Article
Biochemistry & Molecular Biology
Renata Swiatkowska-Stodulska, Agata Berlinska, Ewelina Puchalska-Reglinska
Summary: This study found that cortisol levels in hospitalized COVID-19 patients are related to clinical outcomes and the degree of inflammation. Abnormal adrenal function is associated with poorer prognosis. Cortisol concentration can be used as an independent prognostic factor for unfavorable outcomes in COVID-19 hospitalized patients.
Article
Medicine, General & Internal
Angela J. Rogers, Deborah Wentworth, Andrew Phillips, Katy Shaw-Saliba, Robin L. Dewar, Neil R. Aggarwal, Abdel G. Babiker, Weizhong Chang, Nila J. Dharan, Victoria J. Davey, Elizabeth S. Higgs, Norman Gerry, Adit A. Ginde, J. W. Awori Hayanga, Helene Highbarger, Jeroen L. Highbarger, Mamta K. Jain, Virginia Kan, Kami Kim, Perrine Lallemand, Bradley G. Leshnower, Joseph K. Lutaakome, Gail Matthews, Ahmad Mourad, Eleftherios Mylonakis, Ven Natarajan, Maria L. Padilla, Lavannya M. Pandit, Roger Paredes, Sarah Pett, Srikanth Ramachandruni, M. Tauseef Rehman, Brad T. Sherman, D. Clark Files, Samuel M. Brown, Michael A. Matthay, B. Taylor Thompson, James D. Neaton, H. Clifford Lane, Jens D. Lundgren
Summary: This study conducted a cross-sectional study of plasma antigen levels in 2540 hospitalized patients with COVID-19, finding that plasma antigen levels were closely associated with the severity of pulmonary disease and clinically important outcomes, with multiple clinical and viral factors associated with baseline plasma antigen levels.
ANNALS OF INTERNAL MEDICINE
(2022)
Article
Multidisciplinary Sciences
Lisa Kurver, Corne H. van den Kieboom, Kjerstin Lanke, Dimitri A. Diavatopoulos, Gijs J. Overheul, Mihai G. Netea, Jaap ten Oever, Reinout van Crevel, Karin Mulders-Manders, Frank L. van de Veerdonk, Heiman Wertheim, Jeroen Schouten, Janette Rahamat-Langendoen, Ronald P. van Rij, Teun Bousema, Arjan van Laarhoven, Marien de Jonge
Summary: Understanding the contagiousness of COVID-19 is crucial for the accurate management of hospitalized patients. This study found that in addition to droplet transmission, aerosolized SARS-CoV-2 also contributes to the spread of infection. Using a disposable modular breath sampler, the researchers successfully detected viral RNA in exhaled air samples from 25% of the hospitalized COVID-19 patients.
SCIENTIFIC REPORTS
(2022)
Article
Immunology
Marco Contoli, Alberto Papi, Luca Tomassetti, Paola Rizzo, Francesco Vieceli Dalla Sega, Francesca Fortini, Francesca Torsani, Luca Morandi, Luca Ronzoni, Ottavio Zucchetti, Rita Pavasini, Alberto Fogagnolo, Carlo Alberto Volta, Nathan W. Bartlett, Sebastian L. Johnston, Savino Spadaro, Gianluca Campo
Summary: This study demonstrates that COVID-19 patients have lower levels of blood IFN-alpha compared to controls, and as the disease progresses, the IFN-alpha levels decrease while IL-10 expression increases. Survivors show a significant increase in IFN-alpha levels, while patients who died had higher levels of IL-10.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Virology
Joshua A. Hill, Manoj P. Menon, Shireesha Dhanireddy, Mark M. Wurfel, Margaret Green, Rupali Jain, Jeannie D. Chan, Joanne Huang, Danika Bethune, Cameron Turtle, Christine Johnston, Hu Xie, Wendy M. Leisenring, H. Nina Kim, Guang-Shing Cheng
Summary: This study found that tocilizumab treatment did not improve clinical outcomes or reduce mortality in hospitalized patients with COVID-19, but may lead to other complications.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Oncology
Isaac A. Klein, Shoshana M. Rosenberg, Kerry L. Reynolds, Leyre Zubiri, Rachel Rosovsky, Andrew J. Piper-Vallillo, Xin Gao, Genevieve Boland, Aditya Bardia, Rachel Gaither, Hannah Freeman, Gregory J. Kirkner, Chanu Rhee, Michael Klompas, Meghan A. Baker, Martha Wadleigh, Eric P. Winer, Camille N. Kotton, Ann H. Partridge
Summary: The study found that patients with a history of cancer hospitalized for COVID-19 had similar mortality rates to matched hospitalized patients with COVID-19 without cancer, and a lower risk of complications. Active cancer, systemic cancer therapy, and a cancer history are not independent risk factors for death from COVID-19 among hospitalized patients, and hospitalized patients without cancer are more likely to have severe COVID-19.
Article
Public, Environmental & Occupational Health
Warren Gavin, Elliott Campbell, Syed-Adeel Zaidi, Neha Gavin, Lana Dbeibo, Cole Beeler, Kari Kuebler, Ahmed Abdel-Rahman, Mark Luetkemeyer, Areeba Kara
Summary: This retrospective study evaluated COVID-19 patients admitted to one site in March 2020 and found that age and gender may impact disease outcomes. Certain biomarkers such as D-dimer, procalcitonin, lactate dehydrogenase, and BNP may serve as early indicators of disease trajectory.
AMERICAN JOURNAL OF INFECTION CONTROL
(2021)
Article
Virology
Priya Duggal, Tristan Penson, Hannah N. Manley, Candelaria Vergara, Rebecca M. Munday, Dylan Duchen, Elizabeth A. Linton, Amber Zurn, Jeanne C. Keruly, Shruti H. Mehta, David L. Thomas
Summary: Understanding and describing the symptoms of COVID-19 patients in community settings months after infection, it was found that nearly one-third of the individuals reported incomplete recovery, and a small percentage reported symptoms severe enough to affect daily activities. Those with post-acute sequelae were more likely to have a history of heart attack. Among those with long-term symptoms, men and women were equally represented, but only women reported symptoms that constrained daily activities, with a majority being caregivers. The types of symptoms varied, with many experiencing a deviation from prior COVID-19 health, such as reduced exercise ability, walking ability, concentration, or breathing.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Review
Medicine, General & Internal
Eleonora Di Salvo, Mario Di Gioacchino, Alessandro Tonacci, Marco Casciaro, Sebastiano Gangemi
Summary: The role of alarmins in patients affected by COVID-19 disease and their relationship with commonly reported comorbidities are the focus of current research. There is limited literature on this specific topic, but preliminary evidence confirms the involvement of danger signals in amplifying the inflammatory reaction associated with SARS-CoV-2 infection.
ANNALS OF MEDICINE
(2021)
Article
Immunology
Isaac Nunez, Angel A. Priego-Ranero, H. Benjamin Garcia-Gonzalez, Brenda Jimenez-Franco, Rebeca Bonilla-Hernandez, Guillermo Dominguez-Cherit, Javier Merayo-Chalico, Jose C. Crispin, Ana Barrera-Vargas, Sergio Ivan Valdes-Ferrer
Summary: The study found that hematological and biochemical markers taken on admission can help predict the severity of COVID-19 patients, including the risk of death or admission to critical care. These simple blood tests can play an important role in the early stages of the disease, helping to identify severe patients early and allocate resources appropriately.
CLINICAL IMMUNOLOGY
(2021)
Article
Nutrition & Dietetics
Androniki Papaemmanouil, Dimitra Rafailia Bakaloudi, Konstantina Gkantali, Georgios Kalopitas, Simeon Metallidis, Georgios Germanidis, Michael Chourdakis
Summary: The study found that handgrip strength (HGS) could be used as an indicator of clinical outcomes in COVID-19 patients, while phase angle (PhA) does not seem to have a clinical impact. However, further research is needed to validate the results of our study.
Article
Infectious Diseases
Milena S. Marcolino, Patricia K. Ziegelmann, Maira V. R. Souza-Silva, I. J. B. Nascimento, Luana M. Oliveira, Luanna S. Monteiro, Thais L. S. Sales, Karen B. Ruschel, Karina P. M. P. Martins, Ana Paula B. S. Etges, Israel Molina, Carisi A. Polanczyk
Summary: This study investigated the characteristics and outcomes of COVID-19 patients hospitalized in Brazilian hospitals. It found that certain parameters at hospital admission, such as age, chronic diseases, laboratory indicators, and treatment methods, were independently associated with a higher risk of in-hospital mortality. The study also highlighted the potential overuse of antimicrobials in COVID-19 patients.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Immunology
Nobuaki Matsunaga, Kayoko Hayakawa, Mari Terada, Hiroshi Ohtsu, Yusuke Asai, Shinya Tsuzuki, Setsuko Suzuki, Ako Toyoda, Kumiko Suzuki, Mio Endo, Naoki Fujii, Michiyo Suzuki, Sho Saito, Yukari Uemura, Taro Shibata, Masashi Kondo, Kazuo Izumi, Junko Terada-Hirashima, Ayako Mikami, Wataru Sugiura, Norio Ohmagari
Summary: This study in Japan examined hospitalized patients with COVID-19, finding that they are typically middle-aged males with close contact to confirmed or suspected cases. The most common comorbidities were hypertension and diabetes. Most patients admitted were nonsevere cases, with a majority not requiring oxygen support during hospitalization.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Virology
Stelvio Tonello, Davide D'Onghia, Daria Apostolo, Erica Matino, Martina Costanzo, Giuseppe Francesco Casciaro, Alessandro Croce, Eleonora Rizzi, Erika Zecca, Anita Rebecca Pedrinelli, Veronica Vassia, Paolo Ravanini, Maria Grazia Crobu, Manuela Rizzi, Raffaella Landi, Luigi Mario Castello, Rosalba Minisini, Gian Carlo Avanzi, Mario Pirisi, Daniele Lilleri, Mattia Bellan, Donato Colangelo, Pier Paolo Sainaghi
Summary: This study aimed to evaluate osteopontin (OPN) as a potential biomarker for predicting the prognosis of COVID-19 patients. The results showed that higher plasma concentrations of OPN at hospital admission were associated with a worsening clinical condition. OPN levels might serve as a promising biomarker for early stratification of COVID-19 severity.
Article
Medicine, General & Internal
Cesar Fernandez-de-Las-Penas, Jorge Rodriguez-Jimenez, Ignacio Cancela-Cilleruelo, Angel Guerrero-Peral, Jose D. Martin-Guerrero, David Garcia-Azorin, Ana Cornejo-Mazzuchelli, Valentin Hernandez-Barrera, Oscar J. Pellicer-Valero
Summary: This study compares the post-COVID-19 symptoms between hospitalized and nonhospitalized patients 2 years after acute SARS-CoV-2 infection. The results show that the post-COVID-19 symptoms are similar between hospitalized and nonhospitalized patients, with some differences in symptoms at the onset of the disease. Additionally, the study finds that the number of preexisting medical comorbidities and the number of symptoms are associated with post-COVID-19 fatigue and dyspnea.
Article
Multidisciplinary Sciences
Elisabetta Cameroni, John E. Bowen, Laura E. Rosen, Christian Saliba, Samantha K. Zepeda, Katja Culap, Dora Pinto, Laura A. VanBlargan, Anna De Marco, Julia di Iulio, Fabrizia Zatta, Hannah Kaiser, Julia Noack, Nisar Farhat, Nadine Czudnochowski, Colin Havenar-Daughton, Kaitlin R. Sprouse, Josh R. Dillen, Abigail E. Powell, Alex Chen, Cyrus Maher, Li Yin, David Sun, Leah Soriaga, Jessica Bassi, Chiara Silacci-Fregni, Claes Gustafsson, Nicholas M. Franko, Jenni Logue, Najeeha Talat Iqbal, Ignacio Mazzitelli, Jorge Geffner, Renata Grifantini, Helen Chu, Andrea Gori, Agostino Riva, Olivier Giannini, Alessandro Ceschi, Paolo Ferrari, Pietro E. Cippa, Alessandra Franzetti-Pellanda, Christian Garzoni, Peter J. Halfmann, Yoshihiro Kawaoka, Christy Hebner, Lisa A. Purcell, Luca Piccoli, Matteo Samuele Pizzuto, Alexandra C. Walls, Michael S. Diamond, Amalio Telenti, Herbert W. Virgin, Antonio Lanzavecchia, Gyorgy Snell, David Veesler, Davide Corti
Summary: The Omicron variant of SARS-CoV-2 has raised concerns due to its 37 amino acid substitutions in the spike protein, particularly in the receptor-binding domain (RBD), leading to increased binding affinity with human ACE2. Neutralizing activity against Omicron was greatly reduced in convalescent and vaccinated individuals compared to the ancestral virus, but this decrease was less significant after a third vaccine dose. Broadly neutralizing monoclonal antibodies recognizing conserved RBD epitopes may be crucial in combating the Omicron variant and future zoonotic transmissions.
Letter
Biochemistry & Molecular Biology
Michael Boeckh, Helen Y. Chu, Janet A. Englund, Christina M. Lockwood, Deborah A. Nickerson, Jay Shendure, Lea Starita
Article
Pediatrics
Linda K. Ko, Lauren Tingey, Magaly Ramirez, Elliott Pablo, Ryan Grass, Francene Larzelere, Oralia Cisneros, Helen Y. Chu, Emily M. D'Agostino
Summary: Using diagnostic testing approaches in schools can accelerate the safe return of students and staff, prevent the spread of COVID-19, and reduce school and work absenteeism. However, the application of community-based participatory research (CBPR) approach in school engagement is limited. This article provides case studies of school-academic partnerships built on CBPR processes and practices, serving as research infrastructure to reach underserved children and families during the pandemic.
Article
Immunology
Julia H. Rogers, Sarah N. Cox, James P. Hughes, Amy C. Link, Eric J. Chow, Idabelle Fosse, Margaret Lukoff, M. Mia Shim, Timothy M. Uyeki, Constance Ogokeh, Michael L. Jackson, Michael Boeckh, Janet A. Englund, Emily Mosites, Melissa A. Rolfes, Helen Y. Chu
Summary: This study found significant disparities in COVID-19 vaccination intent among homeless individuals based on race, education level, and prior vaccine history. There was no observed trend towards increased vaccine acceptance over the study period.
Article
Microbiology
Allison J. Greaney, Rachel T. Eguia, Tyler N. Starr, Khadija Khan, Nicholas Franko, Jennifer K. Logue, Sandra M. Lord, Cate Speake, Helen Y. Chu, Alex Sigal, Jesse D. Bloom
Summary: Exposure to SARS-CoV-2 variants and vaccinations affects the specificity of antibody responses. The Delta variant elicits a neutralizing antibody response focused on the receptor-binding domain, similar to early 2020 viruses but different from the Beta variant. Mutations to the class 1 epitope have a significant impact on antibody binding and neutralization in the Delta spike.
Article
Medicine, General & Internal
Sarah Wulf Hanson, Cristiana Abbafati, Joachim G. Aerts, Ziyad Al-Aly, Charlie Ashbaugh, Tala Ballouz, Oleg Blyuss, Polina Bobkova, Gouke Bonsel, Svetlana Borzakova, Danilo Buonsenso, Denis Butnaru, Austin Carter, Helen Chu, Cristina De Rose, Mohamed Mustafa Diab, Emil Ekbom, Maha El Tantawi, Victor Fomin, Robert Frithiof, Aysylu Gamirova, Petr Glybochko, Juanita A. Haagsma, Shaghayegh Haghjooy Javanmard, Erin B. Hamilton, Gabrielle Harris, Majanka H. Heijenbrok-Kal, Raimund Helbok, Merel E. Hellemons, David Hillus, Susanne M. Huijts, Michael Hultstrom, Waasila Jassat, Florian Kurth, Ing-Marie Larsson, Miklos Lipcsey, Chelsea Liu, Callan D. Loflin, Andrei Malinovschi, Wenhui Mao, Lyudmila Mazankova, Denise McCulloch, Dominik Menges, Noushin Mohammadifard, Daniel Munblit, Nikita A. Nekliudov, Osondu Ogbuoji, Ismail M. Osmanov, Jose L. Penalvo, Maria Skaalum Petersen, Milo A. Puhan, Mujibur Rahman, Verena Rass, Nickolas Reinig, Gerard M. Ribbers, Antonia Ricchiuto, Sten Rubertsson, Elmira Samitova, Nizal Sarrafzadegan, Anastasia Shikhaleva, Kyle E. Simpson, Dario Sinatti, Joan B. Soriano, Ekaterina Spiridonova, Fridolin Steinbeis, Andrey A. Svistunov, Piero Valentini, Brittney J. van de Water, Rita Van den Berg-Emons, Ewa Wallin, Martin Witzenrath, Yifan Wu, Hanzhang Xu, Thomas Zoller, Christopher Adolph, James Albright, Joanne O. Amlag, Aleksandr Y. Aravkin, Bree L. Bang-Jensen, Catherine Bisignano, Rachel Castellano, Emma Castro, Suman Chakrabarti, James K. Collins, Xiaochen Dai, Farah Daoud, Carolyn Dapper, Amanda Deen, Bruce B. Duncan, Megan Erickson, Samuel B. Ewald, Alize J. Ferrari, Abraham D. Flaxman, Nancy Fullman, Amiran Gamkrelidze, John R. Giles, Gaorui Guo, Simon Hay, Jiawei He, Monika Helak, Erin N. Hulland, Maia Kereselidze, Kris J. Krohn, Alice Lazzar-Atwood, Akiaja Lindstrom, Rafael Lozano, Deborah Carvalho Malta, Johan Mansson, Ana M. Mantilla Herrera, Ali H. Mokdad, Lorenzo Monasta, Shuhei Nomura, Maja Pasovic, David M. Pigott, Robert C. Reiner Jr, Grace Reinke, Antonio Luiz P. Ribeiro, Damian Francesco Santomauro, Aleksei Sholokhov, Emma Elizabeth Spurlock, Rebecca Walcott, Ally Walker, Charles Shey Wiysonge, Peng Zheng, Janet Prvu Bettger, Christopher J. L. Murray, Theo Vos
Summary: This study estimated the proportion and duration of Long COVID symptoms in individuals with symptomatic SARS-CoV-2 infection in 2020 and 2021. The results showed differences in the prevalence and duration of Long COVID symptoms across different age and gender groups.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2022)
Review
Microbiology
Eric J. Chow, Timothy M. Uyeki, Helen Y. Chu
Summary: The COVID-19 pandemic has significantly affected global respiratory virus infections, with varying degrees of changes seen in different virus types. Non-pharmaceutical interventions have been implemented by governments, with differences observed after the availability of COVID-19 vaccines. Reductions in respiratory virus infections have resulted in decreased hospitalizations and deaths associated with these infections.
NATURE REVIEWS MICROBIOLOGY
(2023)
Article
Multidisciplinary Sciences
Young-Jun Park, Dora Pinto, Alexandra C. Walls, Zhuoming Liu, Anna De Marco, Fabio Benigni, Fabrizia Zatta, Chiara Silacci-Fregni, Jessica Bassi, Kaitlin R. Sprouse, Amin Addetia, John E. Bowen, Cameron Stewart, Martina Giurdanella, Christian Saliba, Barbara Guarino, Michael A. Schmid, Nicholas M. Franko, Jennifer K. Logue, Ha V. Dang, Kevin Hauser, Julia di Iulio, William Rivera, Gretja Schnell, Anushka Rajesh, Jiayi Zhou, Nisar Farhat, Hannah Kaiser, Martin Montiel-Ruiz, Julia Noack, Florian A. Lempp, Javier Janer, Rana Abdelnabi, Piet Maes, Paolo Ferrari, Alessandro Ceschi, Olivier Giannini, Guilherme Dias De Melo, Lauriane Kergoat, Herve Bourhy, Johan Neyts, Leah Soriaga, Lisa A. Purcell, Gyorgy Snell, Sean P. J. Whelan, Antonio Lanzavecchia, Herbert W. Virgin, Luca Piccoli, Helen Y. Chu, Matteo Samuele Pizzuto, Davide Corti, David Veesler
Summary: SARS-CoV-2 Omicron sublineages have spike mutations that allow them to evade antibodies from previous infection or vaccination. Hybrid immunity or booster shots can generate neutralizing antibodies against Omicron variants, and breakthrough infections lead to the production of neutralizing antibodies in the nasal mucosa. Antibodies derived from memory B cells or plasma cells of Omicron breakthrough cases show cross-reactivity with different receptor-binding domains, while primary Omicron infections elicit B cells with narrow specificity. A highly potent pan-variant-neutralizing antibody has been identified as a potential candidate for clinical development.
Article
Immunology
Jason D. Goldman, Kai Wang, Katharina Roltgen, Sandra C. A. Nielsen, Jared C. Roach, Samia N. Naccache, Fan Yang, Oliver F. Wirz, Kathryn E. Yost, Ji-Yeun Lee, Kelly Chun, Terri Wrin, Christos J. Petropoulos, Inyoul Lee, Shannon Fallen, Paula M. Manner, Julie A. Wallick, Heather A. Algren, Kim M. Murray, Jennifer Hadlock, Daniel Chen, Chengzhen L. Dai, Dan Yuan, Yapeng Su, Joshua Jeharajah, William R. Berrington, George P. Pappas, Sonam T. Nyatsatsang, Alexander L. Greninger, Ansuman T. Satpathy, John S. Pauk, Scott D. Boyd, James R. Heath
Summary: Recovery from COVID-19 does not guarantee immunity, as reinfection with a different strain can occur. In this study, we present a case of reinfection with a variant strain carrying the D614G mutation. By analyzing antibodies, B cells, and T cells, we provide evidence of adaptive immunity during reinfection. Our findings have implications for vaccine programs and establishing benchmarks for protection against SARS-CoV-2 reinfection.
Article
Infectious Diseases
Denise J. McCulloch, Julia H. Rogers, Yongzhe Wang, Eric J. Chow, Amy C. Link, Caitlin R. Wolf, Timothy M. Uyeki, Melissa A. Rolfes, Emily Mosites, Jaydee Sereewit, Jeffrey S. Duchin, Nancy K. Sugg, Alexander L. Greninger, Michael J. Boeckh, Janet A. Englund, Jay Shendure, James P. Hughes, Lea M. Starita, Pavitra Roychoudhury, Helen Y. Chu
Summary: Respiratory syncytial virus (RSV) causes disproportionate morbidity and mortality in vulnerable populations. In a study conducted in homeless shelters in Seattle, RSV was detected in 35 out of 15,364 tested specimens, compared to 77 cases of influenza. Both RSV and influenza showed similar symptoms of cough and rhinorrhea, and significantly impacted individuals' ability to perform regular activities.
INFLUENZA AND OTHER RESPIRATORY VIRUSES
(2023)
Article
Virology
Linhui Hao, Tien-Ying Hsiang, Ronit R. Dalmat, Renee Ireton, Jennifer F. Morton, Caleb Stokes, Jason Netland, Malika Hale, Chris Thouvenel, Anna Wald, Nicholas M. Franko, Kristen Huden, Helen Y. Chu, Alex Sigal, Alex L. Greninger, Sasha Tilles, Lynn K. Barrett, Wesley C. Van Voorhis, Jennifer Munt, Trevor Scobey, Ralph S. Baric, David J. Rawlings, Marion Pepper, Paul K. Drain, Michael Gale
Summary: New variants of SARS-CoV-2 continue to emerge and evade immunity. Convalescence from the ancestral virus provides limited protection against variants. Vaccination enhances immunity against viral variants, but the protection is weaker against Omicron BA.1, and a three-dose vaccine regimen provides significantly better protection against it compared to a two-dose.
Article
Immunology
Catherine Liu, Leah H. Yoke, Pooja Bhattacharyya, Ryan D. Cassaday, Guang-Shing Cheng, Zahra Kassamali Escobar, Cristina Ghiuzeli, Denise J. McCulloch, Steven A. Pergam, Pavitra Roychoudhury, Frank Tverdek, Joshua T. Schiffer, Emily S. Ford
Summary: Persistent symptomatic COVID-19 in patients with hematologic cancer and/or profound immunosuppression is challenging to manage. Two patients with symptomatic COVID-19 for almost 6 months were successfully treated in the ambulatory setting with extended courses of nirmatrelvir-ritonavir. B-cell dysfunction may contribute to the persistence of COVID-19 infection in immunosuppressed individuals, and nirmatrelvir/ritonavir could be an effective treatment option.
OPEN FORUM INFECTIOUS DISEASES
(2023)
Article
Immunology
Woody Sorey, Elizabeth M. Krantz, Jessica Morris, John Klaassen, Ania Sweet, Frank Tverdek, Zahra K. Escobar, Denise J. McCulloch, Steven A. Pergam, Catherine Liu
Summary: Among 133 cancer outpatients diagnosed with influenza between 2016 and 2018, 83% were prescribed oseltamivir. Among 109 with a known symptom onset date, 53% presented for care and 31% were prescribed oseltamivir within 48 hours. Patient/provider education and rapid diagnostics are needed to improve early oseltamivir use among cancer patients with influenza.
OPEN FORUM INFECTIOUS DISEASES
(2023)
Article
Multidisciplinary Sciences
Amin Addetia, Luca Piccoli, James Brett Case, Young-Jun Park, Martina Beltramello, Barbara Guarino, Ha Dang, Guilherme Dias de Melo, Dora Pinto, Kaitlin Sprouse, Suzanne M. Scheaffer, Jessica Bassi, Chiara Silacci-Fregni, Francesco Muoio, Marco Dini, Lucia Vincenzetti, Rima Acosta, Daisy Johnson, Sambhavi Subramanian, Christian Saliba, Martina Giurdanella, Gloria Lombardo, Giada Leoni, Katja Culap, Carley Mcalister, Anushka Rajesh, Exequiel Dellota, Jiayi Zhou, Nisar Farhat, Dana Bohan, Julia Noack, Alex Chen, Florian A. Lempp, Joel Quispe, Lauriane Kergoat, Florence Larrous, Elisabetta Cameroni, Bradley Whitener, Olivier Giannini, Pietro Cippa, Alessandro Ceschi, Paolo Ferrari, Alessandra Franzetti-Pellanda, Maira Biggiogero, Christian Garzoni, Stephanie Zappi, Luca Bernasconi, Min Jeong Kim, Laura E. Rosen, Gretja Schnell, Nadine Czudnochowski, Fabio Benigni, Nicholas Franko, Jennifer K. Logue, Courtney Yoshiyama, Cameron Stewart, Helen Chu, Herve Bourhy, Michael A. Schmid, Lisa A. Purcell, Gyorgy Snell, Antonio Lanzavecchia, Michael S. Diamond, Davide Corti, David Veesler
Summary: The recently emerged BQ.1.1 and XBB.1.5 variants of SARS-CoV-2 have a higher affinity for the host ACE2 receptor and more efficiently promote fusion with host cell membranes compared to earlier Omicron variants. Although the neutralizing activity is reduced, vaccine-induced human plasma antibodies still cross-react with and trigger effector functions against current Omicron variants, providing a mechanism of protection against disease.
Article
Infectious Diseases
Collrane Frivold, Denise J. Mcculloch, Seda Ekici, Emily T. Martin, Michael L. Jackson, Helen Y. Chu
Summary: Acute respiratory infections (ARIs) during pregnancy are associated with poor maternal and fetal outcomes. By testing for respiratory viruses among pregnant and non-pregnant individuals, we found differences in virus detection based on pregnancy status.
INFLUENZA AND OTHER RESPIRATORY VIRUSES
(2023)