RIPK3 collaborates with GSDMD to drive tissue injury in lethal polymicrobial sepsis

Sepsis: mechanisms of bacterial injury to the patient

(2019) Hayk Minasyan   Scandinavian Journal of Trauma Resuscitation & Emergency Medicine

Dihydromyricetin Alleviates Sepsis-Induced Acute Lung Injury through Inhibiting NLRP3 Inflammasome-Dependent Pyroptosis in Mice Model

(2019) Yu-chang Wang et al.   INFLAMMATION

Inflammasome Activation Triggers Blood Clotting and Host Death through Pyroptosis

(2019) Congqing Wu et al.   IMMUNITY

Inflammatory Response to Different Toxins in Experimental Sepsis Models

(2019) Kayle Dickson et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Caspase-8 Collaborates with Caspase-11 to Drive Tissue Damage and Execution of Endotoxic Shock

(2018) Pratyusha Mandal et al.   IMMUNITY

RIP kinase 1–dependent endothelial necroptosis underlies systemic inflammatory response syndrome

(2018) Matija Zelic et al.   JOURNAL OF CLINICAL INVESTIGATION

The clinical relevance of necroinflammation—highlighting the importance of acute kidney injury and the adrenal glands

(2018) Wulf Tonnus et al.   CELL DEATH AND DIFFERENTIATION

RIPK3-MLKL-mediated necroinflammation contributes to AKI progression to CKD

(2018) Hui Chen et al.   Cell Death & Disease

Pyroptosis versus necroptosis: similarities, differences, and crosstalk

(2018) Daniel Frank et al.   CELL DEATH AND DIFFERENTIATION

The Endotoxin Delivery Protein HMGB1 Mediates Caspase-11-Dependent Lethality in Sepsis

(2018) Meihong Deng et al.   IMMUNITY

Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016

(2017) Andrew Rhodes et al.   INTENSIVE CARE MEDICINE

Caspase-11–mediated endothelial pyroptosis underlies endotoxemia-induced lung injury

(2017) Kwong Tai Cheng et al.   JOURNAL OF CLINICAL INVESTIGATION

Protein kinase D at the Golgi controls NLRP3 inflammasome activation

(2017) Zhirong Zhang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Active MLKL triggers the NLRP3 inflammasome in a cell-intrinsic manner

(2017) Stephanie A. Conos et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Assessment of Global Incidence and Mortality of Hospital-treated Sepsis. Current Estimates and Limitations

(2016) Carolin Fleischmann et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Pyroptosis is driven by non-selective gasdermin-D pore and its morphology is different from MLKL channel-mediated necroptosis

(2016) Xin Chen et al.   CELL RESEARCH

The immune system's role in sepsis progression, resolution, and long-term outcome

(2016) Matthew J. Delano et al.   IMMUNOLOGICAL REVIEWS

Controlled detonation: evolution of necroptosis in pathogen defense

(2016) Michelle Brault et al.   IMMUNOLOGY AND CELL BIOLOGY

Necroptosis in development, inflammation and disease

(2016) Ricardo Weinlich et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

An endogenous caspase-11 ligand elicits interleukin-1 release from living dendritic cells

(2016) Ivan Zanoni et al.   SCIENCE

Programmed necrosis in inflammation: Toward identification of the effector molecules

(2016) D. Wallach et al.   SCIENCE

Disseminated intravascular coagulation

(2016) Satoshi Gando et al.   Nature Reviews Disease Primers

Gasdermin D is an executor of pyroptosis and required for interleukin-1β secretion

(2015) Wan-ting He et al.   CELL RESEARCH

The coagulopathy of acute sepsis

(2015) Jeff Simmons et al.   Current Opinion in Anesthesiology

A Role for Tubular Necroptosis in Cisplatin-Induced AKI

(2015) Y. Xu et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling

(2015) Nobuhiko Kayagaki et al.   NATURE

The diverse role of RIP kinases in necroptosis and inflammation

(2015) John Silke et al.   NATURE IMMUNOLOGY

Systemic Inflammatory Response Syndrome Criteria in Defining Severe Sepsis

(2015) Kirsi-Maija Kaukonen et al.   NEW ENGLAND JOURNAL OF MEDICINE

RIPK3 promotes cell death and NLRP3 inflammasome activation in the absence of MLKL

(2015) Kate E. Lawlor et al.   Nature Communications

Distinct roles of RIP1–RIP3 hetero- and RIP3–RIP3 homo-interaction in mediating necroptosis

(2014) X-N Wu et al.   CELL DEATH AND DIFFERENTIATION

Leukocyte Migration into Inflamed Tissues

(2014) Sussan Nourshargh et al.   IMMUNITY

Systemic inflammatory response syndrome (SIRS)

(2013) Robert A Balk   Virulence

Inhibitor of Apoptosis Proteins Limit RIP3 Kinase-Dependent Interleukin-1 Activation

(2012) James E. Vince et al.   IMMUNITY

Unknown

(2012) Andreas Linkermann et al.   MOLECULAR MEDICINE

The NLRP3 inflammasome in health and disease: the good, the bad and the ugly

(2011) P. Menu et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

RIP Kinase-Dependent Necrosis Drives Lethal Systemic Inflammatory Response Syndrome

(2011) Linde Duprez et al.   IMMUNITY

Programmed necrosis: backup to and competitor with apoptosis in the immune system

(2011) Jiahuai Han et al.   NATURE IMMUNOLOGY

Immunodesign of experimental sepsis by cecal ligation and puncture

(2009) Daniel Rittirsch et al.   Nature Protocols

RIP3, an Energy Metabolism Regulator That Switches TNF-Induced Cell Death from Apoptosis to Necrosis

(2009) D.-W. Zhang et al.   SCIENCE