Review
Biochemistry & Molecular Biology
Chiara Mazziotta, Carmen Lanzillotti, Maria Rosa Iaquinta, Francesca Taraballi, Elena Torreggiani, John Charles Rotondo, Lucia Oton-Gonzalez, Elisa Mazzoni, Francesca Frontini, Ilaria Bononi, Monica De Mattei, Mauro Tognon, Fernanda Martini
Summary: MSCs are important source for bone regeneration and play a crucial role in osteogenic differentiation. MiRNAs regulate gene expression in osteogenic differentiation of MSCs and are involved in controlling important signaling pathways such as TGF-beta/BMP and Wnt/beta-catenin.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Sepideh Saghati, cigir Biray Avci, Ayla Hassani, Sajed Nazifkerdar, Hassan Amini, Solmaz Saghebasl, Mahdi Mahdipour, Behnaz Banimohamad-Shotorbani, Atieh Rezaei Namjoo, Fateme Nazary Abrbekoh, Reza Rahbarghazi, Hamid Tayefi Nasrabadi, Ali Baradar Khoshfetrat
Summary: This study investigated the osteogenic properties of phenolated alginate hydrogel containing collagen and nano-hydroxyapatite on human mesenchymal stem cells. The results showed that the combination of alginate/collagen/nano-hydroxyapatite had suitable mechanical features and promoted cell viability, osteoblast differentiation, and new bone formation through involving the Wnt signaling pathway.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Review
Biochemistry & Molecular Biology
Natalia Todosenko, Igor Khlusov, Kristina Yurova, Olga Khaziakhmatova, Larisa Litvinova
Summary: The major challenges in Osteosarcoma (OS) therapy are its heterogeneity and drug resistance. The search for specific molecular targets and promising innovative approaches, including drug delivery methods, is urgently needed. This review focuses on signaling pathways and miRNAs involved in the development of OS and describes the role of MSCs in oncogenesis and their potential for antitumor cell-based therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Cell Biology
Ekaterina Sergeevna Novoseletskaya, Pavel Vladimirovich Evdokimov, Anastasia Yurievna Efimenko
Summary: The extracellular matrix plays a crucial role in regulating cell behavior and fate in stem cell microenvironments. Different types of stem cells possess molecules that interact with the extracellular matrix and cause changes in gene expression. Signals from the extracellular matrix are important for embryonic and postnatal development, as well as tissue renewal and repair. Various methods are used to study the cellular signaling networks from the extracellular matrix and predict the pathways in target cells.
CELL COMMUNICATION AND SIGNALING
(2023)
Article
Biochemistry & Molecular Biology
Ting-Wei Kao, Arthur Chiou, Keng-Hui Lin, Yi-Shiuan Liu, Oscar Kuang-Sheng Lee
Summary: Research shows that mechanical stimulation affects the intracellular viscoelasticity of human mesenchymal stem cells, with cells cultured in rigid matrix displaying higher elastic and viscous moduli. This effect remains consistent throughout the differentiation process.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Dentistry, Oral Surgery & Medicine
Rogerio S. Ferreira, Rahyza I. F. Assis, Georgia da S. Feltran, Iasmin Caroline do Rosario Palma, Beatriz G. Francoso, Willian F. Zambuzzi, Denise C. Andia, Rodrigo A. da Silva
Summary: The study investigated the impact of individual epigenetic and transcriptional profiles on osteogenic potential using mesenchymal cells from periodontal ligament. Results showed distinct epigenetic and transcriptional differences among PDLCs, which were maintained after osteogenic induction. These findings suggest that individual donor characteristics have a significant impact on the acquisition of the osteogenic phenotype.
JOURNAL OF PERIODONTOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Haoran Li, Wuling Zhou, Shiwei Sun, Tianlong Zhang, Tieqi Zhang, Haitian Huang, Minghai Wang
Summary: This study found that MFAP5 regulates osteogenesis in BMSCs through the Wnt/beta-catenin and AMPK signaling pathways, and may serve as a therapeutic target for patients with osteoporosis.
MOLECULAR MEDICINE
(2021)
Article
Reproductive Biology
Abbas Sadeghi, Kaveh Khazaeel, Mohammad Reza Tabandeh, Fereshteh Nejaddehbashi, Masoumeh Ezzati Givi
Summary: This study found that crude oil vapor (COV) reduces the proliferation and differentiation of fetal mesenchymal stem cells (fMSCs) through the activation of PI3K and ERK1/2 signaling pathways. Quercetin (QT) treatment increases the proliferation and differentiation of fMSCs in COV-exposed rats.
REPRODUCTIVE TOXICOLOGY
(2023)
Review
Cell Biology
Chao Yang, Maowen Luo, Yu Chen, Min You, Qiang Chen
Summary: MicroRNAs play a critical role in regulating the differentiation of mesenchymal stem cells, providing clues for therapeutic strategies in regenerative medicine and biotherapy for related diseases.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Laidi Wu, Zhixin Liu, Li Xiao, Mi Ai, Yingguang Cao, Jing Mao, Ke Song
Summary: This review comprehensively elucidates the specific roles of Gli1+ MSCs in craniofacial bone osteogenesis and tissue repair, offering new insights into bone regeneration therapy.
Article
Biotechnology & Applied Microbiology
Amber F. MacDonald, Ruby D. Trotter, Christopher D. Griffin, Austin J. Bow, Steven D. Newby, William J. King, Lisa L. Amelse, Thomas J. Masi, Shawn E. Bourdo, Madhu S. Dhar
Summary: This study provides a detailed overview of gene expressions when human mesenchymal stem cells are cultured on graphene surfaces derived from either adipose tissue or bone marrow. Results show that both MSC sources achieved osteogenesis on graphene surfaces by 21 days, but exhibited genetically different responses. Additionally, upregulated angiogenic markers suggest graphene could attract ingrowth of blood vessels in vivo.
JOURNAL OF NANOBIOTECHNOLOGY
(2021)
Article
Cell Biology
Shi-Wei Ren, Guang-Qing Cao, Qing-Run Zhu, Min-Gang He, Fang Wu, Su-Mei Kong, Zhao-Yan Zhang, Qiang Wang, Feng Wang
Summary: This study investigated the function of exosomes derived from human umbilical cord mesenchymal stem cells (HUC-MSCs) in the treatment of postmenopausal osteoporosis. It was found that exosomes can enhance osteogenesis and cell proliferation, with the AKT signaling pathway playing an important role.
Review
Biotechnology & Applied Microbiology
Runyuan Liu, Saixuan Wu, Wanqing Liu, Lina Wang, Ming Dong, Weidong Niu
Summary: Mesenchymal stem cells (MSCs) and their small extracellular vesicles (sEVs) deliver microRNAs (miRNAs) to alter gene expression and enhance bone regeneration.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Multidisciplinary Sciences
Sook-Kyoung Heo, Yunsuk Choi, Yoo Kyung Jeong, Lan Jeong Ju, Ho-Min Yu, Do Kyoung Kim, Hye Jin Seo, Yoo Jin Lee, Jaekyung Cheon, SuJin Koh, Young Joo Min, Eui-Kyu Noh, Jae-Cheol Jo
Summary: Osteoporosis is a progressive skeletal disease affecting millions worldwide, currently treated with drugs that have severe side effects. Cell replacement therapy using mesenchymal stem cells may be a future treatment strategy. This study found that LIGHT can enhance osteogenesis of hBM-MSCs, possibly through WNT/β-catenin pathway activation.
Review
Cell & Tissue Engineering
Armin Ahmadi, Radman Mazloomnejad, Mohammadreza Kasravi, Babak Gholamine, Soheyl Bahrami, Mohammad Mahdi Sarzaeem, Hassan Niknejad
Summary: Bone-related diseases have a significant impact on the health of elderly individuals, and current treatments have limitations and complications. Regenerative medicine using stem cells shows promise in healing bone fractures and skeletal defects. This review discusses the use of small molecules to activate signaling pathways involved in osteogenesis and summarizes recent data on the differentiation of stem cells into bone-forming cells using these molecules.
STEM CELL RESEARCH & THERAPY
(2022)