Health
Hassan Nasirian
Summary: This study conducted a review on the global annual CCHFV infection rates, CCHFV infection trend in ticks and ticks infested animals, and the role of ticks as CCHFV vectors. The results showed no significant differences in infection rates among different tick species and genders, and between ticks and tick-infested animals. Ticks are considered both as reservoirs and vectors for CCHFV, playing a key role in maintaining and disseminating the virus in natural enzootic cycles.
TRAVEL MEDICINE AND INFECTIOUS DISEASE
(2022)
Editorial Material
Public, Environmental & Occupational Health
Hassan Nasirian
TRAVEL MEDICINE AND INFECTIOUS DISEASE
(2023)
Article
Medicine, General & Internal
Hassan Nasirian, Abedin Saghafipour
Summary: The study evaluated the efficacy of various insecticide formulations against American cockroaches in sewers, with results showing significant effectiveness within one month but a decrease in efficacy after five months. It is recommended to repeat the insecticide formulations every three months and use a combination of integrated pest management strategies for successful control of American cockroaches.
BANGLADESH JOURNAL OF MEDICAL SCIENCE
(2021)
Article
Agriculture, Dairy & Animal Science
Amirhossein Zahirnia, Mitra Boroomand, Hassan Nasirian, Aref Salehzadeh, Sara Soleimani-Asl
Article
Public, Environmental & Occupational Health
Amirhossein Zahirnia, Mitra Boroomand, Hassan Nasirian, Sara Soleimani-Asl, Aref Salehzadeh, Dara Dastan
PAN AFRICAN MEDICAL JOURNAL
(2019)
Review
Medicine, General & Internal
Hassan Nasirian
BANGLADESH JOURNAL OF MEDICAL SCIENCE
(2019)
Article
Agriculture, Dairy & Animal Science
Hassan Nasirian, Aref Salehzadeh
Review
Parasitology
Hassan Nasirian
Article
Immunology
V. Sharma, P. Kaur, R. S. Aulakh, R. Sharma, R. Verma, B. B. Singh
Summary: Brucellosis is a neglected zoonosis that affects animals and people in the underdeveloped world. This study aimed to isolate and identify Brucella species from faeces of sero positive cattle in Punjab, India. Fourteen Brucella species were isolated, with 11 identified as Brucella abortus and 3 identified as Brucella melitensis. The study highlights the potential risk of animal faeces for animal and human health and emphasizes the need for careful handling of faeces from seropositive cattle.
COMPARATIVE IMMUNOLOGY MICROBIOLOGY AND INFECTIOUS DISEASES
(2024)
Article
Immunology
Yilei Zhang, Guojun Chen, Siyi Zhou, Lingru He, Olalekan Opeyemi Ayanniyi, Qianming Xu, Zhenyu Yue, Congshan Yang
Summary: The development of the Animal Parasitic Diseases and Drugs Database (APDDD) provides a comprehensive and intuitive tool for studying animal parasitic diseases and antiparasitic drugs, allowing users to understand the relationships between parasitic diseases, drugs, and targeted genes more effectively.
COMPARATIVE IMMUNOLOGY MICROBIOLOGY AND INFECTIOUS DISEASES
(2024)
Article
Immunology
Arthur Nery Finatto, Sulove Koirala, Fernanda Luiza Facioli, Jessica Aparecida Barbosa, Roman Nosach, Matheus de Oliveira Costa
Summary: The study revealed that Streptococcus equi subsp. zooepidemicus rapidly disseminated in various organs of pigs following oronasal inoculation, with tonsil samples consistently harboring the pathogen throughout the study period. The varying bacterial loads in mesenteric lymph nodes indicated persistence, replication, and a potential source for shedding.
COMPARATIVE IMMUNOLOGY MICROBIOLOGY AND INFECTIOUS DISEASES
(2024)
