期刊
CELL CALCIUM
卷 60, 期 2, 页码 74-87出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.ceca.2016.04.005
关键词
Apoptosis; Autophagy; Endoplasmic reticulum; IP3 receptor; Lysosomes; Mitochondria
类别
资金
- Research Fund-Flanders (FWO)
- FWO
- Research Council of the KU Leuven
- Interuniversity Attraction Poles Programmes (Belgian Science Policy)
The endoplasmic reticulum (ER), mitochondria and lysosomes are physically and/or functionally linked, establishing close contact sites between these organelles. As a consequence, Ca2+ release events from the ER, the major intracellular Ca2+-storage organelle, have an immediate effect on the physiological function of mitochondria and lysosomes. Also, the lysosomes can act as a Ca2+ source for Ca2+ release into the cytosol, thereby influencing ER-based Ca2+ signaling. Given the important role for mitochondria and lysosomes in cell survival, cell death and cell adaptation processes, it has become increasingly clear that Ca2+ signals from or towards these organelles impact these processes. In this review, we discuss the most recent insights in the emerging role of Ca2+ signaling in cellular survival by controlling basal mitochondrial bioenergetics and by regulating apoptosis, a mitochondrial process, and autophagy, a lysosomal process, in response to cell damage and cell stress. (C) 2016 Elsevier Ltd. All rights reserved.
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