Review
Biochemistry & Molecular Biology
Dalgisio Lecis, Gianluca Massaro, Daniela Benedetto, Marco Di Luozzo, Giulio Russo, Alessandro Mauriello, Massimo Federici, Giuseppe Massimo Sangiorgi
Summary: Atherosclerotic cardiovascular disease is a common cause of morbidity and death worldwide. It can be controlled through modulation of immune system activity and finding new treatment strategies is of common interest. This review discusses the experimental and clinical data supporting immune-based therapies, specifically vaccination strategies, for lowering cardiovascular risk.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Cardiac & Cardiovascular Systems
Diede Smeets, Anton Gistera, Stephen G. Malin, Dimitrios Tsiantoulas
Summary: B cells play a crucial role in the pathophysiology of atherosclerotic cardiovascular disease, with both protective and harmful functions. Their unique ability to produce and secrete antigen-specific antibodies that can have effects at distant sites is a key factor in the development of atherosclerosis. The atherogenic environment can impact the homeostasis, differentiation, and antibody production of B cells, but it is unclear if their responses are directed by atherosclerosis-specific antigens. Understanding the full spectrum of B cell properties in atherosclerosis is essential for developing innovative therapies.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Jiao Luo, Jesper Qvist Thomassen, Borge G. Nordestgaard, Anne Tybjaerg-Hansen, Ruth Frikke-Schmidt
Summary: This study investigated the associations between neutrophil counts and nine cardiovascular endpoints using observational and genetic approaches. The results showed that high neutrophil counts were associated with an increased risk of all cardiovascular outcomes. Genetic studies also supported this finding. No robust associations were found for other types of leukocytes in the two-sample MR analysis.
EUROPEAN HEART JOURNAL
(2023)
Review
Immunology
Wei Yu, Iqra Ilyas, Xuerui Hu, Suowen Xu, Hui Yu
Summary: Paeoniflorin, a bioactive monomer extracted from P. lactiflora Pall., has shown anti-atherosclerosis effects by regulating inflammation and immune-related pathway dysfunction in vascular endothelial cells, smooth muscle cells, and other cells. It has the potential to be a promising therapeutic agent for the treatment of atherosclerosis and its complications.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, General & Internal
Craig S. Miller, Richard J. Kryscio, Amy L. Doneen, Bradley F. Bale
Summary: This study observed a link between dental infection and circulating levels of inflammation, suggesting that oral infection could be a risk factor for atherosclerotic cardiovascular disease.
AMERICAN JOURNAL OF MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Laura Diez-Ricote, Paloma Ruiz-Valderrey, Victor Mico, Ruth Blanco, Joao Tome-Carneiro, Alberto Davalos, Jose M. Ordovas, Lidia Daimiel
Summary: Atherosclerosis is strongly influenced by lifestyle and can be regulated by the miR-17/92 cluster. TMAO, a metabolite of choline, betaine, and L-carnitine, has been associated with atherosclerosis. This study found that TMAO modulates the expression of the miR-17/92 cluster and increases the expression of target genes related to inflammation and blood clotting, potentially promoting atherosclerosis and cardiovascular disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Hematology
Tarik Zahr, Longhua Liu, Michelle Chan, Qiuzhong Zhou, Bishuang Cai, Ying He, Nicole Aaron, Domenico Accili, Lei Sun, Li Qiang
Summary: This study found that PPARγ deacetylation prevents the development of aging-associated atherosclerosis and hypercholesterolemia. This protective effect may be achieved through suppression of inflammation and promotion of macrophage polarization.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)
Review
Hematology
Megan V. Perkins, Sarah B. Joseph, Dirk P. Dittmer, Nigel Mackman
Summary: HIV infection has transitioned from a fatal disease to a chronic one managed by antiretroviral therapy. However, long-term HIV infection is associated with chronic inflammation, which can lead to cardiovascular disease and thrombosis. More research is needed to understand the mechanisms driving inflammation in PLWH and develop better therapies to reduce chronic inflammation and improve overall mortality.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)
Article
Rheumatology
Daisy Vedder, Martijn Gerritsen, Michael T. Nurmohamed, Ronald F. van Vollenhoven, Christian Lood
Summary: The study revealed elevated levels of neutrophil activation markers, MPO and calprotectin, in gout patients compared to healthy controls. These markers were associated with various risk factors for cardiovascular disease, including hyperlipidemia, hypertension, and diabetes. Furthermore, the presence of a neutrophil activation signature was strongly linked to an increased 10-year risk of cardiovascular mortality in these patients.
Review
Medicine, General & Internal
Linsey J. F. Peters, Alexander Jans, Matthias Bartneck, Emiel P. C. van der Vorst
Summary: Nanomedicine is an emerging field in medicine that utilizes nanoparticles as efficient drug carriers to repair, control, and monitor biological and physiological systems. In the context of cardiovascular diseases, nanomedicine can target cellular receptors or processes related to the disease, offering potential new possibilities for treatment. Clinical trials focusing on nanoparticles in cardiovascular diseases are ongoing, providing insights into this research area.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Cell Biology
Hannah Hinkley, Daniel A. Counts, Elizabeth Voncanon, Michael Lacy
Summary: Atherosclerosis is a chronic inflammatory disease characterized by the accumulation of lipid-rich plaques within arterial walls. T cells play a pivotal role in the pathogenesis of atherosclerosis in which they help orchestrate immune responses and contribute to plaque development and instability. This article discusses the recognition of atherosclerosis-related antigens that may trigger T cell activation and the roles of diverse subsets of T cells in atherosclerosis.
Review
Biochemistry & Molecular Biology
Subhapradha Rangarajan, Davit Orujyan, Patrida Rangchaikul, Mohamed M. Radwan
Summary: Recent research on resolving inflammation in the body is providing new insights for the management of cardiovascular diseases. This narrative review discusses the pathophysiology of atherosclerosis, the discovery of specialized pro-resolving mediators (SPMs), and the potential impact on cardiovascular treatment options. Further research is expected to translate these findings into clinical trials for conditions with an inflammatory basis.
Review
Biochemistry & Molecular Biology
Leticia Gonzalez, Katherine Rivera, Marcelo E. Andia, Gonzalo Martinez Rodriguez
Summary: The IL-1 superfamily of cytokines, consisting of 11 cytokines and 10 receptors, is a crucial regulator of immunity and inflammation. It is tightly regulated through decoy receptor, receptor antagonists, and signaling inhibitors. Inflammation plays a central role in the development of atherosclerosis, and studies have shown the involvement of IL-1 cytokines and receptors in cardiovascular disease pathogenesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Helen Williams, Corinne D. Mack, Stephen C. H. Li, John P. Fletcher, Heather J. Medbury
Summary: Monocytes play a crucial role in cardiovascular disease by infiltrating vessel walls to form atherosclerotic plaques. Different subsets of monocytes, including intermediate and nonclassical, have been associated with CVD and changes in inflammatory markers. Dyslipidemia can impact monocyte proportion and function, with lipid lowering medication showing some effect in reversing these changes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cardiac & Cardiovascular Systems
Timoteo Marchini, Sara Malchow, Lourdes Caceres, Abed Al Hadi El Rabih, Sophie Hansen, Timothy Mwinyella, Lisa Spiga, Sven Piepenburg, Hauke Horstmann, Tijani Olawale, Xiaowei Li, Lucia Sol Mitre, Mark Colin Gissler, Heiko Bugger, Andreas Zirlik, Timo Heidt, Ingo Hilgendorf, Peter Stachon, Constantin von Zur Muehlen, Christoph Bode, Dennis Wolf
Summary: Using a novel assay, this study found that circulating human ApoB auto-antibodies are associated with cardiovascular risk factors but not with the clinical appearance of atherosclerosis. This finding suggests that humoral immune responses against ApoB are shaped by cardiovascular risk factors rather than the disease itself. This tool could be helpful for immune-based risk stratification in clinical atherosclerosis in the future.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Monica Centa, Hong Jin, Lisa Hofste, Sanna Hellberg, Albert Busch, Roland Baumgartner, Nienke J. Verzaal, Sara Lind Enoksson, Ljubica Perisic Matic, Sanjay Boddul, Dorothee Atzler, Daniel Y. Li, Changyan Sun, Goran K. Hansson, Daniel F. J. Ketelhuth, Ulf Hedin, Fredrik Wermeling, Esther Lutgens, Christoph J. Binder, Lars Maegdesfessel, Stephen G. Malin
Article
Biochemistry & Molecular Biology
Magnus Back, Goran K. Hansson
Review
Cardiac & Cardiovascular Systems
Peter Libby, Goran K. Hansson
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2019)
Article
Cardiac & Cardiovascular Systems
Martin Berg, Konstantinos A. Polyzos, Hanna Agardh, Roland Baumgartner, Maria J. Forteza, Ilona Kareinen, Anton Gistera, Gerhard Bottcher, Eva Hurt-Camejo, Goran K. Hansson, Daniel F. J. Ketelhuth
CARDIOVASCULAR RESEARCH
(2020)
Article
Cardiac & Cardiovascular Systems
Arnar Rafnsson, Ljubica Perisic Matic, Mariette Lengquist, Ali Mahdi, Alexey Shemyakin, Gabrielle Paulsson-Berne, Goran K. Hansson, Anders Gabrielsen, Ulf Hedin, Jiangning Yang, John Pernow
Article
Cardiac & Cardiovascular Systems
Urszula Rykaczewska, Bianca E. Suur, Samuel Rohl, Anton Razuvaev, Mariette Lengquist, Maria Sabater-Lleal, Sander W. van der Laan, Clint L. Miller, Robert C. Wirka, Malin Kronqvist, Maria Gonzalez Diez, Mattias Vesterlund, Peter Gillgren, Jacob Odeberg, Jan H. Lindeman, Fabrizio Veglia, Steve E. Humphries, Ulf de Faire, Damiano Baldassarre, Elena Tremoli, Janne Lehtio, Goran K. Hansson, Gabrielle Paulsson-Berne, Gerard Pasterkamp, Thomas Quertermous, Anders Hamsten, Per Eriksson, Ulf Hedin, Ljubica Matic
CIRCULATION RESEARCH
(2020)
Article
Medicine, General & Internal
G. Karadimou, A. Gistera, A. L. Gallina, A. S. Caravaca, M. Centa, M. Salagianni, E. Andreakos, G. K. Hansson, S. Malin, P. S. Olofsson, G. Paulsson-Berne
JOURNAL OF INTERNAL MEDICINE
(2020)
Editorial Material
Cardiac & Cardiovascular Systems
Goran K. Hansson, Jan Nilsson
NATURE REVIEWS CARDIOLOGY
(2020)
Article
Medicine, General & Internal
R. Baumgartner, M. Berg, L. Matic, K. P. Polyzos, M. J. Forteza, S. A. Hjorth, T. W. Schwartz, G. Paulson-Berne, G. K. Hansson, U. Hedin, D. F. J. Ketelhuth
Summary: The study elucidates the potential role of the kynurenine pathway in human atherosclerosis through multiplatform analysis of tissue samples. It reveals that deviation in the kynurenine pathway is associated with an increased probability of developing symptomatic unstable atherosclerotic disease, with important implications for the regulation of vascular inflammation.
JOURNAL OF INTERNAL MEDICINE
(2021)
Article
Hematology
Urszula Rykaczewska, Quanyi Zhao, Peter Saliba-Gustafsson, Mariette Lengquist, Malin Kronqvist, Otto Bergman, Zhiqiang Huang, Kent Lund, Katarina Waden, Zara Pons Vila, Kenneth Caidahl, Josefin Skogsberg, Vladana Vukojevic, Jan H. N. Lindeman, Joy Roy, Goran K. Hansson, Eckardt Treuter, Nicholas J. Leeper, Per Eriksson, Ewa Ehrenborg, Anton Razuvaev, Ulf Hedin, Ljubica Matic
Summary: This study investigated the molecular signatures in carotid plaques stratified by echogenicity and found that gene expression is correlated with plaque stability. The BCLAF1 gene was identified as the most significant gene associated with plaque vulnerability and plays a role in the survival and transdifferentiation of smooth muscle cells (SMCs).
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2022)
Article
Medicine, Research & Experimental
Hildur Arnardottir, Silke Thul, Sven-Christian Pawelzik, Glykeria Karadimou, Gonzalo Artiach, Alessandro L. Gallina, Victoria Mysdotter, Miguel Carracedo, Laura Tarnawski, April S. Caravaca, Roland Baumgartner, Daniel Fj Ketelhuth, Peder S. Olofsson, Gabrielle Paulsson-Berne, Goran K. Hansson, Magnus Back
Summary: Chronic inflammation in atherosclerosis is driven by an imbalance in proinflammatory and proresolving signaling. The human GPR32 receptor plays a crucial role in resolving inflammation and protecting against atherosclerosis in vivo, as evidenced by studies using transgenic mouse models.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Letter
Multidisciplinary Sciences
Goran K. Hansson, Gunnar von Heijne
Article
Cardiac & Cardiovascular Systems
Xintong Jiang, Feilong Wang, Yajuan Wang, Anton Gistera, Joy Roy, Gabrielle Paulsson-Berne, Ulf Hedin, Amir Lerman, Goran K. Hansson, Joerg Herrmann, Zhong-qun Yan
JACC-BASIC TO TRANSLATIONAL SCIENCE
(2019)
Article
Cardiac & Cardiovascular Systems
Suzanne M. Eken, Tinna Christersdottir, Greg Winski, Traimate Sangsuwan, Hong Jin, Ekaterina Chernogubova, John Pirault, Changyan Sun, Nancy Simon, Hanna Winter, Alexandra Backlund, Siamak Haghdoost, Goran K. Hansson, Martin Halle, Lars Maegdefessel
JACC-BASIC TO TRANSLATIONAL SCIENCE
(2019)