Review
Cardiac & Cardiovascular Systems
Edoardo Bertero, Jan Dudek, Clement Cochain, Murilo Delgobo, Gustavo Ramos, Brenda Gerull, Takahiro Higuchi, Martin Vaeth, Alma Zernecke, Stefan Frantz, Ulrich Hofmann, Christoph Maack
Summary: The interplay between the cardiovascular system, metabolism, and inflammation plays a central role in the pathophysiology of cardiovascular diseases. This paper provides an overview of the interrelation between inflammation and metabolism, discusses the involvement of disrupted immuno-metabolic interface in cardiovascular disease, and presents new technologies and therapeutic approaches.
CARDIOVASCULAR RESEARCH
(2022)
Article
Cardiac & Cardiovascular Systems
Nadine Godsman, Michael Kohlhaas, Alexander Nickel, Lesley Cheyne, Marco Mingarelli, Lutz Schweiger, Claire Hepburn, Chantal Munts, Andy Welch, Mirela Delibegovic, Marc Van Bilsen, Christoph Maack, Dana K. Dawson
Summary: This study investigates the specific metabolic adaptations in takotsubo patients and their implications for future therapies. The study reveals dysregulation of glucose and lipid metabolic pathways, impaired Ca2+ handling, inflammation, and upregulation of remodeling pathways in the hearts of takotsubo patients. However, the integrity of both mitochondria and cardiomyocytes is preserved.
CARDIOVASCULAR RESEARCH
(2022)
Review
Cardiac & Cardiovascular Systems
Brian Schwartz, Petro Gjini, Deepa M. Gopal, Jessica L. Fetterman
Summary: Mitochondrial abnormalities and dysfunction play a significant role in the development of cardiomyopathies and heart failure. Recent studies have shown that heart failure with preserved ejection fraction may have distinct metabolic characteristics compared to heart failure with reduced ejection fraction. The mitochondrial ecosystem, consisting of intricate metabolic pathways and dynamic changes in mitochondrial networks and subcellular locations, is in delicate balance and disruptions in one component can have widespread effects on cellular pathways. Understanding the mitochondrial ecosystem in heart failure is crucial for developing therapeutics to improve outcomes.
JACC-BASIC TO TRANSLATIONAL SCIENCE
(2022)
Review
Biochemistry & Molecular Biology
Tom Kretzschmar, Jasmine M. F. Wu, P. Christian Schulze
Summary: Heart failure remains the most common cause of death in the industrialized world, and despite new therapeutic interventions, complete prevention of its development and progression is still not possible, highlighting the need for further research to understand the underlying mechanisms. This review provides a detailed overview of the contribution of impaired mitochondrial dynamics and energy homeostasis during heart failure progression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Jane Falconer, Valentina Pucino, Sally A. Clayton, Jennifer L. Marshall, Sabrina Raizada, Holly Adams, Andrew Philp, Andrew R. Clark, Andrew Filer, Karim Raza, Stephen P. Young, Christopher D. Buckley
Summary: The study aims to identify metabolic changes occurring early in inflammatory disease pathogenesis to support sustained cellular activation. Findings show differences in FLS metabolism persisting after ex vivo culture, indicating disease-associated metabolic changes are long-lasting, termed as 'metabolic memory'. This study suggests the potential to modulate mitochondrial function at sites of inflammation to restore cell metabotypes, with implications for treatment of RA and related inflammatory conditions where fibroblasts play a role.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Frank Yu, Bianca McLean, Mitesh Badiwala, Filio Billia
Summary: Cardiovascular disease is the leading cause of mortality globally, with heart failure affecting millions of people. The use of metabolomics and lipidomics has improved our understanding of heart failure and revealed new pathways and potential interventions. The discovery of metabolic effects of heart failure drugs, particularly sodium-glucose transport protein 2 inhibitors, has revolutionized the treatment of heart failure.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Xiaonan Sun, Jalen Alford, Hongyu Qiu
Summary: Mitochondrial remodeling is crucial for maintaining normal cellular function and dysregulation can lead to complex diseases. Understanding the molecular basis and regulatory network of mitochondrial remodeling is important for elucidating the pathogenesis of cardiac diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Yuting Zheng, Andrew A. Gibb, Hongkai Xu, Siqi Liu, Bradford G. Hill
Summary: In this study, we investigated the composition and abundance of mitochondrial supercomplexes in murine cardiac mitochondria. We found that the provision of respiratory substrates and the alteration of the cardiac glucose-fatty acid cycle can influence the levels of supercomplexes. Our findings suggest that the energetic state of the heart plays a regulatory role in supercomplex assembly and stability.
Review
Pharmacology & Pharmacy
Dragan B. Djordjevic, Goran Koracevic, Aleksandar D. Djordjevic, Dragan B. Lovic
Summary: Diabetic cardiomyopathy (DCM) is a complication that is increasingly recognized in clinical practice, characterized by left ventricular dysfunction rather than significant stenosis of coronary blood vessels. Adequate glycemic control is not enough to prevent or slow the progression of DCM, highlighting the importance of new treatment options.
CURRENT VASCULAR PHARMACOLOGY
(2021)
Review
Biology
Christina Schenkl, Estelle Heyne, Torsten Doenst, Paul Christian Schulze, Tien Dung Nguyen
Summary: Despite advances in treating cardiac disorders, heart failure (HF) continues to increase globally and poses a medical and economic burden. HF is characterized by metabolic remodeling in the mitochondria, affecting energy homeostasis, calcium handling, oxidative stress, and inflammation. This study focuses on highlighting mitochondrial metabolic alterations and their impact on the pathophysiology of HF, as well as discussing potential metabolic approaches to improve cardiac function.
Review
Biochemistry & Molecular Biology
Ashley Mulcahy Toney, Darius Fox, Virginia Chaidez, Amanda E. Ramer-Tait, Soonkyu Chung
Summary: UroA, a gut metabolite derived from ellagic acid-containing foods, shows promising therapeutic potential for metabolic diseases by attenuating inflammation in various tissues and potentially delaying the onset of diseases. Recent research highlights the anti-inflammatory properties of UroA and how it may help prevent diseases such as Alzheimer's, diabetes, and fatty liver disease.
Article
Cardiac & Cardiovascular Systems
Yan Deng, Maodi Xie, Qian Li, Xuewen Xu, Wei Ou, Yabing Zhang, Haitao Xiao, Hai Yu, Yanyi Zheng, Yu Liang, Chunling Jiang, Guo Chen, Dan Du, Wen Zheng, Shisheng Wang, Meng Gong, Yaohui Chen, Rong Tian, Tao Li
Summary: This study identified the interplay of mitochondrial hyperacetylation and inflammation as a key driver in HFpEF pathogenesis, and showed that increasing beta-hydroxybutyrate levels can ameliorate the disease by reducing inflammation and mitochondrial dysfunction.
CIRCULATION RESEARCH
(2021)
Review
Cardiac & Cardiovascular Systems
E. Douglas Lewandowski
Summary: Cardiac function relies on efficient metabolic support, which is a dynamic process that adjusts to the demands of the heart. Flux through metabolic pathways provides energy and signaling molecules to meet these demands. Inability of metabolic flux to keep pace with cardiomyocyte demands leads to dysfunction and contributes to cardiac disease. Studying metabolic mechanisms as therapeutic targets and detecting metabolic flux in the heart will provide important insights into cardiac function and disease.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2023)
Review
Oncology
Vicente Javier Clemente-Suarez, Alexandra Martin-Rodriguez, Laura Redondo-Florez, Pablo Ruisoto, Eduardo Navarro-Jimenez, Domingo Jesus Ramos-Campo, Jose Francisco Tornero-Aguilera
Summary: Recent research suggests a strong link between the functioning of mitochondria and the development of cancer. Healthy mitochondria play a vital role in maintaining metabolic processes and controlling cell death, but inflammation can harm their function and lead to tissue damage. Engaging in both endurance and resistance exercises, in addition to maintaining an active lifestyle, can help improve mitochondrial functioning and reduce the risk of cancer.
Review
Cardiac & Cardiovascular Systems
Zhiwei Li, Hongmei Zhao, Jing Wang
Summary: Heart failure patients often have multiple comorbidities, leading to poor prognosis. The reciprocal correlation between comorbidities and HF suggests common causes and biological mechanisms. Metabolism and inflammation play a vital role in the pathophysiological processes, providing opportunities for common therapeutic strategies for HF and comorbidities.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Physiology
Jussara M. do Carmo, Alexandre A. da Silva, Sydney P. Moak, Fernanda S. da Silva, Frank T. Spradley, John E. Hall
Editorial Material
Peripheral Vascular Disease
John E. Hall, Michael E. Hall
Editorial Material
Cardiac & Cardiovascular Systems
Giuseppe Mancia, John E. Hall
CIRCULATION RESEARCH
(2019)
Article
Cardiac & Cardiovascular Systems
Thomas E. Lohmeier, John E. Hall
CIRCULATION RESEARCH
(2019)
Article
Physiology
Zhen Wang, Jussara M. do Carmo, Alexandre A. da Silva, Kandice C. Bailey, Nicola Aberdein, Sydney P. Moak, John E. Hall
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
(2019)
Review
Peripheral Vascular Disease
Alexandre A. da Silva, Jussara M. do Carmo, Zhen Wang, John E. Hall
CURRENT HYPERTENSION REPORTS
(2019)
Review
Cardiac & Cardiovascular Systems
Alexandre A. da Silva, Jussara M. do Carmo, Xuan Li, Zhen Wang, Alan J. Mouton, John E. Hall
CANADIAN JOURNAL OF CARDIOLOGY
(2020)
Review
Peripheral Vascular Disease
Zhen Wang, Jussara M. do Carmo, Alexandre A. da Silva, Yiling Fu, John E. Hall
CURRENT HYPERTENSION REPORTS
(2020)
Article
Peripheral Vascular Disease
Stephen P. Juraschek, Edgar R. Miller, Alexander R. Chang, Cheryl A. M. Anderson, John E. Hall, Lawrence J. Appel
Review
Endocrinology & Metabolism
Alexandre A. da Silva, Jussara M. do Carmo, John E. Hall
CURRENT DIABETES REPORTS
(2020)
Review
Cardiac & Cardiovascular Systems
John E. Hall, Alan J. Mouton, Alexandre A. da Silva, Ana C. M. Omoto, Zhen Wang, Xuan Li, Jussara M. do Carmo
Summary: Obesity contributes significantly to human primary hypertension risk, particularly in driving cardiovascular and kidney diseases, with kidney dysfunction and neurohormonal, renal, and inflammatory mechanisms playing key roles in the development of obesity-induced hypertension.
CARDIOVASCULAR RESEARCH
(2021)
Biographical-Item
Peripheral Vascular Disease
John E. Hall, L. Gabriel Navar, Allen W. Cowley, Richard L. Summers, Robert L. Hester
Editorial Material
Peripheral Vascular Disease
Michael E. Hall, John E. Hall
Article
Multidisciplinary Sciences
Chinni Yalamanchili, Amar G. Chittiboyina, Saqlain Haider, Yelkaira Vasquez, Shabana Khan, Jussara M. do Carmo, Alexandre A. da Silva, Mark Pinkerton, John E. Hall, Larry A. Walker, Ikhlas A. Khan