Article
Multidisciplinary Sciences
Weiwei Lin, Rui Niu, Seong-Min Park, Yan Zou, Sung Soo Kim, Xue Xia, Songge Xing, Qingshan Yang, Xinhong Sun, Zheng Yuan, Shuchang Zhou, Dongya Zhang, Hyung Joon Kwon, Saewhan Park, Chan Il Kim, Harim Koo, Yang Liu, Haigang Wu, Meng Zheng, Heon Yoo, Bingyang Shi, Jong Bae Park, Jinlong Yin
Summary: The IGFBP5-ROR1/HER2-CREB signaling axis is a potential therapeutic target for glioblastoma (GBM) to inhibit the invasion capacity and gene expression of GBM stem-like cells (GSCs) and suppress tumor growth.
NATURE COMMUNICATIONS
(2023)
Article
Oncology
Xueran Chen, Wanxiang Niu, Xiaoqing Fan, Haoran Yang, Chenggang Zhao, Junqi Fan, Xuebiao Yao, Zhiyou Fang
Summary: In this study, it was found that Oct4A can impact the tumorigenic activity of glioblastoma and its stability is maintained through palmitoylation. Oct4A palmitoylation helps to integrate Sox4 and Oct4A in the SOX2 enhancement subregion, thereby maintaining the stem performance of glioma stem cells. The study also designed Oct4A palmitoylation competitive inhibitors that can inhibit the self-renewal ability and tumorigenicity of glioma stem cells.
Article
Cell Biology
Mathilde Kerherve, Sara Rosinska, Kilian Trillet, Alya Zeinaty, Magalie Feyeux, Steven Nedellec, Julie Gavard
Summary: Glioblastoma multiforme (GBM) is a rare but devastating brain tumor in adults, with current treatments being generally ineffective. This study focused on a population of self-sustaining transformed cells with stem-like properties (GSCs) within GBM, which play a crucial role in tumor initiation, growth, invasion, and recurrence. An ex vivo model was established to explore the invasive behavior of GSCs, and it was found that the glycoprotein Neuropilin-1 (NRP1) contributes to their spreading and invasion. This study proposes a reliable approach to studying invasive properties of patient glioma cells and identifies NRP1 as a mediator in this malignant process.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Karla Montalban-Hernandez, Cesar Casado-Sanchez, Jose Avendano-Ortiz, Jose Carlos Casalvilla-Duenas, Gloria C. Bonel-Perez, Julia Prado-Montero, Jaime Valentin-Quiroga, Roberto Lozano-Rodriguez, Veronica Terron-Arcos, Fatima Ruiz de la Bastida, Laura Cordoba, Fernando Laso-Garcia, Luke Diekhorst, Carlos del Fresno, Eduardo Lopez-Collazo
Summary: This study successfully generated a new hybrid cell population, named foam hybrid cell (FHC), through co-culture. The FHC exhibited enhanced motility, proliferation, immunomodulation properties, and maintained stemness features. This finding is of great significance for stem cell therapy and regenerative medicine.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Xueliang Li, Zhaowei Sun, Li Wang, Qinlei Wang, Maobing Wang, Jingyun Guo, Haoran Li, Menshou Chen, Guanghua Cao, Yanan Yu, Haochen Zhong, Hao Zou, Kai Ma, Bingyuan Zhang, Guolei Wang, Yujie Feng
Summary: lncRNA ROR1-AS1 is increased in cholangiocarcinoma (CCA), and patients with higher ROR1-AS1 expression have a shorter overall survival period. Knockdown of ROR1-AS1 significantly reduces cell proliferation and inhibits migration in CCA cells. In addition, ROR1-AS1 knockdown cells injected into mice grow slower than normal CCA cells. These results demonstrate that ROR1-AS1 may promote CCA progression and serve as a potential new target for diagnosis and treatment.
Article
Biochemistry & Molecular Biology
Yuanke Liang, Danielle Voshart, Judith T. M. L. Paridaen, Nynke Oosterhof, Dong Liang, Arun Thiruvalluvan, Inge S. Zuhorn, Wilfred F. A. den Dunnen, Guojun Zhang, Haoyu Lin, Lara Barazzuol, Frank A. E. Kruyt
Summary: This study reveals the important role of the cell adhesion molecule CD146 in regulating the aggressiveness of the brain tumor Glioblastoma (GBM). Elevated CD146 levels are correlated with higher tumor grades, poor response to treatment, and worse overall survival. CD146 overexpression enhances mesenchymal and invasive properties, stemness, and radiotherapy resistance in GBM. These findings suggest that CD146 could be a potential therapeutic target for GBM treatment.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Haima Li, Jia Ouyang, Ruen Liu
Summary: The study demonstrated that Platycodin D (PD) suppresses glioma development by regulating the expression of S phase kinase-related protein 2 (Skp2) in GBM cells.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Jen-Fu Yang, Tzu-Min Chen, Hsin-Han Chang, Yu-Ling Tsai, Wen-Chiuan Tsai, Wen-Yen Huang, Cheng-Hsiang Lo, Chun-Shu Lin, Po -Chien Shen, Ying Chen
Summary: This study found that guggulsterone (GS) can inhibit the migration and invasion abilities of glioblastoma multiforme (GBM) cells, and the underlying mechanism may involve degradation by proteasomes and lysosomes.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Oncology
Constantinos Kolliopoulos, Mohamad Moustafa Ali, Casimiro Castillejo-Lopez, Carl-Henrik Heldin, Paraskevi Heldin
Summary: CD44 plays an important role in the progression of glioblastoma multiforme (GBM) by influencing cell growth, stemness, senescence, and interaction with the hyaluronan-enriched microenvironment.
Article
Biochemistry & Molecular Biology
Manjusha Vaidya, Sandeep Sreerama, Maxine Gonzalez-Vega, Jonhoi Smith, Melvin Field, Kiminobu Sugaya
Summary: Glioblastoma multiforme (GBM) possesses cancer stem cells (CSCs) that contribute to its invasiveness, recurrence, and metastasis. The transcriptional profiles of the cancer cells change when cocultured with neural stem cells (NSCs), resulting in upregulation of stemness and drug resistance genes in GBM and triggering NSCs differentiation. Cell-secreted signaling molecules and extracellular vesicles (EVs) are likely involved in the reciprocal communication and transcription modification between GBM and NSCs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Aude Brunel, Sophie Hombourger, Elodie Barthout, Serge Battu, Donat Koegel, Patrick Antonietti, Elise Deluche, Sofiane Saada, Stephanie Durand, Fabrice Lalloue, Marie-Odile Jauberteau, Gaeelle Begaud, Barbara Bessette, Mireille Verdier
Summary: This study demonstrates that silencing autophagy-related genes can enhance the expression of CSC markers and promote proliferation and clonogenicity, enabling tumor cells to bypass treatment. The results highlight the adaptability and plasticity of CSCs in response to autophagy inhibition.
Article
Biochemistry & Molecular Biology
Julia Penas-Martinez, Gines Luengo-Gil, Salvador Espin, Nataliya Bohdan, Carmen Ortega-Sabater, Maria Carmen Rodenas, David Zaragoza-Huesca, Maria Jose Lopez-Andreo, Carme Plasencia, Vicente Vicente, Alberto Carmona-Bayonas, Irene Martinez-Martinez
Summary: Our study reveals the versatile anti-tumor properties of prelatent antithrombin on U-87 MG glioblastoma multiforme cells, inhibiting migration and invasion while having a lesser effect on proliferation. Prelatent antithrombin down-regulated the expression of VEGFA, pSTAT3, and pERK1/2 in U-87 MG cells.
Article
Oncology
Alberto Visioli, Nadia Trivieri, Gandino Mencarelli, Fabrizio Giani, Massimiliano Copetti, Orazio Palumbo, Riccardo Pracella, Maria Grazia Cariglia, Chiara Barile, Luigi Mischitelli, Amata Amy Soriano, Pietro Palumbo, Federico Legnani, Francesco Dimeco, Leonardo Gorgoglione, Graziano Pesole, Angelo L. Vescovi, Elena Binda
Summary: This study demonstrates that distinct pools of GSCs enrich the functional inter-cluster variances in GBM patients. Two novel functional biomarkers that selectively represent GSCs pools were identified, capable of discriminating GBM patient stratification, survival, and drug response. These findings provide the groundwork for personalized diagnostic and prognostic strategies, as well as patient-selective treatment protocols.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Qiong Wu, Anders E. Berglund, Robert J. MacAulay, Arnold B. Etame
Summary: This study identifies BIRC3 as a key regulator of stemness reprogramming in GBM, and demonstrates its role in driving stemness reprogramming through the regulation of BMP4 signaling axis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Ye Yuan, Mengsi Zhang, Guangning Yan, Qinghua Ma, Zexuan Yan, Lihong Wang, Kaidi Yang, Deyu Guo
Summary: Nanog, highly expressed in GBM, plays a critical role in promoting stem-like traits, increasing the expression of cancer stem cell markers, and enhancing sphere formation and migration of GBM cells. Targeting Nanog may have therapeutic benefits in treating GBM.
FRONTIERS IN BIOSCIENCE-LANDMARK
(2021)
Review
Biochemistry & Molecular Biology
Kumaresan Ramanathan, Minale Fekadie, Giri Padmanabhan, Henok Gulilat
Summary: Long noncoding RNAs (lncRNAs) play critical roles in kidney disease development and their dysregulation can lead to various disease processes. Understanding the function and potential application of lncRNAs in kidney disease may provide new diagnostic and therapeutic opportunities. This review provides an overview of lncRNA characteristics, function, and specific studies related to kidney disease treatment.
CELL BIOCHEMISTRY AND FUNCTION
(2024)