Cancer cells that survive checkpoint adaptation contain micronuclei that harbor damaged DNA

Cytotoxic amounts of cisplatin induce either checkpoint adaptation or apoptosis in a concentration-dependent manner in cancer cells

(2016) Lucy H. Swift et al.   BIOLOGY OF THE CELL

53BP1 contributes to a robust genomic stability in human fibroblasts

(2016) Lauren S. Fink et al.   Aging-US

Chromothripsis: A New Mechanism for Rapid Karyotype Evolution

(2015) Mitchell L. Leibowitz et al.   Annual Review of Genetics

Progression of chromosomal damage induced by etoposide in G2 phase in a DNA-PKcs-deficient context

(2015) Micaela Palmitelli et al.   CHROMOSOME RESEARCH

Replication stress in early S phase generates apparent micronuclei and chromosome rearrangement in fission yeast

(2015) Sarah A. Sabatinos et al.   MOLECULAR BIOLOGY OF THE CELL

Stress induced by premature chromatin condensation triggers chromosome shattering and chromothripsis at DNA sites still replicating in micronuclei or multinucleate cells when primary nuclei enter mitosis

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Pharmacological inactivation of CHK1 and WEE1 induces mitotic catastrophe in nasopharyngeal carcinoma cells

(2015) Joyce P.Y. Mak et al.   Oncotarget

Genotoxic Anti-Cancer Agents and Their Relationship to DNA Damage, Mitosis, and Checkpoint Adaptation in Proliferating Cancer Cells

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Chk1 protects against chromatin bridges by constitutively phosphorylating BLM serine 502 to inhibit BLM degradation

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Catastrophic Nuclear Envelope Collapse in Cancer Cell Micronuclei

(2013) Emily M. Hatch et al.   CELL

A western blot assay to measure cyclin dependent kinase activity in cells or in vitro without the use of radioisotopes

(2013) Cody W. Lewis et al.   FEBS LETTERS

ATG5 is induced by DNA-damaging agents and promotes mitotic catastrophe independent of autophagy

(2013) Dipak Maskey et al.   Nature Communications

Human cells enter mitosis with damaged DNA after treatment with pharmacological concentrations of genotoxic agents

(2012) Philip M. Kubara et al.   BIOCHEMICAL JOURNAL

Genome Sequencing of Pediatric Medulloblastoma Links Catastrophic DNA Rearrangements with TP53 Mutations

(2012) Tobias Rausch et al.   CELL

Genomic Estimates of Aneuploid Content in Glioblastoma Multiforme and Improved Classification

(2012) B. Li et al.   CLINICAL CANCER RESEARCH

DNA breaks and chromosome pulverization from errors in mitosis

(2012) Karen Crasta et al.   NATURE

Comprehensive molecular characterization of human colon and rectal cancer

(2012)   NATURE

Enhanced Genotoxicity of Silver Nanoparticles in DNA Repair Deficient Mammalian Cells

(2012) Hui Kheng Lim et al.   Frontiers in Genetics

Characterization of novel Checkpoint kinase 1 inhibitors by in vitro assays and in human cancer cells treated with topoisomerase inhibitors

(2011) Gilles Ferry et al.   LIFE SCIENCES

DNA replication occurs in all lamina positive micronuclei, but never in lamina negative micronuclei

(2011) A. Okamoto et al.   MUTAGENESIS

The amount of DNA damage needed to activate the radiation-induced G2 checkpoint varies between single cells

(2011) Kinga Tkacz-Stachowska et al.   RADIOTHERAPY AND ONCOLOGY

Molecular mechanisms of micronucleus, nucleoplasmic bridge and nuclear bud formation in mammalian and human cells

(2010) M. Fenech et al.   MUTAGENESIS

Genetic activities in micronuclei: Is the DNA entrapped in micronuclei lost for the cell?

(2010) Mariona Terradas et al.   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH

Thymoquinone Induces Telomere Shortening, DNA Damage and Apoptosis in Human Glioblastoma Cells

(2010) Resham Lal Gurung et al.   PLoS One

Centromere-localized breaks indicate the generation of DNA damage by the mitotic spindle

(2010) A. A. Guerrero et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An unusual DNA binding compound, S23906, induces mitotic catastrophe in cultured human cells

(2009) Nathalie Cahuzac et al.   CANCER LETTERS

Merotelic kinetochore orientation, aneuploidy, and cancer

(2008) Daniela Cimini   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Aberrant Polo-Like Kinase 1-Cdc25A Pathway in Metastatic Hepatocellular Carcinoma

(2008) X. Q. Wang et al.   CLINICAL CANCER RESEARCH

Comprehensive genomic characterization defines human glioblastoma genes and core pathways

(2008) Roger McLendon et al.   NATURE