Article
Genetics & Heredity
Kristina Jevnikar, Luka Lapajne, Daniel Petrovic, Andrej Meglic, Mateja Logar, Natasa Vidovic Valentincic, Mojca Globocnik Petrovic, Ines Cilensek, Polona Jaki Mekjavic
Summary: This study found that the presence of the AGTR2 rs1403543-AA genotype is associated with an increased risk of COVID-19 retinopathy. However, the genotype frequencies of other selected gene polymorphisms are not significantly associated with the presence or severity of COVID-19.
Article
Medical Laboratory Technology
Sadra Mohaghegh, Parisa Motie, Saeed Reza Motamedian
Summary: Studies have found that ACE2 has a protective effect against COVID-19, but the virus can use ACE2 for entry into host cells. The expression of ACE2 can be influenced by factors such as hypertension, diabetes, obesity, and androgens, which may increase the severity of infection. Research on the impact of ACE gene polymorphism is ongoing, with contradictory results reported.
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2021)
Article
Medicine, Research & Experimental
Mauro G. Silva, Gerardo R. Corradi, Juan Perez Duhalde, Myriam Nunez, Eliana M. Cela, Daniel H. Gonzales Maglio, Ana Brizzio, Martin R. Salazar, Walter G. Espeche, Mariela M. Gironacci
Summary: This study found that COVID-19 patients have higher levels of ACE2 expression and enzymatic activity in their blood compared to healthy individuals, while levels of AngII and Ang-(1-7) are lower. Even when excluding COVID-19 patients under RAS blockade treatment, ACE2 expression and enzymatic activity remain higher in COVID-19 patients, suggesting the involvement of RAS in COVID-19.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Multidisciplinary Sciences
Atila Duque Rossi, Joao Locke Ferreira de Araujo, Tailah Bernardo de Almeida, Marcelo Ribeiro-Alves, Camila de Almeida Velozo, Jessica Maciel de Almeida, Isabela de Carvalho Leitao, Samila Natiane Ferreira, Jessica da Silva Oliveira, Hugo Jose Alves, Helena Toledo Scheid, Debora Souza Faffe, Rafael Mello Galliez, Renata Eliane de Avila, Gustavo Gomes Resende, Mauro Martins Teixeira, Orlando da Costa Ferreira Junior, Terezinha Marta P. P. Castineiras, Renan Pedra Souza, Amilcar Tanuri, Renato Santana de Aguiar, Shana Priscila Coutinho Barroso, Cynthia Chester Cardoso
Summary: ACE2 and TMPRSS2 levels are positively correlated with age, which is strongly associated with respiratory distress. Increased ACE2 levels have a protective effect against this outcome, while the TMPRSS2/ACE2 ratio is associated with risk. In modeling COVID-19 severity, the TMPRSS2/ACE2 ratio outperforms ACE2.
SCIENTIFIC REPORTS
(2021)
Review
Cell Biology
Aisha Tabassum, Mohammad Shahid Iqbal, Sadia Sultan, Raghad Ali Alhuthali, Deena Ismail Alshubaili, Raghad Salah Sayyam, Lama Mohammed Abyad, Ahmed H. Qasem, Ahmad F. Arbaeen
Summary: Understanding the interaction between SARS-CoV-2, ACE2, bradykinin, and its metabolite des-Arg9-bradykinin is crucial in understanding the pathogenesis of COVID-19 and developing new treatment approaches.
MEDIATORS OF INFLAMMATION
(2022)
Review
Biochemistry & Molecular Biology
Tomas Rajtik, Peter Galis, Linda Bartosova, Ludovit Paulis, Eva Goncalvesova, Jan Klimas
Summary: This study explores the mechanisms of alternative RAS branches under different types of hypoxic stimuli, including acute, intermittent, and chronic hypoxia, the effects on tissues like the heart, vessels, and lungs, and the clinical relevance of the studied phenomenon. Additionally, it presents future strategies for utilizing alternative RAS as a diagnostic tool and a promising pharmacological target in severe hypoxia-associated cardiovascular and cardiopulmonary diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Genetics & Heredity
Mitra Rezaei, Hadiseh Mohammadpour, Mahya Eftekhari, Mihan Pourabdollah, Farinaz Nasr Azadani, Payam Tabarsi, Majid Marjani, Seyed Ali Ziai
Summary: This study aimed to investigate the correlation between angiotensin I converting enzyme (ACE) insertion/deletion polymorphism and the severity of symptoms in COVID-19 patients. The study found that the ACE D allele was associated with an increased risk of disease severity.
FRONTIERS IN GENETICS
(2022)
Article
Medicine, Research & Experimental
Shilong Li, Rangaprasad Sarangarajan, Tomi Jun, Yu-Han Kao, Zichen Wang, Ke Hao, Emilio Schadt, Michael A. Kiebish, Elder Granger, Niven R. Narain, Rong Chen, Eric E. Schadt, Li Li
Summary: The study found that the use of ACE-I/ARB during hospitalization was significantly associated with a reduced in-hospital mortality rate in COVID-19 positive African American patients. Specifically, ARB hospital use was significantly associated with reduced in-hospital mortality in the African American population.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Review
Immunology
Jieqiong Wang, Huiying Zhao, Youzhong An
Summary: ACE2 is a crucial component of the RAS and serves as the receptor for SARS-COV-2. The role of sACE2 in the pathology of the disease is not completely understood. Recent studies have shown that sACE2 also acts as a receptor for SARS-COV-2 and elevated concentrations of sACE2 are associated with the disease. Recombinant human ACE2 may be a potential treatment for COVID-19, but further research is needed.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Critical Care Medicine
Genevieve L. Y. Rocheleau, Terry Lee, Yassene Mohammed, David Goodlett, Kevin Burns, Matthew P. Cheng, Karen Tran, David Sweet, John Marshall, Arthur S. Slutsky, Srinivas Murthy, Joel Singer, David M. Patrick, Bin Du, Zhiyong Peng, Todd C. Lee, John H. Boyd, Keith R. Walley, Francois Lamontagne, Robert Fowler, Brent W. Winston, Greg Haljan, Donald C. Vinh, Alison McGeer, David Maslove, Santiago Perez Patrigeon, Puneet Mann, Kathryn Donohoe, Geraldine Hernandez, James A. Russell
Summary: This study examined the effects of angiotensin receptor blockers (ARBs) and angiotensin-converting enzyme (ACE) inhibitors in hospitalized COVID-19 patients, focusing on gender differences. The results showed that ARBs were associated with reduced use of ventilation and vasopressors in male patients, but not in female patients. Additionally, sex-based differences in the renin-angiotensin system (RAS) components may contribute to variations in outcomes and responses to ARBs in COVID-19.
CRITICAL CARE MEDICINE
(2022)
Article
Endocrinology & Metabolism
Joshua R. Cook, John Ausiello
Summary: SARS-CoV-2 virus primarily uses ACE2 as its main receptor, associated with the renin-angiotensin system. ACE2 deficiency may contribute to the multisystem dysfunction of COVID-19, leading to angiotensin imbalance.
REVIEWS IN ENDOCRINE & METABOLIC DISORDERS
(2022)
Article
Multidisciplinary Sciences
Seiji Hamada, Tomoharu Suzuki, Yasuharu Tokuda, Kiyosu Taniguchi, Kenji Shibuya
Summary: Continued use of Renin-Angiotensin-Aldosterone inhibitors in COVID-19 patients may lead to better clinical outcomes. However, it is still unknown whether ACEi or ARB is superior in terms of clinical outcomes. A retrospective study in Japan found that ARB had potential in reducing hospital stay duration, but did not significantly reduce in-hospital mortality compared to ACEi. Further prospective studies are needed to draw a definitive conclusion.
SCIENTIFIC REPORTS
(2023)
Review
Cell Biology
Zheng Ma, Mei-Ping Wang, Lian Liu, Shuang Yu, Tian-Ran Wu, Lei Zhao, Ye-Ping Zhang, Hai-Feng Liang, Xin-Chun Yang
Summary: The meta-analysis suggests that the use of ACEI/ARB may increase the risk of COVID-19 infection in the general population, but not in hypertensive individuals. Additionally, ACEI/ARB usage was not associated with adverse outcomes in COVID-19 patients.
Article
Medicine, General & Internal
Michael A. Puskarich, Nicholas E. Ingraham, Lisa H. Merck, Brian E. Driver, David A. Wacker, Lauren Page Black, Alan E. Jones, Courtney Fletcher, Andrew M. South, Thomas A. Murray, Christopher Lewandowski, Joseph Farhat, Justin L. Benoit, Michelle H. Biros, Kartik Cherabuddi, Jeffrey G. Chipman, Timothy W. Schacker, Faheem W. Guirgis, Helen T. Voelker, Joseph S. Koopmeiners, Christopher J. Tignanelli
Summary: This study found that oral administration of losartan did not improve the PaO2:FiO(2) ratio at 7 days in hospitalized patients with COVID-19 and acute lung injury. The use of losartan also did not improve secondary clinical outcomes and resulted in fewer vasopressor-free days compared to placebo.
Article
Multidisciplinary Sciences
Ailiana Santosa, Stefan Franzen, Jonatan Natman, Bjorn Wettermark, Ingela Parmryd, Fredrik Nyberg
Summary: The impact of statins on COVID-19 risk and severity was investigated using Swedish population-based register data. The study found that statin users had lower hospitalization rates and COVID-19 mortality compared to non-users in the general population and among COVID-19 patients.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Majede Rezaei, Mostafa Saadat
BIOCHEMICAL GENETICS
(2019)
Article
Genetics & Heredity
Akram Qasemian-Talgard, Mostafa Saadat
Letter
Medical Laboratory Technology
Mostafa Saadat
CLINICA CHIMICA ACTA
(2020)
Letter
Psychiatry
Fatemeh Zahra Darvishi, Mostafa Saadat
PSYCHIATRY RESEARCH
(2021)
Article
Substance Abuse
Fatemeh Zahra Darvishi, Mostafa Saadat
Summary: This study found that the mRNA levels of hTERT and TERF2 in cells treated with morphine decrease with increasing exposure time, but this alteration is reversible when morphine is removed from the culture medium. Additionally, there was no reduction in the relative expression of hTERT and TERF2 in cells co-treated with N-acetyl cysteine (NAC) and morphine.
DRUG AND ALCOHOL DEPENDENCE
(2021)
Article
Medicine, General & Internal
Mostafa Saadat
Summary: The study revealed a positive correlation between the frequency of the M55 allele and the prevalence and mortality of COVID-19, indicating that countries with higher M55 frequency tend to have higher rates of spread and mortality from the disease.
PROCEEDINGS OF SINGAPORE HEALTHCARE
(2021)
Article
Genetics & Heredity
Mostafa Saadat
EGYPTIAN JOURNAL OF MEDICAL HUMAN GENETICS
(2023)
Article
Genetics & Heredity
Mostafa Saadat
Summary: This study found that in countries with higher rates of consanguineous marriage, the prevalence and mortality of COVID-19 were lower compared to countries with lower rates of marriage between relatives.
EGYPTIAN JOURNAL OF MEDICAL HUMAN GENETICS
(2022)
Article
Genetics & Heredity
Khyber Saify, Mohammad Sarwar Alborz, Mostafa Saadat
Summary: This study found that the Rh- phenotype significantly increased the risk of COVID-19, while the A(-) blood group also greatly increased the risk, with a significant interaction between ABO and Rh.
EGYPTIAN JOURNAL OF MEDICAL HUMAN GENETICS
(2021)
Letter
Biochemistry & Molecular Biology
Mostafa Saadat
Article
Genetics & Heredity
Fariba Boroumand, Iraj Saadat, Mostafa Saadat
EGYPTIAN JOURNAL OF MEDICAL HUMAN GENETICS
(2019)
Article
Genetics & Heredity
Fatemeh Zahra Darvishi, Fariba Boroumand, Mostafa Saadat
Article
Genetics & Heredity
Mostafa Saadat
Article
Genetics & Heredity
Mostafa Saadat
EGYPTIAN JOURNAL OF MEDICAL HUMAN GENETICS
(2020)
