期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 26, 期 40, 页码 8676-8688出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201904699
关键词
anticancer complexes; antimicrobial complexes; bioinorganic chemistry; bioorganometallic chemistry; coordination chemistry
资金
- National Research Foundation (NRF) of South Africa
- ERC [247450]
- EPSRC [EP/F034210/1]
- Royal Society
- Wellcome Trust
- CRUK
- EPSRC [EP/F034210/1] Funding Source: UKRI
Resistance to chemotherapy is a current clinical problem, especially in the treatment of microbial infections and cancer. One strategy to overcome this is to make new derivatives of existing drugs by conjugation to organometallic fragments, either by an appropriate linker, or by direct coordination of the drug to a metal. We illustrate this with examples of conjugated organometallic metallocene sandwich and half-sandwich complexes, Ru-II and Os-II arene, and Rh-III and Ir-III cyclopentadienyl half-sandwich complexes. Ferrocene conjugates are particularly promising. The ferrocene-chloroquine conjugate ferroquine is in clinical trials for malaria treatment, and a ferrocene-tamoxifen derivative (a ferrocifen) seems likely to enter anticancer trails soon. Several other examples illustrate that organometallic conjugation can restore the activity of drugs to which resistance has developed.
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