Article
Environmental Sciences
Fan Hu, Weifeng Liang, Linke Zhang, Huan Wang, Zimu Li, Yifeng Zhou
Summary: The study found that both BPA and BPS exposure in mice can negatively impact emotion and social interaction, and high-dose exposure can lead to abnormal local neuronal activation. Although BPS has less adverse effects on mice at low doses compared to BPA, there are still risks associated with prolonged high-volume exposure.
Article
Multidisciplinary Sciences
Wouter van Elzelingen, Jessica Goedhoop, Pascal Warnaar, Damiaan Denys, Tara Arbab, Ingo Willuhn
Summary: Dopamine signals in the striatum play a critical role in motivated behavior. The release and modulation of dopamine in different regions of the striatum vary, while prediction-error signals are limited to specific regions.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Neurosciences
Jana Lieberz, Simone G. Shamay-Tsoory, Nira Saporta, Alisa Kanterman, Jessica Gorni, Timo Esser, Ekaterina Kuskova, Johannes Schultz, Rene Hurlemann, Dirk Scheele
Summary: This study aimed to investigate the behavioral and neural correlates of social avoidance in loneliness, revealing that lonely individuals show a distinct pattern of behavioral and neural responsiveness to social decision-making and social feedback compared to social anxiety.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Environmental Sciences
Jinshan Wang, Shizhen Jin, Wenshuang Fu, Yufeng Liang, Yani Yang, Xiaohong Xu
Summary: The study found that pubertal exposure to BPA may affect the actions of both androgens and estrogens in the brain, inhibit the AVP system of social circuits, resulting in impaired social recognition in adult male mice.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Behavioral Sciences
Nicole C. Ferrara, Maya Opendak
Summary: Social behaviors are influenced by the maturation of neural circuits, particularly the basalateral region of the amygdala (BLA), which undergoes significant changes in excitation, inhibition, and dopaminergic modulation. BLA circuits mature and are influenced by dopaminergic systems, guiding transitions from attachment-focused behaviors in infancy to peer-peer interactions in adolescence. Manipulation of these transitions through viral circuit dissection and early adversity paradigms reveals the importance of the BLA in producing age-appropriate social behavior.
NEUROBIOLOGY OF LEARNING AND MEMORY
(2023)
Article
Neurosciences
Xinqi Zhou, Ting Xu, Yixu Zeng, Ran Zhang, Ziyu Qi, Weihua Zhao, Keith M. Kendrick, Benjamin Becker
Summary: Social deficits and dysregulations in dopaminergic midbrain-striato-frontal circuits are common symptoms across psychiatric disorders. The present study investigated the effects of the AT1R antagonist losartan on social reward and punishment processing in humans. The findings suggest that losartan modulates approach-avoidance motivation and emotional salience during social punishment versus social reward by influencing the core nodes of the midbrain-striato-frontal circuits.
JOURNAL OF NEUROSCIENCE
(2023)
Article
Neurosciences
Ryoma Hattori, Nathan G. Hedrick, Anant Jain, Shuqi Chen, Hanjia You, Mariko Hattori, Jun-Hyeok Choi, Byung Kook Lim, Ryohei Yasuda, Takaki Komiyama
Summary: The orbitofrontal cortex mediates meta-reinforcement learning by training mice and deep RL models on a probabilistic reversal learning task, showing that Ca2+/calmodulin-dependent protein kinase II-dependent synaptic plasticity in OFC supports meta-learning for adaptive decision-making.
NATURE NEUROSCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Ornela Kljakic, Helena Janickova, Miguel Skirzewski, Amy Reichelt, Sara Memar, Salah El Mestikawy, Yulong Li, Lisa M. Saksida, Timothy J. Bussey, Vania F. Prado, Marco A. M. Prado
Summary: In the striatum, cholinergic interneurons can release both acetylcholine and glutamate, and their individual and combined contributions to behavior regulation were assessed in mice using reward-based touchscreen tests. Changes in VAChT and VGLUT3 levels have different effects on reward responses, and the simultaneous loss of both vesicular transporters affects dopamine signaling and behavior in a more severe way than the loss of VAChT alone. This shows that the ability of CINs to secrete two different neurotransmitters allows for complex modulation of various behaviors.
Article
Neurosciences
Jessica Goedhoop, Tara Arbab, Ingo Willuhn
Summary: By comparing two different experimental paradigms, this study reveals that dopamine signals contain both reward-related and action-related information. The action component of dopamine release is characterized by sustained signals, which reflect the motivation for appetitive action.
JOURNAL OF NEUROSCIENCE
(2023)
Article
Neurosciences
Adrienne C. Loewke, Adelaide R. Minerva, Alexandra B. Nelson, Anatol C. Kreitzer, Lisa A. Gunaydin
Summary: The dorsomedial prefrontal cortex (dmPFC) plays a key role in controlling defensive behavior through specific top-down projections. The dmPFC-amygdala projection is involved in reflexive fear behavior, while the dmPFC-striatum projection regulates anxious avoidance behavior. These findings provide important insights into the neural mechanisms underlying anxiety disorders.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Biology
Ali Mohebi, Val L. Collins, Joshua D. Berke
Summary: This study investigates the role of cholinergic interneurons (CINs) in the regulation of dopamine (DA) release and its impact on motivated behavior. The findings highlight the crucial influence of CINs on DA dynamics and provide insights into the underlying mechanisms of motivation.
Article
Biochemistry & Molecular Biology
Vsevolod V. V. Nemets, Alex L. L. Deal, Vladislav E. E. Sobolev, Vladimir P. P. Grinevich, Raul R. R. Gainetdinov, Evgeny A. A. Budygin
Summary: The study found that a single exposure to social defeat in rats resulted in profound alterations in dopamine release in the nucleus accumbens, as measured by fast-scan cyclic voltammetry. The defeated rats showed enhanced dopamine responses compared to control animals, which was associated with increased immobility time in the forced swim test. The administration of a dopamine D2 receptor antagonist resulted in increased dopamine release, but the effect was less pronounced in defeated rats compared to control animals. These findings suggest a promising path for understanding the neurobiological mechanisms underlying stress-induced behavioral abnormalities.
Article
Multidisciplinary Sciences
Maxi Becker, Yuhua Yu, Roberto Cabeza
Summary: The affective component of insight can motivate future behavior, such as risky decision making. Insight activates reward-related brain areas, modulating decision making.
SCIENTIFIC REPORTS
(2023)
Article
Clinical Neurology
Fernando Caravaggio, Alexander J. Barnett, Shinichiro Nakajima, Yusuke Iwata, Julia Kim, Carol Borlido, Wanna Mar, Philip Gerretsen, Gary Remington, Ariel Graff-Guerrero
Summary: This study investigated the effects of AMPT-induced dopamine depletion on resting-state functional connectivity of the basal ganglia and canonical resting-state networks in healthy individuals. The results showed reduced connectivity between the caudate and the medial prefrontal cortex, as well as decreased connectivity between several brain regions and the occipital cortex, while increased connectivity was observed between the dorsal caudate and the sensorimotor network. AMPT also significantly decreased self-reported motivation and increased fatigue. Moreover, greater fatigue was associated with reduced connectivity between the substantia nigra and the medial prefrontal cortex, and decreased motivation was correlated with decreased connectivity between the ventral tegmental area and the left sensorimotor cortex.
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Hidekazu Sotoyama, Hiroyoshi Inaba, Yuriko Iwakura, Hisaaki Namba, Nobuyuki Takei, Toshikuni Sasaoka, Hiroyuki Nawa
Summary: Dopamine in the prefrontal cortex has opposing effects on social behavior depending on the duration of its activation. Sustained dopamine activation suppresses social behavior while acute activation enhances it. The duration of social interactions is positively correlated with transient dopamine release and negatively correlated with sustained dopamine increase in the prefrontal cortex. Dopamine levels also modulate neural calcium signaling and c-Fos induction triggered by social stimuli in prefrontal neurons.
