Article
Medicine, General & Internal
Maria Rosa Burg, Carolin Mitschang, Tobias Goerge, Stefan Werner Schneider
Summary: Livedoid vasculopathy is a rare, chronic-recurrent occlusive disorder in the microcirculation of dermal vessels. Diagnosis is made through a synopsis of history, clinical, and histopathological findings. Early and adequate therapy is crucial for maintaining the quality of life for patients.
FRONTIERS IN MEDICINE
(2022)
Review
Medicine, General & Internal
Robert G. Micheletti
Summary: This manuscript summarizes the available evidence and proposes a therapeutic ladder for the management of different types of skin-limited vasculitis.
FRONTIERS IN MEDICINE
(2022)
Review
Dermatology
Ko-Ron Chen
Summary: This article examines the frequent association of cutaneous vasculitis with three monogenic autoinflammatory diseases (AIDs). Familial Mediterranean fever (FMF), deficiency of adenosine deaminase type 2 (DADA2), and VEXAS syndrome are the three diseases. FMF is characterized by small-vessel vasculitis and arteritis-like vasculitis; DADA2 presents with a wide range of clinical symptoms similar to polyarteritis nodosa (PAN); VEXAS syndrome is a life-threatening condition associated with Sweet syndrome-like eruption, livedo racemosa, and other manifestations.
JOURNAL OF DERMATOLOGY
(2023)
Review
Rheumatology
Minerva Gomez-Flores, Genesis Herrera-Argaez, Osvaldo Vazquez-Martinez, Maira Herz-Ruelas, Jorge Ocampo-Candiani, Alejandra Villarreal-Martinez, Dionicio A. Galarza-Delgado, Ivan Hernandez-Galarza, Sonia Chavez-Alvarez
Summary: This article reviews the cutaneous findings in patients with Antiphospholipid syndrome (APS), including prevalence, description, pathogenesis, and histopathology.
Article
Rheumatology
Songwei He, Xiaofang Zhen, Yan Hu
Summary: This study aimed to analyze the clinical characteristics of juvenile primary Sjogren's syndrome (pSS) with cutaneous involvement. Over half of the children with juvenile pSS presented with cutaneous lesions, with palpable purpura being the main type. Children with cutaneous lesions were more likely to have fever and arthritis, had stronger inflammatory response, and were less likely to have serious complications.
CLINICAL RHEUMATOLOGY
(2021)
Review
Urology & Nephrology
Gavin A. Esson, Amaani B. Hussain, Simon J. Meggitt, Nick J. Reynolds, John A. Sayer
Summary: Acute kidney injury (AKI) is a common medical problem and prompt diagnosis and treatment are crucial in preventing complications. Cutaneous signs can provide diagnostic clues of underlying systemic diseases causing AKI.
CLINICAL KIDNEY JOURNAL
(2022)
Article
Pediatrics
Fiona Price-Kuehne, Ebun Omoyinmi, Maha Younes, Matthew Edwards, Despina Eleftheriou, Paul Brogan
Summary: Marfan syndrome (MFS) is a genetic disorder caused by variants in the FBN1 gene, which leads to connective tissue abnormalities. We report a case of MFS with an unusual skin rash resembling cutaneous vasculitis and mild aortic root dilatation, where a rapid diagnosis was made through genetic testing of a saliva sample. The patient had an FBN1 frameshift variant that has been associated with MFS. This early diagnosis had a significant impact on patient management, including avoiding invasive investigations and unnecessary immunosuppression, as well as facilitating genetic counseling and lifelong monitoring for aortic root involvement.
FRONTIERS IN PEDIATRICS
(2023)
Review
Clinical Neurology
Fouad Mitri, Anna Bersano, Dominique Herve, Markus Kraemer
Summary: Moyamoya angiopathy is a cerebrovascular disease characterized by stenosis of certain arteries in the brain, which can lead to strokes. It can be idiopathic or associated with other conditions, and may present with various skin manifestations such as cafe-au-lait spots, hypomelanosis of Ito, and premature graying of hair.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Article
Dermatology
Jeff R. Gehlhausen, David A. Wetter, Caroline Nelson, Sarika Ramachandran, Jennifer M. McNiff, Christine J. Ko
Summary: The study evaluated inpatient consultations for complex purpura and found that different morphologies and types of vasculitis help determine the final diagnosis. Dependent nonbranching purpura is often associated with IgA vasculitis or skin-limited small-vessel vasculitis, while branching purpura is typically linked to microvascular occlusion and has a higher mortality rate.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2021)
Review
Medicine, General & Internal
Alberto Corra, Alice Verdelli, Elena Biancamaria Mariotti, Valentina Ruffo di Calabria, Lavinia Quintarelli, Cristina Aimo, Cord H. Sunderkoetter, Marzia Caproni
Summary: This study aims to collect multiple cases from the literature and analyze the frequency of different forms of induced vasculitis, as well as their histological and immunopathological features. Although rare, CV induced by SARS-CoV-2 and vaccines may provide useful insights into the mechanisms underlying cutaneous and systemic vasculitis.
FRONTIERS IN MEDICINE
(2022)
Review
Medicine, General & Internal
Danielle M. DeHoratius
Summary: This review discusses the clinical manifestations, etiologies, work up, and treatment considerations of cutaneous small vessel vasculitis. It emphasizes the importance of being able to diagnose vasculitis and proceed with the appropriate laboratory studies and work-up. Investigation of associated etiologies such as infection and drugs will guide additional diagnostic studies.
POSTGRADUATE MEDICINE
(2023)
Review
Medicine, General & Internal
Erkan Alpsoy
Summary: Vasculitides are a group of diseases characterized by inflammation and damage to blood vessels. Dermatologists have an advantage in diagnosing the disease early due to the high prevalence of skin involvement. A stepwise algorithmic approach can assist in the diagnosis of vasculitis, but should not be seen as strict rules.
FRONTIERS IN MEDICINE
(2022)
Article
Hematology
Jecko Thachil
Summary: This passage explores the interesting connection between the color purple and platelets, as well as how purpuric disorders cause skin manifestations in different diseases. It attempts to link the discovery of the color purple with how thrombocytopenia and vascular disorders lead to purpura.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2021)
Article
Rheumatology
Mario Sestan, Nastasia Kifer, Betul Sozeri, Ferhat Demir, Kadir Ulu, Clovis A. Silva, Reinan T. Campos, Ezgi Deniz Batu, Oya Koker, Matej Sapina, Sasa Srsen, Martina Held, Alenka Gagro, Adriana Rodrigues Fonseca, Marta Rodrigues, Donato Rigante, Giovanni Filocamo, Francesco Baldo, Merav Heshin-Bekenstein, Josip Juraj Strossmayer, Teresa Giani, Janne Kataja, Marijan Frkovic, Nicolino Ruperto, Seza Ozen, Marija Jelusic
Summary: The purpose of the research was to determine whether severe skin manifestations were associated with a more severe disease course. The results showed that patients with severe skin manifestations were older, more likely to develop nephritis with worse outcome, and had higher frequencies of severe gastrointestinal complications. These patients also had higher D-dimer concentrations and more frequent need for treatment with systemic glucocorticoids.
SEMINARS IN ARTHRITIS AND RHEUMATISM
(2023)
Article
Dermatology
Robert G. Micheletti
Summary: Cutaneous vasculitis can be a manifestation of systemic vasculitis, a variant of systemic vasculitis limited to the skin, or a type of vasculitis limited to the skin only. Careful evaluation is required to differentiate these possibilities and identify underlying conditions. Treatment depends on the type and severity of the disease.
AMERICAN JOURNAL OF CLINICAL DERMATOLOGY
(2023)
Article
Dermatology
Renaud Felten, Dan Lipsker, Jean Sibilia, Francois Chasset, Laurent Arnaud
Summary: The term lupus has been used since the Middle Ages to refer to several diseases characterized by ulcerous lesions. In the 19th century, a distinction between different types of lupus emerged, and the systemic nature of the disease was recognized. Modern treatments such as glucocorticoids, hydroxychloroquine, and immunosuppressive agents emerged in the second half of the 20th century. In the 21st century, there has been a deeper understanding of the disease's pathogenesis and the development of biologic and targeted treatments.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2022)
Letter
Dermatology
Antoine Braud, Antoine Mahe, Catherine Michel, Bernard Cribier, Dan Lipsker, Cedric Lenormand
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2021)
Letter
Dermatology
V. Reymann, D. Bessis, B. Bergeret, D. Lipsker, A. Du-Thanh, N. Terrail, M. Dandurand, O. Dereure
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2021)
Letter
Dermatology
B. Bergeret, L. -P. Secco, V. Pallure, C. Daien, Y. -M. Pers, J. Gottlieb, S. Barete, C. Girard, D. Lipsker, D. Bessis
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2021)
Article
Dermatology
Cedric Lenormand, Gaelle Marzolf, Dan Lipsker
Summary: Adenopathy and an extensive skin patch overlying a plasmacytoma (AESOP) syndrome is a condition characterized by a slowly expanding red or brown patch overlying a solitary plasmacytoma of the bone. Early recognition is crucial as it may progress to the more serious POEMS syndrome. The syndrome has two forms, classic and morphea-like variants, with treatment depending on the final hematologic diagnosis and requiring radiation of the plasmacytoma.
CLINICS IN DERMATOLOGY
(2021)
Letter
Dermatology
Gaelle Marzolf, Cedric Lenormand, Catherine Michel, Bernard Cribier, Dan Lipsker
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2021)
Review
Dermatology
C. Lenormand, D. Lipsker
Summary: This article reviews the various skin manifestations in patients with lupus erythematosus, discussing their diagnostic, pathogenic and prognostic relevance, as well as their impact on therapeutic choices. Specific skin lesions of LE, such as tumid lupus and lupus profundus, are characterized by autoimmune pathomechanisms and allow for simple diagnosis through clinicopathological correlation. Recognition of certain dermatological signs, like reticulated erythema and splinter hemorrhages, is important for identifying lupus patients at increased cardiovascular risk and with a worse overall prognosis. Neutrophilic cutaneous lupus erythematosus, including entities like neutrophilic urticarial dermatosis, suggests a role of autoinflammatory mechanisms in certain lupus manifestations. Treatment options, such as antimalarials and dapsone, are discussed for different skin manifestations.
ANNALES DE DERMATOLOGIE ET DE VENEREOLOGIE
(2021)
Letter
Dermatology
F. Bourlond, C. Velter, D. Lipsker
ANNALES DE DERMATOLOGIE ET DE VENEREOLOGIE
(2021)
Letter
Dermatology
F. Pham, C. Schissler, M. Schaeffer, H. -J. Lachmann, D. Lipsker
CLINICAL AND EXPERIMENTAL DERMATOLOGY
(2021)
Letter
Dermatology
Didier Bessis, Jean-David Bouaziz, Francois Chasset
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2022)
Letter
Dermatology
Dan Lipsker
Article
Allergy
Miriam Gross, Carsten Speckmann, Annette May, Tania Gajardo-Carrasco, Katharina Wustrau, Sarah Lena Maier, Marcus Panning, Daniela Huzly, Abbas Agaimy, Yenan T. Bryceson, Sharon Choo, C. W. Chow, Gregor Dueckers, Anders Fasth, Sylvie Fraitag, Katja Graewe, Sabine Haxelmans, Dirk Holzinger, Ole Hudowenz, Judith M. Huebschen, Claudia Khurana, Korbinian Kienle, Roman Klifa, Klaus Korn, Heinz Kutzner, Tim Laemmermann, Svea Ledig, Dan Lipsker, Marie Meeths, Nora Naumann-Bartsch, Jelena Rascon, Anne Schaenzer, Maximilian Seidl, Bianca Tesi, Christelle Vauloup-Fellous, Beate Vollmer-Kary, Klaus Warnatz, Claudia Wehr, Benedicte Neven, Pablo Vargas, Fernando E. Sepulveda, Kai Lehmberg, Annette Schmitt-Graeff, Stephan Ehl
Summary: This study investigated the defective effector mechanism allowing rubella vaccine virus persistence in granulomas by studying patients with cytotoxicity defects and granuloma. The results suggest a critical role of T cells in rubella elimination.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Article
Medicine, General & Internal
Francois Maurier, Maud Michaud, Roxane Reviron, Dan Lipsker
Summary: This is a case of scar-like skin lesions that appeared after reduction mammoplasty. The patient also developed symptoms of neuromyotonia, causing muscle contractions and abnormal movements. The diagnosis of neuromyotonia was based on clinical and electromyographic findings, while the skin lesions were diagnosed as morphea. Treatment with antiepileptic drugs and corticosteroids was effective.
Article
Ophthalmology
Mathieu Wurtz, Elisa Ruhland, XuanLi Liu, Izzie-Jacques Namer, Viola Mazzoleni, Dan Lipsker, Daniel Keller, Gilles Prevost, David Gaucher
Summary: The study confirmed that PVL activates oxidative pathways and alters neurotransmitter retinal concentrations and release, supporting the hypothesis that PVL could induce a neurogenic inflammation in the retina.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2021)