Article
Pharmacology & Pharmacy
Talagavadi Channaiah Anudeep, Madhan Jeyaraman, Sathish Muthu, Ramya Lakshmi Rajendran, Prakash Gangadaran, Prabhu Chandra Mishra, Shilpa Sharma, Saurabh Kumar Jha, Byeong-Cheol Ahn
Summary: Alopecia, including scarring and non-scarring types, is a common diagnosis in clinical practice. The most prevalent type is non-scarring alopecia, with androgenetic alopecia and alopecia areata being the majority of cases. Traditional treatments have significant downsides, leading to the exploration of regenerative therapies. Growth factor-rich and stem cell-rich treatments have shown potential, but standardization is lacking. Further understanding and standardization of regenerative cellular therapies for hair restoration are needed.
Review
Biotechnology & Applied Microbiology
Yun-Feng Zhou, Di Zhang, Wan-Ting Yan, Kai Lian, Zheng-Zheng Zhang
Summary: This article reviews the therapeutic potential of multipotent stromal cells (MSCs) in repairing meniscal injuries and discusses the avenues for utilizing these cells. The current progress on biomaterial implants is also reviewed.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Review
Cell Biology
Jayden A. Smith, Alexandra M. Nicaise, Rosana-Bristena Ionescu, Regan Hamel, Luca Peruzzotti-Jametti, Stefano Pluchino
Summary: Multiple sclerosis is a chronic inflammatory disease of the central nervous system characterized by demyelination and axonal degeneration. While current treatments for progressive MS are limited, stem cell transplantation shows promise in providing neurotrophic support, immunomodulation, and cell replacement to combat chronic neuroinflammation.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Ruei-Hong Lin, Hsu-Tung Lee, Chun-An Yeh, Yi-Chin Yang, Chiung-Chyi Shen, Kai-Bo Chang, Bai-Shuan Liu, Hsien-Hsu Hsieh, Hui-Min David Wang, Huey-Shan Hung
Summary: The research shows that using AuNPs at concentrations of 1.25 and 2.5 ppm can enhance cell proliferation, reduce reactive oxygen species generation, and attenuate platelet/monocyte activation. AuNPs can also promote cell adhesion, increase the expression of matrix metalloproteinase (MMP-2/9), decrease cell apoptosis and the release of inflammatory cytokines. Animal model experiments demonstrate that treating with 1.25 and 2.5 ppm AuNPs exhibits better biocompatibility and endothelialization. This suggests that AuNPs can be used as a biocompatible nanomedicine for regeneration research.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Cell Biology
Yuxuan Zhong, Xiang Li, Fanglin Wang, Shoushuai Wang, Xiaohong Wang, Xiaohong Tian, Shuling Bai, Di Miao, Jun Fan
Summary: Recent studies have shown that various exosomes can influence the adipogenic differentiation of stem cells. Exosomes play an important role in promoting tissue regeneration and provide new ideas for adipose tissue engineering research.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Cell Biology
Jayavardini Vasanthan, Narasimman Gurusamy, Sheeja Rajasingh, Vinoth Sigamani, Shivaani Kirankumar, Edwin L. Thomas, Johnson Rajasingh
Summary: Mesenchymal stem cells (MSCs) are multipotent cells with the potential for tissue regeneration, can be easily isolated and cultured in vitro, and have been proven to be valuable for therapy. Quality control parameters, mechanisms of action, and applications in regenerative medicine and tissue engineering are important aspects to consider when utilizing MSCs.
Article
Biochemistry & Molecular Biology
Zhihou Guo, Yaping Zhang, Furong Yan
Summary: Pulmonary fibrosis is a common pathological feature of inflammatory lung diseases, and there is currently no effective clinical treatment. Mesenchymal stem cells are considered to be an ideal cell source for treating pulmonary fibrosis, but further research is needed to optimize the treatment methods and mechanisms of MSC administration.
DNA AND CELL BIOLOGY
(2022)
Review
Cell Biology
Diana M. Carp, Yun Liang
Summary: Mesenchymal stem/stromal cells (MSCs) have great potential for treating autoimmune diseases due to their immunomodulatory properties. Choosing the best universal donor and comparing universal and personalized approaches is crucial. Factors such as MHC matching, age, sex, and biological sources of MSCs can impact therapy outcomes.
Review
Biochemistry & Molecular Biology
Arsinoe C. Thomaidou, Maria Goulielmaki, Antonis Tsintarakis, Panagiotis Zoumpourlis, Marialena Toya, Ioannis Christodoulou, Vassilis Zoumpourlis
Summary: The human body contains multipotent cells known as mesenchymal stem cells (MSCs) that have the potential to self-renew and differentiate into various cell types. MSCs are attractive candidates for therapeutic applications due to their ability to migrate to inflammation sites and their secretion of factors involved in tissue regeneration and immune regulation. MSCs derived from fetal, perinatal, or neonatal tissues possess additional advantages, such as increased proliferation potential, responsiveness to environmental cues, and low immunogenicity. MicroRNAs (miRNAs) play a crucial role in regulating MSC differentiation, and the identification of relevant miRNAs and miRNA signatures can enhance the understanding of MSC biology and aid in the development of regenerative and therapeutic protocols. This review focuses on umbilical cord-derived MSCs (UCMSCs) and discusses their miRNA-guided differentiation and regulatory mechanisms, highlighting their potential applications in treating various diseases and injuries while minimizing adverse events.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell & Tissue Engineering
Naruphong Phunikom, Nittaya Boonmuen, Pakpoom Kheolamai, Kanoknetr Suksen, Sirikul Manochantr, Chairat Tantrawatpan, Duangrat Tantikanlayaporn
Summary: Andrographolide (AP) has been shown to promote proliferation, osteogenic differentiation, and bone formation of placenta-derived mesenchymal stem cells. It may be an effective novel agent for improving placenta-derived MSCs and stem cell-based therapy for bone regeneration. The compound enhances Wnt/beta-catenin signaling and osteoblast-specific gene expressions, promoting bone formation and increasing osteocalcin levels.
STEM CELL RESEARCH & THERAPY
(2021)
Review
Biotechnology & Applied Microbiology
Romina Keshavarz, Sara Olsen, Bethany Almeida
Summary: In this review, the recent progress in the field of treatment for chronic, nonhealing wounds, particularly focusing on the combined MSC-biomaterial therapy, is highlighted. The biomaterial acts as a scaffold to protect MSC and provides stimuli that can direct MSC immunomodulatory behavior. However, there are still challenges in the clinical translation of these therapies.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Songyue Lou, Yongtao Duan, Huizong Nie, Xujie Cui, Jialing Du, Yongfang Yao
Summary: Mesenchymal stem cells (MSCs) have immunomodulatory functions and transplantation potential, making them suitable for the treatment of various diseases. They have broad clinical application prospects in tissue regeneration, immunomodulation, and oncology.
Article
Biochemistry & Molecular Biology
Martyna Smeda, Kerstin M. Galler, Melanie Woelflick, Andreas Rosendahl, Christoph Moehle, Beate Lenhardt, Wolfgang Buchalla, Matthias Widbiller
Summary: Both dental pulp and apical papilla are potential sources of stem cells for regenerative endodontic treatments. This study compared the molecular characteristics of dental pulp stem cells (DPSC) and stem cells from the apical papilla (SCAP). The results showed that both cell types expressed similar mesenchymal stem cell markers and had the ability to differentiate into various lineages. However, differences were observed in the profiles of secreted molecules and gene regulation. Overall, both DPSC and SCAP are suitable for dental pulp tissue engineering from a molecular biological perspective.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Giuliana Minani Bertolino, Marie Maumus, Christian Jorgensen, Daniele Noel
Summary: Extracellular vesicles (EVs) isolated from induced pluripotent stem cells (iMSCs) show promise in regenerative medicine for the treatment of various diseases. However, the heterogeneity between MSC donors may lead to batch-to-batch variability in the use of EVs as cell-free therapeutic agents.
Review
Cell & Tissue Engineering
Ahmed Lotfy, Aya Elgamal, Anna Burdzinska, Ayman A. Swelum, Reham Soliman, Ayman A. Hassan, Gamal Shiha
Summary: Autoimmune hepatitis is a chronic inflammatory liver disease, and adult stem cells (ASCs) have been investigated as potential therapies with positive effects. Hematopoietic stem cells (HSCs) and mesenchymal stem cells (MSCs) interact with immune response pathways and are potentially valuable in treating autoimmune diseases like autoimmune hepatitis.
STEM CELL RESEARCH & THERAPY
(2021)