Article
Multidisciplinary Sciences
Aziza Kantri, Jihane Ziati, Mohamed Khalis, Amal Haoudar, Karim El Aidaoui, Youssef Daoudi, Inas Chikhaoui, Khalid El Yamani, Mohammed Mouhaoui, Jalila El Bakkouri, Nezha Dini, Mohammed Mahi, Abdelhamid Naitlho, Abdelkrim Bahlaoui, Ahmed Bennana, Mustapha Noussair, Lahcen Belyamani, Chafik El Kettani
Summary: This study critically analyzed the clinical and biological characteristics of 134 patients from the North African Mediterranean region with COVID-19, finding that factors such as age, comorbidities, gender, and infection type were associated with disease progression to a severe state. Abnormalities in certain parameters were closely linked to disease deterioration.
Article
Medicine, General & Internal
Xuyan Li, Ming Hu, Ruiqiang Zheng, Yishan Wang, Hanyujie Kang, Li Jiang, Ming Zhong, Ling Sang, Xia Zheng, Chun Pan, Wei Zhang, Haibo Qiu, Bin Du, Zhaohui Tong
Summary: In severe COVID-19 patients, ECMO should be initiated within 24 hours after meeting the criteria to decrease mortality rates. Early initiation of ECMO is associated with higher ECMO weaning rates and reduced mortality rates in COVID-19 patients.
FRONTIERS IN MEDICINE
(2021)
Article
Multidisciplinary Sciences
Harpal Singh Sandhu, Joshua Lambert, Zach Steckler, Lee Park, Arnold Stromberg, Julio Ramirez, Chi-fu Jeffrey Yang
Summary: This study aimed to evaluate whether outpatient medications approved by the FDA reduce the risk of COVID-19 hospitalization. A retrospective cohort study of COVID-19 patients in the US in 2020 found that rosuvastatin, empagliflozin-metformin, metformin, and enoxaparin showed protective effects against COVID-19 hospitalization. Well-designed clinical trials are needed to assess the efficacy of these agents in therapeutic or prophylactic settings.
Article
Multidisciplinary Sciences
Julia Diaz-Escobar, Nelson E. Ordonez-Guillen, Salvador Villarreal-Reyes, Alejandro Galaviz-Mosqueda, Vitaly Kober, Raul Rivera-Rodriguez, Jose E. Lozano Rizk
Summary: The study evaluates and compares deep-learning techniques for detecting COVID-19 infections from lung ultrasound imagery. The findings suggest that the InceptionV3 network provides the most promising predictive results, which can be used to further develop a viable computer-assisted screening tool for COVID-19 based on ultrasound imagery.
Article
Medicine, General & Internal
Barbara Ruaro, Paola Confalonieri, Riccardo Pozzan, Stefano Tavano, Lucrezia Mondini, Elisa Baratella, Alessandra Pagnin, Selene Lerda, Pietro Geri, Marco Biolo, Marco Confalonieri, Francesco Salton
Summary: ARDS caused by COVID-19 is associated with reduced surfactant levels and dysfunctional ATII cells, suggesting a potential role for exogenous surfactant therapy. This study presents two cases of COVID-19 ARDS successfully treated with diluted surfactants administered via bronchoalveolar lavage.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Virology
Enric Monreal, Sainz S. de la Maza, Pedro Gullon, Elena Natera-Villalba, Juan Luis Chico-Garcia, Alvaro Beltran-Corbellini, Javier Martinez-Sanz, Nuria Garcia-Barragan, Javier Buisan, Rafael Toledano, Araceli Alonso-Canovas, Paula Perez-Torre, Maria C. Matute-Lozano, Jose Luis Lopez-Sendon, Guillermo Garcia-Ribas, Inigo Corral, Jesus Fortun, Beatriz Montero-Errasquin, Luis Manzano, Luis Maiz-Carro, Lucienne Costa-Frossard, Jaime Masjuan
Summary: This study found that immunosuppression may reduce the risk of moderate to severe ARDS in COVID-19 patients, especially among those with autoimmune diseases.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Review
Pediatrics
Reza Sinaei, Sara Pezeshki, Saeedeh Parvaresh, Roya Sinaei
Summary: Research suggests that children are less frequently and severely affected by SARS-CoV-2 infection compared to adults, potentially due to factors such as a healthier respiratory system, less vigorous immune response, and other immune characteristics.
WORLD JOURNAL OF PEDIATRICS
(2021)
Article
Multidisciplinary Sciences
Jun Wu, Boyun Liang, Cunrong Chen, Hua Wang, Yaohui Fang, Shu Shen, Xiaoli Yang, Baoju Wang, Liangkai Chen, Qi Chen, Yang Wu, Jia Liu, Xuecheng Yang, Wei Li, Bin Zhu, Wenqing Zhou, Huan Wang, Sumeng Li, Sihong Lu, Di Liu, Huadong Li, Adalbert Krawczyk, Mengji Lu, Dongliang Yang, Fei Deng, Ulf Dittmer, Mirko Trilling, Xin Zheng
Summary: The study quantified IgM and IgG antibodies recognizing SARS-CoV-2 in 349 symptomatic COVID-19 patients over 6 months, showing that IgM levels dropped after 3 months while IgG responses contracted but remained high at 6 months.
NATURE COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Atsuko Deguchi, Tomoko Yamamoto, Noriyuki Shibata, Yoshiro Maru
Summary: This study investigates the potential role of S100A8 in COVID-19-associated ARDS and proposes a treatment method. Pathological similarities, clinical information, and experimental results collectively support the importance of S100A8 in COVID-19.
Article
Medicine, General & Internal
Ning Jiang, Yan-Nan Liu, Jing Bao, Ran Li, Wen-Tao Ni, Xing-Yu Tan, Yu Xu, Li-Ping Peng, Xiao-Rong Wang, Yi-Ming Zeng, Dai-Shun Liu, Qing Xue, Jia-Shu Li, Ke Hu, Ya-Li Zheng, Zhan-Cheng Gao
Summary: This study found that patients aged ≥65 years, male, with comorbid diabetes, and presenting with cough and/or diarrhea upon admission were at a higher risk for severe COVID-19. Further stratification analysis showed that male patients with diabetes were more likely to develop severe COVID-19, highlighting the importance of close monitoring for these high-risk individuals.
CHINESE MEDICAL JOURNAL
(2021)
Review
Microbiology
Jessica A. Plante, Brooke M. Mitchell, Kenneth S. Plante, Kari Debbink, Scott C. Weaver, Vineet D. Menachery
Summary: Despite the development of vaccines, COVID-19 caused by SARS-CoV-2 continues to be a global concern due to the emergence of new variants, raising worries about increased spread and potential impacts on immunity.
CELL HOST & MICROBE
(2021)
Article
Critical Care Medicine
Mehdi C. Shelhamer, Paul D. Wesson, Ian L. Solari, Deanna L. Jensen, William Alex Steele, Vihren G. Dimitrov, John Daniel Kelly, Shazia Aziz, Victor Perez Gutierrez, Eric Vittinghoff, Kevin K. Chung, Vidya P. Menon, Herman A. Ambris, Sanjiv M. Baxi
Summary: Prone positioning in patients with moderate to severe ARDS due to COVID-19 is associated with reduced mortality and improved physiologic parameters, with one in-hospital death averted for every 8 patients treated. The results suggest that prone positioning may represent an additional therapeutic option in patients with ARDS due to COVID-19, but further replication and scaling of the intervention are important.
JOURNAL OF INTENSIVE CARE MEDICINE
(2021)
Article
Physiology
Faeq Husain-Syed, Istvan Vadasz, Jochen Wilhelm, Hans-Dieter Walmrath, Werner Seeger, Horst-Walter Birk, Birgit Jennert, Hartmut Dietrich, Susanne Herold, Janina Trauth, Khodr Tello, Michael Sander, Rory E. Morty, Heiko Slanina, Christian G. Schuttler, John Ziebuhr, Shadi Kassoumeh, Claudio Ronco, Fiorenza Ferrari, Klaus Warnatz, Klaus Stahl, Benjamin Seeliger, Marius M. Hoeper, Tobias Welte, Sascha David
Summary: This study found that IgG deficiency is common in critically ill patients with COVID-19, leading to increased disease severity, higher risk of complications, and worse prognosis. Therefore, IgG deficiency should be considered as a potential therapeutic target and marker of disease severity in the treatment of COVID-19.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2021)
Article
Immunology
Wendong Hao, Meimei Liu, Cairong Bai, Xin Liu, Siqian Niu, Xiushan Chen
Summary: The objective of this study was to identify potential predictors of clinical outcome in severe COVID-19 patients and investigate the relationship between immunological parameters and duration of illness. A single-center retrospective study recruited 73 patients with severe or critical COVID-19. The results showed that CX3CL1, D-dimer, PCT, and IL-6 could effectively predict mortality in severe COVID-19 patients, and only CX3CL1 and D-dimer levels were significantly associated with duration of illness.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Xu Yuyun, Yu Lexi, Wang Haochu, Shu Zhenyu, Gong Xiangyang
Summary: The study found differences in lung involvement between ordinary and severe/critical COVID-19 patients at different time points. Quantitative analysis based on chest CT images can provide early warning information for potentially severe/critical patients.
FRONTIERS IN PUBLIC HEALTH
(2021)
Article
Multidisciplinary Sciences
Yang Li, Shuhan Li, Ran Zhou, Guqiang Li, Xiangyou Li
Summary: In this study, a high-antibacterial activity SOD-like nanozyme based on hybrid Ag/CeO2 nanocomposite was prepared using selective laser welding in liquid. The prepared nanozyme exhibited a high antimicrobial effect against Staphylococcus aureus under visible light illumination, with a sterilization rate as high as 82.4%, which was significantly higher than pure Ag and pure CeO2. The enhanced antibacterial activity was attributed to the anchoring of Ag nanospheres on the surface of CeO2 nanosheets, promoting visible light harvesting and generating abundant reactive oxygen species.
JOURNAL OF ADVANCED RESEARCH
(2023)
Article
Urology & Nephrology
Jun Wu, Jushuang Li, Baohong Feng, Zhimin Bi, Geli Zhu, Yanxia Zhang, Xiangyou Li
Summary: Activation of the AMPK-PGC-1 alpha pathway improves PD-related PF by enhancing mitochondrial biogenesis, suggesting a potential new therapeutic approach for PD-related PF.
Review
Chemistry, Analytical
Zheng Li, Hao Li, Jie Yin, Yan Li, Zhenguo Nie, Xiangyou Li, Deyong You, Kai Guan, Wei Duan, Longchao Cao, Dengzhi Wang, Linda Ke, Yang Liu, Ping Zhao, Lin Wang, Kunpeng Zhu, Zhengwen Zhang, Liang Gao, Liang Hao
Summary: Spatter, an undesired phenomenon in laser powder bed fusion (L-PBF), has a significant impact on forming quality. Research on spatter is crucial in improving L-PBF systems.
Article
Engineering, Manufacturing
Jianqiang Gong, Kaiwen Wei, Mengna Liu, Wenji Song, Xiangyou Li, Xiaoyan Zeng
Summary: This paper investigates the application of LPBF/DED hybrid laser additive manufacturing technology in the manufacturing of aluminum alloy components. The results show that there are no obvious defects at the LPBF/DED interface, but the microstructure around the interface changes significantly. The LPBF zone has higher microhardness and tensile strength, while the DED zone has better elongation. The tensile strength of the LPBF/DED interface is not lower than the DED zone. The findings have important implications for understanding and applying LPBF/DED hybrid laser additive manufacturing technology.
ADDITIVE MANUFACTURING
(2022)
Article
Biochemistry & Molecular Biology
Yimiao Zhao, Le Shi, Zhendong Jiang, Na Zeng, Huan Mei, Yu Lu, Jinfeng Yang, Fenshu Jin, Shuyu Ni, Shuilin Wu, Sizhen Su, Yongbo Zheng, Kai Yuan, Wei Yan, Siwei Sun, Shiqiu Meng, Jie Sun, Zunera Khan, Dag Aarsland, Jie Shi, Xiangyou Li, Yanping Bao, Lin Lu
Summary: Long-term sequelae clustering phenotypes play a crucial role in providing precise health care management for COVID-19 survivors. In this study, we examined 1000 survivors in China 20 months after their COVID-19 diagnosis. The results showed that generalized symptoms were most common, followed by mental, cardiopulmonary, neurological, and digestive symptoms. Four clusters were identified based on symptom patterns, ranging from no or mild symptoms to severe impairment. Factors such as physical comorbidities, history of mental disorders, longer hospitalization periods, and severe acute illness were associated with more severe symptoms. This study highlights the importance of identifying and addressing specific sequelae clusters in COVID-19 survivors for targeted recovery interventions.
MOLECULAR PSYCHIATRY
(2023)
Review
Chemistry, Physical
Yang Li, Zhong Zheng, Jiujiang Yan, Bing Lu, Xiangyou Li
Summary: The purpose of photocatalysis is to convert solar energy into chemical energy, and developing a high-performance photocatalyst under visible-light irradiation is crucial. Conventional methods for preparing photocatalysts rely on wet chemical routes, yielding high quantities but with impurities that hinder photocatalytic performance enhancement. Pulsed laser heating in a liquid medium has emerged as a powerful tool for rapidly preparing nanocomposites with synergistic effects and high crystallinity, leading to improved photocatalytic performance. This review summarizes the characteristics of pulsed laser heating in liquids and the applications of nanocomposites prepared through this method, highlighting the innovative works while addressing the specific challenges and prospects in this field.
Article
Engineering, Manufacturing
Xin Li, Zhenlin Hu, Jian Lai, Wenzhong Gao, Mengcheng Gong, Chen Zhang, Ming Gao
Summary: Current studies of laser-arc plasma interaction have overlooked the layering behaviors of the metal inert gas (MIG) arc, leading to a lack of understanding of laser-MIG hybrid welding. This study investigated the effects of laser power on the double-layer MIG, which consists of an outer plasma layer and a core metal vapor layer. The results showed that the emergence of arc layering was delayed by laser-arc plasma interaction, with the outer layer expanding and the core layer constricting due to laser power. These findings provide a more reasonable explanation for weld shape variations and highlight the importance of considering arc layering in laser-arc hybrid processes.
JOURNAL OF MANUFACTURING PROCESSES
(2023)
Article
Thermodynamics
Xin Li, Suning Zhao, Laihege Jiang, Yang Lu, Mengcheng Gong, Chen Zhang, Ming Gao
Summary: Current studies have shown that laser-arc interaction affects droplet transfer behaviors. This study quantitatively analyzed the effects of laser power on droplet transfer frequency, detachment time, and motion behaviors in laser-MIG hybrid welding of aluminum alloy. The results revealed that the droplet growth and detachment in hybrid welding was accelerated by 22%, while the droplet flight motion was prolonged by 36% at maximum. The mechanism of these effects was discussed based on droplet force analysis.
INTERNATIONAL JOURNAL OF HEAT AND MASS TRANSFER
(2023)
Article
Materials Science, Multidisciplinary
Qiao Zhong, Kaiwen Wei, Taoyuan Ouyang, Xiangyou Li, Xiaoyan Zeng
Summary: The study investigates the effects of rotation angles on the surface morphology, microstructure, and mechanical properties of Inconel 718 alloy produced by high-power laser powder bed fusion (HP-LPBF). Low rotation angles result in poor surface finish and lack-of-fusion defects, while high rotation angles lead to smaller surface roughness and better relative density. There are noticeable edge effects and a downward trend in maximal heights with increased rotation angle. The tensile property is slightly enhanced with increasing rotation angle.
JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
(2023)
Article
Environmental Sciences
Chenwei Zhu, Shuhan Li, Yang Li, Kun Liu, Ji Chen, Bing Lu, Xiangyou Li
Summary: With the increasing use of lead-containing perovskite solar cells (PSCs), monitoring Pb pollution from PSCs in the environment is crucial. Laser-induced breakdown spectroscopy (LIBS) has shown good performance in rapidly quantifying elements without using toxic and expensive chemicals, making it a potential method for detecting and quantifying Pb in the environment. This study assessed a Pb migration model in the PSCs-soil-Houttuynia plants system based on LIBS data, and calculated Pb transfer rates and uptake coefficients to evaluate Pb migration from PSCs to plants. The results demonstrated the importance of not underestimating Pb leakage from PSCs and highlighted the viability and speed of LIBS as an analytical method for monitoring Pb.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Chemistry, Analytical
Jiangtao Li, Zhiyang Tang, Zhongqi Hao, Zhijie Huang, Chenwei Zhu, Qingzhou Li, Bing He, Ji Chen, Xiangyou Li
Summary: This study proposed a method that combines LIBS-LIF with SAM to improve the quantitative analysis performance of La element in rare earth ore. The results showed that this method has good linearity, low detection limit, and small relative error, and can accurately determine the concentration of La in rare earth ore.
JOURNAL OF ANALYTICAL ATOMIC SPECTROMETRY
(2022)
Article
Chemistry, Analytical
Ke Liu, Zhiyang Tang, Wen Zhang, Xiangyou Li
Summary: Chlorinated volatile organic compounds (Cl-VOCs) are priority pollutants in most countries due to their severe toxicity and low biodegradability. Traditional monitoring methods with low temporal resolutions are insufficient for intermittent air pollution. Laser-induced breakdown spectroscopy (LIBS) has been considered a viable technology for Cl-VOCs analysis, but faces challenges due to the absorption of Cl atomic lines by oxygen in air. However, a novel approach using LIBS assisted with molecular spectra shows promise for sensitive and real-time analysis of Cl-VOCs.
JOURNAL OF ANALYTICAL ATOMIC SPECTROMETRY
(2022)
Article
Chemistry, Analytical
Jiujiang Yan, Qingzhou Li, Fangjun Qin, Liangfen Xiao, Xiangyou Li
Summary: Spectral features are crucial for the classification performance of laser-induced breakdown spectroscopy (LIBS). This study proposes a method called polynomial interactive reconstruction (PIC) to improve the accuracy of portable LIBS classification. Experimental results show that the proposed method significantly outperforms other single original features and achieves a higher classification accuracy.
JOURNAL OF ANALYTICAL ATOMIC SPECTROMETRY
(2022)
Article
Optics
Li Xiangyou, Liu Ke, Zhou Ran, Zhang Wen
Summary: The physical and chemical properties of materials are determined by their element compositions and contents. Finding a newer, faster, and more adaptive detection technology has become a research hotspot. Laser induced breakdown spectroscopy (LIBS) is an element analysis technology that shows great application prospects in many fields due to its unique advantages of simultaneous detection of multiple elements, simple structure, fast detection speed, and being not affected by sample morphology.
CHINESE JOURNAL OF LASERS-ZHONGGUO JIGUANG
(2022)
Article
Chemistry, Analytical
Ji Chen, Qingzhou Li, Ke Liu, Xiangyou Li, Bing Lu, Guqiang Li
Summary: Moisture is a critical factor that interferes with laser-induced breakdown spectroscopy (LIBS) spectra and reduces the analysis accuracy. This study established regression models for volatile content and proposed a random spectral attenuation method to reduce moisture content disturbance. The results showed improved accuracy and speed of LIBS analysis with the use of these methods.
JOURNAL OF ANALYTICAL ATOMIC SPECTROMETRY
(2022)