Article
Pathology
Craig R. Soderquist, Suzanne K. Lewis, Alejandro A. Gru, George Vlad, Eli S. Williams, Susan Hsiao, Mahesh M. Mansukhani, David C. Park, Carlos E. Bacchi, Bachir Alobeid, Peter H. Green, Govind Bhagat
Summary: Refractory celiac disease type II (RCD II), a rare disorder with poor prognosis that often progresses to EATL, has a complex pathogenesis involving genetic mutations impacting the JAK-STAT signaling pathway. Immunophenotypic and genomic analyses provide insights into early genetic events in EATL formation and indicate potential therapeutic targets.
AMERICAN JOURNAL OF SURGICAL PATHOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Nicoletta Bianchi, Luisa Doneda, Luca Elli, Cristian Taccioli, Valentina Vaira, Alice Scricciolo, Vincenza Lombardo, Anna Terrazzan, Patrizia Colapietro, Leonardo Terranova, Carlo Bergamini, Maurizio Vecchi, Lucia Scaramella, Nicoletta Nandi, Leda Roncoroni
Summary: This study identified a set of microRNAs in serum that can differentiate between different types of refractory diseases and aid in monitoring disease progression. The study also revealed the functions of these microRNAs, including cell signaling, epigenetic regulation, and inflammatory profiles.
Article
Genetics & Heredity
Chang Li, Bo Wei, Jianyu Zhao
Summary: This study identified differentially expressed mRNAs, lncRNAs, and miRNAs in Type 1 diabetes (T1D) samples compared to normal samples, and built a regulatory network involving multiple genes. The TRG-AS1-miR-23b-PPM1L and GAS5-miR-320a-SERPINA1 regulatory axises may impact the pathogenesis of T1D.
BMC MEDICAL GENOMICS
(2021)
Article
Gastroenterology & Hepatology
Luca Elli, Pietro Soru, Leda Roncoroni, Francesca Gaia Rossi, Valeria Ferla, Luca Baldini, Nicoletta Nandi, Lucia Scaramella, Alice Scricciolo, Alessandro Rimondi, Nicola Fuscoi, Giorgio Alberto Croci, Umberto Gianelli, Lilla Crog, Marzia Barbierig, Vincenza Lombardob, Andrea Costantinoa, Valentina Vairaa, Stefano Ferrero, Gian Eugenio Tontini, Giulio Barigellettih, Sabrina Fabianoh, Luisa Doneda, Maurizio Vecchi
Summary: This study describes the clinical and histological features of a cohort of patients with refractory celiac disease (RCeD) at diagnosis, after therapy, and at lymphoma onset, as well as evaluates the rate and causes of death over a 17-year follow-up. The results show differences in clinical severity, response to therapy, and mortality between RCeD-I and RCeD-II, with atrophy extension being associated with disease severity and mortality.
DIGESTIVE AND LIVER DISEASE
(2023)
Article
Medicine, General & Internal
Jonathan Soldera, Karina Salgado, Karla Lais Pegas
Summary: Refractory celiac disease is a rare condition that is often treated with immunosuppressive medications, with type 2 patients carrying a high risk for lymphoma and mortality. An effective treatment option for this condition may be oral budesonide, as seen in the case of the 41-year-old female patient achieving histological remission after six months of treatment.
REVISTA DA ASSOCIACAO MEDICA BRASILEIRA
(2021)
Article
Engineering, Electrical & Electronic
Yongfang Liu, Hang Rao, Yu Zhao, Fan Zhang, Panfeng Huang
Summary: This brief investigates the time-varying formation problem of Lipschitz-type nonlinear multi-agent systems and proposes an event-triggered adaptive controller. The protocol ensures the desired final configuration of Lipschitz-type agents by solving algebraic Riccati equation, making it more practical and feasible in engineering scenarios. Continuous adaptive modification eliminates the need for some global information, such as eigenvalues of the Laplacian matrix and the Lipschitz constant.
IEEE TRANSACTIONS ON CIRCUITS AND SYSTEMS II-EXPRESS BRIEFS
(2022)
Article
Engineering, Electrical & Electronic
Chengxin Xian, Yu Zhao, Xiwang Dong, Guanghui Wen, Hai-Tao Zhang
Summary: This paper investigates the event-triggered cooperative tracking problem for multiple autonomous agents described by Lipschitz-type nonlinear dynamics. A new event-triggered cooperative tracking strategy is proposed, which uses model-based local sampled state information and the state-dependent gain approach. The extended dynamics of the agents in this study can better meet practical engineering needs. Furthermore, the cooperative tracking algorithms overcome the infeasibility of linear matrix inequality conditions and address the problem by solving an algebraic Riccati equation, feasible for stabilizable systems.
IEEE TRANSACTIONS ON CIRCUITS AND SYSTEMS II-EXPRESS BRIEFS
(2022)
Letter
Gastroenterology & Hepatology
Andrea Sorge, Gian Eugenio Tontini, Lucia Scaramella, Nicoletta Nandi, Flaminia Cavallaro, Maurizio Vecchi, Luca Elli
Article
Gastroenterology & Hepatology
Andrea Sorge, Luca Elli, Emanuele Rondonotti, Marco Pennazio, Cristiano Spada, Sergio Cadoni, Renato Cannizzaro, Carlo Calabrese, Roberto de Franchis, Carlo Maria Girelli, Riccardo Marmo, Maria Elena Riccioni, Clelia Marmo, Salvatore Oliva, Giuseppe Scarpulla, Marco Soncini, Maurizio Vecchi, Gian Eugenio Tontini
Summary: This study used the Delphi process to establish a consensus on the definitions of bleeding entities and the role of enteroscopy in managing small bowel bleeding. After three rounds of voting, 33 statements were approved, providing clear definitions and a unified strategy for standardizing the management of small bowel bleeding.
DIGESTIVE AND LIVER DISEASE
(2023)
Article
Gastroenterology & Hepatology
Luca Elli, Pietro Soru, Leda Roncoroni, Francesca Gaia Rossi, Valeria Ferla, Luca Baldini, Nicoletta Nandi, Lucia Scaramella, Alice Scricciolo, Alessandro Rimondi, Nicola Fuscoi, Giorgio Alberto Croci, Umberto Gianelli, Lilla Crog, Marzia Barbierig, Vincenza Lombardob, Andrea Costantinoa, Valentina Vairaa, Stefano Ferrero, Gian Eugenio Tontini, Giulio Barigellettih, Sabrina Fabianoh, Luisa Doneda, Maurizio Vecchi
Summary: This study describes the clinical and histological features of a cohort of patients with refractory celiac disease (RCeD) at diagnosis, after therapy, and at lymphoma onset, as well as evaluates the rate and causes of death over a 17-year follow-up. The results show differences in clinical severity, response to therapy, and mortality between RCeD-I and RCeD-II, with atrophy extension being associated with disease severity and mortality.
DIGESTIVE AND LIVER DISEASE
(2023)
Article
Gastroenterology & Hepatology
Elisa Farina, Paolo Cantu, Flaminia Cavallaro, Veronica Iori, Erik Rosa-Rizzotto, Maurizio Cavina, Gian Eugenio Tontini, Nicoletta Nandi, Lucia Scaramella, Romano Sassatelli, Roberto Penagini, Maurizio Vecchi, Luca Elli
Summary: The effectiveness of double-balloon enteroscope-assisted retrograde cholangiopancreatography (DBE-ERCP) in patients with surgically altered anatomy (SAA) was investigated. The study found that DBE-ERCP was successful in these challenging patients, and there has been improvement in the results over the years, suggesting the need for adequate training and centralization of patients in specialized centers.
DIGESTIVE AND LIVER DISEASE
(2023)
Article
Gastroenterology & Hepatology
Marco Vincenzo Lenti, Nicola Aronico, Paola Ilaria Bianchi, Carmela Cinzia D'Agate, Matteo Neri, Umberto Volta, Maria Gloria Mumolo, Marco Astegiano, Antonino Salvatore Calabro, Fabiana Zingone, Giovanni Latella, Antonio Di Sario, Antonio Carroccio, Carolina Ciacci, Francesco Luzza, Carmela Bagnato, Massimo Claudio Fantini, Luca Elli, Giovanni Cammarota, Antonio Gasbarrini, Piero Portincasa, Mario Andrea Latorre, Clarissa Petrucci, Claudia Quatraccioni, Chiara Iannelli, Nicoletta Vecchione, Carlo Maria Rossi, Giacomo Broglio, Gianluca Ianiro, Ilaria Marsilio, Stefano Bibbo, Beatrice Marinoni, Donatella Tomaselli, Ludovico Abenavoli, Riccardo Pilia, Giovanni Santacroce, Erica Lynch, Antonella Carrieri, Pasquale Mansueto, Margherita Gabba, Giacomo Alunno, Chiara Rossi, Francesca Onnis, Konstantinos Efthymakis, Nicola Cesaro, Marta Vernero, Federica Baiano Svizzero, Francesco Paolo Semeraro, Marco Silano, Alessandro Vanoli, Catherine Klersy, Gino Roberto Corazza, Antonio Di Sabatino
Summary: This study investigated the diagnostic delay in coeliac disease (CD) and identified patient-dependent and physician-dependent factors that contribute to the delay. It highlights the importance of implementing a proper screening strategy for CD.
DIGESTIVE AND LIVER DISEASE
(2023)
Article
Gastroenterology & Hepatology
Marco Pennazio, Emanuele Rondonotti, Edward J. Despott, Xavier Dray, Martin Keuchel, Tom Moreels, David S. Sanders, Cristiano Spada, Cristina Carretero, Pablo Cortegoso Valdivia, Luca Elli, Lorenzo Fuccio, Begona Gonzalez Suarez, Anastasios Koulaouzidis, Lumir Kunovsky, Deirdre McNamara, Helmut Neumann, Enrique Perez-Cuadrado-Martinez, Enrique Perez-Cuadrado-Robles, Stefania Piccirelli, Bruno Rosa, Jean-Christophe Saurin, Reena Sidhu, Ilja Tacheci, Erasmia Vlachou, Konstantinos Triantafyllou
Summary: According to the recommendations from ESGE, small-bowel capsule endoscopy is the recommended first-line examination for suspected small-bowel bleeding due to its excellent safety profile and patient tolerability. In cases of overt suspected small-bowel bleeding, small-bowel capsule endoscopy should be conducted as soon as possible, ideally within 48 hours after the bleeding episode to maximize diagnostic and therapeutic benefits. Routine second-look endoscopy before small-bowel capsule endoscopy is not recommended for patients with suspected small-bowel bleeding or iron-deficiency anemia. Conservative management is recommended for patients with suspected small-bowel bleeding and negative small-bowel capsule endoscopy. If lesions are identified, device-assisted enteroscopy can be used for confirmation and possibly treatment. Small-bowel capsule endoscopy is recommended as the first-line examination for patients with iron-deficiency anemia when small bowel evaluation is indicated. Small-bowel capsule endoscopy is also recommended in patients with suspected Crohn's disease and negative ileocolonoscopy findings, as well as in patients with unremarkable or nondiagnostic findings from dedicated small-bowel cross-sectional imaging if it is likely to influence patient management. A patency capsule should be used before small-bowel capsule endoscopy in patients with established Crohn's disease to decrease the capsule retention rate. Device-assisted enteroscopy can be used as an alternative to surgery for retrieving foreign bodies in the small bowel in patients without acute intestinal obstruction. Additionally, DAE-endoscopic retrograde cholangiopancreatography (DAE-ERCP) is recommended as a first-line endoscopic approach to treat pancreaticobiliary diseases in patients with surgically altered anatomy, except for Billroth II patients.
Editorial Material
Gastroenterology & Hepatology
Gian Eugenio Tontini, Alessandro Rimondi, Flaminia Cavallaro, Nicoletta Nandi, Lucia Scaramella, Maurizio Vecchi, Luca Elli
Article
Oncology
Emanuela Palmerini, Marco Gambarotti, Antoine Italiano, Michael J. Nathenson, Ravin Ratan, Palma Dileo, Salvatore Provenzano, Robin L. Jones, Steven G. DuBois, Javier Martin-Broto, Enrique de Alava, Giacomo G. Baldi, Giovanni Grignani, Virginia Ferraresi, Antonella Brunello, Luca Paoluzzi, Rossella Bertulli, Nadia Hindi, Michael Montemurro, Christian Rothermundt, Stefania Cocchi, Carmen Salguero-Aranda, Davide Donati, Juan D. Martin, Amr H. Abdelhamid Ahmed, Alessandro Mazzocca, Elisa Carretta, Marilena Cesari, Michela Pierini, Alberto Righi, Marta Sbaraglia, Maria A. Laginestra, Katia Scotlandi, Angelo P. Dei Tos, Toni Ibrahim, Silvia Stacchiotti, Bruno Vincenzi
Summary: This study aimed to define the clinical characteristics, treatment, and outcome of undifferentiated small round cell sarcomas (URCSs) patients. The results showed significant differences in prognosis between URCS subtypes, and a full molecular assessment is needed to confirm the diagnosis. Prospective studies are needed to determine the optimal treatment strategy for each URCS subtype.
EUROPEAN JOURNAL OF CANCER
(2023)
Article
Immunology
Ilaria Righi, Valentina Vaira, Letizia Corinna Morlacchi, Giorgio Alberto Croci, Valeria Rossetti, Francesco Blasi, Stefano Ferrero, Mario Nosotti, Lorenzo Rosso, Mario Clerici
Summary: This pilot study found that PD-1-expressing T lymphocytes were associated with acute rejection and the development of chronic lung allograft dysfunction (CLAD) in lung transplant patients, indicating a central role of PD-1 in the pathogenesis of rejection.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Nutrition & Dietetics
Chris J. J. Mulder, Luca Elli, Benjamin Lebwohl, Govind K. Makharia, Kamran Rostami, Alberto Rubio-Tapia, Michael Schumann, Jason Tye-Din, Jonas Zeitz, Abdulbaqi Al-Toma
Summary: For patients with celiac disease, a gluten-free diet is necessary to resolve symptoms and minimize long-term morbidity. Follow-up care should involve a multidisciplinary approach, improved access through telemedicine, and adherence to guidelines informed by evidence-based research. However, data is lacking on optimal clinic visit intervals and outcomes, as well as quality indicators and resource utilization.
Article
Endocrinology & Metabolism
Chiara Verdelli, Giulia Stefania Tavanti, Irene Forno, Valentina Vaira, Riccardo Maggiore, Leonardo Vicentini, Paolo Dalino Ciaramella, Francesca Perticone, Giovanni Lombardi, Sabrina Corbetta
Summary: This study found that osteocalcin (OC), a bone matrix protein, can modulate the function of parathyroid tumor cells by activating the calcium sensing receptor (CASR). OC reduces the activity of pERK/ERK and increases the levels of active beta-catenin through CASR activation. It also affects the expression of related genes to influence the physiological functions of parathyroid tumor cells.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Oncology
Annamaria Morotti, Francesco Gentile, Gianluca Lopez, Giulia Passignani, Luca Valenti, Marco Locatelli, Manuela Caroli, Claudia Fanizzi, Stefano Ferrero, Valentina Vaira
Summary: In this study, the differences in the epigenome of brain metastasis from colon cancer and lung cancer were analyzed and compared with primary tumors. The results show that colon tumors have a higher degree of genome-wide methylation compared to lung cancers. Brain metastasis from lung cancer deeply activates neural signatures, while colon brain metastases show activation of metabolic signaling. These signatures are specific for metastatic tumors and shed light on the epi/molecular mechanisms that colon and lung cancers adopt to thrive in the brain environment.
Editorial Material
Gastroenterology & Hepatology
Nicoletta Nandi, Gian Eugenio Tontini, Lucia Scaramella, Andrea Sorge, Tommaso Pessarelli, Matilde Topa, Luca Elli
Article
Gastroenterology & Hepatology
Matilde Topa, Nicoletta Nandi, Lucia Scaramella, Michele Puricelli, Marco Pennazio, Reena Sidhu, David S. Sanders, Gian Eugenio Tontini, Roberto Penagini, Maurizio Vecchi, Luca Elli
Summary: This study assessed the clinical impact of videocapsule endoscopy (VCE) and double-balloon enteroscopy (DBE) in patients with indications other than suspected small bowel bleeding (OSBB), and compared them to a control group of suspected small bowel bleeding (SSBB) patients. The results showed that VCE and DBE are effective and safe in patients with indications other than suspected small bowel bleeding, similar to their role in suspected small bowel bleeding patients.
THERAPEUTIC ADVANCES IN GASTROENTEROLOGY
(2023)
Article
Nutrition & Dietetics
Vincenza Lombardo, Alice Scricciolo, Andrea Costantino, Luca Elli, Giorgia Legnani, Angel Cebolla, Luisa Doneda, Federica Mascaretti, Maurizio Vecchi, Leda Roncoroni
Summary: The aim of this study was to evaluate the clinical efficacy of urinary gluten immunogenic peptides (uGIP) in the follow-up of celiac disease (CD). The results showed that uGIP test can accurately assess the adherence to gluten-free diet and correlated significantly with duodenal biopsy results.
