GPR91: expanding the frontiers of Krebs cycle intermediates

Succinate causes α-SMA production through GPR91 activation in hepatic stellate cells

(2015) Ying Hui Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Succinate causes pathological cardiomyocyte hypertrophy through GPR91 activation

(2014) Carla J Aguiar et al.   Cell Communication and Signaling

Targeted Disruption of theSUCNR1Metabolic Receptor Leads to Dichotomous Effects on Obesity

(2014) Kenneth J. McCreath et al.   DIABETES

Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS

(2014) Edward T. Chouchani et al.   NATURE

Inhibition of high glucose-induced VEGF release in retinal ganglion cells by RNA interference targeting G protein-coupled receptor 91

(2013) Jianyan Hu et al.   EXPERIMENTAL EYE RESEARCH

Discovery of a potent and selective small molecule hGPR91 antagonist

(2011) Debnath Bhuniya et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Ischemic neurons prevent vascular regeneration of neural tissue by secreting semaphorin 3A

(2011) J.-S. Joyal et al.   BLOOD

Succinate modulates Ca2+ transient and cardiomyocyte viability through PKA-dependent pathway

(2009) Carla J. Aguiar et al.   CELL CALCIUM

The role of the GPR91 ligand succinate in hematopoiesis

(2009) Yaron Hakak et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Activation of the Succinate Receptor GPR91 in Macula Densa Cells Causes Renin Release

(2009) S. L. Vargas et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Localization of the succinate receptor in the distal nephron and its signaling in polarized MDCK cells

(2009) Joris H. Robben et al.   KIDNEY INTERNATIONAL

Triggering the succinate receptor GPR91 on dendritic cells enhances immunity

(2008) Tina Rubic et al.   NATURE IMMUNOLOGY

The succinate receptor GPR91 in neurons has a major role in retinal angiogenesis

(2008) Przemyslaw Sapieha et al.   NATURE MEDICINE