Review
Microbiology
Jakob J. Malin, Isabelle Suarez, Vanessa Priesner, Gerd Fatkenheuer, Jan Rybniker
Summary: Remdesivir is the first approved treatment for COVID-19, showing therapeutic and prophylactic effects in animal models of various viruses. However, it failed in a clinical trial on ebolavirus disease but showed beneficial effects for patients with COVID-19 in a placebo-controlled trial.
CLINICAL MICROBIOLOGY REVIEWS
(2021)
Article
Medicine, Research & Experimental
Luigi Angelo Vaira, Giovanna Deiana, Jerome R. Lechien, Andrea De Vito, Andrea Cossu, Marco Dettori, Arcadia Del Rio, Sven Saussez, Giordano Madeddu, Sergio Babudieri, Alessandro G. Fois, Clementina Cocuzza, Claire Hopkins, Giacomo De Riu, Andrea Fausto Piana
Summary: This study aimed to evaluate the correlations between the severity and duration of olfactory dysfunctions in COVID-19 patients. The presence of OD does not seem to be useful in identifying super-spreaders or predicting long-term OD development. Similarly, the pathogenesis of OD is probably related to individual factors rather than viral load.
Review
Biochemistry & Molecular Biology
Sabrina Esposito, Gianluca D'Abrosca, Anna Antolak, Paolo Vincenzo Pedone, Carla Isernia, Gaetano Malgieri
Summary: An unprecedented effort is being made by the global scientific community to tackle COVID-19 and understand the role of zinc finger proteins in the disease. This understanding could lead to important therapeutic developments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Tiago Fazolo, Karina Lima, Julia C. Fontoura, Priscila Oliveira de Souza, Gabriel Hilario, Renata Zorzetto, Luiz Rodrigues Junior, Veridiane Maria Pscheidt, Jayme de Castilhos Ferreira Neto, Alisson F. Haubert, Izza Gambin, Aline C. Oliveira, Raissa S. Mello, Matheus de Bastos Balbe E Gutierres, Rodrigo Benedetti Gassen, Lais Durco Coimbra, Alexandre Borin, Rafael Elias Marques, Ivaine Tais Sauthier Sartor, Gabriela Oliveira Zavaglia, Ingrid Rodrigues Fernandes, Helder Nakaya, Fernanda Hammes Varela, Marcia Polese-Bonatto, Thiago J. Borges, Sidia Maria Callegari-Jacques, Marcela Santos Correa da Costa, Jaqueline de Araujo Schwartz, Marcelo Comerlato Scotta, Renato T. Stein, Cristina Bonorino
Summary: The study reveals that children with COVID-19 exhibit stronger cellular immunity but higher viral load compared to adults, suggesting a differential response mechanism between children and adults in the disease manifestation.
NATURE COMMUNICATIONS
(2021)
Review
Virology
Varada Anirudhan, Hyun Lee, Han Cheng, Laura Cooper, Lijun Rong
Summary: The review provides information on potential treatment strategies for COVID-19 that target the essential proteins of the virus, specifically 3CL(pro) and PLpro, which are key in inhibiting viral replication and may offer insights from previous experience with SARS-CoV.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Multidisciplinary Sciences
Viviane Fongaro Botosso, Soraia Attie Calil Jorge, Renato Mancini Astray, Ana Marcia de Sa Guimaraes, Monica Beatriz Mathor, Patricia dos Santos de Carneiro, Edison Luiz Durigon, Dimas Covas, Danielle Bruna Leal de Oliveira, Ricardo das Neves Oliveira, Durvanei Augusto Maria, Silas Fernandes Eto, Neuza Maria Frazatti Gallina, Giselle Pidde, Carla Cristina Squaiella-Baptistao, Dilza Trevisan Silva, Isadora Maria Villas-Boas, Dayanne Carla Fernandes, Aline Vivian Vatti Auada, Alexandre Campos Banari, Antonio Francisco de Souza Filho, Camila Bianconi, Carla Lilian de Agostini Utescher, Denise Cristina Andre Oliveira, Douglas Oscar Ceolin Mariano, Flavia Ferreira Barbosa, Giuliana Rondon, Josana Kapronezai, Juliana Galvao da Silva, Mauricio Barbugiani Goldfeder, Priscila Comone, Regis Edgar Castilho Junior, Taiana Taina Silva Pereira, Fan Hui Wen, Denise Tambourgi, Ana Marisa Chudzinski-Tavassi
Summary: The new outbreak of COVID-19 has caused millions of deaths worldwide. Efforts are being made to find effective treatments, such as using immunoglobulin from immunized animals or plasma from convalescent patients. Clinical trials using anti-SARS-CoV-2 immunoglobulins from horses immunized with spike protein are underway. Researchers have developed an anti-SARS-CoV-2 equine F(ab ')(2) immunoglobulin that successfully neutralizes the virus, is safe in animal models, and reduces the severity of the disease in a hamster model of SARS-CoV-2 infection.
SCIENTIFIC REPORTS
(2022)
Article
Microbiology
Laura Campogiani, Marco Iannetta, Andrea Di Lorenzo, Marta Zordan, Pier Giorgio Pace, Luigi Coppola, Mirko Compagno, Vincenzo Malagnino, Elisabetta Teti, Massimo Andreoni, Loredana Sarmati
Summary: Despite clinical efficacy, there is still conflicting data on the virological effects of SARS-CoV-2 direct antivirals used in clinical practice. This retrospective study compared virologic and laboratory data of patients treated with different antivirals or no direct antiviral drugs. The study found that viral clearance was slower in COVID-19 non-survivors and was not influenced by the antiviral treatment received.
Article
Microbiology
Emily Happy Miller, Medini K. Annavajhala, Alexander M. Chong, Heekuk Park, Yael R. Nobel, Ali Soroush, John W. Blacken, Anna Krigel, Meaghan M. Phipps, Daniel E. Freedberg, AJason Zucker, Ellen D. Sano, Anne-Catrin Uhlemann, Julian A. Abrams
Summary: The study compared the saliva microbiota of COVID-19 patients and controls, finding no significant difference in microbial diversity and composition between the two groups, but identified significant differential abundance of various taxa based on SARS-CoV-2 viral load.
MICROBIOLOGY SPECTRUM
(2021)
Article
Immunology
Nhu Ngoc Nguyen, Linda Houhamdi, Van Thuan Hoang, Jeremy Delerce, Lea Delorme, Philippe Colson, Philippe Brouqui, Pierre-Edouard Fournier, Didier Raoult, Philippe Gautret
Summary: The reinfection rate of SARS-CoV-2 is low, and the severity of the first and second episodes of infection is similar. The severity of the second episode of COVID-19 is not higher than that of the first infection, even for patients with antibodies.
EMERGING MICROBES & INFECTIONS
(2022)
Review
Clinical Neurology
Michael S. Xydakis, Mark W. Albers, Eric H. Holbrook, Dina M. Lyon, Robert Y. Shih, Johannes A. Frasnelli, Axel Pagenstecher, Alexandra Kupke, Lynn W. Enquist, Stanley Perlman
Summary: COVID-19 is often associated with olfactory dysfunction, providing a research opportunity to study the natural course of this neurological finding. However, limited by sample sizes and lack of advanced neuroimaging data, there is still a substantial gap in knowledge regarding the mechanisms of olfactory impairment. Persistent olfactory deficits post-SARS-CoV-2 infection could potentially be a marker for increased long-term risk of neurological disease.
Review
Chemistry, Multidisciplinary
Bo Chen, Puqi Jia, Jie Han
Summary: The characteristics of indoor aerosol particles and their impact on human respiratory infections may increase the risk of COVID-19.
ENVIRONMENTAL CHEMISTRY LETTERS
(2021)
Article
Medicine, Research & Experimental
Salma AlBahrani, Mohammed Alghamdi, Nawaf Zakary, Arulanantham Zechariah Jebakumar, Samirah Jamaan AlZahrani, Mohamed Hany ElGezery, Khaled Omar Abdallah, Jaffar A. Al-Tawfiq
Summary: The connection between initial viral cycle threshold (Ct) values of the SARS-CoV-2 with symptoms and hospital course is not clearly studied. This study aims to examine the relationship between initial Ct values and clinical presentations and outcomes in hospitalized COVID-19 patients.
EUROPEAN JOURNAL OF MEDICAL RESEARCH
(2022)
Article
Microbiology
Christina M. Kackos, Sherri L. Surman, Bart G. Jones, Robert E. Sealy, Trushar Jeevan, Christopher J. H. Davitt, Sergei Pustylnikov, Tamarand L. Darling, Adrianus C. M. Boon, Julia L. Hurwitz, Marcelo M. Samsa, Richard J. Webby
Summary: SARS-CoV-2 continues to disrupt everyday life and cause excess morbidity and mortality worldwide. Vaccination has been key to quelling the impact of this respiratory pathogen, and mRNA vaccines have led the charge on this front. The emergence of SARS-CoV-2 variants has threatened vaccine efficacy, but the mRNA vaccines developed by GreenLight Biosciences have shown robust protective efficacy against the wild-type virus and its variants.
MICROBIOLOGY SPECTRUM
(2023)
Article
Medicine, General & Internal
Rahul Dnyaneshwar Pawar, Lakshman Balaji, Shivani Mehta, Andrew Cole, Xiaowen Liu, Natia Peradze, Anne Victoria Grossestreuer, Mahmoud Salah Issa, Parth Patel, James Edward Kirby, Christopher Francis Rowley, Katherine Margaret Berg, Ari Moskowitz, Michael William Donnino
Summary: In COVID-19 patients, there is no clear association between viral load and disease severity, although viral load was higher in non-intubated ICU patients than in intubated ICU patients.
INTERNAL AND EMERGENCY MEDICINE
(2022)
Article
Immunology
Mar Masia, Guillermo Telenti, Marta Fernandez, Jose A. Garcia, Vanesa Agullo, Sergio Padilla, Javier Garcia-Abellan, Lucia Guillen, Paula Mascarell, Jose C. Asenjo, Felix Gutierrez
Summary: The study found that viral replication determines the magnitude of antibody response to SARS-CoV-2 in COVID-19 patients, which contributes to viral clearance. Some patients are unable to produce antibodies, exhibiting different virological and clinical profiles.
OPEN FORUM INFECTIOUS DISEASES
(2021)
Article
Genetics & Heredity
Ji Hong Park, Jung Min Ko, Min Sun Kim, Man Jin Kim, Moon-Woo Seong, Taekyeong Yoo, Byung Chan Lim, Jong-Hee Chae
Summary: Tay-Sachs disease is a rare lysosomal storage disease caused by mutations in the HEXA gene. Three Korean children were diagnosed with infantile-type TSD through enzyme assay and genetic analysis, showing the importance of fundus examination for early diagnosis of neurodevelopmental regression in children.
MOLECULAR GENETICS & GENOMIC MEDICINE
(2021)
