Article
Immunology
Yingping Wu, Shufa Zheng, Tian Liu, Xueke Liu, Huina Tang, Yutong He, Wei Xu, Lele Li, Wenxu Yu, Ke Xing, Xiaoping Xia
Summary: Whole-genome sequencing analysis of three COVID-19-confirmed patients revealed that the haplotype diversity of SARS-CoV-2 may lead to viral adaptation for persistent shedding in multiple recurrences, impacting the clinical management of COVID-19 patients with long-term hospitalization or cases of recurrence.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Immunology
Fatemeh Fotouhi, Mostafa Salehi-Vaziri, Behrokh Farahmand, Ehsan Mostafavi, Mohammad Hassan Pouriayevali, Tahmineh Jalali, Vahideh Mazaheri, Mona Sadat Larijani, Mahsa Tavakoli, Azita Eshratkhah Mohammadnejad, Neda Afzali, Afsaneh Zokaei, SeyedeAtefe Hosseini, Mohamad Mahdi Mortazavipour, FaridehNiknam Oskouei, Amitis Ramezani
Summary: The study investigated the viral shedding duration and antibody development against SARS-CoV-2 in 255 COVID-19 suspected individuals, finding a median viral shedding duration of 34.16 days and presence of IgG in 84% of patients after 150 days. This suggests that a 14-day isolation period may not be sufficient for proper control, and the persistence of IgG in a majority of patients for nearly 6 months brings hope for vaccine effectiveness and application.
MICROBES AND INFECTION
(2021)
Article
Public, Environmental & Occupational Health
Arwa E. Alsaud, Arun Prabhakaran Nair, Ahmad S. Matarneh, Sreethish Sasi, Rania El Hassan, Fahmi Khan, Peter Coyle, Mohamed Abu Khattab, Mouhand F. H. Mohamed
Summary: COVID-19 is a multi-organ disease that primarily affects the respiratory system, and RT-PCR testing is the preferred method for diagnosis. Patients may shed SARS-CoV-2 for several weeks, and the implications of prolonged viral shedding on management and isolation decisions require further research.
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
(2021)
Article
Virology
Tong-Zeng Li, Zhen-Huan Cao, Yu Chen, Miao-Tian Cai, Long-Yu Zhang, Hui Xu, Jia-Ying Zhang, Chun-Hua Ma, Yang Liu, Li-Juan Gao, Zhong-Hui Duan, Dan-Lei Mou, Lian-Chun Liang
Summary: This study found that corticosteroid treatment, fever (temperature>38.5 degrees C), and longer time from onset to hospitalization were associated with prolonged viral shedding duration in COVID-19 patients.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Virology
Sung Woon Kang, Heedo Park, Ji Yeun Kim, Sunghee Park, So Yun Lim, Sohyun Lee, Joon-Yong Bae, Jeonghun Kim, Seongman Bae, Jiwon Jung, Min Jae Kim, Yong Pil Chong, Sang -Oh Lee, Sang -Ho Choi, Yang Soo Kim, Sung-Cheol Yun, Man-Seong Park, Sung -Han Kim
Summary: This study developed a clinical scoring system to predict viable viral shedding in patients with COVID-19. By identifying clinical predictors, the system provides objective probability of culture-negative state, which could be useful for implementing personalized de-isolation policies.
JOURNAL OF CLINICAL VIROLOGY
(2022)
Article
Virology
Seongman Bae, Ji Yeun Kim, So Yun Lim, Heedo Park, Hye Hee Cha, Ji-Soo Kwon, Mi Hyun Suh, Hyun Jung Lee, Joon Seo Lim, Jiwon Jung, Min Jae Kim, Yong Pil Chong, Sang-Oh Lee, Sang-Ho Choi, Yang Soo Kim, Ho Young Lee, Sohyun Lee, Man-Seong Park, Sung-Han Kim
Summary: The study found that asymptomatic COVID-19 patients have a similar viral load to symptomatic patients during the early stages of the disease, but their infectivity rapidly decreases with the loss of symptoms.
Article
Medicine, General & Internal
Huan Yang, Xiangyu Xi, Weimin Wang, Bing Gu
Summary: The study revealed that COVID-19 patients with gastrointestinal symptoms were more likely to experience fatigue, elevated levels of creatine kinase and lactate dehydrogenase, increased neutrophil-to-lymphocyte ratio, and were at higher risk of developing into severe disease.
FRONTIERS IN MEDICINE
(2021)
Article
Infectious Diseases
Victor C. Passarelli, Klinger Faico-Filho, Luiz Vinicius Leao Moreira, Ana Paula Cunha, Joseane Mayara Almeida Carvalho, Gabriela Rodrigues Barbosa, Clarice Camargo, Danielle D. Conte, Ana H. Perosa, Nancy Bellei
Summary: The universal masking policy in the hospital has proven effective in reducing nosocomial transmissions, but more rigorous protective measures are needed during visitation periods to further reduce the risk of transmission within the hospital.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Cardiac & Cardiovascular Systems
Hui-ru Cao, Xin-yun Zhu, Lin Zhou, Hua Zhang, Bin-bin Gu, Wei Tang, Jian Ding, Jianan Huang, Xing-hua Shen, Cheng Chen
Summary: This retrospective study on 87 hospitalized patients in Suzhou identified excessive cumulative corticosteroid use, hospitalization within 5 days from illness onset, and arbidol-included therapy as independent risk factors for delayed COVID-19 RNA shedding. These findings could help clinicians tailor treatment strategies for patients with delayed viral shedding.
RESPIRATORY MEDICINE
(2021)
Letter
Oncology
Changqian Bao, Xiandong Tao, Wei Cui, Yuanyuan Hao, Shuaike Zheng, Bin Yi, Tiewen Pan, Ken H. Young, Wenbin Qian
Summary: COVID-19 patients are discharged based on two consecutive negative viral RNA tests, improved respiratory symptoms, and obvious absorption of inflammation in pulmonary imaging. Differences in various blood cell counts and infection-related parameters were found between severe and non-severe groups. Higher counts of certain immune cells were associated with faster clearance of the virus and better outcomes.
EXPERIMENTAL HEMATOLOGY & ONCOLOGY
(2021)
Article
Immunology
Yue Zhou, Xuelian Liao, Xiangrong Song, Min He, Fei Xiao, Xiaodong Jin, Xiaoqi Xie, Zhongwei Zhang, Bo Wang, Chenliang Zhou, Yan Kang, Wei Zhang
Summary: During the COVID-19 pandemic, some critically ill patients were unable to be discharged from the ICU despite negative viral tests, leading to a study on the gene expression profiles of peripheral immune cells. The findings showed severely decreased expression of adaptive immunity-related genes in these patients, particularly related to T/B cells and HLA molecules, resulting in long-term secondary infections. No significant change was observed in classic immunosuppression molecules, suggesting that this adaptive immune suppression may be caused by dysregulated host response to severe infection.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Public, Environmental & Occupational Health
N. Esther Babady, Bevin Cohen, Tara McClure, Karin Chow, Mario Caldararo, Krupa Jani, Tracy McMillen, Ying Taur, Monika Shah, Elizabeth Robilotti, Anoshe Aslam, Mini Kamboj
Summary: In this retrospective study, it was found that cancer patients with hematologic malignancy had longer duration of viral shedding and time to attain cycle threshold >30 compared to those with solid tumors, which has important implications for public health.
INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY
(2022)
Article
Public, Environmental & Occupational Health
Jinzhuo Hu, Yang Zhang, Qingqing Xue, Yun Song, Fei Li, Ran Lei, Jinlun Wu, Jinghua Qian
Summary: The study aimed to analyze the early mental health and quality of life of discharged patients with COVID-19 to provide a scientific basis for intervention programs. The results showed that discharged COVID-19 patients experienced higher anxiety and depression rates, as well as decreased quality of life, especially among women. Interventions should focus on strengthening psychological condition and improving physical function, with gender-specific rehabilitation programs to enhance psychological status and quality of life.
FRONTIERS IN PUBLIC HEALTH
(2021)
Article
Medicine, General & Internal
Asuka Ito, Takayuki Okada, Naoki Minato, Fumiyuki Hattori
Summary: This article reported a case of a recovered COVID-19 patient who tested negative for PCR before surgery but tested positive during the operation. Pathological analysis showed the presence of virus-like particles, and cell-based assay revealed a higher concentration of type-I interferons in the patient's serum, indicating ongoing internal viral shedding and immune response after recovery.
FRONTIERS IN MEDICINE
(2022)
Review
Medicine, General & Internal
Kingsley Badu, Kolapo Oyebola, Julien Z. B. Zahouli, Adeniyi Francis Fagbamigbe, Dziedzom K. de Souza, Natisha Dukhi, Ebenezer F. Amankwaa, Mai F. Tolba, Augustina A. Sylverken, Lydia Mosi, Priscilla Kolibea Mante, Damaris Matoke-Muhia, Nowsheen Goonoo
Summary: The evolving nature of SARS-CoV-2 requires periodic revisions of COVID-19 patient treatment and discharge guidelines. The WHO plays a crucial role in handling country-level pandemic preparedness and patient management protocols. Patients can be released from isolation centers on the 10th day following clinical symptom manifestation, with at least 72 additional hours following the resolution of symptoms.
FRONTIERS IN MEDICINE
(2021)
Article
Medicine, Research & Experimental
Qinyue Guo, Lin Xu, Jiali Liu, Huixia Li, Hongzhi Sun, Shufang Wu, Bo Zhou
EXPERIMENTAL BIOLOGY AND MEDICINE
(2017)
Article
Allergy
Qinyue Guo, Huixia Li, Jiali Liu, Lin Xu, Lan Yang, Zhongmin Sun, Bo Zhou
Article
Rheumatology
Qinyue Guo, Ping Fan, Jing Luo, Shufang Wu, Hongzhi Sun, Lan He, Bo Zhou
Article
Cardiac & Cardiovascular Systems
Bowen Lou, Xiao Liang, Yue Wu, Yangyang Deng, Bo Zhou, Zuyi Yuan, Jianqing She
AMERICAN JOURNAL OF CARDIOLOGY
(2018)
Review
Obstetrics & Gynecology
Qinyue Guo, Zhengfei Yang, Jian Guo, Lei Zhang, Lan Gao, Bo Zhou, Qindong Shi
BMC PREGNANCY AND CHILDBIRTH
(2018)
Article
Medicine, Research & Experimental
Jianqing She, Manyun Guo, Hongbing Li, Junhui Liu, Xiao Liang, Peining Liu, Bo Zhou, Simin Liu, Yangyang Deng, Bowen Lou, Chaofeng Sun, Zuyi Yuan, Yue Wu
Article
Medicine, General & Internal
Bowen Lou, Yongbai Luo, Xiang Hao, Lizhe Sun, Yangyang Deng, Manyun Guo, Junhui Liu, Bo Zhou, Zuyi Yuan, Jianqing She
JOURNAL OF INVESTIGATIVE MEDICINE
(2019)
Review
Medicine, Research & Experimental
Bo Zhou, Jianqing She, Lan Yang, Bo Zhu
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
(2020)
Letter
Infectious Diseases
Bo Zhou, Jianqing She, Yadan Wang, Xiancang Ma
JOURNAL OF INFECTION
(2020)
Article
Cardiac & Cardiovascular Systems
Bo Zhou, Jianqing She, Yadan Wang, Xiancang Ma
JOURNAL OF THROMBOSIS AND THROMBOLYSIS
(2020)
Article
Biochemistry & Molecular Biology
Bo Zhou, Yulong Xia, Jianqing She
LIPIDS IN HEALTH AND DISEASE
(2020)
Article
Biochemistry & Molecular Biology
Lin Yang, Liang Wang, Yangyang Deng, Lizhe Sun, Bowen Lou, Zuyi Yuan, Yue Wu, Bo Zhou, Junhui Liu, Jianqing She
LIPIDS IN HEALTH AND DISEASE
(2020)
Article
Multidisciplinary Sciences
Bo Zhou, Bowen Lou, Junhui Liu, Jianqing She
SCIENTIFIC REPORTS
(2020)
Article
Clinical Neurology
Bo Zhou, Jianqing She, Yadan Wang, Xiancang Ma
FRONTIERS IN NEUROLOGY
(2020)
