Article
Multidisciplinary Sciences
SeungHye Han, Minho Lee, Youngjin Shin, Regina Giovanni, Ram P. Chakrabarty, Mariana M. Herrerias, Laura A. Dada, Annette S. Flozak, Paul A. Reyfman, Basil Khuder, Colleen R. Reczek, Lin Gao, Jose Lopez-Barneo, Cara J. Gottardi, G. R. Scott Budinger, Navdeep S. Chandel
Summary: Alveolar epithelial type 1 (AT1) cells are necessary for gas exchange, while alveolar epithelial type 2 (AT2) cells play a role in lung development and repair. In this study, deleting a specific subunit of the mitochondrial electron transport chain complex I in lung epithelial cells led to abnormal alveolar development and death. Restoring NAD(+) regeneration was able to correct the developmental defects and prevent lethality. These findings highlight the importance of mitochondrial complex I-dependent NAD(+) regeneration in directing cell fate during lung development.
Article
Biology
Qiuying Liu, Mariah K. Novak, Rachel M. Pepin, Taylor Eich, Wenqian Hu
Summary: The study reveals that Ago2 is the major developmentally regulated Argonaute protein in mESCs, and Mir182/Mir183 can also repress Ago2. Specific inhibition of this microRNA-mediated repression results in stemness defects and accelerated differentiation.
Article
Microbiology
Xi Chen, Xiaojian Cao, Yingying Lei, Aikebaier Reheman, Wei Zhou, Bing Yang, Weipan Zhang, Weize Xu, Shuang Dong, Rohit Tyagi, Zhen F. Fu, Gang Cao
Summary: Mycobacterium tuberculosis can inhibit lysosome acidification in certain cell lines, but in others, it is targeted to acidified phagolysosomes. The gene profile analysis identified the role of ITGB3 in promoting M. tuberculosis clearance in endothelial cells, suggesting a new defense mechanism against the pathogen.
Article
Biochemistry & Molecular Biology
Kevin Y. L. Ho, Rohan J. Khadilkar, Rosalyn L. Carr, Guy Tanentzapf
Summary: In the Drosophila hematopoietic organ, gap junctions form a network that coordinates fate decisions between blood progenitors, maintaining hematopoietic homeostasis.
Article
Cell Biology
Luca Orlando, Borko Tanasijevic, Mio Nakanishi, Jennifer C. Reid, Juan L. Garcia-Rodriguez, Kapil Dev Chauhan, Deanna P. Porras, Lili Aslostovar, Justin D. Lu, Zoya Shapovalova, Ryan R. Mitchell, Allison L. Boyd, Mickie Bhatia
Summary: Phosphorylation state of HV H2A.X regulates self-renewal and differentiation of human pluripotent stem cells and leukemic progenitors, with potential implications for somatic cancer stem cell control by targeting specific genomic loci.
Article
Cell Biology
Lemonia Chatzeli, Ignacio Bordeu, Seungmin Han, Sara Bisetto, Zahra Waheed, Bon-Kyoung Koo, Maria P. Alcolea, Benjamin D. Simons
Summary: The development of the mouse salivary gland involves a process of branching morphogenesis, in which progenitor cells transition from a multipotent state to unipotent states via two distinct bipotent states. Notch signaling and Kras activation play important roles in promoting specific lineages. These findings provide insights into the mechanisms underlying lineage segregation and ductal patterning.
DEVELOPMENTAL CELL
(2023)
Article
Neurosciences
Himanshu K. Mishra, Atulya D. Mandyam, Wulfran Trenet, Heather Wei, Caroline M. Nievergelt, Adam X. Maihofer, Paul D. Shilling, Martin Alda, Elliot Gershon, John R. Kelsoe, Michael J. McCarthy, Melvin G. McInnis
Summary: Bipolar disorder (BD) is a psychiatric illness characterized by manic and depressive episodes. Lithium is commonly used as a treatment, but only a subset of patients respond to it. This study examined the effects of METH on neuronal cells derived from lithium responder (Li-R) and nonresponder (Li-NR) BD patients, as well as healthy controls. The results showed that Li-R cells were less vulnerable to METH-induced cell death compared to Li-NR cells and controls. Additionally, pre-treatment with a dopamine receptor antagonist reversed the neurotoxic effects of METH. These findings suggest that dopamine signaling and lithium response may play a role in the pathophysiology of BD.
Article
Developmental Biology
Koichi Hasegawa, Takeshi K. Matsui, Junpei Kondo, Ken-ichiro Kuwako
Summary: This study demonstrates the crucial role of N-WASP-Arp2/3 signaling in the maturation of cerebellar Purkinje cell (PC) dendrites in vivo in mice, with proper activation of the signaling pathway being essential for the multiple steps of PC dendrite maturation.
Article
Biology
Charlene Guillot, Yannis Djeffal, Arthur Michaut, Brian Rabe, Olivier Pourquie
Summary: This passage describes the contribution of neuromesodermal progenitors (NMPs) to vertebrate embryonic development, challenging traditional developmental models. The study reveals that NMPs initially act as monopotent progenitors before acquiring a bipotential fate later in the process, playing a crucial role in body formation.
Article
Cell & Tissue Engineering
Adam Ramzy, David M. Thompson, Kirsten A. Ward-Hartstonge, Sabine Ivison, Laura Cook, Rosa Garcia, Jackson Loyal, Peter T. W. Kim, Garth L. Warnock, Megan K. Levings, Timothy J. Kieffer
Summary: This study evaluates the safety and efficacy of implanting pancreatic endoderm cells for treating type 1 diabetes, showing increased C-peptide levels and mature beta cell phenotype in grafts after implantation. The findings provide evidence of meal-regulated insulin secretion by differentiated stem cells in patients.
Article
Biodiversity Conservation
Tine Engedal, Jakob Magid, Veronika Hansen, Jim Rasmussen, Helle Sorensen, Lars Stoumann Jensen
Summary: Cover crops can increase carbon inputs to agricultural soils and mitigate climate change through enhanced soil organic carbon storage. This study investigated the fate of belowground carbon inputs associated with different root traits in mineral-associated organic carbon (MAOC) and particulate organic carbon (POC) pools. Results indicated that root morphology played a key role in determining rhizodeposition carbon, and the remaining MAOC and POC were positively correlated with belowground inputs in absolute terms. Furthermore, the importance of rhizodeposition and root morphology for longer-term carbon stabilization was found to be greater than substrate C:N ratio.
GLOBAL CHANGE BIOLOGY
(2023)
Article
Cell Biology
Stefania Militi, Reshma Nibhani, Morteza Jalali, Siim Pauklin
Summary: The retinoblastoma family proteins (RBs) and E2F transcription factors not only regulate cell cycle progression but also affect cell fate choices. This study reveals that RBs, especially RBL2/p130, repress WNT ligands to direct ectoderm specification. The cooperation between RBs, E2Fs, and GCN5, as well as the temporal fluctuations of WNT/β-catenin and DLL/NOTCH signaling activity, play a crucial role in neuroepithelial and neural crest specification. This non-cell-autonomous function of RBL2-E2F has significant implications for cell fate specification in stem cells, tissue homeostasis, and tumorigenesis.
Article
Developmental Biology
Fion Shiau, Philip A. Ruzycki, Brian S. Clark
Summary: Recent advancements in high throughput single-cell RNA sequencing technology have allowed researchers to simultaneously study the transcriptomic profiles of thousands of individual cells in various species, including the retina. These studies have deepened our understanding of retinal development, progenitor cell competence, cell fate specification, and differentiation, while also pointing out outstanding questions in the field that could soon be addressed with advances in single-cell data generation and analysis.
DEVELOPMENTAL BIOLOGY
(2021)
Review
Gastroenterology & Hepatology
Min-Jiao Pang, Joseph R. Burclaff, Ramon Jin, Mahliyah Adkins-Threats, Luciana H. Osaki, Yunan Han, Jason C. Mills, Zhi-Feng Miao, Zhen-Ning Wang
Summary: This article discusses the research on gastric organoids, with a focus on the advantages of culturing human tissues and the use of mouse organoid models. It introduces the methods for culturing healthy gastric tissue and highlights the applications of organoids in drug screening and precision medicine.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Editorial Material
Gastroenterology & Hepatology
Charles J. Cho, Jason C. Mills
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Medicine, Research & Experimental
Saeed Soleymanjahi, Valerie Blanc, Elizabeth A. Molitor, David M. Alvarado, Yan Xie, Vered Gazit, Jeffrey W. Brown, Kathleen Byrnes, Ta-Chiang Liu, Jason C. Mills, Matthew A. Ciorba, Deborah C. Rubin, Nicholas O. Davidson
Summary: RNA-binding protein 47 (RBM47) plays an important role in embryonic endoderm development, and this study found that it also has implications in adult intestine function. Knockout mice lacking Rbm47 showed increased cell proliferation and abnormal morphology in the intestine, while Rbm47-deficient mice were protected against colitis-associated cancer. The findings suggest that RBM47 is a cell-intrinsic modifier of intestinal growth, inflammatory, and tumorigenic pathways.
Article
Cell Biology
Yongji Zeng, Qing K. Li, Sujayita Roy, Jason C. Mills, Ramon U. Jin
Summary: Plasticity is an important property of the gastrointestinal tract and plays a role in both normal response to injury and cancer development. This study focuses on the development of gastric and esophageal cancers from intestinal metaplasia, and findings indicate that Barrett's esophagus exhibits incomplete intestinal metaplasia with concurrent expression of gastric and intestinal traits. Understanding the molecular pathways involved in the development of these cancers will lead to improved diagnostic and therapeutic approaches.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Gastroenterology & Hepatology
Spencer G. Willet, Nattapon Thanintorn, Helen McNeill, Sung-Ho Huh, David M. Ornitz, Won Jae Huh, Stella G. Hoft, Richard J. DiPaolo, Jason C. Mills
Summary: Acute and chronic gastric injury can lead to pyloric metaplasia, which is characterized by the death of parietal cells and the reprogramming of chief cells into proliferative, mucin-rich metaplasia cells. The transcription factor SOX9 has been identified as a potential regulator of mucous neck and metaplasia cell identity in the stomach. SOX9 is expressed in early gastric progenitors and mature mucous neck cells, and its misexpression can lead to an expansion of mucous gene expression in the gastric epithelium.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Hanwei Huang, Mingyang Liu, Mengchi Sun, Shijie Duan, Siwei Pan, Pengfei Liu, Zhenguo Cheng, Onder Ergonul, Fusun Can, Zhenning Wang, Zhiqing Pang, Funan Liu
Summary: Preventing the interaction between oncolytic adenoviruses (OVs) and key virus-protein corona components in the plasma can significantly prolong circulation time and improve tumor distribution, leading to enhanced antitumor efficacy. This finding provides a new perspective on intravenous delivery of OVs.
Article
Chemistry, Multidisciplinary
Zhonghua Wu, Bicheng Qu, Minxian Yuan, Jingjing Liu, Cen Zhou, Mingwei Sun, Zhexu Guo, Yaqing Zhang, Yongxi Song, Zhenning Wang
Summary: The overexpression of cysteine-rich intestinal protein-1 (CRIP1) in gastric cancer promotes lymphangiogenesis and lymphatic vessel permeability, leading to lymphatic metastasis. This study uncovers the role and mechanism of CRIP1 in mediating gastric cancer lymphatic metastasis, providing potential targets for future therapeutics.
Article
Gastroenterology & Hepatology
Kristina R. Rivera, R. Jarrett Bilton, Joseph Burclaff, Michael J. Czerwinski, Jintong Liu, Jessica M. Trueblood, Caroline M. Hinesley, Keith A. Breau, Halston E. Deal, Shlok Joshi, Vladimir A. Pozdin, Ming Yao, Amanda L. Ziegler, Anthony T. Blikslager, Michael A. Daniele, Scott T. Magness
Summary: This study investigated the effects of hypoxia on human intestinal stem cells using a micro-physiological system. The results showed that hypoxia induces a dormant state in intestinal stem cells, but they can be reactivated by specific interleukins. These findings are important for understanding the mechanisms of intestinal epithelial regeneration caused by inflammatory hypoxia.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Meeting Abstract
Biochemistry & Molecular Biology
Xiaobo Lin, Jason C. Mills, Jeffrey W. Brown
Meeting Abstract
Gastroenterology & Hepatology
Spencer G. Willet, Jason Mills
Meeting Abstract
Gastroenterology & Hepatology
Ramon Jin, Jean S. Wang, Qing K. Li, Jason Mills
Meeting Abstract
Gastroenterology & Hepatology
Xiaobo Lin, Yan Kefalov, Ramon Jin, Jason Mills, Jeffrey W. Brown
Meeting Abstract
Gastroenterology & Hepatology
Charles J. Cho, Jason Mills
