Article
Chemistry, Organic
Nastja Riemer, Martin Riemer, Mandy Krueger, Guy J. Clarkson, Michael Shipman, Bernd Schmidt
Summary: exo-Methylene-beta-lactams were synthesized in high yields as single isomers in a two-step reaction involving a Heck-type arylation with arene diazonium salts. The Pd-catalyzed coupling reaction showed high exo-regioselectivity and E-stereoselectivity in the beta-hydride elimination step. However, coupling products with aryl iodides, triflates, or bromides were obtained only in low yields due to extensive decomposition of the starting materials at elevated temperatures.
JOURNAL OF ORGANIC CHEMISTRY
(2021)
Article
Chemistry, Organic
Lixia Liu, Bo Luo, Chengming Wang
Summary: A variety of symmetrical thiosulfonates are synthesized through Cu-catalyzed reductive homocoupling of aryl sulfonyl chlorides, using organic amine as a mild reductant and low-cost copper as an effective catalyst. This method features a broad substrate scope and good functional group tolerance, with the thiosulfonate products being able to be converted into diverse functional molecules.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2021)
Article
Chemistry, Inorganic & Nuclear
Zhanhu Ma, Lingling Shan, Xiaoyu Ma, Xiaojun Hu, Yong Guo, Qing-Yun Chen, Chao Liu
Summary: A one-pot procedure for the direct introduction of sulfonyl fluoride groups into arenes from arylamines is developed using K2S2O5 and NFSI as the sulfur dioxide surrogate and fluorine source. It features mild and practical conditions and good functional group tolerance.
JOURNAL OF FLUORINE CHEMISTRY
(2022)
Article
Chemistry, Organic
Rapelly Venkatesh, Adesh Kumar Singh, Yong Rok Lee, Jeyakumar Kandasamy
Summary: The method described involves the preparation of alpha-aryl acetophenones from styryl ethers and aryldiazonium salts, catalyzed by palladium acetate at room temperature without the need for ligand or base. The method is highly attractive in terms of reaction conditions, substrate scope, functional group tolerance, and yields, as demonstrated by the synthesis of alpha-aryl indoles and 3-aryl isocoumarin from styryl ethers.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Lian Yang, Cheng-Pan Zhang
Summary: The thermal and photochemical Balz-Schiemann reaction was revisited in commonly used solvents under catalyst and additive-free conditions. It was found that using low- or non-polar solvents could enhance the fluorination of aryldiazonium tetrafluoroborates, allowing for effective reactions at low temperatures or under visible-light irradiation. PhCl and hexane were identified as cost-effective and reliable solvents for these reactions, providing good to excellent yields of aryl fluorides.
Article
Chemistry, Organic
Fabian Schlimpen, Clotilde Placais, Eliot Starck, Valerie Beneteau, Patrick Pale, Stefan Chassaing
Summary: The potential of copper(I)-zeolite catalysis was evaluated in the synthesis of α-tertiary propargylamines via a three-component KA(2)-coupling, showing efficiency and broad functional group tolerance. In addition, decarboxylative and desilylative methods were successfully used to bypass selectivity issues and achieve sequential one-pot processes under full copper(I)-zeolite catalysis.
JOURNAL OF ORGANIC CHEMISTRY
(2021)
Article
Chemistry, Organic
Ankun Li, Yuxuan Li, Junjie Liu, Jingqi Chen, Kui Lu, Di Qiu, Maurizio Fagnoni, Stefano Protti, Xia Zhao
Summary: This protocol for the synthesis of aryl trifluoromethyl thioethers under visible-light-driven conditions does not require the use of photocatalysts or metal catalysts. It utilizes the unique properties of arylazo sulfones and S-trifluoromethyl arylsulfonothioates as precursors, making the procedure easy to handle.
JOURNAL OF ORGANIC CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Jizhang Chen, Minfeng Chen, Weijun Zhou, Xinwu Xu, Bo Liu, Wenqing Zhang, Chingping Wong
Summary: A facile and time-saving electrochemical etching method is developed to synthesize F-free and Cl-containing Ti3C2Tx. Sonification alone is able to delaminate Ti3C2Tx without using any hazardous organic intercalant. The obtained Ti3C2Tx flakes exhibit suitable size and stability, and show excellent performance in supercapacitors and hybrid capacitors.
Article
Chemistry, Organic
Qijun Pan, Yongan Liu, Wan Pang, Jingjing Wu, Xiaoyu Ma, Xiaojun Hu, Yong Guo, Qing-Yun Chen, Chao Liu
Summary: This paper describes a novel copper-catalyzed synthesis of arenesulfonyl fluorides, using arylhydrazine hydrochlorides as safe precursors of aryl radicals, along with DABSO and NFSI as sulfonyl and fluorine sources, under mild conditions to achieve high yields.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2021)
Article
Chemistry, Physical
Yiyang Liu, Hongliang Bao, Jinrong Yang, Xiao-Bin Fu, Ling Han, Jing Yang, Min Ge, Zheng Jiang, Yu-Ying Huang, Yuan Qian, Jian-Qiang Wang, Yi Gao, Hong-Tao Liu
Summary: A method of high dissolution of copper in molten LiCl-KCleutectic salt is reported, which results in the formation of nanoclusters with a few atoms in the salt. These nanoclusters can be frozen and maintained for over one year. By washing the solidified salt, ligand-free subnanometer copper clusters can be obtained, enabling low-cost scaled-up preparation of metal nanoclusters for fundamental research and industrial applications.
CHEMISTRY OF MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Jida Zhang, Xiaomei Feng, Taiyang Guo, Xuliang Han, Haodong Liu, Xiangye Li, Xin Wang, Hansheng Li, Xinjin Li
Summary: A mild and efficient copper-mediated trifluoromethylation method was developed for the synthesis of trifluoromethylated arenes using readily available fluoroform and diaryliodonium salts. The reaction showed excellent functional group tolerance and provided good yields. This approach enables the straightforward incorporation of CF3 group into complex molecules, which is important for drug discovery applications.
Article
Chemistry, Organic
Konstantinos Afratis, Joseph M. Bateman, Benjamin F. Rahemtulla, Oliver Hughes, Benjamin C. Milgram, Thomas A. Mulhern, Eric P. A. Talbot
Summary: The synthesis of fully substituted fused pyrroles through a multicomponent reaction between a thioamide, an aldehyde, and ammonium acetate is reported. This process offers advantages over a frequently used route in patent literature by eliminating the need for potentially hazardous oxidants that lead to the formation of side products and require a stringent derisking process for large-scale applications. The reaction proceeds under mild conditions, exhibits excellent tolerance towards functional groups, and enables diversification through multiple pathways.
Article
Chemistry, Multidisciplinary
Akshay M. Nair, Indranil Halder, Chandra M. R. Volla
Summary: We report a highly selective cascade reaction for the synthesis of highly functionalized dihydrochromenones. The reaction involves arylsulfonylation, radical cyclization, and selenylation of alkynyl cyclohexadienones. Aryldiazonium salts and DABSO are used as reactants, with DABSO also serving as a benign SO2 source and redox mediator. A visible light mediated protocol using diaryliodonium salts as reactants was also developed.
CHEMICAL COMMUNICATIONS
(2022)
Review
Chemistry, Multidisciplinary
Jianli Chen, Xiaoxuan Xie, Jiming Liu, Zhiqun Yu, Weike Su
Summary: Aryl diazonium salts are important in chemical transformations, but their explosive nature restricts their use in batch reactions. Continuous flow technology provides a safer and more efficient way to utilize diazotization and aryl diazonium salts, improving reaction efficiency and industrial potential. However, the transition from batch to continuous flow also presents new challenges.
REACTION CHEMISTRY & ENGINEERING
(2022)
Article
Chemistry, Multidisciplinary
Qixing Lu, Tao Wang, Qian Wu, Lijing Cheng, Han Luo, Lei Liu, Guobiao Chu, Lufeng Wang, Baosheng Li
Summary: In this study, a catalyst-free reaction of beta-OTf-substituted enamides with aromatics was developed to achieve aryl-substituted aza-1,4-dicarbonyl compounds, which can be transformed into aryl-imidazole, aryl-thiazole, and aryl-oxazole. This method provides a simple, efficient, clean, and scalable strategy for C-H heteroarylation of aromatics, and is compatible with various aromatics of varying complexities.
Article
Computer Science, Artificial Intelligence
He Zhang, Qiuhong Chen, Pengbo Ni, Haibo Liang, Min Mao, Jialing Zou
Summary: This paper proposes a method for identifying the lithology of a drilled formation using element and gamma spectrum measurement, as well as establish an intelligent identification model. The field application shows that the accuracy of the proposed method can reach 90.9%, verifying the feasibility of using this approach for intelligent identification of formation lithology during drilling.
NEURAL COMPUTING & APPLICATIONS
(2022)
Article
Cell Biology
Huanjia Gao, Jeremy Bigalke, Enshe Jiang, Yuanyuan Fan, Bojun Chen, Qing-Hui Chen, Zhiying Shan
Summary: The study revealed that TNF alpha can induce inflammatory response in brain neurons and PVN of rats, with Dahl-S rats showing a more significant response to TNF alpha compared to SD rats. This increased inflammatory response in Dahl-S rats may indicate an underlying mechanism for enhanced pressor reactivity to salt intake in the Dahl-S rat model.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2022)
Article
Chemistry, Inorganic & Nuclear
Abdelmoneim Bakur, Hongyun Lu, Tarig Elshaarani, Dafaallah Albashir, Anas Mohammed, Qihe Chen
Summary: This study introduces a green method for fabricating biocomposites using microbial glycolipids, showing strong antioxidant properties and effectiveness in inhibiting the growth of liver cancer cells.
JOURNAL OF CLUSTER SCIENCE
(2022)
Article
Engineering, Environmental
Hua Guo, Jiamiao Chen, Hongxia Zhang, Jingzhi Yao, Nan Sheng, Qi Li, Yong Guo, Chengying Wu, Weidong Xie, Jiayin Dai
Summary: This study investigated the toxicity of GenX and its novel analogs compared to PFOA, and found that bile acid metabolism disorder may be a prominent adverse effect induced by exposure to these substances. Additionally, the results showed that PFMO2HpA may be a potential alternative to GenX.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2022)
Article
Architecture
Biao Zhou, Jiazhi Sun, Xukun Sun, Kai Wang, Chen Qingqing, Xuan Wang, Yajun Han
Summary: Chinese historic buildings with wooden structures are prone to fire disasters. The effects of hydrogen fluoride (HF) released during fire suppression on these buildings are unclear. Experimental results show that flame enhancement occurs at the early stage of fire suppression with various types of fire agents.
INTERNATIONAL JOURNAL OF ARCHITECTURAL HERITAGE
(2023)
Article
Biochemical Research Methods
Ping Yu, Xinxin Wang, Jian Ma, Qili Zhang, Qingwei Chen
Summary: This study investigated the chaperone-assisted soluble expression of high molecular weight chitinase chiZJ408 in Escherichia coli BL21 and its optimal conditions for activity. Results showed that introduction of the chaperone GroELS improved the correct folding and solubility of chitinase chiZJ408. Additionally, Mg(2+) and Ca2+ were found to significantly impact the activity of chitinase chiZJ408.
PREPARATIVE BIOCHEMISTRY & BIOTECHNOLOGY
(2022)
Article
Biochemical Research Methods
Min He, Jian Ma, Qingwei Chen, Qili Zhang, Ping Yu
Summary: The study successfully enhanced the production of PLP in E. coli by constructing a recombinant strain, and determined the optimal conditions for production, laying a good foundation for the efficient production of PLP.
PREPARATIVE BIOCHEMISTRY & BIOTECHNOLOGY
(2022)
Review
Chemistry, Applied
Yixin Wu, Yu Li, Yang Wang, Qian Liu, Qingguo Chen, Minghua Chen
Summary: Developing highly foldable batteries with no safety hazard is crucial for portable, wearable, and implantable electric devices. Solid-state batteries, particularly those based on PVDF electrolytes, show great potential, but also face challenges such as lower ionic conductivity and lack of reactive groups. Recent research has focused on gel polymer electrolytes and all solid polymer electrolytes based on PVDF to address these issues.
JOURNAL OF ENERGY CHEMISTRY
(2022)
Article
Chemistry, Organic
Zhanhu Ma, Yongan Liu, Xiaoyu Ma, Xiaojun Hu, Yong Guo, Qing-Yun Chen, Chao Liu
Summary: By utilizing a radical sulfur dioxide insertion and fluorination strategy, we have successfully developed an efficient method for synthesizing aliphatic sulfonyl fluorides. This method utilizes readily available carboxylic acids, a reductant, a sulfur dioxide surrogate, and the electrophilic fluorination reagent NFSI under reduction conditions. The protocol allows for the synthesis of various aliphatic sulfonyl fluorides and is compatible with a wide range of functional groups.
ORGANIC CHEMISTRY FRONTIERS
(2022)
Article
Engineering, Environmental
Jingzhi Yao, Nan Sheng, Yong Guo, Leo W. Y. Yeung, Jiayin Dai, Yitao Pan
Summary: This study discovered new species of PFASs in effluent and surface waters from a fluorochemical industrial zone. A novel compound called C7 HFPO-TA was found to have extremely high concentrations in the effluent and its concentration continued to grow in Taihu Lake. Further research on C7 HFPO-TA is urgently needed.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2022)
Article
Chemistry, Organic
Liping Zheng, Xin Qiu, Zhiwei Xiao, Xiaoyu Ma, Tianzeng Gao, Xiumiao Zhou, Yufei Wang, Yong Guo, Qing-Yun Chen, Chao Liu
Summary: A direct electrophilic difluoroalkylthiolation reaction using methyl 2,2-difluoro-2-(chlorsulfonyl)acetate derived from Chen's reagent is described. The reactions provide high yields of the corresponding difluoroalkylthiolation products and exhibit high functional group compatibility, making it a promising alternative protocol for difluoroalkylthiolation of various heterocycles.
JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Shanwei Guo, Yong Guo, Meiwei Huang, Libo Qian, Zhaoben Su, Qing-Yun Chen, Chengying Wu, Chao Liu
Summary: In this study, two short-chain fluorinated surfactants with ether bonds were synthesized and their surface activity, foam performance, and wettability were measured. The results showed that both surfactants outperformed the alternatives to PFOS in terms of surface activity, foamability, and foam stability.
Article
Chemistry, Organic
Lingling Shan, Zhanhu Ma, Caiyun Ou, Yinxia Cai, Yuyang Ma, Yong Guo, Xiaoyu Ma, Chao Liu
Summary: We developed an efficient palladium-catalyzed fluorosulfonylation reaction using aryl thianthrenium salts, Na2S2O4, and NFSI to prepare aryl sulfonyl fluorides. This one-pot synthesis avoids the separation of aryl thianthrenium salts and has demonstrated practicality through gram-scale synthesis and high yields.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2023)
Article
Education & Educational Research
Guangtian Zhu, Xiaoling Su, Juan Du, Qingwei Chen, Bolong Xiong, Feng-Kuang Chiang
Summary: The study explored the effects of different scaffolds on students' physics problem solving, with MAPS scaffold showing more effective results. Future research will focus on the application of dynamic figures in physics problem-solving.
INTERACTIVE LEARNING ENVIRONMENTS
(2023)
Article
Computer Science, Information Systems
Xuan Hua, Jungang Han, Chen Zhao, Haipeng Tang, Zhuo He, Qinghui Chen, Shaojie Tang, Jinshan Tang, Weihua Zhou
Summary: This paper presents a novel end-to-end ECG signal classification algorithm using a segmentation strategy and 1D Convolutional Neural Networks (CNN). The proposed method achieves high accuracy in classifying different types of heartbeats, reducing the workload of physicians. Experimental results demonstrate better performance compared to state-of-the-art methods.
MULTIMEDIA SYSTEMS
(2022)
